Amycolatopsis mediterranei U32: AMED_0618 Help Entry AMED_0618         CDS       T01269                                  Symbol rifB Name (GenBank) rifamycin polyketide synthase   KO K15671   rifamycin polyketide synthase modules 4, 5 and 6 Organism amd  Amycolatopsis mediterranei U32 Pathway amd01051   Biosynthesis of ansamycins amd01052   Type I polyketide structures Brite KEGG Orthology (KO) [BR:amd00001]  09100 Metabolism   09109 Metabolism of terpenoids and polyketides    01052 Type I polyketide structures     AMED_0618 (rifB)    01051 Biosynthesis of ansamycins     AMED_0618 (rifB)  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:amd01008]     AMED_0618 (rifB) Polyketide biosynthesis proteins [BR:amd01008]  Polyketide synthase (PKS)   Modular type I PKS    cis-AT PKS     Rifamycin PKS      AMED_0618 (rifB) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C PKS_DH_N PS-DH PP-binding SpnB_Rossmann KAsynt_C_assoc adh_short Thiolase_N RhiE-like_linker Epimerase CurL-like_PKS_C Sacchrp_dh_NADP Polysacc_synt_2 GDP_Man_Dehyd Shikimate_DH Docking RmlD_sub_bind DUF7080 Glu_dehyd_C SDR NmrA Motif Other DBs NCBI-ProteinID:  ADJ42438 UniProt:  A0A0H3CVW3 LinkDB All DBs Position 643882..659064 Genome browser AA seq 5060 aa AA seqDB search MSAPNEQIVDALRASLKENVRLQQENSALAAAAAEPVAIVSMACRYAGGIRGPEDFWRVV SEGADVYTGFPEDRGWDVEGLYHPDPDNPGTTYVREGAFLQDAAQFDAGFFGISPREALA MDPQQRQLLEVSWETLERAGIDPHSVRGSDIGVYAGVVHQDYAPDLSGFEGFMSLERALG TAGGVASGRVAYTLGLEGPAVTVDTMCSSSLVAIHLAAQALRRGECSMALAGGSTVMATP GGFVGFARQRALAFDGRCKSYAAAADGSGWAEGVGVLLLERLSVARERGHQVLAVIRGSA VNQDGASNGLTAPNGPAQQRVIRKALASAGLTPSDVDTVEGHGTGTVLGDPIEVQALLAT YGQGRDPQQPLWLGSVKSVVGHTQAASGVAGVIKMVQSLRHGQLPATQHVDAPTPQVDWS AGAIELLAEGREWPRNGHPRRGGISSFGASGTNAHMILEEAPEDEPVTEAPAPTGVVPLV VSAATAASLAAQAGRLAEVGDVSLADVAGTLVSGRAMLSERAVVVAGSHEEAVTGLRALA RGESAPGLLSGRGSGVPGKVVWVFPGQGTQWAGMGRELLDSSEVFAARIAECETALGRWV DWSLTDVLRGEADLLDRVDVVQPASFAVMVGLAAVWASLGVEPEAVVGHSQGEIAAACVS GALSLEDAAKVVALRSQAIAASLAGRGGMASVALSEEDATARLEPWAGRVEVAAVNGPTS VVIAGDAEALDEALDALDDQGVRIRRVAVDYASHTRHVEAARDALAEMLGGIRAQAPEVP FYSTVTGGWVEDAGVLDGGYWYRNLRRQVRFGPAVAELIEQGHRVFVEVSAHPVLVQPIN ELVDDTEAVVTGTLRREDGGLRRLLASAAELFVRGVTVDWSGVLPPSRRVELPTYAFDHQ HYWLQMGGSATDAVSLGLAGADHPLLGAVVPLPQSDGLVFTSRLSLKSHPWLAGHAIGGV VLIPGTVYVDLALRAGDELGFGVLEELVIEAPLVLGERGGVRVQVAVSGPNETGSRAVDV FSMREDGDEWTRHATGLLGASTSREPSRFDFAAWPPAGAEPIDVENFYTDLTERGYAYSG AFQGMRAVWRRGDEVFAEVALPDDHREDAGKFGLHPALLDAALHTNAFANPDDDRSVLPF AWNGLVLHAVGASALRVRVAPGGPDALTFQAADETGGLVVTMDSLVSREVSAAQLETAAG EERDSLFQVDWIEVPATETAATEHAEVLEAFGEAAPLELTSRVLEAVQSWLADAADEARL VVVTRGAVREVTDPAGAAVWGLVRAAQAENPGRIILVDTDGDVPLGAVLASGEPQLAVRG NAFSVPRLARATGEVPEAPAVFSPEGTVLLTGGTGSLGGLVAKHLVARHGVRRLVLASRR GVAAEDLVTELTEQGATVSVVACDVSDRDQVAALLAEHRPTGIVHLAGLLDDGVIGALNR ERLAGVFAPKVDAVQHLDELTRDLGLDAFVVFSSAAALMGSAGQGNYAAANAFLDGLMAG RRAAGLPGVSLAWGLWEQADGLTANLSATDQARMSRGGVLPMTPAEALDIFDIGLAAEQA LLVPIKLDLRTLRGQATAGGEVPHLLRGLVRASRRVTRTAAASGGGGLVHKLAGRPAEEQ EAVLLGIVQAEAAAVLGFNAPELAQGTRGFSDLGFDSLTAVELRNRLSAATGVKLPATLV FDYPTPVALARHLREELGETVAGAPATPVTTVADAGEPIAIVGMACRLPGGVMSPDDLWR MVAEGRDGMSPFPGDRGWDLDGLFDSDPERPGTAYIRQGGFLHEAALFDPGFFGISPREA LAMDPQQRLLLEASWEALERAGIDPTKARGDAVGVFSGVSIHDYLESLSNMPAELEGFVT TATAGSVASGRVSYTFGFEGPAVTVDTACSSSLVAIHLAAQALRQGECTMALAGGVAVMG SPIGVIGMSRQRGMAEDGRVKAFADGADGTVLSEGVGIVVLERLSVARERGHRVLAVLRG SAVNQDGASNGLTAPNGPSQQRVIRSALAGAGLQPSEVDVVEAHGTGTALGDPIEAQALL ATYGKSRETPLWLGSLKSNIGHTQAAAGVAAVIKMVQALRHDTLPPTLHVQEPTKQVDWS AGAVELLTEGREWARNGHPRRAGVSSFGISGTNAHLILEEAPADDTAEADVPDAVVPVVI SARSTGSLAGQAGRLAAFLDGDVPLTRVAGALLSTRATLTDRAVVVAGSAEEARAGLTAL ARGESASGLVTGTAGMPGKTVWVFPGQGTQWAGMGRELLEASPVFAERIEECAAALQPWI DWSLLDVLRGEGELDRVDVLQPACFAVMVGLAAVWASVGVVPDAVLGHSQGEIAAACVSG ALSLEDAAKVVALRSQAIAAELSGRGGMASIQLSHDEVAARLAPWAGRVEIAAVNGPASV VIAGDAEALTEAVEVLGGRRVAVDYASHTRHVEDIQDTLAETLAGIDAQAPVVPFYSTVA GEWITDAGVVDGGYWYRNLRNQVGFGPAVAELIEQGHGVFVEVSAHPVLVQPISELTDAV VTGTLRRDDGGVRRLLTSMAELFVRGVPVDWATMAPPARVELPTYAFDHQHFWLSPPAVA DAPALGLAGADHPLLGAVLPLPQSDGLVFTSRLSVRTHPWLADGVPAAALVELAVRAGDE AGCPVLADLTVEKLLVLPESGGLRVQVIVSGERTVEVYSQLEGAEDWIRNATGHLSATAP AHEAFDFTAWPPAGAQQVDGLWRRGDEIFAEVALPEELDAGAFGIHPFLLDAAVQPVLAD DEQPAEWRSLVLHAAGASALRVRLVPGGALQAADETGGLVLTADSVAGRELSAGKTRAGS LYRVDWTEVSIADSAVPANIEVVEAFGEEPLELTGRVLEAVQTWLVTAADDARLVVVTRG AVREVTDPAGAAVWGLVRAAQAENPGRIFLIDTDGEIPALTGDEPEIAVRGGKFFVPRIT RAEPSGAAVFRPDGTVLISGAGALGGLVARRLVERHGVRKLVLASRRGRDADGVADLVAD LAADVSVVACDVSDRAQVAALLDEHRPTAVVHTAGVIDAGVIETLDRDRLATVFAPKVDA VRHLDELTRDRDLDAFVVYSSVSAVFMGAGSGSYAAANAFLDGLMANRRAAGLPGLSLAW GLWDQSTGMAAGTDEATRARMSRRGGLQIMTQAEGMDLFDAALSSAESLLVPAKLDLRGV RADAAAGGVVPHMLRGLVRAGRAQARAASTVDNGLAGRLAGLAPADQLTLLLDLVRAQVA AVLGHADASAVRVDTAFKDAGFDSLTAVELRNRMRTATGLKLPATLVFDYPNPQALARHL RDELGGAAQTPVTTAAAKADLDEPIAIVGMACRLPGGVAGPEDLWRLVAEGRDAVSSFPT DRGWDTDSLYDPDPARPGKTYTRHGGFLHEAGLFDAGFFGISPREAVAMDPQQRLLLEAS WEAMEDAGVDPLSLKGNDVGVFTGMFGQGYVAPGDSVVTPELEGFAGTGGSSSVASGRVS YVFGFEGPAVTIDSACSSSLVAMHLAAQSLRQGECSMALAGGATVMANPGAFVEFSRQRG LAVDGRCKAFAAAADGTGWAEGVGVVILERLSVARERGHRILAVLRGSAVNQDGASNGLT APNGPSQQRVIRRALVSAGLAPSDVDVVEAHGTGTTLGDPIEAQALLATYGKDRESPLWL GSLKSNIGHAQAAAGVAGVIKMVQALRHEVLPPTLHVDRPTPEVDWSAGAVELLTEAREW PRNGRPRRAGVSAFGVSGTNAHLILEEAPAEEPVPTPEVPLVPVVVSARSRASLAGQAGR LAGFVAGDASLAGVARALVTNRAALTERAVMVVGSREEAVTNLEALARGEDPAAVVTGRA GSPGKLVWVFPGQGSQWIGMGRELLDSSPVFAERVAECAAALEPWIDWSLLDVLRGESDL LDRVDVVQPASFAMMVGLAAVWQSVGVRPDAVVGHSQGEIAAACVSGALSLQDAAKVVAL RSQAIATRLAGRGGMASVALSEEDATAWLAPWADRVQVAAVNSPASVVIAGEAQALDEVV DALSGQEVRVRRVAVDYGSHTNQVEAIEDLLAETLAGIEAQAPKVPFYSTLIGDWIRDAG IVDGGYWYRNLRNQVGFGPAVAELVRQGHGVFVEVSAHPVLVQPLSELSDDAVVTGSLRR EDGGLRRLLTSMAELYVQGVPLDWTAVLPRTGRVDLPKYAFDHRHYWLRPAESATDAASL GQAAADHPLLGAVVELPQSDGLVFTSRLSVRTHPWLADHAVGGVVILPGSGLAELAVRAG DEAGCTALDELIIEAPLVVPAQGAVRVQVALSGPDETGSRTVDLYSQRDGGAGTWTRHAT GVLSTAPAQEPEFDFHAWPPADAERIDVETFYTDLAERGYGYGPAFQGLQAVWRRDGDVF AEVALPEDLRKDAGRFGVHPALLDAALQAATAVGGDEPGQPVLAFAWNGLVLHAAGASAL RVRLAPSGPDTLSVAAADETGGLVLTMESLVSRPVSAEQLGAAADAGHDAMFRVDWTELP AVPRAELPPWVRIDTADDVAALAEKADAPPVVVWEAAGGDPALAVSSRVLEIMQAWLAAP AFEEARLVVTTRGAVPAGGDHTLTDPAAAAVWGLVRSAQAEHPDRVVLLDTDGEVPLGAV LASGEPQLAVRGTTFFVPRLARATRLSDAPPAFDPDGTVLVSGAGSLGTLVARHLVTRHG VRRVVLASRQGRDAEGAQDLITELTGEGADVSFVACDVSDRDQVAALLAGLPDLTGVVHT AGVFEDGVIEALTPDQLANVYAAKVTAAMHLDELTRDRDLGAFVVFSSVAGVMGGGGQGP YAAANAFLDAAMASRQAAGLPGLSLAWGLWERSSGMAAHLSEVDHARASRNGVLELTRAE GLALFDLGLRMAESLLVPIKLDLAAMRASTVPVLFRGLVRPSRTQARTASTVDRGLAGRL AGLPVAERAAVLVDLVRGQVAVVLGYDGPEAVRPDTAFKDTGFDSLTSVELRNRLREATG LKLPATLVFDYPNPLAVARYLGARLVPDGTANGNGNGNGHSEDDRLRHALAAIAAEDAGE ERSIADLGVDDLVQLAFGDE NT seq 15183 nt NT seq  +upstreamnt  +downstreamnt atgtccgcgccgaacgagcagatcgttgacgcactgcgcgcgtcgctgaaggagaacgtc cggcttcagcaggagaacagcgcgctcgccgcggccgccgcggagcccgtcgcgatcgtc tccatggcctgccgctacgcgggcgggatccgcggcccggaggacttctggcgggtggtg tcggaaggcgccgacgtctacaccggcttccccgaggaccgcggctgggacgtcgaaggc ctctaccacccggaccccgacaaccccggcacgacgtacgtgcgggagggcgccttcctg caggacgcggcccagttcgacgccgggttcttcggcatctcgccgcgcgaggcgctggcc atggacccccagcagcggcagctcctggaggtgtcctgggagaccttggaacgggccggc atcgacccgcattcggtgcggggcagcgacatcggcgtctacgccggggtcgtgcaccag gactacgcccccgacctcagcgggttcgaaggcttcatgagcctggagcgcgccctgggc accgcgggcggtgtcgcctccggccgggtcgcctacacgctcgggctcgaaggccccgcc gtcaccgtcgacacgatgtgctcgtcgtcgctggtggcgattcaccttgccgcgcaagct cttcgccgtggtgagtgctcgatggccctcgcgggcggctcgaccgtgatggcgaccccg ggcgggttcgtcggcttcgcgcgtcagcgggcgttggccttcgacgggcgctgcaagtcc tacgccgcggccgccgacggttccggctgggccgagggcgtcggcgtgctgctgctggag cggctgtcggtggcgcgcgagcgcgggcaccaggtgctggccgtcatccgcggcagcgcg gtcaaccaggacggcgcttccaacggcctgaccgcgcccaacggcccggcgcagcagcgg gtcatccgcaaggcactggcgagcgccgggctgacaccgtccgatgtggacaccgtggag ggccacggcaccggcaccgtcctcggcgacccgatcgaggtccaggcgctgctggccacc tacggccagggccgcgacccgcagcaaccgctgtggctgggctcggtcaagtccgtcgtc gggcacacgcaggcggcatccggtgtggccggcgtgatcaagatggtccagtcgctgcgg cacgggcagctcccggcgacccagcacgtcgacgcgcccacgccgcaagtggactggtcg gccggagcgatcgagctgctggccgagggccgggagtggccgcgcaacggccacccgcgc cggggcggcatctcgtcgttcggggccagcggcacgaacgcgcacatgatcctcgaagaa gcgcccgaggacgagccggtgaccgaagcgccggcgcccacgggtgtcgtaccgctggtg gtgtcggcggcgaccgctgcttccctggccgcccaggccggtcggctggcggaggtcggc gacgtctccctggcggatgtcgccgggacgctggtgtccggccgcgcgatgctcagcgag cgcgcggtcgtcgtggccggctcccacgaagaagccgtgaccgggctgcgggcgctggcc cgcggcgagagcgcgcccggcctgctttccggccgcggctcgggggtcccgggcaaggtc gtctgggtgttccccggccagggcacgcagtgggccggcatgggccgcgagctgctggac tcctcggaggtgttcgccgcgcggatcgccgagtgcgagaccgcgctcgggcggtgggtc gactggtcgctgaccgacgtgctgcgcggcgaggccgacctgctggaccgggtcgacgtg gtgcaaccggcgagcttcgccgtgatggtcgggcttgccgccgtctgggcctccctcggc gtcgagcccgaggccgtggtgggccactcgcagggcgagatcgcggccgcatgcgtgtcc ggggcactgtccctggaggacgcggcgaaggtggtggcgttgcgcagccaggcgatcgcc gcctcgctggccggccggggcggcatggcgtcggtcgcgttgagcgaagaagacgcgacc gcgcggctcgagccgtgggcgggccgcgtggaggtcgccgccgtcaacgggccgacgtcc gtggtgatcgccggggacgccgaggcgctggacgaagccctcgacgcgctcgacgaccaa ggcgtccggatccggcgggtggcggtggactacgcctcccacacccggcacgtcgaagcc gcgcgcgacgcactggccgagatgctgggcgggatccgcgcgcaggcgccggaagtgccg ttctactcgaccgtgaccggcggctgggtcgaagacgccggcgtgctcgacggcggctac tggtaccggaacctccgccgtcaggtgcggttcggcccggcggtggccgagctgatcgag cagggccaccgggtgttcgtcgaggtcagcgcgcatcccgtgctggttcagccgatcaac gaactcgtcgacgacaccgaagccgtggtcaccgggacgctgcggcgcgaggacggcggc ctccggcgcctgctggcctcggcggccgagctcttcgtccgcggcgtgaccgtggactgg tccggtgtgctgccaccgtcccgccgggtcgagctgccgacgtacgccttcgaccaccag cactactggctgcagatgggcgggtcggccaccgacgccgtgtcgctgggcctggccggc gccgaccacccgctgctgggcgcggtcgtcccgctgccgcagtccgacgggctcgtcttc acctcgcggctgtcgctgaagtcgcacccgtggctggccgggcacgcgatcggcggggtc gtgctcattccgggcacggtgtacgtcgacctcgcgctgcgcgccggcgacgagctcggc ttcggcgtcctggaagagctcgtgatcgaggcaccgctggtgctgggcgagcgcggcggc gttcgcgtgcaggtcgccgtgagcgggccgaacgagaccggctcgcgtgcggtggacgtc ttctccatgcgggaagacggcgacgaatggacccggcacgcgaccggtctcctcggggcg tcgacgtcccgggaaccgagccgcttcgacttcgccgcctggccgccggccggggcggag ccgatcgacgtcgaaaacttctacaccgacctcaccgagcgcgggtacgcctacagcggc gccttccagggcatgcgggcggtctggcggcgcggtgacgaggtcttcgccgaggtcgcg ctgcctgacgaccaccgcgaggacgccggcaagttcggcctccaccccgccctcctcgac gccgctctgcacacgaacgccttcgcgaacccggacgacgaccgcagtgtgctgccgttc gcgtggaacggcctggtcctgcacgccgtgggcgcgtcggcgctgcgggtgcgggtggcg ccgggcggtccggacgcgctgacgttccaggccgccgacgagaccggtggcctggtcgtc accatggattcgctggtgtcccgcgaggtgtcggccgcgcagctggagacggcggcgggc gaagagcgcgactcgctgttccaggtggactggatcgaggtccccgcgaccgagaccgcg gccaccgagcacgccgaggtgctcgaagccttcggcgaggcagcgcccctcgagctgacc agccgggtgctggaggccgtgcagtcctggctcgccgacgcggccgacgaagcacggttg gtcgtggtgacccgtggcgccgtgcgcgaggtgacggacccggccggtgccgccgtgtgg ggtttggtgcgagccgcccaggcggagaacccgggccggatcatcctcgtcgacaccgac ggcgacgtcccgctgggtgcggtgctggccagtggtgagccgcagctcgccgtgcgcggc aacgctttctccgtcccgcgcctcgcccgggccaccggcgaggtgccggaggcccccgcg gtgttcagtccggaagggacggtcctgctcaccggcggcaccggctcgctgggcggtctg gtggccaagcacctggttgcccggcacggcgtccggcggctggtgctcgccagccgccga ggcgtggccgcggaagacctcgtcaccgagctgaccgagcagggcgcgacggtgtccgtg gtggcttgcgacgtctccgaccgcgaccaggtggccgcgttgctggccgaacaccgcccg accggcatcgtgcacctggccggcctgctggacgacggcgtcatcggagccctgaaccgg gagcggctggccggggtgttcgcgcccaaggtcgatgccgtccagcacctcgacgaactg acccgcgacctcggcctcgacgcgttcgtcgtgttctcgtccgcagccgcgctcatgggc tccgccggccagggcaactacgcggccgccaacgccttcctcgacggcttgatggccggg cgccgcgcggcgggcctgccaggcgtgtccctggcgtggggcctgtgggagcaggcggac ggcctgaccgcgaacctcagcgccaccgaccaggcccggatgagccgcggcggcgtgctg ccgatgacaccggccgaggccctggacatcttcgacatcggcctggccgccgagcaggcc ctgctggtcccgatcaagctcgacctgcggacgctgcgcggccaggccaccgccggcggc gaggtgccgcacctgctgcgcggcctggtccgcgcgagccgccgcgtgacccgcacggct gccgcgagtggcggcggtggcctggtccacaagctcgccgggcggccagccgaagagcag gaagccgtgctgctgggcatcgtccaggcggaggcggccgcggtgctcggcttcaacgcc cccgagctggcccagggcacccgcgggttcagcgacctcggcttcgactcgctgaccgcg gtcgagctgcggaaccggctgagcgcggcgaccggcgtcaaattgcccgccacgctcgtc ttcgactacccgacgccggtcgcgctcgcccgccacctgcgcgaagagctgggcgagacg gtggcgggtgcgccggccacgccggtgacgaccgtcgccgacgcgggcgagccgatcgcc atcgtcggcatggcgtgccgcctgccgggcggcgtgatgagccccgacgacctctggcgg atggtcgccgagggccgcgatgggatgtcgccgttccccggagaccgcggctgggacctg gacggcctgttcgactcggaccccgagcgcccgggcaccgcctacatccgccaaggcggc ttcctgcacgaggccgcgctgttcgacccgggcttcttcgggatctcgccgcgcgaagcc ctggccatggacccgcagcagcggctgctgctcgaagcctcctgggaagccctggagcgc gcgggcatcgacccgaccaaggcccgcggtgacgccgtcggcgtcttctccggcgtctcc atccacgactacctcgagtccctgagcaacatgcccgccgagctcgaaggcttcgtcacc acggccacggcgggcagcgtcgcctcgggccgggtgtcctacaccttcgggttcgagggc ccggcggtcacggtggacacggcgtgctcgtcgtcgctggtcgcgatccacctggccgca caggcactgcggcagggcgagtgcacgatggccctggccggcggtgtcgccgtgatgggc tcgccgatcggtgtcatcggcatgtcgcggcagcgcggcatggccgaggacggccgggtc aaggcgttcgccgacggcgcggacggcaccgtcctgtccgaaggcgtcggcatcgtcgtc ctcgaacggctttcggtggcccgcgaacgcgggcaccgggtgctcgccgtgctccgcggc agcgcggtcaaccaggacggcgcttcgaacggcctgaccgcgcccaacgggccgtcgcag cagcgggtgatccgcagcgcgctggccggggccggactgcaaccgtccgaagtggacgtc gtcgaggcgcacggcaccgggaccgcgctgggcgacccgatcgaggcccaggccctgctg gccacctacggcaagagccgcgagacgccgttgtggctcgggtcgctgaagtcgaacatc ggccacacccaggcggccgcgggcgtggcggccgtgatcaagatggtccaggcgctgcgg cacgacaccctgccgccgaccctccacgtgcaggaacccaccaagcaggtggactggtcc gcgggtgcggtcgagctgctgaccgaaggccgggagtgggcccgcaacggccacccgcgc cgggccggtgtctcgtcgttcggcatcagcggcaccaacgcgcacctcatcctggaagag gcgcccgccgacgacaccgccgaggcggacgtgcccgacgccgtggtgcccgtggtgatc tccgcgcgcagcaccggatccctggcgggccaggccggacgcctggcggcgttcctcgac ggagacgtcccgctgacccgcgtggcgggtgccctgctgtcgacccgggcgacgctgacc gaccgggccgtcgtcgtggcgggctcggccgaggaggcccgggcggggctgaccgcgctg gcccgcggcgagagcgcgagcgggcttgtgaccggtaccgcagggatgccgggcaagacg gtctgggtgttccccggccaggggacgcagtgggcgggcatgggccgggagctcctcgaa gcgtccccggtgttcgccgagcgcattgaggaatgcgcggccgcgctgcagccgtggatc gactggtcgctgctggacgtcctccgtggcgaaggtgagctggatcgggtcgacgtgctg cagccggcgtgtttcgcggtgatggtggggctggccgccgtctgggcctcggtcggcgtc gtgccggacgcggtcctgggccactcccagggcgagattgccgccgcctgcgtgtcgggt gcactgtccctcgaggacgcagccaaggtcgtcgcgctgcgcagccaggcgatcgcggcg gagctgtcgggccgcgggggcatggcgtcgatccagctgagccacgacgaggtggctgcc cggctcgcgccgtgggcgggccgcgtcgagatcgccgccgtcaacggtccggcctcggtc gtgatcgccggtgacgccgaagcgctcaccgaggccgtcgaagtcctcggcggtcggcgg gtggcggtggactacgcgtcccacacgcggcacgtcgaggacatccaggacaccctcgcc gagactctggccgggatcgacgcgcaggcccccgtggtgcccttctactccacggtcgcc ggcgagtggatcaccgatgccggggtcgtcgacggcgggtactggtaccggaacctgcgc aaccaggtcggcttcggcccggccgtggccgagctgatcgagcaggggcacggggtgttc gtcgaggtcagtgcgcatccggtgctggtgcagccgatcagcgagctcaccgatgcggtc gtcaccgggacgttgcggcgcgacgacggtggggtgcggcggctgctgacctcgatggcc gaactgttcgtccgcggtgtcccggtcgactgggccacgatggcgccgcccgcgcgcgtc gagctgccgacctacgccttcgaccaccagcacttctggctcagcccgcccgccgtggcg gacgcgcccgcgctcggcctggccggcgccgaccacccgctgctgggggcggttctcccg ctgccgcagtccgacggcctggtgttcacctcgcgcctgtcggtgcggacgcatccgtgg ctggccgacggcgtccccgccgccgccttggtggagctggccgtgcgggccggtgacgaa gccggttgcccggtcctcgccgacctgaccgtcgaaaagctgctggtgctgccggagagc ggtggcctgcgcgtccaggtgatcgtgagcggcgagcgcacggtcgaggtgtattcgcag ctcgaaggcgccgaagactggatccggaacgccaccgggcacctgtccgccacggctccg gcgcacgaggccttcgacttcaccgcctggccgcccgccggagcccagcaggtcgacggc ctctggcggcgcggcgacgagatcttcgccgaggtcgccctgccggaggagctggacgcc ggcgcgttcggcatccaccccttcctgctggacgcggccgtgcagccggtcctcgcggac gacgagcagccggcggagtggcgcagcctggtcctgcacgccgcgggtgcctcggcgctg cgcgtgcggctggtgcccggcggtgccctccaagcggcggacgaaaccggcgggctggtc ctcacggcggattcggtggcaggccgggaactctcggccgggaagacccgcgccggatcg ctgtaccgggtcgactggaccgaagtgtccattgcagacagtgcggtgccggccaacatc gaggtcgtcgaagccttcggtgaagagcccctggaactgaccggccgggtcctggaggct gtgcagacctggctcgtcaccgcggccgacgatgcgcggctggtcgtggtgacccgcggc gccgtgcgcgaggtgaccgaccccgccggtgcggccgtgtggggcctggtccgagccgcg caggcggagaaccccggtcgcatcttcctgatcgacaccgacggcgagatcccggccctg accggtgacgagcccgagatcgcggtgcgcggcgggaagttcttcgtgccccgcatcact cgcgcggagccgagcggggccgccgtgttccgcccggacgggacagtgctgatctcgggc gcgggtgcgctcggtggcctggtggcccggcgtctcgtcgaacgccacggcgtgcggaag ctcgtgctggcgtcccggcgcggccgagacgccgacggcgtggcggacctggtcgccgac ctggccgcggacgtgtccgtggtggcttgcgacgtctccgatcgcgcccaggtggcggcc ctgctcgacgagcaccggccgaccgccgtcgtgcacaccgccggcgtcatcgacgcgggc gtgatcgagacgctggaccgggaccggctggccacggtgttcgcgccgaaggtcgacgcc gtgcggcacctcgacgagctgacccgcgaccgcgacctcgacgccttcgtcgtctactcc tcggtctcggccgtgttcatgggcgcgggcagcggcagttacgccgcggcgaacgccttc ctggacggcctgatggcgaaccgccgggcggcgggcctgccgggcctgtcgctggcgtgg ggcctgtgggaccagagcaccggtatggccgccggcaccgacgaggccacccgggcgcgg atgagccgccgcggtggcctgcagatcatgacgcaggccgagggcatggacctgttcgac gccgcgctgtcgtcggccgagtcgctgctggtgcccgccaagctcgacctgcgtggggtg cgcgccgacgccgccgcgggcggggtcgtgccgcacatgctgcgtggcctggtccgcgcg ggccgggcgcaggcccgcgcggcgtccactgtggacaacgggctggccggacggctggcc gggctcgccccggcggaccagctcacgctgctcctggacctggtccgggcgcaggtcgcg gccgtgctcgggcacgccgacgcgagcgccgtccgcgtcgacacggccttcaaggacgcc ggcttcgactcgctgaccgcggtcgagctgcgcaaccgcatgcggaccgccaccggcctg aagctgcccgcgacgctcgtcttcgactacccgaacccccaggcgctcgcccggcacctg cgcgacgaactcggtggtgcggcccagacgccggtgaccacagcggccgcgaaggccgac ctcgacgagccgatcgccatcgtcgggatggcgtgccgcttgccgggcggggtcgccggg cccgaggacctctggcggctggtcgccgagggccgggacgcggtgtcgagcttcccgacc gaccgcggctgggacaccgacagcctgtacgaccccgatccggcccgcccgggcaagacc tacacccggcacggcggcttcctgcacgaagccgggctcttcgacgcgggcttcttcggg atctcgccacgcgaggccgtcgccatggacccgcagcagcggctgctgctggaggcctcc tgggaggccatggaagacgccggggtcgacccactttcgctgaagggcaacgacgtcggc gtgttcaccggcatgttcggccagggttacgtcgctcccggggacagcgtcgtcacgccg gagctggagggtttcgcgggcacgggcgggtcgtcgagtgtcgcgtccggccgcgtgtcg tacgtgttcgggttcgaaggcccggccgtgacgatcgactcggcgtgctcgtcctcgctg gtcgcgatgcacctcgccgcgcagtcgctgcggcagggcgagtgctcgatggccttggcc ggcggcgcgacggtgatggcgaaccccggcgcattcgtggagttctcgcggcagcggggc ctcgccgtcgacggtcgctgcaaggcgttcgccgccgcggccgacggcaccggctgggcc gagggcgtcggtgtggtcatcctcgagcggctgtcggtggcgcgggaacgcggccaccgg atcctggccgtgctgcgcggcagcgcggtcaaccaggacggcgcctcgaacggcctgacc gcgccgaacgggccgtcgcagcagcgggtgatccgccgggcgctggtgagcgccgggctg gcaccgtccgatgtggacgtcgtcgaggcgcacggcaccgggaccacgctgggtgacccg atcgaggcgcaagctctgctggctacctacggcaaggaccgcgagtcgccgctgtggctc ggctcgctgaagtcgaacatcggccacgcgcaggccgccgcgggggtcgccggcgtcatc aagatggtccaggcgctccggcacgaagtcctgccgccgacgctgcacgtcgaccggcct acccccgaggtcgactggtcggccggtgccgtcgaactgctgacggaagcccgcgagtgg ccgcgcaacgggcgcccgcgccgggccggggtctccgcgttcggcgtcagcggcacgaac gcgcacctgatcctggaggaggcgcccgccgaagagccggtgcccacacccgaggttccc ctggtgccggtcgtggtctccgcgcggagcagggcgtccctggccggtcaggccggtcgc ctcgccggattcgtggcgggtgacgcgtccttggccggtgtggcccgggcgctggtgacg aaccgggccgcgctgaccgagcgcgcggtcatggtcgtgggctctcgcgaagaagccgtg acgaacctggaagcgctggcccgcggcgaagacccggccgcggtggtcaccggccgggcg ggttcgccgggcaagctcgtctgggtcttccccggccagggctcgcagtggatcgggatg ggccgggaactcctggactcttcgccggtcttcgccgagcgggtcgccgaatgcgcggcc gccctggaaccgtggatcgattggtcactgctcgacgtgctgcgcggggagtccgacctg ctggaccgggtcgacgtcgtgcagcccgccagcttcgcgatgatggtcggcctggccgcg gtgtggcagtcggtgggtgtccgcccggatgccgtcgtcggccactcgcagggcgagatc gccgccgcctgcgtctcgggcgcgctgtcgctgcaggacgccgcgaaggtggttgccttg cgcagccaggcgatcgccacccggctggccgggcgcggcggcatggcttccgtggcgttg agcgaagaagacgcgaccgcgtggctggcgccgtgggccgaccgggtccaggtggccgcg gtcaacagccctgcctccgtggtgatcgccggggaagcccaggccctcgacgaggtcgtc gacgcgttgtccggtcaggaagtccgcgtccggcgggtggccgtggactacgggtcccac accaaccaggtcgaagccatcgaggatctgctggccgagaccttggccggcatcgaggcg caggccccgaaggtgcccttctactcgaccctgatcggtgactggatccgtgacgccggg atcgtcgacggcggctactggtaccggaacctgcgcaaccaggtcgggttcggtccggcc gtcgcggagctcgttcgccagggccacggggtgttcgtcgaggtcagcgcgcacccggtg ctggtccagccgctcagtgaactcagcgacgacgcggtggtgaccgggtcgctgcggcgc gaagacggtggcctgcgccgcctgctgacgtcgatggccgagctgtacgtgcagggtgtc ccgctcgactggaccgcggtcctgccgcggaccggccgggtcgacctgccgaagtacgcc ttcgaccaccggcactactggctgcggcccgccgagtccgcgaccgacgcggcttcgctg ggccaggcggcggccgaccacccgctgctgggcgcggtcgtcgagctgccgcagtccgac ggcctggtgttcacctcgcggctgtccgtgcggacgcacccgtggctggccgaccacgcg gtcggtggcgtggtcatcctccccggctccgggctggccgaactggccgtccgggccggc gacgaagccgggtgcaccgccctcgacgagctgatcatcgaagctccgctggtcgtgccc gcccaaggcgcggtccgcgtccaggtcgcgttgagcggcccggacgagaccggctcgcgc acggtggacctctactcccagcgcgacggcggcgcggggacgtggacgcggcacgccacc ggcgtgctgtcgacggcccccgctcaggaacccgagttcgacttccacgcctggccgccc gcggatgccgagcggatcgacgtcgagaccttctacaccgacctggccgagcgtggttac ggctacgggccggcgttccaggggctgcaagcggtgtggcggcgtgacggcgacgtcttc gccgaggtcgccctgcccgaggacctgcgcaaggacgcgggccggttcggcgtccacccg gcgctgctcgacgcggcgctgcaggccgccacggccgtgggcggcgacgagcccggtcag ccggtgctggcgttcgcgtggaacggcctggtcctgcacgccgcgggcgcgtcggccctg cgggtccggctcgcgccgagcggcccggacacgctgtccgtggcagccgccgacgaaacc ggcggcttggtcctgaccatggaatcgctggtctcccggccggtttcggccgagcagctc ggcgccgcggccgacgcgggccacgacgcgatgttccgcgtcgactggaccgagctgcct gccgtgccccgcgcggaactgccgccgtgggtgcggatcgacaccgccgacgacgtcgcg gccttggcggagaaggcggacgcaccaccggtggtggtctgggaagccgccgggggagac ccggccctggccgtgagttcccgggtgctcgagatcatgcaggcctggctggccgcgccc gcgttcgaggaggcccggctggtcgtgacgacccgcggcgcggtacccgccggcggtgac cacacactgaccgacccggccgcggccgcggtgtggggcctggtccggtccgcgcaggcg gaacacccggaccgggtcgtcctgctggacaccgacggcgaagttccgctgggcgcggtg ctggcctccggtgagccgcagctcgcggtgcgcggaacgacgttcttcgtgccccggctg gcccgcgccacccggctctcggacgcgcctcctgcgttcgacccggacgggaccgtgctg gtctcgggcgccggatcgctgggcaccttggtggcccggcacctggtcacccggcacggc gtgcgccgggtggtgctggccagccggcagggccgggacgccgagggcgcccaggacctg atcaccgagctcaccggcgaaggcgcggacgtgtccttcgtggcctgtgacgtctccgat cgcgaccaggtggccgcgctgctcgcgggcctcccggacctgaccggggtggtgcacacc gccggcgtcttcgaggacggcgtgatcgaggcgctgacgcccgaccagctcgcgaacgtg tacgcggccaaggtcacggccgcgatgcacctcgacgagctcacccgcgaccgggatctc ggcgcgttcgtcgtgttctcctccgtcgcgggggtgatgggtggtggcggtcaaggcccg tacgcggcggcgaacgccttcctggacgcggcgatggcgagtcgtcaggccgcgggcctg ccgggcctgtccctggcgtggggcctctgggaacgcagcagcggcatggccgcccacctc agcgaggtcgaccacgcgcgggcgagccgcaacggtgtcctggaactgacccgggccgag ggcctggcgctgttcgacctcgggctgcggatggccgagtcgctgctcgtgccgatcaag ctcgacctcgccgcgatgcgggcgagcacggtcccggtcctgttccgcggcctggtccgg ccgagccggacccaggcgcgcacggcgtccactgtggaccgggggctggccgggcggctc gccgggctgccggtggccgagcgggcggcggtgctggtcgacctggtgcgcgggcaggtc gcggtcgtgctcggctacgacgggccggaggccgtccgcccggacacggcgttcaaggac accgggttcgactcgctgacgtcggtggaactgcgcaaccggctgcgcgaggcgaccggg ctcaagctccccgccacgctcgtcttcgactacccgaaccccttggcggtggcgcgctac ctgggcgcgcggctggtcccggacgggaccgcgaacggcaacgggaacgggaatgggcac agcgaagacgaccggctgcggcacgcgctggcggccatcgcggccgaggacgcgggcgag gagcggtcgatcgccgacctgggcgtcgacgacctcgtgcaactggctttcggcgacgag tga

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