Anopheles gambiae (malaria mosquito): 1282011 Help Entry 1282011           CDS       T01036                                  Name (RefSeq) protein purity of essence   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism aga  Anopheles gambiae (malaria mosquito) Brite KEGG Orthology (KO) [BR:aga00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:aga04121]     1282011 Enzymes [BR:aga01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      1282011 Ubiquitin system [BR:aga04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     1282011 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N UBR4 zf-UBR Motif Other DBs NCBI-GeneID:  1282011 NCBI-ProteinID:  XP_061506461 LinkDB All DBs Position 2:complement(663243..681558) Genome browser AA seq 5515 aa AA seqDB search MAAAHSGGVEWAAILKPFLSSSSENISKTDVLNLVKTIILNENEILEHDAAHKQFFDNFV VLAAENITNQVTSLSQTQLPQFTEAASILIRYIILHLDTTAPCKPSILLMALKVLCEGKR ATENQPNATSSASSIISVSGMKYLKYPEIPGNKPGSVGAASSSTSGGSGASAGDKESPKA EMKRSRSDLSTVILQQLTTPLCSWAVTFAALSEEQIDCTDLFVKQNLQCMIAINAGESLL QWCTTALGTPAKYRFKYEESTMLGRPLYLPVTHTEANAIKNIFNLMESDITNLQLAISVP LLEPLTPKKITLLSQCAMSALYCCVLTSTAVSVITMASAGSQKTASSGQLQQAQGQTGAT QTQKENEEEEDFARAIVDKGLEIFTKIGNLLKTSTRTHIYQNLICMGAWLLISGIQGTMG ASGNASGLQQMVPVSAKTTEESLKGRSPLKTLDVPQMASAQPSPALRVNLFKVQQGFGVL NAAIARHSIMLMTELIDDLKIDSRTDEEEYSSIESAGFDILGQYTSIQRVVRVLNSATLQ QLLTFLATVSYRKACTLRRINTKNTNDGEPMSYSDSTTYFNDTFSCSEESEPEEEDSDSY LGLWFKETLSPDMNEEMTESQEQENKDEKGRHGANLVPAKDEPHEYLSLASLIFNFFDVS LGGNHVYLNRYVKTGLSEQQMVLLANILRDLDRDSARGEIDIPGCMQWQNAMVKFSGAVG RYLHNLISNSLLNESLQSALLLHLGVSPWTQDSNVWPLQVYSRTLAVLVQILLLKPSQEK EAACLSVWHRLVNTIVEGICSTQTIPNESEIEDLNVEHAQLLLFLFHSLNLMQKKSILLL TAGGVIRCSEVCRSVTPDKPLRDNQIMLLSRLLLFLEYLMKHLYNPPNVLLEQVRWNLFS VFTLDSEQKLADLVNYKTKMMSFCRKDIEDKHRKLANEFSVGGVKPKFYSLTTVESKVQQ EFKLDGLAWNFILCTPDKLKYPWLIDALIDILGITDMCLARIPFQTLCAVHYCFSLSWKL LLGLPPSTQHVEALMQEKSPNLHSLLWSIRCLHPITHSHYLIVNSLVKQGMYTQSAEAMW IRLTEHVSDVKYSLKMTLLGLESFAKNFSSDQPRLSKIILLDSLMSHLFAVCWAEKEGVN VKTPKSTGTSAASSTSGSVATSNTGSAAAVTSDGNVSGSSSTIVSAGGNNSAPGSSSAVF DGSPCSISAEVSRADLTKNIMHALLDVLEIVREATYKTMFQNLSGQIPSCLIEPLIAIAG TKNSFCSELAQQLVNCITGHDKDVITVEWRKSLGTLTEENFVSGSFPVETHTLTVIEAHL TEVSKHLSYSILLSLKNALKSAINLIYYMLPNYDDVKLDERLKEILIPMVFDLRAEYLHA PINKCLESLLGGDSNCEAYQLAAFSNIIRHSYQFLIEYTDLCATGRATNIDESVLCNILK YWESMLEKSNGLRAMRNFFYESKSGNLVQILLSFTGTNISQAYSTRVLQFFEKLFQAAEK LDAPFDEEELCACIAELAVTDSARLKSWLSHILLGPGGISLTANASNNSSNVPTPTNMAT VSAIPSITDQLAASGTAAGGAGEAGLSDNNTTAANVPTTTEGEQQDAMDIDYECMTKGSG WQAAATSCGKVAIEDASGESLERNGKLLQSLVKYIVAENRISSSVSEALFQALIQIGHNL LSPSQEAIEFSDLLQVMITLADAGKGRGHALLFAAAIDWLDVCRAQVLEAGKSGSSGWRA AIQLDNVTAILKYMSDLLLGLGAKGSKSMNPPWDEESLIDADDILEELGGEEEDSTVEDS DEDSLGNKLCTFSITQKDFMNQHWYYCHTCKMVDGVGVCSVCARVCHKNHDISYAKYGNF FCDCGAKEDGSCQALSRRSNSGHGEESILGSTSSASLLTRSNDADSVLLASSLLRRRHPS SPAHEGSSTSRTSQGKLSEKEQQLAKIIETSREALNNPSQWKTVIRCILVFFNSLMPTIK EHCARYSPVGCYWRAKSALERLHRPEKSYVLSDEIMIATLGSQEGAFENVRMNYSGEQGQ TIKQLLSTYLVRRVALCCLASPHGKRQQLAISHEKGKVTILQLSALLKQADAAKRKLTLT RLASAPVPCTVLSLASNPANEDFLAVCGLKECHILTFTSTGTANDHIVLTPQLDTGNFIK RAIWLPSSQTKIALVTADFVKIYDLAEDSYSPQYYFLVPSGKIRDCTFVYDQDGTYYMLI MSSLGYIYTQPLSDESLAKHGPFYVTSTLELDHPLITDDNGQILAGGVSIYYSHVLQLLF FSYAAGRNFMAPLTNVNDGVKCVINLVCNPSSKLLSKSTTQPLCQWTEIPGHPGLVCAMM QSLNNPVIFMIKPDGYMAQEIKAQNAKAKIMDMVAIRHSVSGVEKTTLILLCEDGSLRIY AAHPENTGYWLSPEVQPVGQQQAFGWYGPGGSMYGKSARKSKKLGKQSAHGAGGASLSAG GKGATGSAPSFPIDFFEHCTLMNEVEYGGNDLLQIYNTQHLKHRLNSTGLYVTSTKANGF TLEVSNNDTNMVITGVRIQIGSQDVTKAPQRVTILGRSVTTVATRARWFDIPLTREESLQ SDKKLSIHFGASVDAEQITILDSIKIYGKTKDVFGWPEETEDAAGGQMANGASGSNGQTT MSNVNAGSDGAAADENDAGGMYMTSLDRMLSSMLHVLDSGVSLLGGPNCDDNYRQTAIDV ATNLILYPTVNVVQQDARNVLMTCHPNKAAYNSYKDKEILNDIYRQLKQMYEATESGDID PEAFYRAVLMMRSIAIQRPQAMAKICAEQQMDILALMMILMKELYRITPAYEEPIAIVKR GLCHTEAVIYSLVEIIYAFALADSEQVEKMAKLFVRLLLDPAPIISHSAKIAMIRLLRPK LKRRKVVLIESPPVCSTPTPSGSGGAAAATAGPSSSTISAGGSSTSGAGPSTSAGSVVAA NEDFAAVAAAAAAAASGGMQEVDAIESLGLEPSAGNQAIASLEALLGVGFPHLLETPDAD DTIMEIAIALSLQDNEADLQLLQQSIANYQGRNRNPAAQSLAAAIAGGSSFNVESNASGG GSDDDEISNVATEGSTLRTSPAGEHAGSGSGGSESGCSGVESIGGTSGRSSTYEEQPNPS PPRTSVVDQMPSQSAGAAATSAQAPAAEAESSDASGETANKLHGLRCSILNQLVENFSAL DTVSGAQCIPFMQVILMLTSDLDGTQEADQQALSLLLQALIDRLEIPSTKMYEMANRNPK TEVQLVVLRLIGVLMGKVKSKSSSSSSSAGTSGAANASSGDRSSVSQAVLDNATFLAQTT ANALMKNNAIPYCLMIMESFLPHWKNASASSIDELASPAIGASNANASANAASSSSGTAN VASNNTGPVITAPGGAPSNVLLKPTMYGVFPDMQPFFARPFPKGSNDVFEMYSQVLTEMA VRLPYQILKLSSGHPSSQEWNHSLCEYMTSTLCEYMMYMQSPVLRRQVRKLLLYICGSKE KYRQLRDLHSLDTHMKAVKKCCEAGYSQASSSPSLTSSHTTILSYDALVELTEHFRACQE IASIRTGNWQKFCGRNSDILSSLLNISTYQLEEGVSTIILQLLQSAICNTSSQGQQSKPS SSGVTVDQQMKVSVVVKDRKDRDKSEESDTMAAPSESKFDAAQCVALVAQIFNQVTPASL SKFIRSFLLETNSTSIRWQAHSLVYAFYENSSDLHKETLLQCLWSLWPLLPAYGKRTAQF VDLLGYLTLNTRSLIDKLPDYTAQAVSVLRQQNELLSKHPNAPIYTALGQVLELEGFYLE SEPCLVCNNPEVPFSNIKLSTIKVDSKFTTTTTIVKLVQSHTISKIVLRIADLKRAKMVR TINIYYNNRTVQAVVELKNRPLMWHKARKVTLQSGQTDVKIDFSLPITACNLMIEYADFY ETVSGSSESLQCPRCSAVVPANPGVCGNCGENVFQCHKCRAINYDEKDPFLCHSCGFCKY AKFDYSIYGRACCAVDPIESAEDRAKTVQTIHTSLEKADRSYKSLQNNKQILELLVQKVS EHKLDRTLDETLVGASVIGGAGGTSQVNKVIQLLAQKYCVESKTTFEELSKIIQKVQACR KELVAYDRSQMDVPPTCGPGAMSTSFASSSGTSSRTTAVTLNKCYGCALASTEQCLTLLR AMASNMACRVGLCSQGLVQELAINNLRRGTHQLQDEVRHLLCLLTRDLPDATGSLCQLLQ DRVKMALSGTVPLATLDSAVRHEMALLEAMTSQDDSCWETKLRTVIELFLQASRDARGPA TAVIHPCLRIVQSLICPPPVLASTVSAGSKQHSKEPTVSSLQDLCTVQPIEGITVSYEKW IAGDANHSFAAWKARMPPAPTANTTGVTSRRTIGENAPPPVVAAAAAPSQPIGTGFRSAL EHRRATVRNAYLVEKYAKRWRQRALAKGVTSIPVELQAAWLQPILFNTNSRLGRQLACAL ITSLSRTNERKRELLDLLTSFLRYVGDSGEASAEFLALYRMLADETPWRQYLALKGVLSL LVQLVTEEIEKIHCLEETTLSTDLAQGYALRQLVELMALFLENPQIRKAYKGKLLGPVLQ GYLDLRKLIVQRTRLIDDAQEKLLEMLEEMTTGTEEETAAFMAVCIDTVRRTPTSDVKTP VFMFERLCSIIHPEENDVGEFFLTLEKDPQQEDYLQGRMLGNPYPSHEAGLGPLMRDVKN KICIDCELVALLDDDNGMELLVHNKIISLDLPVKEVYKKIWLQEGGERDSMRIVYRMRGL LGDATEEFIETLNAKSQEEVDNEQLYRMANVLADCGGLKVMLERIGSLQNVSKSRTLLQV LLKLFLLSVKVSRCQEVLCQPELSAINTLLKVLQLCLQSNESDAQQSAVTEQLLEIMETI LSKAASDTLDSFLQFSLTFGGPEYVQALLSCTNCSNVRCNPSVLRHLIRVLAALVYGNDI KMALLCEHFRSVLNFDRFDAERSAEEEFKMELFCVLTTGIEHNSIGGTLKDYIMSLGIVE KALGYIKSHAPCVKPTLLRTDSDELKEFISRASLKYILRFLTGLATKHEATQLAVAQDII PIIHRLEQVSSDEHVGSLAENLLEALCTEPATAKRVQEVRDFTRAEKKRLAMATREKQLD ALGMRTNEKGQVTAKGSILSQIEKLREETGLACFICREGYACQPNKVLGIYTFSKRANVE EFEMKQKKTTGYTTVTHFNVVHVDCHMNAIRLARSRDEWESASLQNANTRCNGLLPLWGP DVSESSFSSSMARHNTYMQECTQRCEITFASSMHDLKLLLWRFAQEKSFHEDAGGGGPQS NMHLVAYLLFYGLYTLLSSRSYSREEMILTNFIGHKPSERWLECAYEAEGPLYLLTMSLA LHTPDLWSRHKLVHLQRLIVIAHARHVSPNSVCKFLAPADKHPKDYTIYKPYLMFWGLVD LIYCNFFRTVTTPKDEDWPISLFNYIRRNDESLLKTADTTLQTFTEEYLPCASFGEFCDV AGLLGEIENPDAWMEDLLQALPAPGGGSSAGGSSAAGSSGGTGPAGAASGSSGAE NT seq 16548 nt NT seq  +upstreamnt  +downstreamnt atggctgctgcccattccggaggtgtagagtgggccgcaattttaaagccttttctttct tcatcaagtgaaaatatcagcaaaaccgatgtgttaaacttggtaaaaaccatcatacta aatgagaacgaaatcctcgaacatgatgcagctcacaagcagtttttcgacaacttcgtg gtcctggccgcagaaaacatcacgaaccaggttacttcgttgtcgcaaactcaacttcca caatttacggaagctgcttcaatattgattcgttacataattcttcatttggatacaacg gcaccatgcaagcccagcatactcctgatggccttaaaagtcctctgcgagggcaaaagg gccaccgaaaaccagcccaacgcgaccagttccgcctcgtctatcatttctgtttccggg atgaagtacttaaagtatccagagataccgggcaataagccgggatcagttggagctgct agcagtagcaccagcggcggatctggtgctagtgctggtgacaaagaaagtcccaaagcg gaaatgaaacgctcccgatcggatctgtctacggtcattttacaacagctaaccaccccg ctgtgcagctgggctgtaacttttgctgcacttagtgaggaacagatcgactgcaccgat ctgttcgtgaagcaaaatttacaatgtatgatcgccatcaatgcaggtgaatcattactg caatggtgcacgactgctctaggaacgcctgctaaatatcgtttcaagtacgaagagtct accatgcttggccgtccgctctaccttccagtaacacataccgaagccaatgctattaaa aacattttcaatttgatggaatcggatataactaacttgcaattggcgatatcggttcca ctgctagaaccgctcactcctaagaagattactctcctgtcgcagtgtgctatgtcagcg ctttactgttgcgtgcttacatccaccgctgtgagtgtcattaccatggcatcggccgga tcgcaaaagaccgcatcctctggccaactacagcaagcacaaggacaaacaggagcaacc caaacgcaaaaggaaaacgaagaggaggaagacttcgcacgtgctatcgttgataaagga ttggaaattttcaccaaaattggaaaccttctgaaaacatcgacacgcactcacatttat caaaacctcatatgtatgggtgcgtggttgttgatatctggaattcagggcacgatgggc gcatccggaaacgccagcggattgcagcaaatggttcctgtttcagcgaaaacaacggaa gaaagtttgaagggacgcagtccgttaaaaacccttgacgtgccgcagatggcatcggct caaccatcgcccgctttgcgcgttaatctgttcaaagtccagcaagggttcggcgttctt aacgctgcgattgcgcgacacagtatcatgctgatgacggaactgatcgatgatctgaag atagactcccgcacagacgaagaggaatacagtagcatcgaatcagctggatttgatatt cttggccagtacacatcaatccagcgcgtagtacgtgtgctaaacagtgctaccctgcag cagctgctcacattccttgccactgtttcgtatcgcaaagcatgcacgctccgtcggatc aacaccaagaacaccaatgacggagaaccgatgagctacagtgactcgaccacctacttc aacgatacgttctcctgctcagaggaaagcgaaccggaagaggaagacagcgacagctac ctcgggctttggtttaaggaaacactctcgccagacatgaacgaggaaatgaccgaatcc caggagcaggaaaataaggatgagaaaggccgtcacggtgcgaaccttgtgccagcaaaa gatgagccacacgagtatctgagccttgcatcgttaatattcaactttttcgatgtttcg cttggcggaaatcacgtatacctgaatcggtatgtgaagacaggcctaagcgaacagcag atggtactgctggctaacattttacgcgatcttgatcgggattcggcacgcggggaaatc gatatacctgggtgcatgcagtggcaaaatgccatggtgaaattttccggagctgtcgga cgctacctacacaatctaatatcaaactcgctgctgaacgaatcgctccagtctgccctt ctgctacatttgggcgtctcgccgtggacgcaagactcaaacgtctggccgctacaggtt tattcaagaacactggcagttttggtgcagattctgcttttgaaaccgtcacaggaaaaa gaagcagcatgcctgtcagtatggcaccgactcgtgaatacgattgtggaaggcatttgc tccacacagaccatcccgaacgagtcggagatagaggacctgaatgttgaacacgcccag ctgctgctgttcctgttccattcgctcaatctgatgcaaaagaaatcgatactgctgctc acggcaggtggtgtaattcgatgctcggaagtttgccgcagcgtcacgcctgataaaccg ttgcgagataatcagataatgctactgtctcggttgctgctgttcctggagtatctgatg aagcacctgtacaatccgccgaatgttttgttggagcaggtgcgctggaacttattcagc gtttttacgctcgatagtgaacagaagctggccgatctggtgaactataaaacgaaaatg atgtcattctgccgaaaggatatagaagacaagcatcgtaagctggcgaacgaattcagt gtaggcggcgttaaacccaagttctactcattgactacagtcgaatcgaaggtacagcaa gagttcaagctcgatggcttggcctggaattttattctgtgtaccccagacaaactgaag tatccgtggcttatagatgcgttgattgatattctgggcataacggatatgtgcctggcc cgcattccgtttcaaacgctgtgtgctgtgcactattgcttcagtcttagctggaaattg ctgctcggattgccaccgtccacacaacacgtcgaagcgctaatgcaggaaaagagcccc aatttgcactccttgttgtggtcgattcgctgtctacatcccataacccattcgcattat ctgattgtaaacagtctcgttaaacaaggaatgtacacccagtcagctgaggctatgtgg attcgtttaacagaacacgtttcggatgtgaagtacagtttgaaaatgacattgctgggg ctggaatcatttgccaagaatttctcatccgaccagccaaggctgtctaagatcattctt cttgacagtctgatgtcccatctgtttgccgtatgctgggcagaaaaggagggtgtgaat gtgaagacgccaaaatccaccggtacttcagctgcatcctcaacttccggcagtgtcgcg acctccaacaccgggtccgcggcggcagtgacaagcgatggtaatgtctcgggttcgagc tcaacaattgtctcggcaggtgggaacaattcagctccaggctcaagctcagctgtgttc gacggttcaccctgttccatctcggcagaggtctcacgtgcagacctgacgaagaacatt atgcatgctttgttggacgttttggaaatcgtgcgagaggctacctacaaaactatgttc cagaatttgagtggccagataccatcttgcttgatcgaaccgcttattgcaattgctggt acgaaaaactcattctgctcggagcttgctcagcagctggttaattgtatcactggtcac gataaagatgtaataaccgtcgagtggcgcaagagtttgggcacactgacggaagaaaac tttgtcagcggatcatttccggtcgagacgcacactttgacagtcatcgaggcgcatcta acggaggtatcaaaacatttgtcgtactccatactgctgtcgttgaagaacgcgctcaaa tcggcgattaacctcatatactacatgctaccgaattacgacgatgttaagttggacgaa cgcctgaaggagatactaatcccgatggttttcgatttgcgtgccgaatacttacacgcg ccaatcaacaaatgtttggaatcgctcttgggtggagatagcaactgcgaagcatatcag ctagccgcattttcaaatattattcgccacagctaccaatttttaattgaatataccgac ctctgcgctacgggacgggcaacaaacatcgatgaatcggtactttgcaatattctcaag tactgggaatcgatgttggaaaaatcgaacggactccgggcgatgcgcaactttttctac gaatcaaagtctggcaatctggtgcaaatattgctatccttcaccggtacgaatatctcc caagcgtactcgacacgtgtgctgcaattcttcgagaagctgttccaagcggcggaaaag ctcgatgcaccattcgatgaggaagagctgtgcgcatgcattgcagagctagccgtgacg gatagtgcgcgattgaagagttggctgagtcacattttacttggtcctggaggaattagc ctgactgcaaacgcatcaaacaactcgagcaacgtcccaactccgacaaacatggcaacg gtgtcggctattccgagcattactgatcagctagcagcatctggaacggccgccggagga gccggagaagctggtttatctgacaacaacaccaccgcagcaaatgtcccaactacaact gagggtgagcaacaggacgccatggatatcgactatgaatgcatgaccaaaggaagtgga tggcaggcggcagcaacgagctgtggaaaagtggccattgaagatgcatcgggagagtca ctcgagcgcaatgggaaactgctccagtcgctggtcaagtacatagttgcggaaaaccgt atctcttcgtcagtatcagaagctctattccaagctttgattcagattggccacaatctt ctgtcgccatcccaggaggcaatcgagttttccgaccttctgcaggttatgatcacgctt gccgatgcgggcaaaggtcgtgggcatgctctcctatttgcagctgccattgattggtta gatgtgtgccgggcacaggtgttggaagctggaaaaagtggatcgagcggttggagggca gctatccaactagataacgtgactgctattttgaagtacatgagcgatcttctgcttgga ctgggcgctaaaggtagcaagtcaatgaatccaccgtgggacgaagagtcgctgatcgac gcagacgatattctggaagagctcggaggtgaagaagaagacagtacggtcgaggactcc gatgaggatagtctcggcaataaactgtgcaccttttccatcacccagaaagatttcatg aaccagcattggtactactgtcacacgtgcaaaatggtggatggggtcggtgtgtgctca gtgtgcgccagagtttgccacaagaatcatgatataagctatgcaaagtatggcaacttc ttctgcgattgcggtgcgaaggaggacggttcatgccaggcgctaagcagacgaagtaat tctggccatggagaagagtcgattttgggctccacatcgtccgcttcacttttaacccgc tccaacgatgccgatagtgtgttgctggccagtagcttgctgagacggcgccatccttcg agtcctgcacacgaaggttccagcacaagccgcacatcccaaggaaagctttccgagaag gagcaacagttggcaaagatcattgaaacgtcgcgtgaagccttgaacaaccccagccaa tggaagacggtgattcggtgcattctggtcttcttcaactctctaatgccaacaattaaa gagcactgcgccaggtactcgcccgtgggatgctattggcgtgctaagagtgccctagaa cgactacaccgtccggaaaagtcgtatgtattgagtgacgaaatcatgattgccacactc gggtcgcaggagggtgcttttgaaaatgtgcggatgaattactcgggcgaacagggtcaa accatcaaacagctactctcgacctatctcgtccgccgggtagcgttgtgctgtttagct tctccccacggaaaaaggcaacaattagctatatcacacgagaaaggaaaagtaacaata ttgcagctgtcagcccttttgaagcaagcagatgcggcgaagcgtaagcttactctcaca cgacttgcatcggctccagttccttgtaccgtgttgtcgctcgcatcgaatcccgccaat gaagatttcctggccgtatgtggcttaaaagagtgtcacatacttactttcaccagcacg ggtacagcaaacgatcacatcgtgttgacgccgcagctcgacacgggcaactttataaag cgggccatctggttgccatcgtcgcagacaaagatagcactagtgacggcagattttgta aaaatctatgatcttgccgaagatagctatagtccacagtactattttctggtgcctagc ggcaagattcgcgattgtacgtttgtgtacgaccaagacggtacgtactacatgctgatt atgtcttcacttggatacatctacacacagcccctcagcgacgaaagcctggcaaagcat ggtcccttctacgtgactagtacgctggaactcgaccatccgttgataacagacgacaat gggcagatactggcaggaggcgtctccatctactattcgcacgtccttcaattgctgttc ttcagctatgccgctggtcgtaactttatggctccgctaacaaatgtcaacgatggcgtg aagtgtgtaattaacctggtttgcaatccaagctccaagttgctctccaagtcgacgacc caaccactttgccagtggacagaaattcctggccatccggggttagtgtgcgccatgatg cagagtcttaacaatcctgtcatctttatgattaaaccagatgggtatatggcacaggaa atcaaggcacagaatgcaaaggccaaaataatggatatggtcgctatccgccacagtgtc tctggggtagagaaaaccacgctaattttgttgtgtgaagacggcagcttgagaatttat gctgcgcatccagaaaacactggttattggctttccccagaagtccagcccgttggacag cagcaggcctttggttggtatggaccgggcggaagcatgtatggcaaatctgcacgcaaa tcgaaaaagctgggcaaacaatcagcccatggagcgggaggtgcgtccttatcagctggc ggaaaaggtgcaaccggatctgctccaagcttcccgatagacttcttcgagcattgcaca ctgatgaatgaagtagaatacggaggaaatgatttactgcaaatctacaatacgcaacac ttgaaacatcgcttaaactcaacagggttgtacgtgacgtctactaaagcaaacggattt acgctggaagtttctaataacgatacgaatatggttataacaggtgttcgtatacagatt ggctcccaggacgtcactaaagcaccacaacgagtgaccattcttggtcgatcagtaaca acggtggctacaagagctcgttggtttgatataccgctaacaagagaagaaagtctgcaa agtgacaagaaactcagcattcacttcggagcttcggtagatgcagaacagataacgatc ctggacagcattaagatatacggaaaaactaaagatgtgtttggttggcccgaagaaaca gaggatgctgctggaggacaaatggcgaacggtgcctctggtagcaatggacagacgacg atgtcaaatgtaaatgctggcagcgatggagctgctgccgacgaaaatgatgcaggtgga atgtacatgacgtcgttggatcgtatgctgtccagcatgctacacgtgctcgacagtggc gtatctctgctaggtggtccaaattgcgacgacaattatcgtcaaacagcgatcgatgtg gctacaaacttgatcctctacccgactgtaaacgtagtccaacaggatgctcgcaacgta ctaatgacgtgccatccgaacaaagcggcgtataattcctacaaagataaagaaattttg aacgacatctaccggcagctgaagcaaatgtacgaagcaaccgagagcggagacattgat ccggaagctttctatcgagcagttttgatgatgcgaagcatcgctattcaacgaccacag gctatggcaaagatctgcgcggaacagcagatggacattctagcgctgatgatgattcta atgaaagagctgtaccgtataactccagcgtatgaagaaccgatcgcgatcgtaaaacgc ggactgtgtcatacggaagcagtcatctactctctggtggaaatcatttatgccttcgcc ttggctgacagtgagcaggtcgagaaaatggccaaactctttgttcgtttgctgctcgac ccagcaccgatcataagtcatagtgcgaaaatagcaatgattcgtttattgcgaccgaag ctcaagcgtcgaaaggtggtccttattgaaagccctcctgtttgttccacacctacaccc tcgggatcgggaggagcagcagctgctactgcaggaccgtcatcatcaacgatatcagct ggaggatcatcaacatcaggagctggtccgtcgacttccgcgggaagtgtagtggcggcg aatgaagattttgctgccgttgcagcggctgcagcagcagccgcgtccggtggaatgcag gaagtggatgcaatcgaatccctggggttggaaccaagtgcaggcaaccaggctattgct tcactggaagccctactgggcgttggttttccgcatttgctagagacacctgatgcggac gacactataatggagatagcgatcgcgcttagcctccaggataatgaggccgatctacag cttttgcagcagagtattgccaattatcagggaagaaatagaaatccagctgcgcaaagc ttggccgcagcaattgccggaggctcttcattcaacgtggaatcaaacgcgtctggaggc ggatcggacgatgatgaaatttccaacgttgccacagaagggtctacgctgcgaacgtct cctgccggtgaacatgccggcagtggaagcggtggatccgagagtggttgcagtggcgta gagagtatcggtggaacttccgggcgcagctcaacatacgaagagcagccgaatccatcg ccaccacgcacttctgtggtcgatcaaatgccgtcacaatcggcaggggcagccgcaact tcagcacaggctcctgctgcggaagcagagtcgtccgacgcaagcggggaaactgccaac aaattacatggtttgcgatgctccattctgaatcagttggtggaaaacttttccgccctg gacaccgtgagtggtgcgcagtgtatcccgttcatgcaggtgattcttatgcttacgtcc gatctggatggcactcaggaagcagaccaacaagctttgagcctattgttacaagcgttg atcgatcggctggaaattccatctacgaaaatgtacgaaatggccaaccgaaaccccaaa acggaggtgcaacttgtggtactacgtttaatcggcgttttgatgggaaaagtgaagtcc aaatcatcatcatcgtcatcctccgccggcacttcaggggcggctaatgcctcgagcgga gatagatcgagtgtcagtcaagccgtgttagataacgcaacatttttggcgcaaactaca gccaatgcgcttatgaagaacaatgccattccgtattgtctcatgataatggaatccttt ttgccgcattggaaaaacgccagcgcttcttcaatcgatgaattggcttcacctgcaata ggagcgtctaacgccaatgcgtcggcgaatgctgcctcttccagcagtggtacagcaaac gtggcttcgaataatacgggaccggtcataacagcaccaggaggagccccgtcgaacgtg ctgcttaaaccaaccatgtatggagtgtttccagatatgcagccgttcttcgccagaccc ttccccaaaggatcaaacgatgtatttgagatgtactcacaggtgctaacggagatggcg gttaggttaccttaccaaattttgaaactgtcttcgggacatccatcatcccaggaatgg aaccattcactgtgcgagtacatgacttccacgctgtgtgaatatatgatgtacatgcag tcgccggttctgcgacgccaggttcgaaagctgttattgtatatttgcggcagtaaagaa aagtatcgccagttgcgtgatctacattcgttggacacacatatgaaagcggtaaaaaaa tgctgtgaagctggctattcccaggcatcatcatcgccatcgctcacaagtagtcatacg accatcctcagctacgatgcgttggttgagctgacggaacatttccgtgcctgtcaagaa atagcatcaatccgcaccggaaactggcaaaagttttgtggtcgcaattcggacatactt tcttcgctattgaacatcagcacgtatcaactggaagaaggcgtatcaacgatcatactg caactccttcaatccgccatctgcaacacgtcatcgcagggacaacagagtaaaccatcg tcttccggcgttacagtggatcagcaaatgaaagtgtcggtcgttgtaaaggatcgaaag gatcgcgacaaatcggaagaatctgacacgatggctgcaccgtcagagtcaaagttcgat gccgctcagtgtgttgccctagtggcacaaatcttcaaccaggtcactccggccagtttg agcaaattcattcgcagcttcctgctcgaaaccaactcgacatcgatccgctggcaagcg catagtcttgtgtacgcattttacgaaaacagcagcgatctacacaaagaaactctgctc cagtgtctgtggagtttgtggccattgctaccagcgtacggtaaacgcactgcacagttt gttgatctgcttggctatctgacgcttaacacacgctcgctgatagataagctgccggac tacactgcccaggctgtttcagtcctacgacagcagaatgagctgctatcaaaacaccca aatgcaccgatctacacagcgctgggtcaagtgttggaactggaaggattctatctggaa tcggaaccgtgtcttgtttgcaacaatccagaagtaccgttttcgaacataaaactgtca accataaaagtggattcaaagtttacgaccactacaacgatcgtgaagctcgtgcaaagc catacgatctcaaaaattgtactacgcattgctgatctgaagcgggccaaaatggtgcgt acgattaacatctactataacaaccgaacggtgcaggcggtggtggagctgaagaatcgc ccgctgatgtggcacaaggcgcggaaggtgaccttgcagtcgggccaaacagatgtaaag atcgacttctccttgccgattacagcctgcaatttgatgatcgaatacgctgatttttac gaaactgtaagtggatcaagcgaaagtctgcagtgtccgcgatgtagcgcagtagttcct gcaaatcccggcgtgtgtggcaactgcggcgagaatgtgttccagtgtcacaaatgccgt gcgataaactacgacgaaaaggatccgttcctttgccattcatgtggattctgcaagtac gctaagttcgactacagcatctatggccgagcgtgctgtgcggtggacccgatcgaatcg gcggaagatcgagcgaaaaccgttcaaacaattcacacatcgctggaaaaagcagaccgc tcgtataaatcgctacagaacaacaaacagattttggagctgctagttcaaaaagtgtcc gagcacaagcttgaccgtacgctcgatgaaacgctcgtcggtgcttcggtcattggagga gctggaggaacttcgcaggttaacaaggtcatacagctgttggcgcaaaagtactgcgtg gaatcaaaaactacttttgaggagctcagcaagattatccaaaaggtgcaggcatgccgc aaagagctagtggcatacgacagaagccaaatggatgttcctcctacgtgtggaccggga gctatgtcgacgagcttcgcctccagttcaggcacgtcatccagaactacggcagtcact ttgaacaagtgttacggctgtgcccttgcatcgaccgaacaatgtctcacgttgcttcga gctatggcatccaacatggcctgtagagtcggcctttgcagccaagggttggtgcaagag cttgcaataaacaatttacgccgtggaacacatcaactgcaggacgaagttcgtcatctg ttgtgcttgctaactcgtgacctgcccgatgctaccggttcgctatgtcagcttctgcag gaccgcgtaaagatggcgctgtcaggaactgtcccattggcaacgttggatagtgctgtg cggcacgagatggctctactggaggcaatgaccagccaggacgatagctgctgggaaaca aagcttcgcaccgttatcgaactattcctgcaggcatctcgtgatgcccgcggtcctgct actgctgtcattcacccctgtttgcgaattgtgcagtcactcatctgcccaccgccggta ctagcgagcacggtctccgctggcagcaagcaacatagcaaagaaccgactgtaagctcg ctgcaagatttgtgtacggtacaaccaatcgaaggaattaccgttagctatgaaaaatgg atcgcaggcgatgcgaatcattcgtttgctgcctggaaagcaaggatgcctcctgcacct acggccaataccaccggcgttaccagtcgtcgtaccataggggaaaatgcaccaccaccc gtggttgctgctgcagctgcaccatcgcagcctatcgggactggattccgttcagctttg gaacatcgacgagctactgtacgcaatgcgtatctggtggaaaaatatgcaaaacgatgg cgacagagggccttagctaaaggggtcacatcgattccggtcgagctgcaagctgcttgg ttgcaacctattctgtttaacaccaattcacgacttggacgtcaactggcctgtgcactc attacatccttgagccgcacaaacgaacgtaaacgggagcttctggatcttttgaccagt tttctgcgctacgtcggagacagtggagaggccagcgccgagtttttggctctctatcgc atgctagcagacgaaacaccctggcgacagtaccttgctttgaaaggtgttttatcattg ctagtgcaactggtaacggaagaaattgagaagattcactgtctggaagaaactacactc tcgaccgatctggcccagggttacgcgctacggcagctggtggaactgatggcgcttttc ttggaaaatccacagatccgaaaagcatacaagggcaaattgctaggaccagtgctccag ggttatcttgacctccgcaagctgatcgtacagcgcacgcgcttgatcgatgatgcacaa gagaagcttctcgaaatgctagaagaaatgacgactggcacggaagaggaaacggctgct tttatggcggtatgcatcgacaccgtgcggcgcacaccgacatcggacgtgaaaacacca gtattcatgttcgagcgactgtgctctataatacacccagaggaaaacgacgtgggcgaa tttttcctcactcttgagaaggacccccagcaggaagactacctgcaagggcgtatgctg ggtaatccctatccttcccatgaggccggtcttggccctctcatgcgtgacgttaaaaac aagatttgcatcgattgcgagcttgtcgctttactggacgatgataatggaatggagcta ttggtgcacaacaagatcatcagtttggatctaccagttaaggaggtgtacaagaaaata tggctccaggaaggcggcgagagagacagtatgcgcattgtgtatcgtatgcgcggcctg ctaggtgacgcgaccgaggaattcatcgaaacactcaacgccaagagccaagaggaggtg gacaacgaacagttgtaccgtatggcaaacgtattagccgattgtggaggactcaaggtc atgctggaacgcatcggaagtttgcagaacgtgtcaaagtcacgtaccctgttgcaggtt ctgttgaaattgttcctgctaagcgtgaaagtgtcccgttgccaggaggtgctctgtcag ccagaactgagcgcaatcaacacgctcctgaaggtgttgcagctgtgcttgcaaagcaac gaaagcgatgctcagcagtcggcagtaacagagcagctgctagagattatggaaacgatt ctgtccaaggccgcttctgatacgttggattcgttcctccagttttcgctcacgttcggc ggaccggagtacgtacaggcgctactatcttgcacaaactgctcgaatgtccggtgcaat ccatccgtactgcgacatctaatccgtgtactagccgctctagtatacggaaatgacatc aagatggcgcttctgtgcgaacatttccgctcggtgctgaacttcgatagattcgatgca gagcgcagtgccgaggaagagttcaagatggagctgttctgtgttttgaccaccggtatt gagcacaattctattggaggaacactgaaagactacatcatgagtttgggcattgtagag aaagcgctcgggtacatcaaatcccatgcaccgtgcgtgaagccaacgctgctgcgcacg gattcggacgagctgaaggaattcatttctcgcgcctcgttaaaatatatactgcgcttc ctcactggcctggccacgaaacacgaagcgacccagctggccgttgcccaggacatcatc ccgatcatacatcggctggagcaagtgtctagtgacgagcatgtaggatcgctggcagaa aacctcctggaagcgctgtgcacagaaccagcgacggccaaacgcgtacaggaagtgcgc gattttacacgcgccgaaaagaagcgactagcaatggcgacccgagagaagcagctggac gcgcttggaatgcgtacaaacgaaaagggacaggtaacggcaaagggttcaatcctgtcg cagattgagaaactgcgcgaagagacgggattggcgtgctttatttgtcgcgaaggatac gcctgccagccaaacaaggtactgggcatctacaccttctccaagcgcgccaacgtggag gagtttgagatgaagcagaagaaaacgaccggctataccacggtaacacacttcaacgtt gtacacgtggactgtcacatgaatgcaatcagattagctcgatcgcgcgatgaatgggaa agtgcctcgctgcagaacgccaacacgcgttgcaacggattgcttccactgtggggcccg gacgtgagtgagtcttcgttctcatcgtcgatggcacgccacaacacctacatgcaggag tgcacgcaacggtgtgaaatcacgttcgctagctcgatgcacgatctgaagctgctgctt tggcgctttgctcaagaaaagagcttccacgaggatgctggcggtggtggtccacagtcg aacatgcatttggtcgcttatctgctgttttatggactgtacacgttgctctcgtctcgg tcatactcgcgggaggagatgatcctgaccaatttcatcggccacaaaccctcggaacgc tggttggaatgtgcgtacgaagcggagggtcccctctatctgctcaccatgtcactagcg ttgcacacgcccgacctgtggtcacgccacaagctggtacatctgcagaggttgattgtg atcgctcatgcccgacacgtaagcccgaactccgtctgcaagttccttgcgcctgccgat aagcatccaaaggattacacgatctacaaaccgtatctgatgttctgggggcttgtcgat ttgatctattgcaactttttccgtaccgtcacaacgccgaaggacgaagattggccgatc tcgctgttcaactacattcgccgaaacgacgagtcccttctcaagacggccgacaccaca ctgcaaacattcacggaggaatacttaccgtgcgcttcgtttggcgaattttgcgacgtg gcaggtctgctcggagaaatagaaaatccagatgcgtggatggaggacctgttgcaagcg ctgccagcaccgggtggtggttcatctgctggaggatcaagtgcagcaggttcaagcggt ggaaccggcccggcgggagctgcatcaggatcgagcggtgcagaatga

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