KEGG   Addendum: CAC20920
Entry
CAC20920          CDS       T10000                                 
Symbol
pimS3
Name
(KEGG) pimaricinolide synthase PimS3
  KO
K19205  pimaricinolide synthase PimS3
Taxonomy
TAX:68242
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces natalensis
SSDB
Motif
Pfam: ketoacyl-synt KR Acyl_transf_1 Ketoacyl-synt_C PKS_DH_N PS-DH KAsynt_C_assoc adh_short PP-binding Thiolase_N Docking Epimerase adh_short_C2 Polysacc_synt_2 ACP_syn_III GDP_Man_Dehyd 3Beta_HSD
Other DBs
NCBI-ProteinID: CAC20920
GB: AJ278573
UniProt: Q9EWA2
LinkDB
AA seq 1808 aa
MTTSSETVVAALRASLKEAENLRRQNRKLVAAATEPIAIVAMACRYPGGVQSPEDLWELL
TAGKDAIGAFPTDRGWDLDALRDAGVDRRGNAVSQEGGFLDGVGDFDADFFGISPRESVT
MDPQQRLLLETSWEAIERAGIDPTTLRGSRTGVFIGTNGQDYAYLLVRSLADATGDIGTG
IAASATSGRLSYTLGLEGPAVTVDTACSSSLVALHTASHALRAGECSLALVGGVNVMSSP
GSLMEFSRQGGLAADGRCKAFSDTADGTGWSEGVGVLVVERLSDARRNGHPVLAVVRGSA
VNQDGASNGFTAPSGPSQQRVIRQALAAAGLSASDVDVVEAHGTGTPLGDPIEAQALLAT
YGQDRDPERPLLLGSVKSNLGHTQAAAGAAGLIKMILAMRHGVLPKTLYADVPSSHVDWT
SGEVELLTEPQEWPKADRPWRAGVSSFGISGTNAHVIVEQAEPDEEPVAEPGLAPAVVPW
LVSAKTEEALAAQLARISSRRGTASPVDVGFSLASGRSAFEHRAVLLAQCPDGELSEAAR
GRAETSRPLAVLFSGQGAQRVGMGRELYVRFPVFAEALDEVLAHFDAGLRDVMFGDAEGL
DETGFTQPALFAIEVALFRLAESLGVRPDFVGGHSIGEIAAAHVAGVFSLTDACALVAAR
ARLMQALPAGGAMVAVQASESEVAARLVDGVSIAAVNGPEAVVLAGDETAVLRIAEELAA
GGRKTQRLPVSHAFHSPLMEPMLEDFRRVAEGLSYGAPQIPLVSNVTGELAVEELVCSPD
YWVRHVRETVRFADGVSALEAEGASAFLELGPDGVLTAMARHTLDETKVAVPVLRKDRPE
ETALLTALAHLHVAGIGVDWSGIFAGTGARRVDLPTYPFQHERYWPRPAVLSGDVAGAGL
RSAEHPLLGATLTLAESGEVVLTGRLSLQTHPWLTDHAIGGNVFFPGTGFLELAMHAADQ
AGCDRVEDLVLMTPLVLAEENGTQVQVLVGPADEAGTRTISIHARPEDDPDQPWMQHAGG
TLTSGERVVDFGSTVWPPQDAVAVDLEGFYEGTGYGPAFQGLRSVWSCGDGAYAEVALPD
HVAEDAGAFGLHPALLDAVLQSHRIAGVGSADDQFLPFAWRGVSLHAGGASVLRVRVVKT
GDDSMSIAAVDAEGAPVLSAEAMVMRAYRDPGTGQAAARHGAERDELLSLEWVSGPEVPP
AGVRCVSLGADELGVGASVASLADLSGDEDFVVLPVSGVGGDVPAAAHELTARTLGLLQE
WSGREGSSGSRLVFVTRNAVSADEGESVRDVAAAAVWGLVRSAQSESPGRIALVDLEADS
GDLAEVLAGLPGLLAAGDAQFVVREGAVRVGRLVESNEGAGVSPREWDADGTVLVTGGTG
GLGRELARHLVVERGVRHLLLVSRSGPEAPGVSGLSDELAAHGAEVTVRACDVADRAAVH
ALVAAVPAEHPLTAVIHTAGVLDDGLVTSLTPERLSTVLRPKVDAAWNLHEATKDLDLAA
FVLYSSISGVLGAPGQANYAAGNVFLDALAWHRMGQGLPAQSLAWGAWTQDGGMTATLSD
TDMQRMASYGTAPLSRQRGLALFDAACARSAAHLVAVGRVGGPVRASAPVPSVLRGLVKG
ARRTAVNTTGETAVSLADRLRAARPEERPRLMTDLVRTEAAAVLGHASAKNVDARREFNE
LGFDSLTSVELRNRLSALTGLRLSAALVFDYPNPTALADHFVSELVEEAATGPALLAELE
RLDSALAAGAPDARTRAAVTARLAQILDDWRDAPAEEDGAEVAERLEAASTDEIFAFIDN
ELGRHSDR
Reference
PMID:11094342
  Authors
Aparicio JF, Fouces R, Mendes MV, Olivera N, Martin JF
  Title
A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.
  Journal
Chem Biol 7:895-905 (2000)
DOI:10.1016/S1074-5521(00)00038-7

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