KEGG   PATHWAY: aly00908
Entry
aly00908                    Pathway                                
Name
Zeatin biosynthesis - Arabidopsis lyrata (lyrate rockcress)
Description
Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
aly00908  Zeatin biosynthesis
aly00908

Other DBs
GO: 0009691
Organism
Arabidopsis lyrata (lyrate rockcress) [GN:aly]
Gene
9324728  adenylate isopentenyltransferase 1, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
9319508  adenylate isopentenyltransferase 7, mitochondrial [KO:K10760] [EC:2.5.1.27 2.5.1.112]
9321363  adenylate isopentenyltransferase 8, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
9303727  adenylate isopentenyltransferase 4 [KO:K10760] [EC:2.5.1.27 2.5.1.112]
9309993  adenylate isopentenyltransferase 5, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
9314564  adenylate isopentenyltransferase 3, chloroplastic [KO:K10760] [EC:2.5.1.27 2.5.1.112]
9323168  cytokinin hydroxylase [KO:K10717]
9304846  cytokinin hydroxylase [KO:K10717]
9325089  cytokinin dehydrogenase 5 [KO:K00279] [EC:1.5.99.12]
9305487  cytokinin dehydrogenase 4 [KO:K00279] [EC:1.5.99.12]
9317846  cytokinin dehydrogenase 1 [KO:K00279] [EC:1.5.99.12]
9308045  cytokinin dehydrogenase 7 [KO:K00279] [EC:1.5.99.12]
9312791  cytokinin dehydrogenase 6 isoform X1 [KO:K00279] [EC:1.5.99.12]
9322103  cytokinin dehydrogenase 2 [KO:K00279] [EC:1.5.99.12]
9302249  cytokinin dehydrogenase 3 [KO:K00279] [EC:1.5.99.12]
9309297  UDP-glycosyltransferase 76C2 [KO:K13493] [EC:2.4.1.-]
9317535  UDP-glycosyltransferase 73C5 [KO:K13496] [EC:2.4.1.-]
9317533  UDP-glycosyltransferase 73C1 [KO:K13496] [EC:2.4.1.-]
9317534  UDP-glycosyltransferase 73C3 [KO:K13496] [EC:2.4.1.-]
9313972  UDP-glycosyltransferase 73C7 [KO:K13496] [EC:2.4.1.-]
110230107  UDP-glycosyltransferase 85A1-like [KO:K23452] [EC:2.4.1.-]
9323796  LOW QUALITY PROTEIN: UDP-glycosyltransferase 85A4 [KO:K23452] [EC:2.4.1.-]
9327177  UDP-glycosyltransferase 85A1 [KO:K23452] [EC:2.4.1.-]
9326572  UDP-glycosyltransferase 85A7 [KO:K23452] [EC:2.4.1.-]
9329284  UDP-glycosyltransferase 85A3 [KO:K23452] [EC:2.4.1.-]
9329285  UDP-glycosyltransferase 85A1 [KO:K23452] [EC:2.4.1.-]
9329283  LOW QUALITY PROTEIN: UDP-glycosyltransferase 85A5 [KO:K23452] [EC:2.4.1.-]
9329282  UDP-glycosyltransferase 85A2 [KO:K23452] [EC:2.4.1.-]
9310046  tRNA dimethylallyltransferase 9 [KO:K00791] [EC:2.5.1.75]
9315206  tRNA dimethylallyltransferase 2 [KO:K00791] [EC:2.5.1.75]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00019  S-Adenosyl-L-methionine
C00020  AMP
C00029  UDP-glucose
C00033  Acetate
C00147  Adenine
C00170  5'-Methylthioadenosine
C00190  UDP-D-xylose
C00235  Dimethylallyl diphosphate
C00371  Zeatin
C00979  O-Acetyl-L-serine
C01513  Lupinate
C01804  Discadenine
C02029  Dihydrozeatin
C03300  O-beta-D-Xylosylzeatin
C03423  O-beta-D-Glucosylzeatin
C04083  N6-(Delta2-Isopentenyl)-adenine
C04432  tRNA containing 6-isopentenyladenosine
C04713  N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
C07330  3-Methyl-2-butenal
C15545  cis-Zeatin
C15546  O-beta-D-Glucopyranosyl-cis-zeatin
C16424  Isopentenyladenosine-5'-triphosphate
C16426  Isopentenyladenosine-5'-diphosphate
C16427  Isopentenyl adenosine
C16428  trans-Zeatin riboside triphosphate
C16429  trans-Zeatin riboside diphosphate
C16430  trans-Zeatin riboside monophosphate
C16431  trans-Zeatin riboside
C16441  cis-Zeatin riboside monophosphate
C16443  trans-Zeatin-7-beta-D-glucoside
C16445  Dihydrozeatin riboside monophosphate
C16447  Dihydrozeatin riboside
C16448  Dihydrozeatin-O-glucoside
C16449  cis-Zeatin riboside
C16467  cis-Prenyl-tRNA
C17324  tRNA adenine
Reference
  Authors
Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.
  Title
Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.
  Journal
J Biol Chem 279:14049-54 (2004)
DOI:10.1074/jbc.M314195200
Reference
  Authors
Takei K, Sakakibara H, Sugiyama T.
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J Biol Chem 276:26405-10 (2001)
DOI:10.1074/jbc.M102130200
Reference
  Authors
Kakimoto T.
  Title
Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.
  Journal
Plant Cell Physiol 42:677-85 (2001)
DOI:10.1093/pcp/pce112
Reference
  Authors
Takei K, Yamaya T, Sakakibara H.
  Title
Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.
  Journal
J Biol Chem 279:41866-72 (2004)
DOI:10.1074/jbc.M406337200
Reference
  Authors
Hou B, Lim EK, Higgins GS, Bowles DJ.
  Title
N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.
  Journal
J Biol Chem 279:47822-32 (2004)
DOI:10.1074/jbc.M409569200
Reference
PMID:9874810
  Authors
Martin RC, Mok MC, Mok DW
  Title
Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.
  Journal
Proc Natl Acad Sci U S A 96:284-9 (1999)
DOI:10.1073/pnas.96.1.284
Reference
  Authors
Martin RC, Mok MC, Mok DW
  Title
A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.
  Journal
Plant Physiol 120:553-8 (1999)
DOI:10.1104/pp.120.2.553
Reference
  Authors
Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC
  Title
O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.
  Journal
Plant Physiol 131:1374-80 (2003)
DOI:10.1104/pp.017210
Reference
  Authors
Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T
  Title
Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.
  Journal
Plant Cell 15:2532-50 (2003)
DOI:10.1105/tpc.014928
Reference
  Authors
Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T
  Title
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 103:16598-603 (2006)
DOI:10.1073/pnas.0603522103
Related
pathway
aly00900  Terpenoid backbone biosynthesis
KO pathway
ko00908   
LinkDB

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