KEGG   Addendum: AAG02355
Entry
AAG02355          CDS       T10000                                 
Symbol
blmX
Name
(KEGG) nonribosomal peptide synthetase protein BlmX
  KO
K16108  nonribosomal peptide synthetase protein BlmX
Taxonomy
TAX:29309
  Lineage
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces verticillus
SSDB
Motif
Pfam: AMP-binding Condensation AMP-binding_C PP-binding
Other DBs
NCBI-ProteinID: AAG02355
GB: AF210249
UniProt: Q9FB27
LinkDB
AA seq 2162 aa
MPRCARGALSTAVHTTRQGSWNVMETANSGYRVSPQQRHLWAMLTRGRDGGRRAFTQSAV
VVDRSLDAARLRAALASVVAAHEPLRTTFTGLAGRTAPVQVVHDPDEQPLSVVDLPPSCA
DGSGPELDELRLRERAALDPRGGPVFRAALARAGEDRAVLVLTAHALVADRLSLRLLAGQ
ILAAYSGETVSPDGPPPLQYADFAAWHHDLLTAEDAAPDRAHWAAHTATAGTGPLPGVVR
PGAAPGPWRAREWELPAELVAGIDGVAGKLSTDPATVLHAAFRIAVWRLAGERNLPVALT
RDGRSHPELRTAIGAFERELPLVHEIRHETAFAEYARALDALVAEGEELLDHCDPELLGS
LDGTAEGPCFTFTHHQAETPVRRAGITFTTVHQDSGTPIPVRLTARRDGARLRMELGYDE
GRIDETFPENAAACLTRILEGVVSAPEGPVGDIRMLSDETARLLREAGLGPRVELPGKAV
HELFAEQAARTPGAVAVSAGEDALTYAELDERSNRLAHHLTGLGVTPGRHVVVSVGRSAE
LLVGLLGVLKAGGAFVPVDVGFPRKRLEFVLRETAAPVLLCTADVRDRIGTRTLDDAGVT
PVALDADRRRIAAHPAGPTGIATTPDAPAYVVYTSGTTGKPNGVRVPHRGLTNYLTWCTG
AYGLDGGTGTLVHTSISFDLTLTTLFGPLLAGGQVVMLSETAGVTGLIAALRSRRDLTLV
KLTPTHLDVVNQLLTPDELRGAVRTLVVGGEAVRAESLEPFRASGTRVVNEYGPSETVVG
SVAHVVDAATPRTGPVPIGRPIANTTVHLLDQRRRPVPDGVVGELWIGGAGVADGYLGRP
ELTGERFLPSDYPPDGGRVYRTGDLARRRADGTLEYLGRTDAQVKIRGVRVEPAETEAVL
ASHPGVGQAVVVARLDEDPGRSSPLAGELTLTGYVVPARGAQAPPHEELIAYCRERLPEH
FVPAVLVTLDALPVTGHGKIDRGALPKPHARARDGAAYVAPRTATEEILAATVAKVLGVE
RVGIDDNYFVLGGDSIRSVMVASRAQARGVEVTVADLHRHPTVRACAAHLDAREDLPRTP
VTEPFALISAEDRALVPDDVEDAFPLNLLQEGMIFHRDFAAKSAVYHAIASVRLRAPFDL
AVLRMVVRQLVERHPMLRTSFDMSRFSRPLQLVHREFADPLHYEDLRGRSAEEQDARVEE
WIEREKERGFELHEFPLIRFMAQRLEDDVFQFTYGFHHEIVDGWSEALMITELFSHYFSV
IYDEPIAIKPPTAGMRDAVALELEALADRRNYEFWDSYLADATLMRLPRPGTGPRADKGD
RDITRIAVPVPTELSDGLKRVAATHAVPLKTVLLAAHMVVMSLYGGHEDTLTYTVTNGRP
ETADGSTAIGLFVNSLALRVRMTGGTWADLITATLESERASMPYRRLPMAELKRHQGNEP
LAETLFFFTNYHVFHVLDRWIDRGVGHVANELYGESTFPFCGIFRLNRETGELEVRIEYD
SLQFSDALMESVRDSYARVLAALVADPDGRYDRHEFRSDRDRAALAVLTRGPEAPAADRC
LHDLVADRAADRPDAPAVQLDTDVLSYGELDRRANRLAHHLRSLGIGPESVVGVLAERSL
AQIIGLLAVLKAGAAYVPLDPAQPDERLAAVIAGSGAAAVLHRPGLEGRLPAGVRALPTD
AADGSTATHDPGPTATPRNAAYVMYTSGSTGEPKGIVVEHRNVVASLAARGAHYAAGPGR
FLLLSSFAFDSSVAGIFWTLTQGGTLVLPGEGQQLDPAALVETIARQRPTHTLAIPSLLA
PVLDQAAPGDLASLRTVIAAGESCPAELAAACRDLLPGSTFHNEYGPTETTVWSTVWSQE
NEHDGPHLPIGRPVAGTWVHPRDHRGRTVPLGVAGELSIGGAGVARGYLGRPRDTAAAFR
PDPEATAPGGRAYATGDLGRYLPDGNLEFLGRADHQVKIRGFRVELGEIEAVLDTHPELQ
RTIVMARGDHPGDQVLVAYVLPAPGRRPEPADIQGYVRDRLPRYMVPTAVIVLDAVPLTA
AGKVDRASLPAPSHAQLTRDQEYVEPGTDTERALAAIWADVLKLDRIGAGDRFFDVGGES
LRAMQATAAANKMFRTRVSVRRLFEAPSLREFAHEIDKARLAGGGTGLTGPAAAPATGGA
AE
Reference
PMID:11048953
  Authors
Du L, Sanchez C, Chen M, Edwards DJ, Shen B.
  Title
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.
  Journal
Chem Biol 7:623-42 (2000)
DOI:10.1016/S1074-5521(00)00011-9
Reference
PMID:10930733
  Authors
Du L, Chen M, Sanchez C, Shen B
  Title
An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.
  Journal
FEMS Microbiol Lett 189:171-5 (2000)
DOI:10.1111/j.1574-6968.2000.tb09225.x

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