KEGG   Acinonyx jubatus (cheetah): 106973880
Entry
106973880         CDS       T04657                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
aju  Acinonyx jubatus (cheetah)
Pathway
aju00562  Inositol phosphate metabolism
aju01100  Metabolic pathways
aju01521  EGFR tyrosine kinase inhibitor resistance
aju01522  Endocrine resistance
aju01524  Platinum drug resistance
aju04012  ErbB signaling pathway
aju04014  Ras signaling pathway
aju04015  Rap1 signaling pathway
aju04024  cAMP signaling pathway
aju04062  Chemokine signaling pathway
aju04066  HIF-1 signaling pathway
aju04068  FoxO signaling pathway
aju04070  Phosphatidylinositol signaling system
aju04071  Sphingolipid signaling pathway
aju04072  Phospholipase D signaling pathway
aju04081  Hormone signaling
aju04140  Autophagy - animal
aju04145  Phagocytosis
aju04150  mTOR signaling pathway
aju04151  PI3K-Akt signaling pathway
aju04152  AMPK signaling pathway
aju04210  Apoptosis
aju04211  Longevity regulating pathway
aju04213  Longevity regulating pathway - multiple species
aju04218  Cellular senescence
aju04360  Axon guidance
aju04370  VEGF signaling pathway
aju04380  Osteoclast differentiation
aju04510  Focal adhesion
aju04517  IgSF CAM signaling
aju04518  Integrin signaling
aju04550  Signaling pathways regulating pluripotency of stem cells
aju04611  Platelet activation
aju04613  Neutrophil extracellular trap formation
aju04620  Toll-like receptor signaling pathway
aju04625  C-type lectin receptor signaling pathway
aju04630  JAK-STAT signaling pathway
aju04650  Natural killer cell mediated cytotoxicity
aju04660  T cell receptor signaling pathway
aju04662  B cell receptor signaling pathway
aju04664  Fc epsilon RI signaling pathway
aju04666  Fc gamma R-mediated phagosome formation
aju04668  TNF signaling pathway
aju04670  Leukocyte transendothelial migration
aju04722  Neurotrophin signaling pathway
aju04725  Cholinergic synapse
aju04750  Inflammatory mediator regulation of TRP channels
aju04810  Regulation of actin cytoskeleton
aju04910  Insulin signaling pathway
aju04914  Progesterone-mediated oocyte maturation
aju04915  Estrogen signaling pathway
aju04917  Prolactin signaling pathway
aju04919  Thyroid hormone signaling pathway
aju04923  Regulation of lipolysis in adipocytes
aju04926  Relaxin signaling pathway
aju04929  GnRH secretion
aju04930  Type II diabetes mellitus
aju04931  Insulin resistance
aju04932  Non-alcoholic fatty liver disease
aju04933  AGE-RAGE signaling pathway in diabetic complications
aju04935  Growth hormone synthesis, secretion and action
aju04960  Aldosterone-regulated sodium reabsorption
aju04973  Carbohydrate digestion and absorption
aju05010  Alzheimer disease
aju05017  Spinocerebellar ataxia
aju05020  Prion disease
aju05100  Bacterial invasion of epithelial cells
aju05132  Salmonella infection
aju05135  Yersinia infection
aju05142  Chagas disease
aju05146  Amoebiasis
aju05160  Hepatitis C
aju05161  Hepatitis B
aju05162  Measles
aju05163  Human cytomegalovirus infection
aju05164  Influenza A
aju05165  Human papillomavirus infection
aju05166  Human T-cell leukemia virus 1 infection
aju05167  Kaposi sarcoma-associated herpesvirus infection
aju05168  Herpes simplex virus 1 infection
aju05169  Epstein-Barr virus infection
aju05170  Human immunodeficiency virus 1 infection
aju05171  Coronavirus disease
aju05200  Pathways in cancer
aju05203  Viral carcinogenesis
aju05205  Proteoglycans in cancer
aju05206  MicroRNAs in cancer
aju05207  Chemical carcinogenesis - receptor activation
aju05208  Chemical carcinogenesis - reactive oxygen species
aju05210  Colorectal cancer
aju05211  Renal cell carcinoma
aju05212  Pancreatic cancer
aju05213  Endometrial cancer
aju05214  Glioma
aju05215  Prostate cancer
aju05218  Melanoma
aju05220  Chronic myeloid leukemia
aju05221  Acute myeloid leukemia
aju05222  Small cell lung cancer
aju05223  Non-small cell lung cancer
aju05224  Breast cancer
aju05225  Hepatocellular carcinoma
aju05226  Gastric cancer
aju05230  Central carbon metabolism in cancer
aju05231  Choline metabolism in cancer
aju05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
aju05415  Diabetic cardiomyopathy
aju05417  Lipid and atherosclerosis
aju05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:aju00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    106973880
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    106973880
   04014 Ras signaling pathway
    106973880
   04015 Rap1 signaling pathway
    106973880
   04370 VEGF signaling pathway
    106973880
   04630 JAK-STAT signaling pathway
    106973880
   04668 TNF signaling pathway
    106973880
   04066 HIF-1 signaling pathway
    106973880
   04068 FoxO signaling pathway
    106973880
   04070 Phosphatidylinositol signaling system
    106973880
   04072 Phospholipase D signaling pathway
    106973880
   04071 Sphingolipid signaling pathway
    106973880
   04024 cAMP signaling pathway
    106973880
   04151 PI3K-Akt signaling pathway
    106973880
   04152 AMPK signaling pathway
    106973880
   04150 mTOR signaling pathway
    106973880
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    106973880
   04517 IgSF CAM signaling
    106973880
   04518 Integrin signaling
    106973880
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    106973880
   04140 Autophagy - animal
    106973880
  09143 Cell growth and death
   04210 Apoptosis
    106973880
   04218 Cellular senescence
    106973880
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    106973880
   04550 Signaling pathways regulating pluripotency of stem cells
    106973880
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    106973880
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    106973880
   04613 Neutrophil extracellular trap formation
    106973880
   04620 Toll-like receptor signaling pathway
    106973880
   04625 C-type lectin receptor signaling pathway
    106973880
   04650 Natural killer cell mediated cytotoxicity
    106973880
   04660 T cell receptor signaling pathway
    106973880
   04662 B cell receptor signaling pathway
    106973880
   04664 Fc epsilon RI signaling pathway
    106973880
   04666 Fc gamma R-mediated phagosome formation
    106973880
   04670 Leukocyte transendothelial migration
    106973880
   04062 Chemokine signaling pathway
    106973880
  09152 Endocrine system
   04910 Insulin signaling pathway
    106973880
   04923 Regulation of lipolysis in adipocytes
    106973880
   04929 GnRH secretion
    106973880
   04915 Estrogen signaling pathway
    106973880
   04914 Progesterone-mediated oocyte maturation
    106973880
   04917 Prolactin signaling pathway
    106973880
   04926 Relaxin signaling pathway
    106973880
   04935 Growth hormone synthesis, secretion and action
    106973880
   04919 Thyroid hormone signaling pathway
    106973880
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    106973880
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    106973880
  09156 Nervous system
   04725 Cholinergic synapse
    106973880
   04722 Neurotrophin signaling pathway
    106973880
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    106973880
  09158 Development and regeneration
   04360 Axon guidance
    106973880
   04380 Osteoclast differentiation
    106973880
  09149 Aging
   04211 Longevity regulating pathway
    106973880
   04213 Longevity regulating pathway - multiple species
    106973880
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106973880
   05206 MicroRNAs in cancer
    106973880
   05205 Proteoglycans in cancer
    106973880
   05207 Chemical carcinogenesis - receptor activation
    106973880
   05208 Chemical carcinogenesis - reactive oxygen species
    106973880
   05203 Viral carcinogenesis
    106973880
   05230 Central carbon metabolism in cancer
    106973880
   05231 Choline metabolism in cancer
    106973880
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    106973880
  09162 Cancer: specific types
   05210 Colorectal cancer
    106973880
   05212 Pancreatic cancer
    106973880
   05225 Hepatocellular carcinoma
    106973880
   05226 Gastric cancer
    106973880
   05214 Glioma
    106973880
   05221 Acute myeloid leukemia
    106973880
   05220 Chronic myeloid leukemia
    106973880
   05218 Melanoma
    106973880
   05211 Renal cell carcinoma
    106973880
   05215 Prostate cancer
    106973880
   05213 Endometrial cancer
    106973880
   05224 Breast cancer
    106973880
   05222 Small cell lung cancer
    106973880
   05223 Non-small cell lung cancer
    106973880
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    106973880
   05170 Human immunodeficiency virus 1 infection
    106973880
   05161 Hepatitis B
    106973880
   05160 Hepatitis C
    106973880
   05171 Coronavirus disease
    106973880
   05164 Influenza A
    106973880
   05162 Measles
    106973880
   05168 Herpes simplex virus 1 infection
    106973880
   05163 Human cytomegalovirus infection
    106973880
   05167 Kaposi sarcoma-associated herpesvirus infection
    106973880
   05169 Epstein-Barr virus infection
    106973880
   05165 Human papillomavirus infection
    106973880
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    106973880
   05135 Yersinia infection
    106973880
   05100 Bacterial invasion of epithelial cells
    106973880
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    106973880
   05142 Chagas disease
    106973880
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    106973880
   05017 Spinocerebellar ataxia
    106973880
   05020 Prion disease
    106973880
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    106973880
   05418 Fluid shear stress and atherosclerosis
    106973880
   05415 Diabetic cardiomyopathy
    106973880
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    106973880
   04932 Non-alcoholic fatty liver disease
    106973880
   04931 Insulin resistance
    106973880
   04933 AGE-RAGE signaling pathway in diabetic complications
    106973880
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    106973880
   01524 Platinum drug resistance
    106973880
   01522 Endocrine resistance
    106973880
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aju04131]
    106973880
Enzymes [BR:aju01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     106973880
Membrane trafficking [BR:aju04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    106973880
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 106973880
NCBI-ProteinID: XP_026917191
UniProt: A0A6J1ZI66
LinkDB
Position
C2:complement(86372874..86454087)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaataccagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaagtccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacatcgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gtcactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtctgtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatacttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcgtattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaaa
caagaaaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
agaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggagacgatttacggcaagatatgttaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcagatt
caatgcaaaggtggcctgaaaggcgcactgcagttcaacagccacactctacaccagtgg
ctcaaagataagaacaaaggcgaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcatactgggaatcggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcat
aagaagaaaaaatttggttataaacgggaacgtgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaattcgaaaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
ctcttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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