KEGG   Addendum: AAM54078
Entry
AAM54078          CDS       T10000                                 
Symbol
asmD
Name
(KEGG) ansamitocin polyketide synthase D
  KO
K16032  ansamitocin polyketide synthase D
Taxonomy
TAX:42197
  Lineage
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Pseudonocardiales; Pseudonocardiaceae; Actinosynnema
Organism
Actinosynnema pretiosum
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PKS_DH_N PP-binding PS-DH KAsynt_C_assoc adh_short Epimerase Thiolase_N GDP_Man_Dehyd CurL-like_PKS_C Docking Polysacc_synt_2 NmrA RmlD_sub_bind RhiE-like_linker ACP_syn_III NaeI
Other DBs
NCBI-ProteinID: AAM54078
GB: AF453501
UniProt: Q8KUF6
LinkDB
AA seq 3324 aa
MSDEKKLRDYLKRALAENERVQQRLRALETAHREPIAVVATACRFPGGVASPEDLWDLVA
RGGDVISGFPADRGWDLDALFDGDPEAQGRSYVREGGFLHDATEFDAAFFGISPREALAM
DPQQRVLLETAWEVVERAGIDPTSLRGSRTGVFTGVVYYDFATRLHPVPEGMEGHLGTGI
APSVISGRVAYVLGLHGPAVTLDTGCSSSLVGLHLAAQALRSGECSLALAGGVTVMSLPG
AFPEFSRQRGLAPDGRCKSFADAADGTAWSEGVGLVLLERLSDAERAGHPVLAVLRGSAV
NSDGASNGLTAPNGVSQQRVIRSALEVAGLRPSDVDLVEAHGTGTRLGDPIEAQAILATY
GQDRAEPVLLGSVKSNLGHTQGAAGAAGLIKVVEALRRGEVPRTLHVDRPSAQVDWSAGN
AALATEHVPWPDRGRPRRAAVSAFGVSGTNAHVVLEGVPAPDLPPRDDRALPLPLSARAE
PALRALAGRVGALLDGPVALADVAGSLADGRARLTHRAVVVAADRAGARTALDALAAGEP
HPDLVTGVADVDGRTAFVFPGQGTAWVGMGARLLTESAVFADSVDRCAAALAPHTDVDLR
AALTGGPLDRVETVQVAAFAIAVSLAGLWRAHGVEPDAVLGHSQGEIAAACVAGALTLED
AALVVALRSRAVAEHLSGRGAMLSVALPPHEVESFGLAVAAVNGPESVVLSGPVADVEAV
LAALTATGVRARRVPVDYASHSPGVDVLREVLATALAPVRPRRAHVPFLSSTTGAWLDGP
ELDAGYWFANLRGAVGFHAATTTLLDAGHRAFVEVSAHPVLTGAVQDSADGRALVTGTLR
RDHGGLHRFRLSAAELHARGVPVDWNAGSGDRWRRVDLPTTPFHRQRCWPDARRAATDQP
GLRAANHPLLDTVVVLAGDDGVVCTGSASTRAHPWLADHAVSGTALLPGACWVELAVRAG
DEVGLPVLDELVVEQPLPLGPRTTPLQVRVGPPDATGRRPVELHSGEGGDWTRHARGHLA
AAAPVTAEDPAEWPPPGAREVDLTGFYERQATTGYGYGPAFRGLRRCWTRDGEVFAEVVL
PGEPGAFGVHPALLDAALHAAAVTAPEGVPVLLPFTWTGVALHATGARALRVRLTTPRAG
ELALTASDGDGRPVVTVDSLVLRPAGDLTATRAPRSLFEVVWTETPALTPAATAPRPVLR
HDVPAASAEDAVCSTLAVVQGFLADPRHADSVLLVVTRGGEGPDGATAATSAVHGLVRSA
QAEEPGRIVLVDTDGSAPDDLITALAAGPEPQLAVRAGRVTAPRLRRAAPEGAAPVLDPE
GTVLVTGGTGVLGAAVARHLVTARGARHLLLLSRRGPDAPGAADLVAELTGAGARVVVRA
VDVADRAALAAALDAVPAAHPLTGVVHLAAALDDGTITALTPDRVRRVLAPKATAAAHLH
ELTSDLALFALFSSASGVLGAPGQGNYAAANAYLDGLARERHAAGLPATSIAWGLWAEAT
GLTGSLSGTDRERMAASGVRPLTEAEGLALFDAALAGPAFVAAGLAGTATGQVPPVLRDV
VRAARPAAAAVRPARTPADLLALVRAESASVLGHPAGEPVDADRAFKEAGFDSLTAVELR
NRLTAATGVRLPATLVFDHPTPAALAAHLVERMGAPPAPRPERAARAASGEPIAIVSIGC
RLPGGVTSPDGLWRLLLDGVDATTGPPDDRGWDPATPYRGGFLDGATAFDAGLFGIGPRE
ALAMDPQQRLLLETSWELFERAGIDPTSLRGTDTGVFAGVMNQDYLSRAAGAPPDAEGFL
STGNSGSVVSGRLAYTYGLEGPALTVDTACSSSLVAVHLAVRSLRSGECSLALAGGVTVM
ATTGLFADFDRQGGLAADGRCKAFSADADGTAFGEGAGLVLLERLSDARRNGHAVLAVLR
GTAVNSDGASNGLTAPNGPAQQRVIRAALADAGLSPAEVDVVEAHGTGTRLGDPIEAQAV
LATYGRDRGEPVLLGSVKSNLGHTQGAAGVTGLIKLVLALRHGVVPATLHAGRASAEVNW
EAGAAELVTGTRPWPRTGRPRRAAVSSFGISGTNAHAVLEQAPPGPEAAPVGGPRAGAAS
AGSGAVGARGAEPVGVARAAGAREPEAGGAVDPGGVCPAPAVGAATRAPDPEAAAPGVPG
PAARPVGAGPDGSARTVDVVGASGPLVPLVVSARDERALAAQVERITALPHDPVDVGWSL
VTTRATLRHRAVLLDGEVVASGVPAPGGTAWLFTGQGGYRPGTGRALRARFPAFRDAFDA
TCAELDRALDGRAEHPVRAVALGERPGLDGTLHAQTAAFALQTALAAQLGAFGLAPDAVA
GHSVGEIAAAHVAGAFPLDAACALVAERGVLMRDLRPGAMVAVEVTEEEALDAIGDLPVA
VAVVNGPEAVVLSGDAEAVVAVAARLGGRRKRLPVDRAFHSPHVDPVLDALRGLATGTPT
TPLISTTTGRTLTHVGHDHWADHARGAVRFADALRALAGSGVTTAVELGPDAVLTPHAAE
VLARAIPALRADHDEVVALLTALAVLHARGAAVDWRPAFEGAGARRVDLPTYPFQRTRYW
LDAAPRATATGHPLVDALDVLPGDEVLLSARWHAGRAGLGATPLAALLEPVIRAGDEVGC
PVVAELDLATPVPLDAGPRHVRVRVTAPDADGRRAVTVHSRPDDEPAWTGHATGVLAPAG
HPEPLPHDSEALAVGTNGAWPPAGADVPAAGANGASLPHGAGTPAAATNGARSALPAAGP
APGAELVLPDGAAPDGFGLHPALWEALLPHPARCADVVLHATGATALRVRGTSPLLAVDG
AGDPVVSVGGVTRVAASPRAVTRGSLFEVVEVPLPAPAPPGPSTALSADLSTALSADLRG
VTPAEALDVLQRFAASDAPRLVVRTDRPDDPWQCAVRGLVRSAQAEEPGRILLVVQDGDG
PEPPPTTREPEVVVRDGALRVPRLRRTAPRHDGVRALPDTVLITGGTGALGSTLARHLAA
GGVRTLVLASRRGPAAPGAPELAADLAGLGARAHLVAADLTDRAALAALLAEHRPGGVVH
TAGVLDDGVLSALTPARLDAVLAPKALVAAHLDELTRDGTTTLFVLFSSAAGVLGTPGQA
NYAAANAFLDGLAARRRAAGLHALSLAWGPWRSGMAAGVDASRAGLHPLDDAEATALFDA
ALADGRPLLAPLSLAATPQDADVPPLLRQLVPVRRRSARAEVAPDPVDRLRGAADHELPE
LLLTLVRAATATVLGHRGPESVDPDEPFWDTGFTSLTAVELRNLLAERTGVRVTAAAVYE
EPTPRALSAHLRAALRAPHTSGTV
Reference
PMID:12060743
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199

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