Entry |
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Symbol |
asmD
|
Name |
(KEGG) ansamitocin polyketide synthase D
|
KO |
K16032 | ansamitocin polyketide synthase D |
|
Taxonomy |
|
Lineage |
Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales; Pseudonocardiaceae; Actinosynnema |
Organism |
Actinosynnema pretiosum
|
SSDB |
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Motif |
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Other DBs |
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LinkDB |
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AA seq |
3324 aa
MSDEKKLRDYLKRALAENERVQQRLRALETAHREPIAVVATACRFPGGVASPEDLWDLVA
RGGDVISGFPADRGWDLDALFDGDPEAQGRSYVREGGFLHDATEFDAAFFGISPREALAM
DPQQRVLLETAWEVVERAGIDPTSLRGSRTGVFTGVVYYDFATRLHPVPEGMEGHLGTGI
APSVISGRVAYVLGLHGPAVTLDTGCSSSLVGLHLAAQALRSGECSLALAGGVTVMSLPG
AFPEFSRQRGLAPDGRCKSFADAADGTAWSEGVGLVLLERLSDAERAGHPVLAVLRGSAV
NSDGASNGLTAPNGVSQQRVIRSALEVAGLRPSDVDLVEAHGTGTRLGDPIEAQAILATY
GQDRAEPVLLGSVKSNLGHTQGAAGAAGLIKVVEALRRGEVPRTLHVDRPSAQVDWSAGN
AALATEHVPWPDRGRPRRAAVSAFGVSGTNAHVVLEGVPAPDLPPRDDRALPLPLSARAE
PALRALAGRVGALLDGPVALADVAGSLADGRARLTHRAVVVAADRAGARTALDALAAGEP
HPDLVTGVADVDGRTAFVFPGQGTAWVGMGARLLTESAVFADSVDRCAAALAPHTDVDLR
AALTGGPLDRVETVQVAAFAIAVSLAGLWRAHGVEPDAVLGHSQGEIAAACVAGALTLED
AALVVALRSRAVAEHLSGRGAMLSVALPPHEVESFGLAVAAVNGPESVVLSGPVADVEAV
LAALTATGVRARRVPVDYASHSPGVDVLREVLATALAPVRPRRAHVPFLSSTTGAWLDGP
ELDAGYWFANLRGAVGFHAATTTLLDAGHRAFVEVSAHPVLTGAVQDSADGRALVTGTLR
RDHGGLHRFRLSAAELHARGVPVDWNAGSGDRWRRVDLPTTPFHRQRCWPDARRAATDQP
GLRAANHPLLDTVVVLAGDDGVVCTGSASTRAHPWLADHAVSGTALLPGACWVELAVRAG
DEVGLPVLDELVVEQPLPLGPRTTPLQVRVGPPDATGRRPVELHSGEGGDWTRHARGHLA
AAAPVTAEDPAEWPPPGAREVDLTGFYERQATTGYGYGPAFRGLRRCWTRDGEVFAEVVL
PGEPGAFGVHPALLDAALHAAAVTAPEGVPVLLPFTWTGVALHATGARALRVRLTTPRAG
ELALTASDGDGRPVVTVDSLVLRPAGDLTATRAPRSLFEVVWTETPALTPAATAPRPVLR
HDVPAASAEDAVCSTLAVVQGFLADPRHADSVLLVVTRGGEGPDGATAATSAVHGLVRSA
QAEEPGRIVLVDTDGSAPDDLITALAAGPEPQLAVRAGRVTAPRLRRAAPEGAAPVLDPE
GTVLVTGGTGVLGAAVARHLVTARGARHLLLLSRRGPDAPGAADLVAELTGAGARVVVRA
VDVADRAALAAALDAVPAAHPLTGVVHLAAALDDGTITALTPDRVRRVLAPKATAAAHLH
ELTSDLALFALFSSASGVLGAPGQGNYAAANAYLDGLARERHAAGLPATSIAWGLWAEAT
GLTGSLSGTDRERMAASGVRPLTEAEGLALFDAALAGPAFVAAGLAGTATGQVPPVLRDV
VRAARPAAAAVRPARTPADLLALVRAESASVLGHPAGEPVDADRAFKEAGFDSLTAVELR
NRLTAATGVRLPATLVFDHPTPAALAAHLVERMGAPPAPRPERAARAASGEPIAIVSIGC
RLPGGVTSPDGLWRLLLDGVDATTGPPDDRGWDPATPYRGGFLDGATAFDAGLFGIGPRE
ALAMDPQQRLLLETSWELFERAGIDPTSLRGTDTGVFAGVMNQDYLSRAAGAPPDAEGFL
STGNSGSVVSGRLAYTYGLEGPALTVDTACSSSLVAVHLAVRSLRSGECSLALAGGVTVM
ATTGLFADFDRQGGLAADGRCKAFSADADGTAFGEGAGLVLLERLSDARRNGHAVLAVLR
GTAVNSDGASNGLTAPNGPAQQRVIRAALADAGLSPAEVDVVEAHGTGTRLGDPIEAQAV
LATYGRDRGEPVLLGSVKSNLGHTQGAAGVTGLIKLVLALRHGVVPATLHAGRASAEVNW
EAGAAELVTGTRPWPRTGRPRRAAVSSFGISGTNAHAVLEQAPPGPEAAPVGGPRAGAAS
AGSGAVGARGAEPVGVARAAGAREPEAGGAVDPGGVCPAPAVGAATRAPDPEAAAPGVPG
PAARPVGAGPDGSARTVDVVGASGPLVPLVVSARDERALAAQVERITALPHDPVDVGWSL
VTTRATLRHRAVLLDGEVVASGVPAPGGTAWLFTGQGGYRPGTGRALRARFPAFRDAFDA
TCAELDRALDGRAEHPVRAVALGERPGLDGTLHAQTAAFALQTALAAQLGAFGLAPDAVA
GHSVGEIAAAHVAGAFPLDAACALVAERGVLMRDLRPGAMVAVEVTEEEALDAIGDLPVA
VAVVNGPEAVVLSGDAEAVVAVAARLGGRRKRLPVDRAFHSPHVDPVLDALRGLATGTPT
TPLISTTTGRTLTHVGHDHWADHARGAVRFADALRALAGSGVTTAVELGPDAVLTPHAAE
VLARAIPALRADHDEVVALLTALAVLHARGAAVDWRPAFEGAGARRVDLPTYPFQRTRYW
LDAAPRATATGHPLVDALDVLPGDEVLLSARWHAGRAGLGATPLAALLEPVIRAGDEVGC
PVVAELDLATPVPLDAGPRHVRVRVTAPDADGRRAVTVHSRPDDEPAWTGHATGVLAPAG
HPEPLPHDSEALAVGTNGAWPPAGADVPAAGANGASLPHGAGTPAAATNGARSALPAAGP
APGAELVLPDGAAPDGFGLHPALWEALLPHPARCADVVLHATGATALRVRGTSPLLAVDG
AGDPVVSVGGVTRVAASPRAVTRGSLFEVVEVPLPAPAPPGPSTALSADLSTALSADLRG
VTPAEALDVLQRFAASDAPRLVVRTDRPDDPWQCAVRGLVRSAQAEEPGRILLVVQDGDG
PEPPPTTREPEVVVRDGALRVPRLRRTAPRHDGVRALPDTVLITGGTGALGSTLARHLAA
GGVRTLVLASRRGPAAPGAPELAADLAGLGARAHLVAADLTDRAALAALLAEHRPGGVVH
TAGVLDDGVLSALTPARLDAVLAPKALVAAHLDELTRDGTTTLFVLFSSAAGVLGTPGQA
NYAAANAFLDGLAARRRAAGLHALSLAWGPWRSGMAAGVDASRAGLHPLDDAEATALFDA
ALADGRPLLAPLSLAATPQDADVPPLLRQLVPVRRRSARAEVAPDPVDRLRGAADHELPE
LLLTLVRAATATVLGHRGPESVDPDEPFWDTGFTSLTAVELRNLLAERTGVRVTAAAVYE
EPTPRALSAHLRAALRAPHTSGTV |
Reference |
|
Authors |
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG |
Title |
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. |
Journal |
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