Actinomadura madurae: LUW76_42500
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Entry
LUW76_42500 CDS
T08933
Name
(GenBank) UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
amaz
Actinomadura madurae
Pathway
amaz00300
Lysine biosynthesis
amaz00550
Peptidoglycan biosynthesis
amaz01100
Metabolic pathways
amaz01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
amaz00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
LUW76_42500
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
LUW76_42500
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
LUW76_42500
Enzymes [BR:
amaz01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
LUW76_42500
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
Cas_Cmr3
Motif
Other DBs
NCBI-ProteinID:
URN00446
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Position
8927297..8928679
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AA seq
460 aa
AA seq
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MIPLPLSTIAEITGGTAHGPPDVVVSGPAVIDSRAVEPGALFAALKGERADGHDFASGAL
ASGAAAVLAQRSVDGPCVVVPDVQEALGRLARGLLERLPALTVVAVTGSAGKTSTKDLIA
QVVSTAGPTVYPPGSFNNEIGLPLTVLRAGAETRHLVLEMGARGIGHIAYLTGIARPDVG
VVLNVGTAHVGEFGGRENIARAKGEIVEAVPPGGTAVLNADDPLVAAMAERTEGEVVTFG
RSPDAVVRAEDETLDERGRARFTLVTPEGTAPVALRLHGAHAVPNALAAAAAARAAGLAP
DAVAAALSDAVPVSRWRMEVTERADGVTVVNDAYNANPDSTRAALDVLAHMARGRRAYAV
LGEMAELGDSSVAEHAKIGQHVARSGIAGLVVVGANAAAMAEGAGQVASWTGECVQVDDV
GAAVTVLRERLAPRDVVLVKGSRVAGLERVAEAILAEDGR
NT seq
1383 nt
NT seq
+upstream
nt +downstream
nt
gtgatcccacttccgctgtcgacgatcgcggagatcacgggaggcaccgcgcacgggcct
ccggacgtggtggtgagcggtcccgcggtcatcgactcccgtgcggtggagcccggggcg
ctgttcgcggcgctgaagggcgagcgcgcggacgggcacgacttcgcgtccggggcgctg
gcgtcgggggccgcggccgtgctcgcgcagcgctcggtggacgggccgtgcgtggtcgtc
ccggacgtccaggaggcactcgggcggctcgccaggggcctgctggagcggctgccggcc
ctcaccgtcgtcgccgtcaccggctcggccggcaagacctccaccaaggacctcatcgcg
caggtcgtgagcaccgcgggcccgacggtctacccgcccggctcgttcaacaacgagatc
gggctgccgctcaccgtgctgcgcgccggcgccgagacccgccacctcgtcctggagatg
ggcgcgcgcgggatcgggcacatcgcctacctgaccggcatcgcccgcccggacgtcggc
gtcgtgctgaacgtcggcaccgcgcacgtcggcgagttcggcggcagggagaacatcgcc
cgcgccaagggcgagatcgtggaggcggtgccgccgggcgggaccgccgtcctcaacgcc
gacgacccgctggtcgccgcgatggccgagcgcaccgagggcgaggtcgtcaccttcggc
cgctccccggacgccgtggtccgcgccgaggacgagaccctcgacgagcggggccgcgcc
cggttcaccctcgtcacgccggaggggacggcgccggtcgcgctgcgcctgcacggcgcg
cacgccgtcccgaacgcgctcgccgcggccgccgccgcgcgcgcggccgggctcgccccg
gacgcggtcgccgcggcgctgtcggacgccgtgccggtcagccggtggcggatggaggtc
accgagcgggccgacggcgtgaccgtggtgaacgacgcctacaacgccaaccccgactcg
acccgcgccgcgctcgacgtgctcgcgcacatggcccgcgggcgccgcgcgtacgcggta
ctgggggagatggccgaactgggtgactcgtccgtggcggaacatgccaagatcgggcag
catgtcgcgcgcagcgggatcgccggactcgtcgtcgtcggagcgaacgcggcggcgatg
gccgaaggggccgggcaggtggcgtcatggacgggagagtgcgtacaggtggatgacgtc
ggcgcggcggtgaccgtgctcagggagcggctcgcgccgcgggacgtcgtgctggtgaag
ggctcccgcgtggccggcctggaacgggtggccgaggcgatcctcgcggaggacggccga
tga
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