KEGG   Artibeus jamaicensis (Jamaican fruit-eating bat): 119044502
Entry
119044502         CDS       T07223                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ajm  Artibeus jamaicensis (Jamaican fruit-eating bat)
Pathway
ajm01521  EGFR tyrosine kinase inhibitor resistance
ajm01522  Endocrine resistance
ajm04010  MAPK signaling pathway
ajm04012  ErbB signaling pathway
ajm04015  Rap1 signaling pathway
ajm04024  cAMP signaling pathway
ajm04062  Chemokine signaling pathway
ajm04068  FoxO signaling pathway
ajm04150  mTOR signaling pathway
ajm04270  Vascular smooth muscle contraction
ajm04510  Focal adhesion
ajm04650  Natural killer cell mediated cytotoxicity
ajm04720  Long-term potentiation
ajm04722  Neurotrophin signaling pathway
ajm04726  Serotonergic synapse
ajm04730  Long-term depression
ajm04810  Regulation of actin cytoskeleton
ajm04910  Insulin signaling pathway
ajm04914  Progesterone-mediated oocyte maturation
ajm04928  Parathyroid hormone synthesis, secretion and action
ajm04934  Cushing syndrome
ajm05010  Alzheimer disease
ajm05022  Pathways of neurodegeneration - multiple diseases
ajm05034  Alcoholism
ajm05160  Hepatitis C
ajm05161  Hepatitis B
ajm05200  Pathways in cancer
ajm05205  Proteoglycans in cancer
ajm05208  Chemical carcinogenesis - reactive oxygen species
ajm05210  Colorectal cancer
ajm05211  Renal cell carcinoma
ajm05212  Pancreatic cancer
ajm05213  Endometrial cancer
ajm05214  Glioma
ajm05215  Prostate cancer
ajm05216  Thyroid cancer
ajm05218  Melanoma
ajm05219  Bladder cancer
ajm05220  Chronic myeloid leukemia
ajm05221  Acute myeloid leukemia
ajm05223  Non-small cell lung cancer
ajm05224  Breast cancer
ajm05225  Hepatocellular carcinoma
ajm05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ajm00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    119044502 (BRAF)
   04012 ErbB signaling pathway
    119044502 (BRAF)
   04015 Rap1 signaling pathway
    119044502 (BRAF)
   04068 FoxO signaling pathway
    119044502 (BRAF)
   04024 cAMP signaling pathway
    119044502 (BRAF)
   04150 mTOR signaling pathway
    119044502 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    119044502 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    119044502 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    119044502 (BRAF)
   04062 Chemokine signaling pathway
    119044502 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    119044502 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    119044502 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    119044502 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    119044502 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    119044502 (BRAF)
   04720 Long-term potentiation
    119044502 (BRAF)
   04730 Long-term depression
    119044502 (BRAF)
   04722 Neurotrophin signaling pathway
    119044502 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    119044502 (BRAF)
   05205 Proteoglycans in cancer
    119044502 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    119044502 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    119044502 (BRAF)
   05212 Pancreatic cancer
    119044502 (BRAF)
   05225 Hepatocellular carcinoma
    119044502 (BRAF)
   05226 Gastric cancer
    119044502 (BRAF)
   05214 Glioma
    119044502 (BRAF)
   05216 Thyroid cancer
    119044502 (BRAF)
   05221 Acute myeloid leukemia
    119044502 (BRAF)
   05220 Chronic myeloid leukemia
    119044502 (BRAF)
   05218 Melanoma
    119044502 (BRAF)
   05211 Renal cell carcinoma
    119044502 (BRAF)
   05219 Bladder cancer
    119044502 (BRAF)
   05215 Prostate cancer
    119044502 (BRAF)
   05213 Endometrial cancer
    119044502 (BRAF)
   05224 Breast cancer
    119044502 (BRAF)
   05223 Non-small cell lung cancer
    119044502 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    119044502 (BRAF)
   05160 Hepatitis C
    119044502 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    119044502 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    119044502 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    119044502 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    119044502 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    119044502 (BRAF)
   01522 Endocrine resistance
    119044502 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ajm01001]
    119044502 (BRAF)
Enzymes [BR:ajm01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     119044502 (BRAF)
Protein kinases [BR:ajm01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   119044502 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 119044502
NCBI-ProteinID: XP_036994752
LinkDB
Position
Unknown
AA seq 763 aa
MAALSGDGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEAL
LDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTSSS
SSSLSVLPSSLSVFQSPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKA
LMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFT
LAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEE
ASLAETSLASGSSPSVPPSDSIGPQILTTPSPSKSIPIPQPFRPADEDHRNQFGQRDRSS
SAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQR
ERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKM
LNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHII
ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW
SGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ
IIFMVGRGYLAPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI
HRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2292 nt   +upstreamnt  +downstreamnt
atggcggcgctgagcggcgacggaggcgcggagcagggccaggctctgttcaacggggac
atggagcccgaggccggcgcgggcgccgcggcctcttctgcagcagaccccgccatcccg
gaggaggtatggaatatcaaacaaatgattaaattgacacaagaacatatagaggcacta
ctggacaaatttggtggagagcataatccaccatcaatatacctggaggcctatgaagaa
tacaccagcaagctagacgccctccagcaaagagaacaacagttactggaatccctgggg
aatggaactgatttttctgtttctagctctgcatcaacggacaccgttacatcttcttcc
tcctctagcctttcagtgctaccttcatctctttcagtttttcaaagtcccacagatgtg
tcacggagcaaccctaagtcaccacagaaacctattgttagagtcttcctgcccaacaaa
cagaggacagtggtacctgcaaggtgtggagtcaccgtccgggacagtctgaagaaggcc
ctgatgatgagaggtctgatcccagagtgctgcgctgtttacaggattcaggatggagag
aagaagccaattggctgggacactgatatctcctggcttactggagaggaattgcatgtg
gaagtattggagaatgttccgcttacaacacacaactttgtacggaaaacatttttcacc
ttagcattttgtgacttttgccgaaagctgcttttccagggtttccgttgtcaaacatgt
ggttataaatttcaccagcgttgtagtaccgaggttccactgatgtgtgttaattatgac
caacttgatttgctgtttgtctccaagttttttgaacaccatccaataccacaggaggag
gcctccttagcagaaacttcccttgcatccggatcatccccttccgtacccccctccgat
tctattgggccccaaatcctcaccactccgtctccttcaaaatccattccaattccacag
cctttccgaccagcagatgaagatcaccgaaatcagtttggacaacgagaccggtcttca
tcagctccaaatgtgcatataaacacaatagaacctgtcaatatcgatgacttgattaga
gaccaagggtttcgtagtgatggaggatcaactacaggtttatctgccacccctcctgcc
tcattacctggctcactcactaatgtgaaagcgttacagaagtctccaggacctcagagg
gagagaaaatcatcttcatcctcggaagacaggaatcgaatgaaaacacttggtagacgg
gattcaagtgatgactgggagattcccgatgggcagatcacagtgggacagagaattgga
tctgggtcgtttggaacagtctacaagggaaagtggcacggtgatgtggcggtgaaaatg
ttgaatgtgacagcacccacacctcaacagttacaagccttcaaaaatgaagtaggagta
ctcaggaaaactcgacatgtgaatattctactcttcatgggctattcaacaaagccacag
ctggctattgtcacccagtggtgtgagggctccagcttatatcaccatctccacatcatt
gagaccaaatttgagatgatcaaacttatagatatcgcacgacagactgcacagggcatg
gattacttacacgccaagtcaatcatccacagagacctcaagagtaataatatttttctt
catgaagacctcacagtaaaaataggtgactttggtctagccacagtgaaatctcgatgg
agtgggtcccatcagtttgagcagttgtctggatccattttgtggatggctccagaagta
atcagaatgcaagataaaaacccgtatagctttcagtcagatgtatatgcatttgggatt
gttctgtatgaattgatgactggacagttaccttattcaaacatcaacaacagggaccag
ataatttttatggtgggacgaggatacctagctccagacctcagtaaggtacgaagtaac
tgtccgaaagccatgaagagattaatggcggagtgcctaaaaaagaaaagagatgagaga
ccactctttccccaaatcctcgcctctattgagctgctggcccgctcattgccaaaaatt
caccgcagtgcatcagaaccctccttgaatcgggctggcttccagacagaggatttcagt
ctctatgcttgtgcttctccgaaaacgcccatccaggcagggggatacggagaatttgca
gccttcaagtag

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