KEGG   Addendum: ADU56322
Entry
ADU56322          CDS       T10000                                 
Symbol
fkbB
Name
(KEGG) polyketide synthase FkbB
  KO
K16375  polyketide synthase FkbB
Taxonomy
TAX:941587
  Lineage
Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces sp. KCTC 11604BP
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 Ketoacyl-synt_C KR PKS_DH_N AMP-binding PS-DH PP-binding KAsynt_C_assoc Thiolase_N adh_short ADH_zinc_N_2 Epimerase AMP-binding_C ADH_N CurL-like_PKS_C ADH_zinc_N ACP_syn_III 3Beta_HSD NAD_binding_4 NmrA Ad_Cy_reg
Other DBs
NCBI-ProteinID: ADU56322
GB: HM116537
UniProt: E9KTI2
LinkDB
AA seq 7646 aa
MHELLRVNAERQGDRIAYVDSRRAVTYAQLRLRTGRIAGHLAAAGVGRGDRIALLLGNRV
ETIETYIAAARAAAVAVPLNPDAGDAEIAHFLTDSGATVLVTDDLHLDQVRRVGTDATVV
LAGRRDPGCTAYEDLAGTEPAYPPRDDLALDEPAWMLYTSGTTGRPKGVVSAQRSGLWSA
LYCDVPSWELTETDELLWPAPLFHSLGHHLCLLAVLTVGASARILGGFVARDVLDALAEH
PSTVLVGVPTMYRYLLGAVSGEPEAGALRAALVAGSTAPASLTADFEAAFGVPLLDTYGC
TETTGSLTANTLTGPRVPGSCGLPVPGLSLRFVDPVSGADVPRGDEGELWASGPSLMLGY
HEQPEATAEVLVDGWYRTGDLARQAETGHVTITGRVKELVIRGGENIHPGEIESVAQAVP
GVRDAAAAGRPHPVLGEIPVLYVVPEGPTVPTDAILAECRRQLAYFKVPDEILQTTEIPR
TASGKVRRGELAGRTTRLVATGSGETALCELVWERRELPTTVTPVPTVITRRAVGIDPAE
VPDADQAALWDEALKDQAADPGSFVLVDTDGEPTGGETTGRETTGGRTTGGETTGGETTD
GETTDGEAADAGAAGAGSIAAAASLGEPLVALRNGTAYVPRLVHAVTTPLPPGPWALRPP
ASGTLRDLAVAPSDAPPHPLATGEVRIEVRAAGLNFRDVLIALGTYPGDGEMGGEAAGIV
TEVGPGVDDLTPGDRVFGLVQDAFRRSVVADRRLIAPVPQGWSFPVAASVPVVFATAWYG
LVDAGGLRPGRKVLIHAATGGVGMAATRIARHLGAEVYATASPAKQHLLYADGFDADHVA
DSRTTAFADAFPPMDVVLNSLTGELLDASVALLAPDGRFIEMGKTDIRHDAQEPFDLSDI
APARLREILELLLELFDRGELSPLPLRAWDIRRARDAFTWMSRARHTGKMVLTVPQPLGP
DTPVLVTGEGADAVAGLLRREVDSGPVFTGDADALATADAVDTSALVHIVLGDPAGADAY
ARSRASEGLPAVTLHGLPGIEEAALTAELIERAVAGGGSYVVTRVGSAGARAEAMAGATP
PILSRLAGRAGPADPDGPGAVDPAWANRLAAAAADRQDILLDLVRDTVATVLGLSNAEHC
APDRTFRENGLDSLTTVEFANIVAARTGLRVPASTAFDHPTPRAFAAHLAGATTAAPAPA
RTVGPGEPIAIVGMACRLPGGVASPEELWRLVESGGDAITEFPADRGWEVESLYDPDPDA
AGRSTTRHGGFLTGATGFDTAFFGISPNEALAMDPQQRLVLETSWEAFEHAGIVPDTLRD
SDTGVFMGAFHQGYGAGRDLGGLGVTAIQTSVLSGRLSYFYGFQGPAVTVDTACSSSLVA
LHQAVQALRSGECSLALTGGVTVMATPQSFVEFSRQRGLAPDGRCKAFADTADGTGFSEG
VGVLVVERLSDAERNGHTVLAVIRGTAVNQDGASNGLSAPNGVAQQRVIRQALASAGLSG
SDVQAVEAHGTGTVLGDPIEAQAVIAVYGQGREVPLYLGSLKSNIGHAQAAAGVAGVIKM
VMAMRYGVLPRTLHVGERSSHVDWSAGAVEVLSEARPWPELGRARRAGVSGFGVSGTNAH
VVLEGVPEVSVSPTESSGGLLPLPVSARSGVGVGVLVERVGGLVGGGCDVGVVADGLVRG
RAVFGHRAVLLGESRVMGVAGEGLRTVFVFPGQGSQWVGMGRELAEVSPVFAARMGECAA
ALAPHVDWSWEEALGSAELLGRVEVVQPLSWAVAVSLAALWGAHGVVPDVVVGHSQGEIA
AACVAGALSLEDGARVVALRSRVIGARLAGRGVMASVALPAADIETVEGVWIAARNGPSS
TVIAGDAQAVEGVLARYESTGVRVRRIAVDYASHTPHVEAIEDELAEVLEGVTTRTPVIP
WWSTVDSGWVEEPVDDGYWYRNLRQPVALDTAITELDGSLFVECSAHPVLLPAIDQQRTV
ASLRTDDGGGDRFTTALAEAWVHGAAVDWTTIVPPTPERLLDLPTYPFDHKRYWLPPAPA
GGSEGIGHPFLSSVVALPGSDGVLLKGRVSLAAHPWLADHAVRDTVLLPGTAFLELVIRA
GDETGCDTIDELVIETPLALPVTGAVDLTVTVDRPDEAGRRPVTVHARLQGTGTWTRHAT
GTLTTGTKRTTDAPDPYTLAQWPPAGAQPASLDRFYEQLAAAGYTYGPAFQGLRAAWTAG
DTIYAEAALDSAEEVDRFGVHPALLDAALHAGRLDAGDALELPFSWTGVRLHAGGATAVR
VALIRGPGGVTVQMADPDGRPVVTVDALVLRPGTGTPSGPKLLGLEWVPVAEAVYDGTLP
DGYTLITAAHPDEPDDLTDLTDMPALTQARTTRTLTALQHHLTTTHHTLIVHTTTDPAGA
AATGLTKTAQNEHPNRIHIIETTHPHTPLPLHQITTLNQPHLRLTHHTLHTPHLTPLHHT
PTPTPPLNPHHAILITGGSGTLAGILARHLNHPHTYLLSRTPPPPTTPGTHIPCDLTDPH
QLTQALHHIPQPLTAIYHTAATLNDATLHNLTPHHLTTTLTTKAHTAWHLHQQTQHHPLT
HFILYSSAAATLGSPGQANYAAANAFLDALATHRHTQGQPATTIAWGMWQTTTNLTTQLT
HTDRQRVRDGFRPLTEAEGRHFLDLSLATDEPFVIAAIPAAPESVSVPESEPARRRVERP
TVRTGEDRGRDLLAVVCSATAAVLGHPDASGIGPATAFKDLGIDSLSGIRLRNRLAETTG
VRLSATAVFDHPTPDALATQLAAALRSAGAPPGGAETAAPAPVPPKAVAGDEPLAIVAMA
CRMPGGADTPEDLWNLVESGGDGITDFPTDRGWDLAALYDPDPDAIGKVSVRHGGFLAGA
ADFDAEFFGISPREALAMDPQQRLILEVSWEAFERAGILPASVRGSDAGVFMGAFGQGYG
AGVDLGGFGATGTPTSVLSGRLSYYFGFEGPSVTVDTACSSSLVALHQAARSLRSGECSL
ALVGGVTVMATTTGFVEFSRQRGLAPDGRAKAFADTADGTSFSEGAGVLIVERLSDATRL
GHPVLAVVRGSAVNSDGASNGLSAPNGPAQQRVIERALADAGLAPGEVDAVEAHGTGTRL
GDPIEAQALEAAYGAGRERPLLIGSLKSNIGHTQAAAGIAGVIKMVMAMRHGVLPRTLYV
DEPSRHVDWDGNVRLLRRNEPWPDTGRARRAGVSSFGISGANAHVVLESGPSAAPGSSAS
LGPSATLGLPAAPGPSTAPVPPAAPVPLPEAETQDVLWPVSARTSDGVRDVAARMAALTA
RAAAIGHSLATTRTAMRHRAVVPARDAEAFARGEEVPDVVRGTADITDPRAVFVFPGQGS
QWAGMGAELLAAEPVFARRLGECAAALAPHTGWDLLDVITQRPGAPALDRVDVVQPASFA
LMVALAELWSVHGVAPAAVVGHSQGEVAAACVAGALTLDDAAKVVALRSRLVAAELAGRG
GMVAVAPADFDAAAWTGRLEVAAVNGPASIVVAGAADAVEEFLAAAPRARRIAVDYASHT
AHVETVRQALLDALADLTPRAPEIPFFSTVDGEWLDRPADAAYWYDNVRRPVRFGVATSR
LDELGYRVFVETSPHPVLTPALEDTLAGQPNTVVVGTLRRGEGGPRRFGKSLAALWVRGV
PVTWSFGVSRSVPLPTYPFRRDRYWIDAEPAGGSGHPLLASLVDRADGEGALATALFSVR
RQPWLTDHEVDGRIIVPGSALVELLAEAGTRLGTPAIAELTIVVPLVVDADAATEVQFTV
GSEVSGQRPVRLHSRTGTGPWTLVATGALSAETREPATPEWPPPDADPVDPAGFYDTLPL
SYGPAFRAVTALWAGRGRAYASVRLGEQLTDARYGLHPVLLDAALHALGMLFDDPERRRL
AFSWTGVRMYTRAATALRVLLERVGADTIRVLAMDEHGAPVLEADGLTVRGAEPGNDALF
EVVWVPVPAAPVPGWTYHADVPEGDTPPVVVLPLEPGDPGDPGDPGDPGDPGDRGGSPGV
RARELGRDLLATVQTWLADPRRAGSRLVVVTRTGDPAQEALGGLVRTAGTENPGRVGLIE
ADEITPATVAAGLAAGDEPRVRVAGGTVRAARLRRVAAAAGASALTGGTVLVTGGTGGLG
RLLVDHLLTVHEAAEIVVASRGGRPGGAPEDDRVRYAAVDVTDRDALAALVDGISGRLRA
VVHMAGIVDDAVVATMRPQQWDDVLRVKADVAWHLHELTRDTELAAFVLYSSISATFGGA
GQANYATGNAFLDALARHRRDRGLPAVSLAWGLWDEADGMGGRLTSTDLGRIARGGMIPM
TAAQGLALFDAALHSDRAALVPVRLDLAAVAAADHVPPILRDLVPAARRTPAPAGSRDML
ELVRTSAAAVLGHRDVHAVEPLRAFKDVGFDSLTGVELRNRLTDATGLTLPATLVFDHPT
PQALAAHLDELAGTRAATRRRTPTPARRHDEPLAIVGMACRLPGGVMSPDDLWRLLESGG
DGITAFPADRGWDLEALYDPDPDRPGTSTVRHGGFLPGAAHFDAAFFGISPREALAMDPQ
QRIVLETSWEALEHAGIDAHTLRGSDTGVFIGGYFYGYGSGSDRGGFGATSTQTSVLSGR
LSYFYGLEGPAVTVDTACSSSLVALHQAGQSLRTGECSLALVGGVTVMASPSGFVDFSQQ
RGLASDGRCKAFADAADGTAFAEGSGVLVVERLSDAERLGHRVLAVVRGSAVNQDGASNG
LSAPNGPSQERVIRQALANARLEPSDVDAVEAHGTGTRLGDPIEARALLETYGQDRTAPL
LLGSLKSNIGHTQAAAGVAGIIKMVLAMRHGTLPPTLHVDRPTTHVDWSAGSIELLTEPR
PWPDTGRPRRAAVSSFGVSGTNAHVILESRPQPEAETPPGAHPAPLLISARTPRALHEHT
TRIRAFRDSGSCDEHAVASALLARTAFRHRAALIGTDLITGTAEPDRRLVWLYSGQGSQR
PGMGDELAAAYDVFARTRRDVLDALRVPTGLDLHDTGYAQPSVFALQVALSAQLDTWGVR
PDVLVGHSIGELAAAYVAGVWSLDDACTLVAARARLMQALPHGGAMAAVVASEQEAQPLL
RDGVEIAAVNGPSSIVLSGDEATVLDTAARLGRFTRLRTSHAFHSARMEPMLDAFREVAE
GLTYHEPKIPMAAGAECATPEYWVRQVRDTVRFGEQIAAYDGALLLEVGPDRNLSRLVDG
IPMLHGDDEPRSAMTALARLHTSGATVDWPKVIGPAPASPPDLPTYPFARDRYWSASRGS
GDTAPAGQLPVDHPVLTAAVSIPGSGELVLTGRVDAADPLAHSVHGIAVLPAAVLVDLAV
TAGDEAGCGVLETFAVDTPLVLPQSGGAALSVTVAAPREDGRRTVTVHARHGNGEWTGHA
TGILAAEAPAPAPALAAPSVWPPATARPLDVGEQADALARAGHTGGPAQPRPHAAWTDEG
AVYAEVSLAEDRLSEAGRYGLHPALLGAALTLAAAGTDLPYAFDDVRVHTGGATAVRVAV
TAHGVHITDGTGRPVATVGAVRSRPLTVEGAVPGLLRPVLAEPAEIQEPPPTTATTGGLD
DPTVPDVVILPAYGTGGAPLDEVRRLGAEVLAALQRFLTDDRYAEAVLAVHTGPGLAAAA
VAGLVRTAQAEHPGRIALVDAAPDTAAPLLAAAAVLGEPQTVLRDGRTYPRRLTPAAPAG
DAPALDPDGTVLITGGSGTLAGIIARHLVDHYGVRRLLMLSRGGTANDVPGAHVTAVACD
IANRDELVSALAGIDPAHPLTAVVHTAAVIDDGVLTGLTPERLDTVLRPKADGAWHLHEL
TKDQDLAAFVLYSSAAGVLGSPGQGNYAAANAFLDELAVQRRATGLPALSLAWGLWEPES
GLTAGAGDRLRRSGVTALSTERGLALFDAALRSPDAALVAADPAGLGDTPLLRAAGRVPR
RRTAGAGALADRIAGLSAAEAEKVALAVVRECAAAVLGHDGADRIEPTATFKELGADSLT
AVRLRNALTEATGVRLPATAVFDFPTPQAVAAKLTTALSGRPAEPTRAPTPAMAVDEPLA
IVGMACRLPGGVASPDGLWRLLESGGEGITAFPADRGWDVDALYDPDPGHPGTSTVRHGG
FLPGAADFDAAFFGISPREALAMDPQQRIVLETSWEALEQAGIVPGTLRGSDTGVFIGAF
SDGYGLGTDLGGFGATGTQTSVLSGRLSYFYGLEGPAVTVDTACSSSLVALHQAGQSLRT
GECSLALVGGVTVMASPSGFVEFSQQRGLASDGRCKAFADAADGTAFAEGSGVLVVERLS
DAERLGHRVLAVVRGSAVNQDGASNGLSAPNGPSQERVIRQALANARLEPSDVDAVEAHG
TGTRLGDPIEATALLATYGQSRTTPLLLGSLKSNIGHTQAAAGVAGIIKMVLAMHHGTLP
RTLHVDTPSSHVDWTAGGVELLTEARPWPGTSRPRRAAVSSFGVSGTNAHVILEAPAAPD
SPSAASPSVAPREPLFLTERTPLPVSARTPEAVEGQIQRLRAHLAEHPGDDPRTVAAALF
STRTEFPHRAVLLGEGAVTGTALTRPRTVFVFPGQGSQWLGMGLKLMAESPVFAARMREC
ADALAEHTGRDLIAMLEDPAVKSRVDVVHPVCWAVMMSLAAVWEAAGVRPDAVIGHSQGE
IAAACVAGAITLEDGARLVALRSALLQRELAGHGAMGSIAFPAADVEAAAAQVDNVWVAG
RNGTGTTIVSGRPDAVETLIARYEARGVWVTRLVVDCPTHTPFVDPLYDEFQRIAAATTS
RTPRIPWFSTADERWIDSPLDDEYWFRNLRNPVGFAAAVAAAREPGDTVFVEVSAHPVLL
PAINGTTVGTLRRGGGADQVVDSLAKAYTAGVAVDWPTVVAAPGTAHDTTRTASGPVPGP
AHDLPTYAFHHERYWIEPSSGTDATGLGLDAVDHPLLAASVALPDTDETLLTGRFSLATH
PWLAGHSVAGEVLLPGPVFVELAGRAADETGCDLLDELVIETPLALPATGAVQVRVTVAA
ADDGGRRAVRIHARKDGDGTWTRHASGRAGIATAEPATTDGPWPPAHAEQLDTAEFYRRL
DDEGYGFGPGFRGLSAAWRHGDTVFAEVAVDGALARDASRYTLHPALLVTALQAGSLSAG
SEDAGVRVPFAFSGVRVHSSGATKARVTFTAADGGARVHLADETGRPVAEIGSLVTRPPA
TPDPGGDVRLYRRTWTGVRAPAAPGTTAVRYPDPGDGTAPGGDPFDTTRPDVLVVRASDP
ADVRTALDDPRTAGATLVVSAAAGTTAGAVAALVDTSPPGRIVLVQTADTITPRRAAAFA
RLDEPHLRLTGGRLEAPRLVPAPPRTDPPPYGGVVLLAGGSDDLARQLTGQGAEVIRHEP
GRLPGSPVTAVVHAAGTAESAWELHRLTRELPLDAFVLLVPPGEAAGPWEALAELRRAEG
LPAMAFTAAEDRQTELLDAARATGEAVVVATAPPPPGDPSPLWRPVRRPTRRAAASGGTL
PERLPDLSPEEQEQAVLGLVRDTAAALLGHADARAVTATAAFKDLGVDSLTALGLRDRLA
EALATPLPATLVFDYPAAGTLTRHLLTLLNPDGSATQDGGEPPVARTPENPQAAEPDNKS
IDDELLDEELIDDMDADALIAHVRKG
Reference
PMID:21175203
  Authors
Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore BS, Lim SK, Yoon YJ
  Title
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
  Journal
J Am Chem Soc 133:976-85 (2011)
DOI:10.1021/ja108399b

DBGET integrated database retrieval system