KEGG   Acinonyx jubatus (cheetah): 106977129
Entry
106977129         CDS       T04657                                 
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
aju  Acinonyx jubatus (cheetah)
Pathway
aju01521  EGFR tyrosine kinase inhibitor resistance
aju01522  Endocrine resistance
aju04010  MAPK signaling pathway
aju04012  ErbB signaling pathway
aju04014  Ras signaling pathway
aju04015  Rap1 signaling pathway
aju04022  cGMP-PKG signaling pathway
aju04024  cAMP signaling pathway
aju04062  Chemokine signaling pathway
aju04068  FoxO signaling pathway
aju04071  Sphingolipid signaling pathway
aju04072  Phospholipase D signaling pathway
aju04140  Autophagy - animal
aju04150  mTOR signaling pathway
aju04151  PI3K-Akt signaling pathway
aju04210  Apoptosis
aju04218  Cellular senescence
aju04270  Vascular smooth muscle contraction
aju04360  Axon guidance
aju04370  VEGF signaling pathway
aju04371  Apelin signaling pathway
aju04510  Focal adhesion
aju04540  Gap junction
aju04550  Signaling pathways regulating pluripotency of stem cells
aju04613  Neutrophil extracellular trap formation
aju04625  C-type lectin receptor signaling pathway
aju04630  JAK-STAT signaling pathway
aju04650  Natural killer cell mediated cytotoxicity
aju04660  T cell receptor signaling pathway
aju04662  B cell receptor signaling pathway
aju04664  Fc epsilon RI signaling pathway
aju04666  Fc gamma R-mediated phagocytosis
aju04720  Long-term potentiation
aju04722  Neurotrophin signaling pathway
aju04726  Serotonergic synapse
aju04730  Long-term depression
aju04810  Regulation of actin cytoskeleton
aju04910  Insulin signaling pathway
aju04912  GnRH signaling pathway
aju04914  Progesterone-mediated oocyte maturation
aju04915  Estrogen signaling pathway
aju04916  Melanogenesis
aju04917  Prolactin signaling pathway
aju04919  Thyroid hormone signaling pathway
aju04921  Oxytocin signaling pathway
aju04926  Relaxin signaling pathway
aju04928  Parathyroid hormone synthesis, secretion and action
aju04929  GnRH secretion
aju04935  Growth hormone synthesis, secretion and action
aju05010  Alzheimer disease
aju05022  Pathways of neurodegeneration - multiple diseases
aju05034  Alcoholism
aju05132  Salmonella infection
aju05152  Tuberculosis
aju05160  Hepatitis C
aju05161  Hepatitis B
aju05163  Human cytomegalovirus infection
aju05164  Influenza A
aju05165  Human papillomavirus infection
aju05167  Kaposi sarcoma-associated herpesvirus infection
aju05170  Human immunodeficiency virus 1 infection
aju05200  Pathways in cancer
aju05205  Proteoglycans in cancer
aju05206  MicroRNAs in cancer
aju05207  Chemical carcinogenesis - receptor activation
aju05208  Chemical carcinogenesis - reactive oxygen species
aju05210  Colorectal cancer
aju05211  Renal cell carcinoma
aju05212  Pancreatic cancer
aju05213  Endometrial cancer
aju05214  Glioma
aju05215  Prostate cancer
aju05218  Melanoma
aju05219  Bladder cancer
aju05220  Chronic myeloid leukemia
aju05221  Acute myeloid leukemia
aju05223  Non-small cell lung cancer
aju05224  Breast cancer
aju05225  Hepatocellular carcinoma
aju05226  Gastric cancer
aju05230  Central carbon metabolism in cancer
aju05231  Choline metabolism in cancer
aju05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:aju00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    106977129
   04012 ErbB signaling pathway
    106977129
   04014 Ras signaling pathway
    106977129
   04015 Rap1 signaling pathway
    106977129
   04370 VEGF signaling pathway
    106977129
   04371 Apelin signaling pathway
    106977129
   04630 JAK-STAT signaling pathway
    106977129
   04068 FoxO signaling pathway
    106977129
   04072 Phospholipase D signaling pathway
    106977129
   04071 Sphingolipid signaling pathway
    106977129
   04024 cAMP signaling pathway
    106977129
   04022 cGMP-PKG signaling pathway
    106977129
   04151 PI3K-Akt signaling pathway
    106977129
   04150 mTOR signaling pathway
    106977129
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    106977129
  09143 Cell growth and death
   04210 Apoptosis
    106977129
   04218 Cellular senescence
    106977129
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    106977129
   04540 Gap junction
    106977129
   04550 Signaling pathways regulating pluripotency of stem cells
    106977129
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    106977129
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    106977129
   04625 C-type lectin receptor signaling pathway
    106977129
   04650 Natural killer cell mediated cytotoxicity
    106977129
   04660 T cell receptor signaling pathway
    106977129
   04662 B cell receptor signaling pathway
    106977129
   04664 Fc epsilon RI signaling pathway
    106977129
   04666 Fc gamma R-mediated phagocytosis
    106977129
   04062 Chemokine signaling pathway
    106977129
  09152 Endocrine system
   04910 Insulin signaling pathway
    106977129
   04929 GnRH secretion
    106977129
   04912 GnRH signaling pathway
    106977129
   04915 Estrogen signaling pathway
    106977129
   04914 Progesterone-mediated oocyte maturation
    106977129
   04917 Prolactin signaling pathway
    106977129
   04921 Oxytocin signaling pathway
    106977129
   04926 Relaxin signaling pathway
    106977129
   04935 Growth hormone synthesis, secretion and action
    106977129
   04919 Thyroid hormone signaling pathway
    106977129
   04928 Parathyroid hormone synthesis, secretion and action
    106977129
   04916 Melanogenesis
    106977129
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    106977129
  09156 Nervous system
   04726 Serotonergic synapse
    106977129
   04720 Long-term potentiation
    106977129
   04730 Long-term depression
    106977129
   04722 Neurotrophin signaling pathway
    106977129
  09158 Development and regeneration
   04360 Axon guidance
    106977129
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106977129
   05206 MicroRNAs in cancer
    106977129
   05205 Proteoglycans in cancer
    106977129
   05207 Chemical carcinogenesis - receptor activation
    106977129
   05208 Chemical carcinogenesis - reactive oxygen species
    106977129
   05230 Central carbon metabolism in cancer
    106977129
   05231 Choline metabolism in cancer
    106977129
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    106977129
  09162 Cancer: specific types
   05210 Colorectal cancer
    106977129
   05212 Pancreatic cancer
    106977129
   05225 Hepatocellular carcinoma
    106977129
   05226 Gastric cancer
    106977129
   05214 Glioma
    106977129
   05221 Acute myeloid leukemia
    106977129
   05220 Chronic myeloid leukemia
    106977129
   05218 Melanoma
    106977129
   05211 Renal cell carcinoma
    106977129
   05219 Bladder cancer
    106977129
   05215 Prostate cancer
    106977129
   05213 Endometrial cancer
    106977129
   05224 Breast cancer
    106977129
   05223 Non-small cell lung cancer
    106977129
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    106977129
   05161 Hepatitis B
    106977129
   05160 Hepatitis C
    106977129
   05164 Influenza A
    106977129
   05163 Human cytomegalovirus infection
    106977129
   05167 Kaposi sarcoma-associated herpesvirus infection
    106977129
   05165 Human papillomavirus infection
    106977129
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    106977129
   05152 Tuberculosis
    106977129
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    106977129
   05022 Pathways of neurodegeneration - multiple diseases
    106977129
  09165 Substance dependence
   05034 Alcoholism
    106977129
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    106977129
   01522 Endocrine resistance
    106977129
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:aju01001]
    106977129
Enzymes [BR:aju01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     106977129
Protein kinases [BR:aju01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   106977129
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 106977129
NCBI-ProteinID: XP_026898474
UniProt: A0A6J1Y1E5
LinkDB
Position
A2:112904582..112986672
AA seq 668 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDATS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSPIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAHRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacaaggggcctggaagacgatcagcaatggctttggattcaaagatgca
gtgtttgatggccccagctgcatctcccccacaatagttcagccatttggctttcagcgt
cgggcatcagatgatggcaaacttacggactcttctaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgagaaatggaatgagcttgcatgat
tgccttatgaaagcactcaaggtgaggggcctgcagccggagtgctgtgcagtgttcaga
cttctccatgaacataaaggtaaaaaagcgcgtttagattggaatactgatgccacctcg
ttgattggagaagaacttcaagtagatttcctggatcacgttcccctcacaacacacaac
tttgctcggaagaccttcctgaagcttgcgttctgtgacatctgtcagaagttcctgcta
aatggatttcgatgtcaaacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgttcccaaattctcct
attggtgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacgttc
aactcttccagcccttcctctgaaggttccctctcccagaggcagaggtcaacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacgggctggtcacagcccaaaacccctgtgccagcacacagagagagggcacca
ggatccgggacccaggagaaaaacaaaatcaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctttccactcggattggatcaggctcattt
ggaacggtgtataagggcaagtggcatggagatgttgcagtgaaaattctaaaagttgtc
gaccccacgccagagcagttccaggccttcaggaatgaggtggctgtcctacgcaaaaca
cggcacgtgaacatcctgctcttcatgggctacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagactaagttc
cagatgttccagttgattgacatcgcccgccagactgctcagggaatggactatttgcat
gcaaagaatatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcgcgctggagcggttctcag
caggtcgaacaacccactggctctgtcctgtggatggcccccgaggtgatccgaatgcag
gataataacccattcagcttccagtctgatgtctactcctacggcattgtgctctatgag
ctcatgacaggggagcttccttactcccacatcaataaccgcgaccagatcatcttcatg
gtgggccgaggatatgcctccccagacctcagtaagctatataagaactgccccaaagca
atgaagaggcttgtagctgactgtgtgaagaaggttaaggaagagaggcctctttttccc
cagatcctgtcttccatcgagcttctccaacactctctgccgaaaatcaaccggagtgct
tctgagccatccctgcaccgggcggcccacactgaggatatcaacgcctgcacgttgacc
acatcccctagactgcctgtcttctag

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