Entry
Symbol
pimS1
Name
(KEGG) pimaricinolide synthase PimS1
KO
K19203 pimaricinolide synthase PimS1
Taxonomy
Lineage
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces natalensis
Taxonomy
SSDB
Ortholog Paralog GFIT
Motif
Motif
Other DBs
LinkDB
All DBs
AA seq
6797 aa AA seq DB search
MSNEEKLREYLKRAIADLHETRQQLDETEAKQREPLAIVSMACRFPGGVRSPEELWELLR
DGVDAVSSFPRNRGWDLDALYHSDPAHQGTSYAREGGFLHDAGEFDPGFFGISPREALAM
DPQQRLLLETAWEAVERAGIDPESLAGSRTGVFVGTGHGGYDAEGRRRADEVGGHLLTGN
HISIASGRISYVLGLEGPALTVDTACSSSLVALHLAMHALRRDECAMALVGGATVMSTPQ
MFVEFSRQRGLAPDGRCKPFAAAADGTGWSEGVGLLLVERLSDAVRNGYPVLAVLKGSAV
NQDGASNGLTAPNGPSQQRVIRQALTGAGLAASDIDAVEAHGTGTTLGDPVEAHALLATY
GQQRAADRPCGLGSMKSNIGHTQAAAGIAGVMKMVLAMRHGHLPRTLHLDEPTGHVDWSE
GNARLLAEPEPWPSAGRPRRAAVSSFGISGTNAHVILEQAPAHEAEPAPEPAARPGALPW
ILSARTEAGLRAQADRLGRHLRDRADLEPAAVAHALADTRTLMEHRAVVVAGDREEFLRG
LDALAAGRTANGLVSGVAVKAASAFLFAGQGSQRPGMGRELHAAHPVFATAFDAVCAELD
PHLDRPLRDIVFAEEGSAEAALLDQTAYTQAALFALETALFRLVESWGVAPRFVAGHSIG
ELTAAHVSGVLTLHDAARLVAARGTLMQALPAGGAMVAVQATEDEIRERLAGHEDHVALA
AANGPDSTVISGDEQAVTEIAAHWEAQGRRTKRLRVSHAFHSPHMDDMLEDFRRVARGLT
FHAPRIPVVSTVTGALATEDELRSPDYWVRQVRETVRFCAAVRTLEAEGVTTFVEIGTGG
VLTPMVQDCLTTLEEPVLVPLLRTGRPETVALTEGVATAFVHGVPVDRSAFPGAPGTSRA
DLPTYAFQRQWYWLDPADHDEGEAAAAEAGEAGFWAAVEREDLQELSAVLAIDGSEADSL
GSFLPTLSSWRRQRRTQAAADRFSYRTHWAPRTASGGPTATGHWLVVLPEGGTDDPWTAR
LLDALNDQGLHTDVRELPADHEPDAWGRHPVDGVLCLLALDERPTRSCPPYRRGLAATTN
AAARPEGAGIQAPLWCVTRGAVAVDRHEALKSPLQAQTWGLGRVAALESPQSWGGLIDLP
DNLDGRAVSALLSTLAGEEDQVAVRPAGVFARRLERITPGGDTGDRWSTHGTVLVTGGTG
ALGAHLAHWLADAGAEHLVLTGRRGPQAPGAPELAAALTDRGVKVTLAACDAADRDALAA
VLADIPPHLPLTGVVHAAGVLDDGVLDALTPERFETVLRPKARAAQNLHELTQDLDLDHF
VLFSSIVGVLGNAGQANYAAANAYLDALAEHRLAQGLPATSVSWGPGQAAAWHDSDAADR
MSRDGLLPMAAAPRRRPAPALAQGMTQVTVADIDWSAYAPALTAVRPSPLIGDLPEARRA
LGPAEGPRRERSPLRDRIGALPPAEQEKAFLTMVREEAARVLGHPSPDTVDAQRAFREQG
FDSLMAVDLRNRLSAATGLRLPATLLFDHPTPLAAAACLRSEVLGAAGPATVVQASTAAL
DEPVAIIGMACRFPGGVHSPEALWRLLAEGGDAITPMPADRGWDLDRLYHPDPDHQGTSY
ARGGGFLDGAADFDADFFGISPREALAMDPQQRLLLETWEVLEQAGIDPESLRGSSTGVF
AGTNTQDYGTALDAAQDEAGGHRLTGNAMSVVSGRVSYTFGFEGPALTVDTACSSSLVAL
HMAAQALRQGECSLAVAGGVTVMATPSSFVEFARQRGLAPDGRCKPFAAAADGTGWSEGV
GLLLVERLSDARRNGHQVLAVVRGSAVNQDGASNGLSAPSGPSQQRVIRQALANARVAAS
EVDAVEAHGTGTTLGDPIEAQALLATYGQERPLLLGAVKSNLGHTQAAAGVAGVMKMVLA
MRHGMLPRTLHVDEPTGHVDWTAGAVELLTEHTDWPETGHPRRAAVSAFGISGTNAHVVL
ELPAAEQPLVEQPSAAEPDAPATAPDRTPTASDGTAPLLLSAKSESALRAQAARLHSHLE
RDPALRLTDAAYTLMTHRTAFAHRAAVRAADHEAALRALTALAAGEADPAVDTGTAHTGR
DAVLFSGQGSQRIGMGRELSGRYPVFAEAFDTVCAALDEHLDRPLRDVVRGEDEELLNRT
VYAQAGLFAIEVALFRLVESWGVRPHYVAGHSVGEIAAAHVAGVFSLADACALVAARGRL
MQALPAGGAMAAIRATEDEVLPHLADSVSIAAVNGPSSVVVSGAEHAVLSIAAHFEGAGR
KTTRLRVSHAFHSPLMDPMLADFRAVAEGLTYGEPELAVVSNVTGQLATPDQLRTPEYWV
THVRAAVRFADGIRALGAEGVTRFLELGPDGVLSALARESAPDDAVCTPVLRKDRSEAAT
LLAALTHLHVHGTEIDWTAFLAGRDAHAVDLPTYAFQHQRFWPTPDHTRTGDLGAVGLEA
TGHPLLSAAVELPDGEGLLFTTRLSLQTHPWLAGHVVMGSVLLPGTAFAELALRAADEVG
CDRVDELTLAAPLVLPEHGGVQLQLRVGPADASGRRTLTARSRAEGDGDRPWVQHATGVL
AEGESTPEPGYDFHTESWPPADAAPVELSGLYPDFAAHGFDYGPHFQGLRTAWRRGDEVF
AEVALPAEAEGEASAYGLHPALLDAALHVVAFNGVDRGVVPFSWESVALHATGASAVRIR
VVRHSGDTVSVDVADTTGEPVASIGTLVLRAVSADQLAGGADPAVRDALFRVQWNPVRLP
PAGAAVTVATLGSLAGAPFDGYPDLASLARSGRVAGAVLVPVEAGAGEVVADDVVGATHA
TAARALDLARSWLADDRFAASRLVFVTRGAVSGADLAGAAVWGLVRSALSEHPGRFGLVD
LDDDAELALVPRVLASDEPQLLVRGGEVLAARLARAQSSHAVTWDPSGTVLVTGGTGGLG
RVMARHLVVEHGVRNLLLVSRRGPAAEGAEELVTELRHSGAEVAVEACDVTDAAAVADLV
ARHRISAVVHTAGVLDDGVVESLTPERLSAVLRPKVDAAWNLHEATRDLDLDAFVVFSSV
AGTIGSPGQANYAAGNAFLDALAHHRRAAGLPAASLAWGPWSRDGGMTGTLTDVDSSASP
GRHARTHPRTGRGLFDAALAAGDAHLLPVRFDWASLRAQGEVPPLLRGLIRTRARRSAVG
GSAAAAGLVGRLSGRGTVERREVLLDLVRAQIAVVLGHANPETIESTRVFQDLGFDSLTA
VELRNRLNNATGLRLSATAVFDYPTADALVDFLLDELFGAQEEAELPAPVPSPAGAADDP
VVIVGMSCRYPGGVGSPEDLWRLVSEGVDAVSDFPTDRGWDVESLYSPDPEALGTSYTRS
GGFLHEAAEFDPDFFGMSPREALATDAQQRLLLETTWEAIERTGIDPASLRGSRTGVFAG
VMYTDYGDLLVGDQFEGYRSNGSAASIASGRVSYTFGFEGPAVTVDTACSSSLVALHWAA
QSLRSGECSLAVAGGVTVMSTPTTFVEFSRQRGLSADGRCKAFADAADGVGWGEGVGMLV
LERLSDARRNGHRVLAVVRGSAVNQDGASNGLTAPNGPAQQRVIRQALASAGLSAADVDA
VEAHGTGTTLGDPIEAQALLATYGQERPEDRPLLLGSVKSNIGHAQAASGVAGVIKMVLA
MRHGVLPRTLHVDEPSSHVDWSAGAVELLTSEAEWPQGEGPRRAGVSSFGVSGTNAHVIL
EQPGPDAADAAPDATVTDPGALAWVLSARNEAALRCQAARLLSLVAGSDALCARDIGHSL
VTGRSSFAHRAVVWGQDRDALVRALSALAVGEADAGLAEGASGAGRTAFLFSGQGSQRLG
MGWELYARYPVFADAFDAVCAALDEHLERPLRDVVWGEDAELLNQTAYAQAGLFAIEVAL
YRLAESWGMRPDFVAGHSIGEVAAAHVSGVFSLPDACALVAARGRLMQQLPSGGAMMAIR
ATEDEVLPHLAEGVSLAAVNGPSSVVISGAEDAVLAIAAHFAGEGRKTTRLRVSHAFHSP
LMEPMLEEFRAVVTRLSFGTPTIPVVSNLTGRLAEPEQLAHADYWVRHVREAVRFADGIQ
ALRAEGVTRFLELGPDGVLSAMARESASDDAVLAPVLRRDRPEETALLGALAQLYVRGAH
VDWTVPFAGSGARWADLPTYAFQHERFWPSGGVARPGDVRSAGLGSAGHPLLGAAVELAG
SGGLLFTGRLSVSSHPWLADHVVLGSVLVPGTALVELVLRAADEAGCDLLEELTLAAPLV
LPASGAAVQVQVAVGEPDEAGRRPVSVHAREGEGPWTLHASGAVTSGAEVPPFDATVWPP
KGAEPVDVADCYDVLADAGLTYGPAFHGLQAAWKLGGDVYAEAKLPESTDGDAYGLHPAL
FDAALHASALGGAEAGGVPFSWAGVSLHATGASHLRVRIREAGGALSVAIADTSGAPVAS
VESLVIRPLSAGQVQAADRDALFKADWVPVPLTDERVEPGTGPEGEPLRTYADLDSLEGA
AVPGTVLVAPPSGAAGTVESVHAATVWALEMVQAWLADDRFATSRLVFVTRGAAFGADLA
AAAVRGLVRSAQSENPGRFGLVDMDGDADTTVPAQALATDEPELLVRGGEVLAARLVRAQ
SSHTVTWDPSGTVLITGGTGGLGRSVARHLVSEHGVRSLLLVSRRGPAAEGAGELVAELR
GSGAEVVIEACDVTDAVAVADLVARHRISAVVHTAGVLDDGVVESLTPERLAVVLRPKVD
AAWNLHEATRGLDLDAFVVFSSVAGTFGSAGQANYAAGNAFLDALAYHRRAVGLPAVSLA
WGPWSQDGGMTGTLSDADVQRIARQGMPPLTVEEGLALFDAALGSAEPMALPVRLDLAAL
RAQGEPQPLLRGLIRTRTRRSGAAAASGIAQRLAGLSTAERREALLDVVRAQIATVLGHA
GPETIAPDRAFQDLGLDSLTAIELRNLLGKATGLRLPATTVFDYPTVDALAAHLLDELFG
AETGTATETPLPVPGLPSLADDPVVIVGMSCRFPGGVASPEDLWRLVADGVDAVSAFPTD
RGWEIDDTYDPEREGAIATRSGGFLHDAAEFDPEFFGMSPREALTTDAQQRLLLETTWEA
LERAGMDPATLRGSRTGVFAGVMYHDYSTLLSGREFEGYQGSGSAGSVASGRVSYTFGFE
GPAVTVDTACSSSLVALHLAAQSLRSGECSLALAGGVTVMSTPLTFVEFSRQGGLSADGR
CKAFADAADGVGWAEGAGILVLERLSDARRNGHRILATVRGSAVNQDGASNGLTAPNGPA
QQRVIRQALASAGLSAADVDAVEAHGTGTTLGDPIEAQALLATYGQERPEDRPLLLGSVK
SNIGHAQAASGVAGVIKMVLAMRHGVLPRTLHVDEPSSHVDWSAGAVELLTSEAEWPQGE
GPRRAGVSSFGISGTNAHVILEQPEPVAAETESITPDTAPDAAEDEAADSGTPVPALLSG
RSASALRAQAARLLSRLDGDPGPRITDVAYSLATGRSAFPHRAVILAANRADLLHSLSAL
AEGHTEAPAVVAQDRARSGKLAFLFSGQGSQRLGMGRELYGRYPAFAEALDAVCAALDAH
LDRPLRDVIWGEDAELLNRTGYAQTGLFAIEVALFRLLESWGVRPDHLLGHSIGEIAAAH
VAGVLSLPDACALVAARGRLMQQLPSGGAMMAIRATEDEVLPHLAEGVSLAAVNGPSSVV
VSGAEDEVLALAAHFEEEGRKTTRLRVSHAFHSPLMEPMLADFRAVADGMTYAAPRIPVV
SNVTGRPATAEELCCAEYWVGHVREAVRFADGVGALREQGVTTFLELGPDGSLSALAAES
AADDSVLAPVLRKNRPEAPALLTALARLHAQGTPVDWSAAFAGTGARWVDLPTYAFQHER
FWPSGGAARAGDVRSAGLGSAGHPLLGAAVELAGSGGRLLTGRLSLSSHPWLADHVVLGS
VLVPGTALMELVLRAADEVDCAAVDELTLAAPLVLPASGAAIQVQVWVGEPDEAGRRPVS
VHAREGEGPWTLHADGALAPAAETVPFDTAIWPPQGAEHLDAAGCYERFADAGFAYGPVF
QGLRAAWKLGEDIYAEVALPEGTDGNAYGLHPALFDAALHAALLGGEGTDEAAVPFSWNG
VTLHATGASRVRVRIRPTEGGTSIALVDTAGAPVASVRSLTARPITAGQLQTGDRDSLFQ
VDWTTLHLTDERANSLALLGKDTEGILDTLSLQPHADLDDLAATGVHDTVLAPLPTRTAG
TVESVHAATTGALALIRSWLADDRFAASRLVFVTRGAVSGTDLAGASVWGLVRSALLEHP
GRFGLVDVDVDQDAEVPLVPRALASDEPQVLVRGGEVLAARLVRAQSSDTVTWDPSGTVL
ITGGTGGLGRSVARHLVSEHGVRSLLLVSRRGPAAEGVDALVAELAECGAQVTVEACDVT
DAVAVADLVARHRISAVVHTAGVLDDGVVESLTPERLSAVLRPKVDAAWNLHEATRGLDL
DAFVVFSSVAGTFGSAGQANYAAGNAFLDALAYHRRAVGLPAVSLAWGPWSQDGGMTGTL
SDADVQRIARQGMPPLTVEEGLALFDAALGSAEPMALPVRLDLAALRAQGEPQPLLRGLI
RTPGRRTAAAATEGDTAAAFAGRLTGLSAAEGREVVLGAVRSQIAGVLGHAEATEIDQDR
AFLDLGFDSLTAVELRNRLGAVTGIRLPATLLFDYPTPAELVAHLHARIAPEPTVGPEAL
LGELERMEKSFGGLDLTEEMHEQIAGRLEVLRAKWDALRDTAAAAGHDGSPSDEDFDFES
ASDDEVFDLLDNELGLS
Reference
Authors
Aparicio JF, Fouces R, Mendes MV, Olivera N, Martin JF
Title
A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.
Journal