| Entry |
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| Symbol |
amphJ
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| Name |
(KEGG) polyene macrolide polyketide synthase
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| KO |
| K16386 | polyene macrolide polyketide synthase |
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| Taxonomy |
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| Lineage |
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces |
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| Organism |
Streptomyces nodosus
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| AA seq |
5644 aa
MEQTMNAPAENVVAALRAAVKETERLRRRNRTIVAAAREPIAVVGMGCRFPGGVDSPQAL
WEMVAGGTDVISEFPDDRGWDLEALRTSGIDDRDTSVSQRGGFLDSIADFDPGFFGISPR
EAVTMDPQQRLLLETAWEAIERARIDATRLRGTRTGTFIGTNGQDYAYLLVRSLDDATGD
VGTGIAASAVSGRLSYTFGLEGPAITVDTACSSSLVALHLAVQSLRNGECTLALAGGVNV
MSTPGSLVEFSRQGGLAGDGRCKAFSDSADGTGWSEGAAVLALERLSDAQRNGHPVLAVI
RGSAVNQDGASNGFTAPNGPSQQRVIRQALSNAGLNPADVDVVEAHGTGTPLGDPIEAQS
ILATYGQDREQPLLLGSIKSNIGHTQSAASGVAGIMKMIMAMRNEVLPKTLHVDRPSTHV
DWTAGKVELLTENRPWPTAPDRPRRSGVSSFGVSGTNAHVIVEQAPQTPAHQPEEAPADP
SDEAPAAPRTAGVLPWVLSARSAAALREQAAALLAHLDAPGAPGALDTGYSLATTRASLE
HRLAVVTGADGTAGREALTSWLAGDPAPDAHEGRPVGRTRSAFLFSGQGAQRLGMGRELH
ARFPVFAEALDQVLDLLDEELDASLGDIIWGEEEAPLNETGFTQPALFAVEVALYRLVES
WGVTPDFVAGHSIGEIAAAHVAGVFSLEDACRLVAARAGLMQALPSGGAMVAVEATEDEV
LPLLTEGVAVAAVNGPTSVVVSGEEKATLAVAEQLAAKGRRTSRLRVSHAFHSPLMDPML
DDFRAVAETLSYDEPQLPVVSNLTGTLAADGQLTSPEYWVRHVREAVRFADGVRALAEAG
ADVLLELGPDGVLAALAQQSATALTVPFLRKDRPEEHSAVTALARLHTAGVTVDWAAFHD
GTGARTGELPTYAFQHERYWPKATATAVDATGLGLASADHPLLGAAMSVAGSDELLLTGT
LSLATHPWLADHSVDGMVVFPGTGFLELAVRAADQAGCDRVQELTVATPLVLPATGAVQM
QISVGAAGEDGSRELRFFTRPGEDFDAEWTQHATGRIASGEHVLGFDTTVWPPRDSEAVD
IEELFDRFASDGLEYGPVFRGLRAAWRQDDTVYAEVELPDSVEDAGAFGLHPALLHAALH
GTAFLSDDSGLLPFAWEGVSLHADGASTLRVRIASCGEDTVEIAAVDPAGQPVLSVESLT
LRAADSGAGAASRREEANSLFRVDWTPRTVAAPAAPATWAVLGEDPFGLTAALAGDSEAV
AGVHAPAATLEELAARSGAVPDMVAVTVRGDADGGPEAARELTREVLALVQGWLAEPAFA
SSRLVVVTRDAVADGERGAVDLAAAPVWGLVRSAQSENPGRLLLADVDDTADSLARLPLL
AGLFDAEEPQAVVREGTVRVGRLARLESGDSSARALDPEGTVLVTGGTGGLASALARHLV
AEHDIRHLLLTSRRGPDAPGAADLVQALAELGAEARVAACDVADREALAALLASVPAEHP
LTAVVHTAGVLDDGIFPSLTPDRLDSVMRPKVDAAWHLHDLTRDLDLAAFVLYSSTAGVM
GSPGQANYAAGNTFLDALAAHRQSLGLPATSLAWGAWEQGVGMTGQLSGQDARRISDAGG
MPLLSVERGLALYDAAMLADEPLVVPLGLGGGGPLPAGAGVPAILRGLVRTGGRRARAAT
AAVARAGLAERLAVLPEEQRRPFVVDLVRAEAAAVLGHGSADAVDSRREFRGLGFDSLTA
IELRNRLGKATGLTLPATLVFDYPTPEQLADHLLDELLGADAIEVFAASQSAADVHDDPV
VIVGMGCRFPGGVGSPEDLWDLLASGSDAITGFPADREWESSRLVAGEAGGVSAQGGFLS
DIAGFDADFFGISPREALAMDPQQRILLEVTWEAIERAGVDPTALRGSRTGVFMGVNGQD
YSSLVMGSRDDVAGHATAGLAVSVVSGRLSYALGLEGPALSVDTACSSSLVSLHLAAQAL
RSGECSMALVGGVTVMTTPANFAGFSRMGGLAQDGRCKAFSDSADGTGWSEGAAVLVVER
LSDARRAGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANAGLRPGDVDAVEA
HGTGTPPGDPIEAQALLATYGSDRDPQQPLLLGSVKSNIGHTQAAAGVAGLVKMVMAMRN
GVLPRTLHITEPSTHVDWSLGAVQVLTEETAWPETGRVRRAGVSSFGISGTNAHVILEGA
PDEPVPAPVADRPVPGAVAWPVSAKSEGALDDQAERLRESADALPALDTAYTLATGRADF
EHRAVLLAADGTLTEVARGVAEPHRSAFLFSGQGAQRLGMGRELHARFPVFAEAFDSVTA
LLESELDTSVREVMWGTDEGALNATAFTQPALFAVEVALYRLVESWGVTPDFVAGHSVGE
IAAAHVAGVFSLEDACRLVAARAGLMQALPSGGAMVAVEATEDEVLPLLTEGVAVAAVNG
PTSVVVSGEEQATLAVAEQLAAQGRRTSRLRVSHAFHSPLMDPMLEDFRAVAETLSYHEP
RIPVVSNLTGEVAAAGVHTHPDYWVRHVREAVRFADGVRGLADRGVTALLEIGPDGVLSA
LAAASLTDTDTVVVPALRKDRDETVSVLSGVARLYVAGVDVDWSAPLSGAGARIADVPTY
AFQHERYWPKAAPAALDATGLGLASADHPLLGAAMSVAGSDELLLTGSLSAATHPWLADH
VVGGMIFFPGTGFLELAVRAADQAGCDRVEELMIAAPLVLPATGAVQVQISVGAADEEGS
RELRFFTRPGEDFDAEWTQHATGRIGSGEQVIDFDATVWPPRDAEAIDIDGMFERYAADG
LEYGPVFRGLRAVWRQDDTVYAEVALPESVEDADAFGLHPALFDAALHSTVFLSAEGDTR
SLLPFAWEGVSLHADGASTLRVRIASCGEDTVQIAAVDPGGQPVVSVESLTLRAAGPGDA
AEPRRDDSNSLLRVDWTARTLGAPAAPATWAVLGEDPFGLTAALAGDSEAVAGVHAPAAT
IEELAARSGAVPDMVAVTVRGDADAGPDDAHELAHEVLALVQGWLAEPAFASSRLVVVTR
NAVADGERGAVDLAAAPVWGLVRSAQSENPGRLLLADVDDTADSLARLPLLAGLFDAEEP
QAVVREGTVRVGRLARLESGTSLVPPAGTPWRLGCRAKGSLDGLALLPYPEAVTPLTGRE
VRIGIRAAGLNFRDVLNALGMYPGEAGLFGSEGAGVVSEVGPDVTGLAPGDRVMGMVFGG
FGPLGVADERLLTRVPDDWSWETASSVPLVFLTAYHALKDLAGLRPGEKILIHAGAGGVG
MAAIQIAHHLGAEVFATASEGKWDVLRSLGVADDHIASSRTLDFETAFTEVAGDKGLDVV
LNALAGEFVDASMRLLGTGGRFLEMGKTDIRDSDAASDGITYRFFDLGMVDPDHIQQMLL
DLVDLFERDVLSPLPVRAWDVRRSREAFRFMSMAKHIGKIVLTMPRAMDPEGTVLVTGGT
GGLASALARHLVAEHGIKHLLLTSRRGPDAPGAADLVQALAELGAEARVAACDVADRDAL
AGLLASVPAERPLTAVVHTAGVLDDGILASLTPDRLDTVMRPKVDAAWHLHDLTRDLDLA
AFVLYSSTSGVFGSPGQANYAAGNTFLDALAAHRQSLGLPATSLAWNAWEQGSGMTSGLS
DEDMRRINDNSGMPLLSVERGLALYDAATLADEPLVVPLGLGGGGSLPPGMSVPAILRGL
VRTGGRRAKAGAAAVARAGLAERLAVLPEEQRLPFVVDLVRAEAATVLGHGSADAVDARR
EFRGLGFDSLTAIELRNRLGKASGLTLTATLVFDYPTPQQLAEHLLDELLGADAAEAFAA
PQTAAAASDDDPVVIVGMGCRFPGGVGSPEELWDLVASGTDAITGFPADREWESSTIGGE
PGDLSGQGGFLSDIADFDADFFGIAPREALAMDPQQRILLEVTWEAVERAGLDPTALRGS
RTGVFMGVSGQDYSGLVMRSRDDIASHATTGLAVSVVSGRLSYTLGLEGPALSVDTACSS
SLVSLHLAAQALRSGECTMALAGGVTVMTTPANFTGFSKMGGLAHDGRCKAFSDSADGTG
WSEGAAVLVLERLSDARRAGHRVLAVVRGSAVNQDGASNGLTAPNGPSQQRVIRQALANA
GLRPGDVDAVEAHGTGTPLGDPIEAQALIATYGSDRDPQQPLLLGSVKSNIGHTQSAAGA
AGLVKMVMAMHQGTLPRTLHVTEPSTHVDWSLGAVRLLTEETAWPETGRVRRAGVSSFGI
SGTNAHVILEGAPEPTADDRSAEDTVTPAVTPWVVSARSEQALDAQLERLRAHAAAHPEL
SGADIGLSLVTSRPSFEHRAVLLAGPDGITEAARAEAGTARTPAFLFSGQGAQRLGMGRE
LHARFPVFAEVFDSVTALLESELGTSVREVMWGTDEAALNSTAFTQPALFAVEVALYRLV
ESWGVTPDFVAGHSVGEIAAAHVAGVFSLEDACRLVAARARLMDALPRGGAMAAVEATED
EVLPLLDDGVAVAAVNGPTSVVVSGPEDGVDQLVALLESDGRRTTRLRVSHAFHSSLMDP
MLEDFRAVAETLSYHEPRIPVVSNLTGEVASAGTHTHPDYWVRHVREAVRFADGVRALAD
RGVTAFLEIGPDGVLSALAAASLPDTGTVVVPALRKDRDETVSVLTALARLHTAGLDTDW
SAHFAGTGARTVELPTYAFQGTRFWPDTTAAPGDAGGLGLDAGGHPLLTAATSVAGSDET
LLSGRLSAAAQPWLTGRTENGTTILPTAVLAELALHAAEACDRTTVENLTVGAPLALTGN
RPQRLQVLVGVPDETGRRTLTVHTRADGDDAPWVERATAMLTDAPAAATPDTVWPPADAT
PVDELPEPTGPSVLRAAWRRGGDVFAEVEITEQSPAEQAFALHPALLDTAVRAAVLLEGD
GGGSGDDTLDAVAWDGLVLHAAHPVLLRVRLTATGDDTWALEATDPQGGPVLSVASVTLG
ATVAAPVTGAPATDDAALLALDWVAPAPAPRSGDSGPWTVLGDALPGLDTALAAVDNVLV
TRADSLAELLDSGAPLPSLMLLPVEGGPTAGHDLPAAVRAATTRVLDLLRRWTSDPRTAD
SRLAIVTRGAVAAGREDVTDLAAAAVWGLVRSAQSENPGCFLLLDLDPADAAEATDAAVL
ASLPALFDAGETQAAVRGGALTVARLTRTEATPAPAADQVRAWDRDGTVLITGGTGGLGA
VLARHLVTGHGIKHLLLAGRRGPDAPGATALSKELSALGAEVTVRACDVSDRSAVDALLA
GLPAEHPLTAVVHTAGVLDDATIGTLTAEQLDTVLRPKADAAWHLHQATRALPLAGFVLY
SSVAGVTGGPGQGNYAAANTFLDALAAHRAAQGLPALSLAWGPWGQGAGMTGTLSDADLE
RMERSGMPPLTERQGLALFDAANGHDEALAVAIRVSRSAAAPDAGEVPAVLRSLVRARRR
AAATAGADGLTRRLAGLGAEQRHETLVGLVRQETAGVLGHSGADAVPADRDFSRLGFDSL
MAVELRTRLSAATGVRLPSTLVFDHPTPAAVARHLADSLTGQDRSGTAASPLAALDRLEA
ELSADGVDEAVRRGVEGRLRRLLAAWDGTGSDGNGPAVEERIEAASAEEIFAFIDNELGR
SSDS |
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| Reference |
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| Authors |
Caffrey P, Lynch S, Flood E, Finnan S, Oliynyk M |
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| Title |
Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes. |
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| Journal |
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