Acinonyx jubatus (cheetah): 106983739 Help Entry 106983739         CDS       T04657                                  Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism aju  Acinonyx jubatus (cheetah) Pathway aju01521   EGFR tyrosine kinase inhibitor resistance aju04151   PI3K-Akt signaling pathway aju04217   Necroptosis aju04380   Osteoclast differentiation aju04550   Signaling pathways regulating pluripotency of stem cells aju04620   Toll-like receptor signaling pathway aju04621   NOD-like receptor signaling pathway aju04630   JAK-STAT signaling pathway aju04658   Th1 and Th2 cell differentiation aju04659   Th17 cell differentiation aju05140   Leishmaniasis aju05145   Toxoplasmosis aju05152   Tuberculosis aju05160   Hepatitis C aju05161   Hepatitis B aju05162   Measles aju05163   Human cytomegalovirus infection aju05164   Influenza A aju05165   Human papillomavirus infection aju05166   Human T-cell leukemia virus 1 infection aju05167   Kaposi sarcoma-associated herpesvirus infection aju05168   Herpes simplex virus 1 infection aju05169   Epstein-Barr virus infection aju05171   Coronavirus disease - COVID-19 aju05200   Pathways in cancer aju05203   Viral carcinogenesis aju05212   Pancreatic cancer aju05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:aju00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     106983739    04151 PI3K-Akt signaling pathway     106983739  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     106983739   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     106983739  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     106983739    04621 NOD-like receptor signaling pathway     106983739    04658 Th1 and Th2 cell differentiation     106983739    04659 Th17 cell differentiation     106983739   09158 Development and regeneration    04380 Osteoclast differentiation     106983739  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     106983739    05203 Viral carcinogenesis     106983739    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     106983739   09162 Cancer: specific types    05212 Pancreatic cancer     106983739   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     106983739    05161 Hepatitis B     106983739    05160 Hepatitis C     106983739    05171 Coronavirus disease - COVID-19     106983739    05164 Influenza A     106983739    05162 Measles     106983739    05168 Herpes simplex virus 1 infection     106983739    05163 Human cytomegalovirus infection     106983739    05167 Kaposi sarcoma-associated herpesvirus infection     106983739    05169 Epstein-Barr virus infection     106983739    05165 Human papillomavirus infection     106983739   09171 Infectious disease: bacterial    05152 Tuberculosis     106983739   09174 Infectious disease: parasitic    05145 Toxoplasmosis     106983739    05140 Leishmaniasis     106983739   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     106983739  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:aju01001]     106983739 Enzymes [BR:aju01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      106983739 Protein kinases [BR:aju01001]  Non-receptor tyrosine kinases   JAK family [OT]    106983739 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Endonuclea_NS_2 Motif Other DBs NCBI-GeneID:  106983739 NCBI-ProteinID:  XP_026914783 UniProt:  A0A6J1ZCI5 LinkDB All DBs Position C1:complement(52768863..52896494) Genome browser AA seq 1156 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPDDSGNILYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKWKKLENKHKKDEEKNKIRE EWNNFSYFPEITHIVIKECVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHH YLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTC FEKSEVVGSLKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMNHLKKQILRTDNISFVLKR CCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGTL LDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVE NIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL AREGIDSEFGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTT LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIM RDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSG SLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDF GLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDS SPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPTNRTTF QNLIKGFEALLEALLK NT seq 3471 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagacggaggtgaatctggaggcccccgaaccaggggtggaagtgctcttc tatctgtccgatagggagccactccggctgggcagcggggagtacacggcagaggagctg tgcatcagggcggcgcaggaatgctgtatctctcctctgtgtcacaacctttttgccctg tatgatgagaacaccaagctttggtacgctccgaatcgcacgatcacagttgacgacaag acatcactccggctccactaccggatgaggttctatttcaccaactggcatgggaccaat gataatgagcagtctgtatggcgacattctccgaagaagcagaaaaatggctacgagaaa aaaaaagttccagatgcaacccctctccttgacgccagctccctggagtatctgtttgct cagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagaccgagcag gatggacacgatattgagaacgagtgtctgggaatggctgtcctggccatctcccactac gccatgatgaagaagatgcaattgccagaactgcccaaggacatcagctacaagcgatat atcccagaaacattgaataagtccatcaggcagaggaatcttctcaccaggatgcggata aataacgttttcaaggatttcctaaaggaatttaacaacaagaccatctgtgacagcagt gtatctactcatgacctgaaggtgaaatacctggcgaccttggagactttgacaaaacat tatggtgctgaaatatttgagacttccatgttactgatttcgtcagaaaatgagatgaat tggtttcatccagatgacagtggaaacattctctatgaagtgatggtaactggaaatctt ggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaaaacaaactg aaatggaaaaagctggaaaataaacacaagaaggatgaggagaaaaacaaaatccgggaa gagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtgtgtg gtcagcatcaataagcaggacaataaaaaaatggaactgaagctttcgtcccacgaggag gccttgtcctttgtgtccctggtagacggctacttccggctcacagcggatgcccatcat tacctctgcactgatgtggctcccccactgattgtccacaacatacagaatggttgtcac ggtcccatctgcacagaatatgccatcaataagttgcggcaagaaggaagcgaggaggga atgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgactgtcacctgc tttgaaaaatctgaggtggtgggtagcctgaaacagttcaagaactttcagatcgaggtg cagaagggccgttacagcctgcatggctcggaccgcagcttccccagcctgggggacctc atgaaccacctcaagaaacagatcctacggacggacaacatcagcttcgtgctgaaacgc tgctgccagcccaagccccgagagatctccaatttgctggtggctactaagaaagcccag gagtggcagcctgtctactctatgagccagctgagttttgaccggatcctcaagaaagat atcgtgcaaggcgagcaccttgggagaggcacgcggacgcatatctactctggaaccctt ctggattacaaagatgacgaaggaacttccgaagaaaagagaataaaagtgatcctcaaa gtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatgatg aggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagatgtggaa aatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcaccggaaa agtgatgtcctcaccacaccgtggaagtttaaagttgccaaacaactggctagtgccttg agttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctcctcttg gcccgtgagggcatcgacagtgagttcggcccgttcatcaagctcagtgaccctggcatc cccatcaccgtgctgtccaggcaagagtgcatagaacgaatcccgtggattgctcccgag tgtgttgaagactccaagaacctgagtgtggccgctgacaaatggagctttggaaccaca ctctgggaaatctgctacaatggcgagatccctctgaaagacaagacactgattgagaaa gagcgattctatgaaagccggtgccggccagtgacaccatcttgtaaggagctggctgac ctcatgacccgctgcatgaactatgaccccaaccagagacccttcttccgagccatcatg agagacatcaataaactggaggagcagaatccagacattgtttcggaacgaaagccggca actgaagtggatcccacacattttgaaaagcggttcttgaagagaatccgtgacttggga gagggccactttgggaaggttgagctctgcagatacgaccctgagggtgacaataccggg gagcaggtggctgtcaaatccctgaagcctgagagtggaggtaaccacatagctgatctg aagaaggaaattgaaatcttaaggaacctctatcatgagaacattgtgaagtacaaaggc atctgtacagaagacggaggaaatggtattaagctcatcatggagtttctaccttcagga agccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacaacagttaaaa tatgctgttcagatttgtaaggggatggactacttggggtctcggcagtacgttcaccgg gacttagcagcaagaaatgtcctcgttgagagtgagcaccaagtgaaaattggagacttc ggtttaaccaaagccattgaaaccgacaaagagtactacacagtcaaggatgatcgggac agccctgtgttttggtatgctccagaatgtttaattcagtgtaaattttatatcgcctct gacgtctggtcgtttggagtgactctgcatgagctgctcacttactgtgactccgattct agccccatggcattgttcctgaaaatgataggcccaacgcatggccagatgacagtcaca agacttgtgaacacgttaaaagaaggaaaacgtttgccctgtccacctaactgcccagat gaggtttatcaactcatgagaaagtgctgggaattccaaccaactaataggacaactttt cagaacctaattaaaggatttgaagcacttttagaagcacttttaaaatag

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