KEGG   Addendum: AAG13918
Entry
AAG13918          CDS       T10000                                 
Symbol
megAII
Name
(KEGG) megalomicin 6-deoxyerythronolide B synthase 2
  KO
K24563  6-deoxyerythronolide B synthase EryAII [EC:2.3.1.94]
Taxonomy
TAX:47868
  Lineage
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micromonosporales; Micromonosporaceae; Micromonospora
Organism
Micromonospora megalomicea
SSDB
Motif
Pfam: Acyl_transf_1 ketoacyl-synt Ketoacyl-synt_C KR Erythro-docking KAsynt_C_assoc PP-binding PKS_DH_N ADH_zinc_N_2 PS-DH RhiE-like_linker CurL-like_PKS_C ADH_zinc_N Thiolase_N adh_short Epimerase ADH_N Docking NmrA GDP_Man_Dehyd
Other DBs
NCBI-ProteinID: AAG13918
GB: AF263245
UniProt: Q9F829
LinkDB
AA seq 3562 aa
MTDNDKVAEYLRRATLDLRAARKRLRELQSDPIAVVGMACRLPGGVHLPQHLWDLLRQGH
ETVSTFPTGRGWDLAGLFHPDPDHPGTSYVDRGGFLDDVAGFDAEFFGISPREATAMDPQ
QRLLLETSWELVESAGIDPHSLRGTPTGVFLGVARLGYGENGTEAGDAEGYSVTGVAPAV
ASGRISYALGLEGPSISVDTACSSSLVALHLAVESLRLGESSLAVVGGAAVMATPGVFVD
FSRQRALAADGRSKAFGAAADGFGFSEGVSLVLLERLSEAESNGHEVLAVIRGSALNQDG
ASNGLAAPNGTAQRKVIRQALRNCGLTPADVDAVEAHGTGTTLGDPIEANALLDTYGRDR
DPDHPLWLGSVKSNIGHTQAAAGVTGLLKMVLALRHEELPATLHVDEPTPHVDWSSGAVR
LATRGRPWRRGDRPRRAGVSAFGISGTNAHVIVEEAPERTTERTVGGDVGPVPLVVSARS
AAALRAQAAQVAELVEGSDVGLAEVGRSLAVTRARHEHRAAVVASTRAEAVRGLREVAAV
EPRGEDTVTGVAETSGRTVVFLFPGQGSQWVGMGAELLDSAPAFADTIRACDEAMAPLQD
WSVSDVLRQEPGAPGLDRVDVVQPVLFAVMVSLARLWQSYGVTPAAVVGHSQGEIAAAHV
AGALSLADAARLVVGRSRLLRSLSGGGGMSAVALGEAEVRRRLRSWEDRISVAAVNGPRS
VVVAGEPEALREWGREREAEGVRVREIDVDYASHSPQIDRVRDELLTVTGEIEPRSAEIT
FYSTVDVRAVDGTDLDAGYWYRNLRETVRFADAMTRLADSGYDAFVEVSPHPVVVSAVAE
AVEEAGVEDAVVVGTLSRGDGGPGAFLRSAATAHCAGVDVDWTPALPGAATIPLPTYPFQ
RKPYWLRSSAPAPASHDLAYRVSWTPITPPGDGVLDGDWLVVHPGGSTGWVDGLAAAITA
GGGRVVAHPVDSVTSRTGLAEALARRDGTFRGVLSWVATDERHVEAGAVALLTLAQALGD
AGIDAPLWCLTQEAVRTPVDGDLARPAQAALHGFAQVARLELARRFGGVLDLPATVDAAG
TRLVAAVLAGGGEDVVAVRGDRLYGRRLVRATLPPPGGGFTPHGTVLVTGAAGPVGGRLA
RWLAERGATRLVLPGAHPGEELLTAIRAAGATAVVCEPEAEALRTAIGGELPTALVHAET
LTNFAGVADADPEDFAATVAAKTALPTVLAEVLGDHRLEREVYCSSVAGVWGGVGMAAYA
AGSAYLDALVEHRRARGHASASVAWTPWALPGAVDDGRLRERGLRSLDVADALGTWERLL
RAGAVSVAVADVDWSVFTEGFAAIRPTPLFDELLDRRGDPDGAPVDRPGEPAGEWGRRIA
ALSPQEQRETLLTLVGETVAEVLGHETGTEINTRRAFSELGLDSLGSMALRQRLAARTGL
RMPASLVFDHPTVTALARYLRRLVVGDSDPTPVRVFGPTDEAEPVAVVGIGCRFPGGIAT
PEDLWRVVSEGTSITTGFPTDRGWDLRRLYHPDPDHPGTSYVDRGGFLDGAPDFDPGFFG
ITPREALAMDPQQRLTLEIAWEAVERAGIDPETLLGSDTGVFVGMNGQSYLQLLTGEGDR
LNGYQGLGNSASVLSGRVAYTFGWEGPALTVDTACSSSLVAIHLAMQSLRRGECSLALAG
GVTVMADPYTFVDFSAQRGLAADGRCKAFSAQADGFALAEGVAALVLEPLSKARRNGHQV
LAVLRGSAVNQDGASNGLAAPNGPSQERVIRQALTASGLRPADVDMVEAHGTGTELGDPI
EAGALIAAYGRDRDRPLWLGSVKTNIGHTQAAAGAAGVIKAVLAMRHGVLPRSLHADELS
PHIDWADGKVEVLREARQWPPGERPRRAGVSSFGVSGTNAHVIVEEAPAEPDPEPVPAAP
GGPLPFVLHGRSVQTVRSQARTLAEHLRTTGHRDLADTARTLATGRARFDVRAAVLGTDR
EGVCAALDALAQDRPSPDVVAPAVFAARTPVLVFPGQGSQWVGMARDLLDSSEVFAESMG
RCAEALSPYTDWDLLDVVRGVGDPDPYDRVDVLQPVLFAVMVSLARLWQSYGVTPGAVVG
HSQGEIAAAHVAGALSLADAARVVALRSRVLRELDDQGGMVSVGTSRAELDSVLRRWDGR
VAVAAVNGPGTLVVAGPTAELDEFLAVAEAREMRPRRIAVRYASHSPEVARVEQRLAAEL
GTVTAVGGTVPLYSTATGDLLDTTAMDAGYWYRNLRQPVLFEHAVRSLLERGFETFIEVS
PHPVLLMAVEETAEDAERPVTGVPTLRRDHDGPSEFLRNLLGAHVHGVDVDLRPAVAHGR
LVDLPTYPFDRQRLWPKPHRRADTSSLGVRDSTHPLLHAAVDVPGHGGAVFTGRLSPDEQ
QWLTQHVVGGRNLVPGSVLVDLALTAGADVGVPVLEELVLQQPLVLTAAGALLRLSVGAA
DEDGRRPVEIHAAEDVSDPAEARWSAYATGTLAVGVAGGGRDGTQWPPPGATALTLTDHY
DTLAELGYEYGPAFQALRAAWQHGDVVYAEVSLDAVEEGYAFDPVLLDAVAQTFGLTSRA
PGKLPFAWRGVTLHATGATAVRVVATPAGPDAVALRVTDPTGQLVATVDALVVRDAGADR
DQPRGRDGDLHRLEWVRLATPDPTPAAVVHVAADGLDDLLRAGGPAPQAVVVRYRPDGDD
PTAEARHGVLWAATLVRRWLDDDRWPATTLVVATSAGVEVSPGDDVPRPGAAAVWGVLRC
AQAESPDRFVLVDGDPETPPAVPDNPQLAVRDGAVFVPRLTPLAGPVPAVADRAYRLVPG
NGGSIEAVAFAPVPDADRPLAPEEVRVAVRATGVNFRDVLLALGMYPEPAEMGTEASGVV
TEVGSGVRRFTPGQAVTGLFQGAFGPVAVADHRLLTPVPDGWRAVDAAAVPIAFTTAHYA
LHDLAGLQAGQSVLVHAAAGGVGMAAVALARRAGAEVFATASPAKHPTLRALGLDDDHIA
SSRESGFGERFAARTGGRGVDVVLNSLTGDLLDESARLLADGGVFVEMGKTDLRPAEQFR
GRYVPFDLAEAGPDRLGEILEEVVGLLAAGALDRLPVSVWELSAAPAALTHMSRGRHVGK
LVLTQPAPVHPDGTVLVTGGTGTLGRLVARHLVTGHGVPHLLVASRRGPAAPGAAELRAD
VEGLGATIEIVACDTADREALAALLDSIPADRPLTGVVHTAGVLADGLVTSIDGTATDQV
LRAKVDAAWHLHDLTRDADLSFFVLFSSAASVLAGPGQGVYAAANGVLNALAGQRRALGL
PAKALGWGLWAQASEMTSGLGDRIARTGVAALPTERALALFDAALRSGGEVLFPLSVDRS
ALRRAEYVPEVLRGAVRSTPRAANRAETPGRGLLDRLVGAPETDQVAALAELVRSHAAAV
AGYDSADQLPERKAFKDLGFDSLAAVELRNRLGVTTGVRLPSTLVFDHPTPLAVAEHLRS
ELFADSAPDVGVGARLDDLERALDALPDAQGHADVGARLEALLRRWQSRRPPETEPVTIS
DDASDDELFSMLDRRLGGGGDV
Reference
PMID:10972798
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
DOI:10.1046/j.1365-2958.2000.02059.x

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