Apis mellifera (honey bee): 408680 Help Entry 408680            CDS       T01057                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism ame  Apis mellifera (honey bee) Brite KEGG Orthology (KO) [BR:ame00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ame04040]     408680    04990 Domain-containing proteins not elsewhere classified [BR:ame04990]     408680 Ion channels [BR:ame04040]  Voltage-gated cation channels   Ryanodine receptor    408680 Domain-containing proteins not elsewhere classified [BR:ame04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    408680 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Serglycin DASH_Spc34 Motif Other DBs NCBI-GeneID:  408680 NCBI-ProteinID:  XP_006569098 BEEBASE:  GB55650 UniProt:  A0A7M7GWS7 LinkDB All DBs Position LG2:complement(12739735..12773483) Genome browser AA seq 5142 aa AA seqDB search MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETQQENLGKGTGSGHRTLLYGNAILLRHQNSDMYLA CLSTSSSNDKLAFDVGLQQHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTW STAPSQNIVIYEGGSVMSQARSLWRLELARTKWAGGFINWLHPMRIRHLTTGRYLGVKEN NELYLVDRNEATIETSTFSLRQEKDDQKIVLEDKDLEVIGTPIIKYGDSTVIMQHATTCL WVSYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLVFSRSQEEESRTARVIRKCSSLFTQF ITGLETLQVDRRASMFFQNVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNKFRALRNRQD LFQEEGILNLILEAIDKINVITSQGFLVALSGDESGQAWDQISGYLYQLLAAIIKGNHTN CAQFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASVRPNIFVGR VENSAVYQKWYFEVTVDHIEQTTHMMPHLRIGWANTSGYMPYPGGGEKWGGNGVGDDLYS FGFDGAYLWTGGRKTQVVHNVTEPYIRKSDVIGCALDLTIPIITFTFNGAPITGSFRNFN LDGMFFPAISCSSKLSCRFLLGGDHGRLKFQPPEEFSPLVESLLPQQILSLDPCFYFGNM NKVVLAGPWLVEDDTAFVPGPVDTSMINLPSYVEQIRDKLAENIHEMWAMNKIEAGWMYG EHRDDMRKIHPCIVQFERLPAAEKRYDTQLAVQTLKTILALGYYITIDKPPSRIKTLRLP NEPFLQSSGYKPAPLDLTAITLTPKMEELVDQLAENTHNLWAKERISQGWTYGLNEDSEM RRSPHLVPYPKVDEAIKKANRDTASETVRTLLVYGYMLEPPTGEQHEALLLEASRLRQLS FRTYRVEKHYAVSNGKWYFEFEVLTAGPMRVGWAKADCMPGSMLGSDENTWAFDGYNVTK VHAGTHESFGHKYQVGDIVGCFIDVADRTISFSLNGELLMDALGGETSFADVQGDCFVPA FTLGVGQKAKLTFGQDVNTLKFFTTCGLQEGYEPFCVNMNRPVTFWYTKDQPIFENTDDM ADTRIDVARIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICQSIFISESEKLRRW QEIKMRQNKLLSEQMEQAQQVPSAHIEQIMKSGFSMSDIKGLQRNYSEDAVEADEMMKES PIPMQRNKPARPPRKGSLYGSRTGNMENAISEADMNGYGDMNGDIKDDKKKRGRSPFRFF SRKAKSPDAKSKTPEPPIRSDVSDKSTKTLSMNKASSRPPQIRISNTDLKVVPPQIPERN APKAMSVLTGSGVEAIGNEIFDTECLKLMNEYFYGVRIFPGQDPTHVYVGWVTSQYHLHT KDFNLSRVRKGSVVITDDYDRPVEQVDRQSCYMVRADELYNEVTQDASGKGASQGMFVGC FVDTATGWVSFTCEGKETSHKFKMEPDTKLFPAIFVEATSKEILQIELGRTSTTLPLSAA VLQNSERHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSDIRGWSMLCEDAISMLA LHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHALCQHVDQKQLLYAI RAEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYIIPLGQELKELYENEEMKHSLRYL ETESVRPQMKMTDIRDDSSSDQAIENIRSLYSPHFPLDVVRDYVMTALNEAVEINQVHNR DPIGGSNENLFLPLLKLVDRLLLVGMLRNEDIMKLLIMIHPETWDPTFEKEGKDEHKKGL LHMKMAEGAKLQMCYLLHHLNDIQLRHRVESIIAFSHDFVGDLQSDQLRRYIEIKQSDLP SAVAAKKTREFRCPPREQMNAILSFKNMEFEDDPENIPCGEELISKMNEFHNNLMSYVSL HALQEAADALEESIEEVQKPGAIKRLFNFINAVKELEEEPKPEPEPEKKTPEEVFRKVLI KTIVSWAEESQIETPKLVREMFSLLVRQYDTVGELIRALEKTYVINSKTKDDVALMWVGL SQIRALLPVQMSQEEEELVRERLWKLVNNHTFFQHPDLIRVLRIHENVMAIMMNTLGRRA QAQSDAQTQPQTTEGEPVSKEKDTSHEMVVACCRFLCYFCRTSRQNQKAMFDHFDFLLEN SNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRCGLQSNSELVEKG YPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEGEGLLR AIIDANKMSEKIADRRKVHDEAEGSTVMQFEHPLPESDDDEDYIDTGAAILNFYCTLVDL LGRCAPDSSVIEQEASTESVGKNESLRARAILRSLVPLDDLQGVLSLRFTLLNPAAGEEK PKSDMPSGLIPGHKQSIVLFLERVYGIETRELFFKILEEAFLPDLRAATMLDRNDGYESD MALAMNRYIGNSILPLLIKHSKFYNEADNYASLLDATLHTVYRLSKNRMLTKGQREAVSD FLVALTREVHELNVSQMQPSMLLKLLRKLTVDVSKLSEYTTVALRLLTLHYDRCAKYYGS TGGQGAYGASSDEEKRLTMVLFSNIFDSLSKMDYDPELFGKALPCLTAIGCALPPDYSLS KNYDDEWYGSKSASAQSPDGPYNPQPINTSSVVLNNDLNQIVQKFSEHYHDAWASRKLEN GWTYGEQWSDMNKTHPRLKPYNMLNDYERERYKEPVRESLKALLAIGWSVEHAEVDVPST NRSSMRRSSKSQGDSANPFNYNPHPVDMTNLTLSREMQNMAERLADNAHDIWAKKKKEEL ITCGGGIHPQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHKPNRGGESEVATAGAS VELRFAYSLLEKLIAYLDKATINMKLLKPSDTFSRRNSFKTSTRDIKFFSKVVLPLMEKY FSTHKNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFGPDVRITVRCLQV LVKGIDAKSLVKNCPEFIRTSMLTFFNNTADDLGHTILNLQEGKYSHLRGTHLKTSTSLS YINSVVLPVLTAMFDHLAACEYGSDLLLDEIQVASYKMLASLYTLGVDATLTHDRKYLKT EIERHKPNLGSCLGAFSSCFPVAFLEPHLNKHNQYSLLNRIADHSLEAQDIMTKMESSMP TLETILTEVDQFVESEKTYNEVPHVVDVILPLLCSYLPFWWAQGPDNVNPTEGTYVSMVT SDHMNQLLKNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELLKDPFLPLAERVRKR TDTMFHKEESLRGFIKSSTDDTSQVEAQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLR NNISEAEDLYNHVAAIFNIWSKSQYFLREEQNFISANEIDNMVLIMPTATRRPAAISDGT APSGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLK KMPEYEIAEFAKTQLTLPDKIDPADEMSWQHYLYSKLGQKKDSMEPVKAQQLEDVVARIT DMAKVLYGLHMIDHPQQQSKGQYRSVVSIQRKRAVIACFRQTSLHSLPRHRAINIFARTY YELWLQDENVGQEVMIEDLTQSFEDAELKKMDKDEDEGKPDPLTQLVTTFCRGAMTERSG ALQEDPLYMSYAQIISKSCGEEEEEGEDEGGGGEEEGGASIHKRGHKPLMRPMHKLMEQE MEKQKLLFHQARLANRGVAEMVLLHISACKGVPSEMVMKTLELGISILRGGNIEIQRGML NHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCA LFRFIQLTCEGHNLDWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELI DPAGKANFFKAIGVASQVFNTLTEVIQGPCAQNQQALAHSRLWDAVGGFLFLFSHMQDKL SKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESAGNVELILKYFD MFLKLKDLVSSPSFLEVDLNSDGWVYPKDFKEKMEQQKSYTDEEIEFLLACCETNHDGKI DYVAFMDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPYLGRIEI LGGNKKIERVYFEIKESNIEQWEKPQIKESKRTYFYNTVVEAGEKEKLETFINFCEDAIF EMQHASALMAVEESGGIGKARESSYTYMTDDDEERNKDPIRRGIQTFKDSIYFFFSIFSP SNIKNKIAEMQQMTFLELFIGFFKMIFYAFYYSGFGVGCVIGYFMKLLLALMKGPHVEEP VVEVKEEEEKPSRHLPALPPTPDESNLQVQAFGMDITKEEGGQIKIAPHESATSTPQSSI EETGESTPEEATGEESARAEGGGDMESPVSLADLLGGEQARAQAAAAAEAAAAQQAAMAA VEAEAKQETIAEPSASSIDFSEYTHRVVSFLARNFYNLKYVALVLAFCINFMLLFYKVSS LDSEGGEEGSGQIVDMLAEMSGEGASGSGNGSGVEIGSGSGEAESEEEEDEYALEYVEVA EDFYYMAHVIRLMAILHAIVSLAMLVAYYHLKVPLAIFKREKEIARRVEFDGLYIAETPE EDDIKAHWDKMVISAKTFPVNYWDKFVKKKVRQKYSETYDFDYISNLLGMEKTSFSQQEE EGSGLIHFIVNIDWRYQVWKAGVTITDNAFLYSLWYFTFSILGNYNNFFFAAHLLDVAVG FKTLRTILQSVTHNGKQLVLTVMLLTIVVYIYTVIAFNFFRKFYIQEEDDEVDKKCHDML TCFVFHLYKGVRAGGGIGDEIGEPDGDDYEVYRIMFDITFFFFVIVILLAIIQGLIIDAF GELRDQLENVKTNMESNCFICGLGKEYFDTVPHGFDTHVQQEHNLANYMFFLMHLINKPD TEYTGQETYVWNMYQQRCWDFFPVGDCFRKQNEAVEEEAKKK NT seq 15429 nt NT seq  +upstreamnt  +downstreamnt atggccgacagcgagggtggctccgagcaggatgacgtatccttccttcgcacggaggat atggtatgtctgtcctgcacggcaaccggtgaaagagtttgcctggcagccgagggattt ggtaatcgacactgtttcctcgagaatatcgcggataagaacataccgcccgacctgtcg caatgcgtattcgtaatagagcaggctctctcggtacgagctttgcaggaattggtcact gctgccggttccgagacgcagcaagaaaatttaggaaagggtacaggatccggacacaga acgttgttgtacggtaacgcaattttactaaggcatcagaacagcgacatgtatttggct tgtctatcgaccagctcgtccaacgacaagttggctttcgacgtgggcctccaacagcat tctcaaggcgaggcttgttggtggacggttcatccagcatcgaagcaaaggtccgagggt gagaaggttcgagtcggcgatgaccttatcctggtatccgtggccacagaaagatacttg cacaccaccaaggagaacgatttgtcggtggtgaacgcctcgttccacgtgacccactgg tccgtgcaaccgtacggaacaggaatcagccggatgaaatacgtcggttacgtatttggc ggtgacgttcttcgattcttccacggtggcgacgaatgtctcaccataccatcaacatgg agcacagcgccaagtcaaaatatagtgatctacgagggagggagcgtgatgagccaagca agatctttatggaggttggagctggcgaggacgaagtgggcaggcggtttcatcaattgg ttgcacccgatgagaatcagacacctgactacaggccggtatctcggcgtgaaagaaaac aacgaattgtatctggtcgataggaacgaggccacgatcgagacctcgacgttctcgttg cggcaagagaaggatgatcaaaagatcgttctcgaggacaaggatctcgaggttatcggt acaccgatcatcaaatacggcgactcgaccgttatcatgcaacacgccaccacttgcctc tgggtctcgtacaaatcgtacgagacgaagaagaagggagtgggcaaggtggaggagaag caagccgtccttcacgaggaagggaaaatggacgacggtttggtcttctcccgttcgcaa gaggaggagtctaggacagctcgagtgattaggaagtgcagcagtctgtttacccaattc atcacaggcctagagacgctgcaagtggatagaagagcgtccatgttcttccaaaatgtg aatctgaacgagatggtgatgtgtctggaagacttgatcaattactttgctcaacccgaa gacgacatggaacacgaggagaaacagaacaaattccgagccctgagaaatcgccaagac ctgttccaagaggaaggtatactgaatctgatcttggaagccatcgacaagatcaacgtg atcacgtctcaaggttttctcgtcgctctttcgggtgacgagagcggtcaagcctgggac caaatatccggatacctgtatcaactgttggcagcgataatcaaagggaatcacacgaat tgcgcccaattcgccaacagcaatcgattgaactggttgttcagccgtttaggctcgcaa gcttcgagcgaggggacggggatgttggacgtgcttcattgcgtcctcatcgactcgccc gaggctttgaacatgatgagggacgagcacatcaaagtgatcatttccctgctcgagaaa cacggaagggacccgaaagtgttggacgttctttgctcgctgtgcgtgggtaacggcgtc gccgtccgatcgtcccagaacaacatctgcgatttcctgctgcccggcaagaatctactc ctgcaaacccaactggtcgaccacgtggcgagcgtgaggccgaacatattcgtcggtaga gtggaaaattcagctgtttaccaaaaatggtacttcgaagtcaccgtcgatcatatagag cagactacgcacatgatgccgcacttgagaataggatgggccaacacttctgggtacatg ccgtatcccggtggtggcgagaaatggggtggaaacggtgtcggcgacgatctctactcg ttcgggtttgacggcgcctatctgtggacgggcggtagaaagacccaagttgtccacaac gtgacggagccttacatcaggaaaagcgacgtgatcggttgcgcgttggatctcacgata cccataatcacgttcaccttcaacggagcgcccattacaggatcgttccgaaatttcaac ctggacggaatgttcttccccgccatcagctgctcgtccaaattatcctgcagattcctg ttaggcggggaccacggccggctcaagttccaacctccggaagaattctcaccgttggtg gagagcctgctaccccaacaaattttgtccctcgatccgtgcttctacttcgggaacatg aacaaagtggtgctggccggcccctggctggtcgaggacgacacggctttcgtcccgggc ccggtcgacacttccatgatcaatctgccgtcctacgtcgagcaaatcagggacaagctg gccgagaacatccacgagatgtgggcgatgaacaaaatcgaggccggatggatgtacggg gagcacagggacgacatgaggaagatacatccttgcatcgttcagttcgagagattgccg gcggcggagaaacgttacgacactcaactggccgtccagactctcaagactattctggcg ttgggctattacatcaccatagacaaaccgccgtcgaggataaaaactttgaggcttccg aacgagcccttcctgcagagcagcggttacaagcccgctcctctcgatctcaccgcgatc accctcacgcccaagatggaggagctggtcgaccaactcgcggagaacacccacaatttg tgggcgaaggaaaggatcagccagggttggacgtacggcctgaacgaggactcggagatg agaaggagcccgcatttggtcccctacccgaaggtggacgaggcgatcaagaaagccaat cgtgacacagccagtgaaacggtgaggacgcttttggtctacggatacatgttggagccg cctacaggggaacagcacgaagcgctgttgttggaggccagcaggttacgccaattgtcg tttagaacttatcgcgttgagaagcattacgcggtgagcaatggaaagtggtacttcgag ttcgaggttctgacggctggtccaatgcgagttggttgggcgaaggcggattgcatgccc ggaagcatgctgggaagcgacgagaacacgtgggcattcgacggttacaacgtaactaaa gtacacgccggtacccacgagtcatttggtcacaaatatcaagtgggcgacattgttgga tgtttcattgacgtcgcggaccgaacgatcagcttttctctaaacggggaactgctgatg gacgcgttgggcggcgagacttcgttcgccgacgtgcagggcgattgcttcgtgccagct ttcactctcggcgtcggtcaaaaagcgaaattaacgtttggacaggacgtgaacaccctg aaattcttcaccacctgcggcttgcaagagggatacgagccgttctgcgtaaacatgaat cgaccggttacattctggtacaccaaggatcaaccgattttcgagaacacggacgacatg gccgacacgaggatagacgtggccaggattccagcgggttccgacaccccgccatgtttg aagatctcgcacaacacgttcgagacgatggagaaggcgaattgggaattccttcgactg tcgttgccagttatctgtcaatcgatcttcatttcggagagcgagaagctgagaagatgg caggagatcaagatgcgacagaacaaattgttgtccgagcagatggagcaagctcaacaa gttccctccgctcacatagagcagatcatgaaatctggtttcagtatgagcgacatcaaa ggattgcaaaggaactattcggaggatgcggtggaagccgacgaaatgatgaaagagtcg ccgattcctatgcagaggaacaaaccggccaggcctccgaggaaaggttccctgtacgga tcgaggactggaaacatggagaacgcgatcagcgaggccgacatgaatggatacggcgac atgaacggcgatatcaaagacgataagaagaaacgtgggcgttcgccgttccgattcttc tcgcggaaagcgaagtctccggatgcgaaatcgaaaacgcccgagccaccgatacgctcc gacgtctctgacaaaagcacaaagacgctatcgatgaacaaagcaagtagccggcctccc caaattcgtatatcaaacacggatttgaaagtggtgccgccccagatcccggaacgaaac gcgcccaaagcaatgtccgttctgaccggaagcggcgtcgaggcgattgggaacgagata ttcgatacggaatgcttgaaattgatgaacgaatacttctacggggtacgaatattccct ggacaggatcccactcacgtttacgtaggatgggtgacctcgcagtaccatttgcacacc aaggacttcaatctgtcccgcgtgaggaagggttccgtagttatcacggatgactacgat cgtcctgtagagcaggttgacaggcaaagttgctacatggtgagagcggacgagctttac aacgaagtgacgcaagacgcgtctggcaagggtgcgtctcaggggatgttcgtcggatgt ttcgtggacacggcgaccggttgggtctcgttcacgtgcgagggaaaggagaccagtcac aagttcaagatggaacccgacacgaaactattccccgccatcttcgtggaggccaccagt aaagagatccttcaaatcgagctcggaagaacttccaccacgttgccactgtccgccgcg gtgttgcagaactctgagcgtcacgtgataccgcagtttccgcccagattgaaggttcaa tgtttgaagcctcaccaatgggccagagttcccaaccagtccctccaagtgcacgcgtta aaattgtccgatatcaggggttggtccatgctatgcgaggacgccatatcgatgctggct ttgcacattcccgaagaagataggtgtatcgatatcttggaactgatcgaaatggacaag ctactcagctttcacgcgcacactctgacgctgtacgcggctctctgctaccaatcgaat tacagagcagcgcacgctctgtgtcagcacgtcgatcagaaacaattgttgtacgcgatt cgagcggaatacatgtccggacccctacgacaaggattctacgacttgctgatcgcgttg cacctcgaatcgcacgcgactacgatggaagtgtgcaagaacgaatacattattccttta ggtcaagaattgaaggaactgtacgaaaacgaagaaatgaaacacagtctcaggtatctg gagaccgaatcggtccgacctcagatgaaaatgacggacatcagggatgattcttccagc gaccaggcgatcgagaacataaggagcctgtacagcccgcacttccccctcgacgtggtg cgggattacgtgatgacagctttgaacgaggccgtcgagatcaatcaagttcacaatcga gatccgatcggaggcagcaatgagaatcttttcctaccacttttgaaacttgtagacagg ttgctcttggttggaatgctcaggaacgaagacatcatgaagcttctgatcatgatccat cccgagacttgggacccaacgtttgaaaaagagggaaaggacgagcacaagaagggattg cttcacatgaaaatggccgagggagctaagctgcagatgtgctaccttctccatcatctg aacgacatccagcttcgacatcgcgtcgagtccatcatcgcgttcagccacgacttcgtc ggtgatctccaatccgatcaacttagacgttacatcgagatcaaacagtccgacttgcca tcggcggtggcagccaagaagaccagagagtttaggtgtccgcctcgagaacagatgaac gctatcttaagtttcaagaatatggaattcgaggatgatcccgagaatataccttgcggg gaagagttgataagcaagatgaacgaattccacaacaatctcatgtcttacgtgtccttg cacgctcttcaggaagcggcggatgctttggaggagtcaatagaagaagttcagaaacct ggcgccattaagaggctgttcaattttatcaacgcggtgaaagagttggaggaggaacct aaacctgaaccggaacctgaaaagaagactccagaagaggtattccgcaaagttcttata aagactatcgtcagctgggccgaggaatctcagatcgagactccaaaattggttcgagaa atgttcagtttgcttgtccgtcaatacgataccgtgggcgaattaattcgagccttggag aagacttacgtgatcaacagcaagacgaaagacgacgttgctttgatgtgggtcggtttg agccagatacgtgccctgttgcctgtccaaatgtcccaagaggaggaggaattggtcaga gaacgactctggaaattggtgaacaatcacactttcttccagcatccagatctgatcaga gtattgagaattcacgagaacgtgatggcgatcatgatgaatacgctgggcagacgtgcg caggcgcagtccgacgctcaaacacaaccgcagacaaccgaaggagaaccagtttccaag gagaaggatacttctcacgaaatggtggtggcatgctgtagattcctgtgctacttttgt cgaacatcgaggcaaaatcagaaggcgatgttcgatcatttcgattttctcttagagaac agcaatattttactgtcgaggccatcgttaagaggttcgacgccattggacgtggcatat tcctctcttatggaaaacacggagcttgctttggcactgagagaacattacctcgaaaag attgccatctacttgtctcgttgcggtttgcaatcgaattcggaattggttgagaaaggt tatcctgatctgggttgggatccagtggaaggtgaacgatacttggacttcttgagattc tgcgtttgggttaatggtgaaagtgtcgaggaaaatgcaaatttagtgatccgtctgctg atcagaagaccagaatgcttgggtccagctcttcgtggtgaaggcgaaggtttattgaga gccatcatagacgccaataagatgtccgaaaaaatcgcggatcgacgaaaagtacacgac gaagcagagggttcaacggtcatgcaattcgaacatccacttccagaatcagacgacgac gaagactatatcgacacgggagccgccatcttgaatttctattgtactttggtggaccta ttaggccgctgcgctccagattcttccgttatcgaacaagaggcttctacagaatctgtc ggaaagaacgaatctcttcgagcgagagccattcttcgatcgttggtgcctcttgatgat ctacaaggtgtcttgtctttaagattcaccttactgaatccagcagcaggtgaagagaaa ccaaagagcgatatgccgtctggtttgattcctggacacaagcagagcatcgttctgttt ctggaacgcgtttacggcatcgaaactcgggaactgttcttcaaaatactcgaggaagct ttcttgcctgatctcagagctgctactatgttggataggaacgatggatacgaatcagat atggcgttagcgatgaatcgttatatcgggaacagtattctaccattattgatcaagcat tccaagttctataacgaggctgacaattacgcgagtttattggacgccacgttacacact gtataccgattgagcaagaacagaatgctgacaaagggtcaacgagaagcagtctcggat ttcctcgtggcattgaccagagaagtccacgagttaaatgtctcccaaatgcagcctagt atgctgttgaagctgcttcgaaaactgaccgtggatgtatccaagctatctgaatacacg accgtcgctttaaggctgctgactttgcattacgatcgttgtgcaaaatattacggttca accggcggacaaggtgcatacggtgcatcgagcgatgaagagaaacgtttgacaatggtt ctgttcagcaacatattcgattcgttgtccaagatggattatgacccagaattgttcgga aaagctctgccttgtctcacagctatcggttgcgcgttaccgcctgactattcgttatct aaaaattacgatgacgagtggtacggaagtaaatctgcgtctgcacagtcgcccgatgga ccatacaatcctcaacctatcaatacgtccagtgtggtgctgaacaatgatcttaatcag atagtacagaaattctccgagcattatcacgatgcttgggccagcaggaagttagaaaat ggttggacgtatggcgaacagtggtccgacatgaacaaaactcatccgagattaaagcct tataacatgttaaacgattatgagagagaacgatacaaagagccagttagggagagttta aaagctttgcttgctataggatggagcgttgaacacgcagaagtggatgtgccctctacg aatcgtagctcgatgagaagatcatcgaaaagtcagggtgattcggcaaatccattcaat tacaatcctcatccagttgatatgaccaacttgactttgagcagagaaatgcaaaatatg gcggaacgtctggcggataatgcgcatgatatttgggcgaaaaagaagaaagaggaactt atcacttgtggaggaggtatccatcctcagctggtcccgtacgatcttttgaccgacaag gagaaacgaaaagaccgcgaacgttcccaagaattcctaaaatatttgcaatatcaaggt tacaagcttcacaaaccgaatcgaggcggagaatcggaagttgcgacagctggtgcctcg gtggagttgcgatttgcatactcgttgctagaaaagttgatagcctacttggacaaggct accatcaatatgaaattgttgaaaccttcagacacgttcagccgtagaaacagtttcaag acgtccacgagagacatcaaattcttcagcaaggtcgttcttccgttgatggaaaaatat ttcagcacgcacaagaattacttcatcgctgtggccacggctaccaacaacgttggagct gcgtctctgaaggagaaagagatggtcgcggctctgttttgcaaattggcaagtctattg agatctagattggctgcgtttggaccagatgttaggatcactgtcagatgccttcaagta ttagtcaaggggatagacgcgaagagtttggtgaagaattgtcccgagttcatcagaacg tcaatgttgactttctttaataatactgcagatgatttaggacacacgattctgaattta caagagggcaagtacagtcatctgaggggaacacatttgaagacttccacgtctttgtcg tacatcaatagcgtagttctgccggttttaacagccatgttcgatcatttggctgcctgc gagtatggtagcgatttgttactggacgagattcaggtagcatcctacaaaatgctggca tctctttacaccttgggcgtagacgcgacgttgacgcacgacagaaagtatttgaagaca gaaatcgagcgtcacaaaccgaatttaggctcttgcctaggtgctttctccagttgtttc cccgtagcgtttttggagccccacttaaacaaacacaatcaatattctcttctgaatcgt atcgccgatcactcgttggaagcgcaggatattatgacgaaaatggaatcgagcatgccc accctcgaaacgattctgacggaggtcgatcaattcgtcgagtctgagaaaacttacaac gaagttcctcacgtggtcgacgttattcttcctctactttgctcttatctgcccttctgg tgggcccagggcccggacaacgtaaatccgaccgaaggaacgtatgtcagtatggttacc agcgatcacatgaatcaattgctgaaaaatgtattaaaattgatcaagaagaacatcggt aatgagaacgcaccttggatgactcgtatcgcggcttacactcaacagatcatcatcaat tcgtcggaggagttgttgaaagatccgttcttaccgctcgctgaacgtgtcagaaagcgt acagatactatgtttcacaaggaggaatctcttcgtggtttcatcaagtcgtcgacggat gacacgtctcaagtcgaagcacagattcaagaagattggcaacttttggttcgtgacatc tattccttctatcctcttttgatcaagtacgttgacttgcaaaggaatcattggttaagg aataacatatcagaagcggaagatctttacaatcacgtggcagcgatatttaacatctgg tcgaaatctcagtacttcttgagagaggagcagaactttatatctgcaaacgagatcgat aatatggtgctcataatgcctactgcgaccaggagacctgccgccatctcggatggaact gcaccttctggaggaggcaagaaaaagaagaaacatcgagacaagaagagggataaagac aaagaggtgcaagcttctttgatggtagcatgtttgaaaagattactcccagttggtctc aatttattcgccggtcgtgaacaagaattagtgcaacactgcaaggacagattcctgaag aagatgccggaatacgaaatcgctgaattcgccaaaacccaattgactttaccggacaag atcgatccagctgacgagatgtcgtggcaacactacttgtactccaagttgggccaaaag aaggactccatggaaccagtgaaagcgcaacaactggaggatgtggttgcgaggatcaca gacatggccaaagttctttatggtttacacatgatagatcatccgcaacagcagagcaag ggtcaatatcgatccgtggtgtcgatacaacgtaaacgagcagtaattgcttgcttccgt caaacttccctacattccttgcccaggcatcgggctataaatattttcgcgcgaacatat tacgagctctggttgcaggatgaaaatgttggccaagaagtgatgattgaagacctaacg caatcctttgaagacgcggaattgaagaaaatggacaaggacgaggacgaaggaaaacca gacccgctcacacaactcgtaacgacgttctgtcgtggcgctatgacagaacgatctggc gcgcttcaagaagatcctttgtacatgagctacgcgcaaattatatcgaaatcttgcggc gaagaggaagaagaaggtgaagatgagggcggagggggcgaggaagaaggcggcgcttcg atccacaagcggggccataagccacttatgcgaccgatgcacaaacttatggaacaagaa atggaaaagcagaagcttcttttccaccaagcgcgactcgcgaatcgtggcgtggcagag atggtactgcttcacatctcagcctgcaaaggtgttcccagcgagatggtgatgaagacc ttggaattgggaatctccatcctacgcggcggtaatatagagattcaacgaggaatgctg aaccatttgaaggaaaaaaaggacgtaggattcttcacatcgattgccggtctcatgaat tcctgcagtgtattggatctggatgcgttcgaaaggaacacgaaagcggaaggtcttggt gttggttccgagggagccgctggagagaagaacatgcacgatgctgagtttacatgtgct ctatttcgttttattcaactgacttgcgagggtcataatcttgactggcagaattatcta agaacgcaagctggtaacacaacaacggtgaacgtagtcatctgcaccgtcgattatcta ctgcgactccaagaatccatcatggacttctattggcactattccagcaaggaactcatc gaccctgccggcaaggctaattttttcaaagctattggcgttgccagtcaggtgttcaat accctcactgaggtgattcaaggaccctgcgcacagaatcaacaagcattggcacattct cgattgtgggacgcggttggtggattccttttccttttctctcacatgcaagacaagttg tccaaacactcgagtcaggtggatctattgaaggagttgctcaacttgcaaaaagatatg atcactatgatgttgtctatgctggaaggtaacgttgtaaatggaactattggaaaacag atggtggacacattggtagaatctgcgggcaatgtcgagttgattctcaaatacttcgac atgttcttaaaactgaaagatctcgtatcatctcctagcttcttagaggtggatttgaac agcgatggctgggtgtatccgaaagattttaaagaaaaaatggaacaacagaagagctat accgacgaggaaatcgaattcttattggcctgttgcgagacgaaccacgacggtaaaatc gactacgtggctttcatggatcgtttccacgaaccggctaaagaaatcggtttcaatctt gccgttctattaaccaatttatcggagcacatgccaaatgaaccaagattggcgagattc ctcgaaacagcaggctctgtgttgaactatttcgagccatacctcggcagaatcgagatt ctcggtggaaacaagaagatcgaacgcgtatactttgagatcaaggaatcaaacatcgag caatgggagaaaccacaaattaaagaatcgaagaggacatatttctacaataccgtagta gaggcaggagagaaagaaaaattggagactttcatcaacttctgcgaagacgctatcttt gagatgcaacacgcgagtgcgttgatggcagtggaagaaagtggaggaatcgggaaagcc agagaatcttcctatacctacatgacggatgacgacgaagaaagaaacaaggatcctatt agaagaggcatccagacgtttaaggatagcatttacttcttcttctccatattctcccct agcaacatcaagaacaagattgccgagatgcaacaaatgacatttttggaactctttatc ggtttcttcaagatgattttctacgcgttctattattctggttttggcgttggttgcgtg atcggatatttcatgaaattactgttggcgttgatgaaaggaccacacgtggaagagccc gtagtcgaggtgaaagaggaggaggagaaaccatcgagacatttgcccgctttgccgcca actccggatgagtctaatctacaggtacaagcgttcggaatggatataacgaaagaggaa gggggacagataaagattgcacctcacgaatcggctacgtctacccctcaatcgagtatc gaggaaacgggcgaaagtacaccggaagaagccactggagaagaaagtgcgagagctgag ggaggtggagacatggaatcgcctgtttcgttggccgatttgttaggaggtgaacaagct agagctcaggctgcagccgcggcagaagcagcggcagctcaacaagcagcaatggctgcg gtcgaggcagaggcgaaacaagaaacgatagcagaaccatcagcctcctctatcgacttt tccgagtacacgcatcgcgtcgtctccttcttggcaaggaatttttataatctgaaatac gtggctctagtgctcgctttctgtatcaattttatgttgctgttctataaggtttcgtct ttggatagcgaaggaggtgaggaaggaagtggtcagatagtggacatgttggcagagatg tctggcgagggtgcatccggttctggaaatggcagtggagttgaaataggtagcggtagc ggggaggctgaatcggaggaagaggaagacgaatacgctctggaatatgtggaagtggcg gaggatttctattacatggcacacgttataaggctcatggctattcttcatgcgatcgtc tctcttgctatgctagttgcctactatcatttgaaagtgccgttggctattttcaaacga gagaaggaaattgcgcgacgcgtggaattcgatggtctgtatattgctgaaacaccggaa gaggatgatatcaaagcacattgggataagatggtgatatcggcaaaaacgttccctgta aattattgggataagttcgtgaagaagaaagttcgacagaagtacagtgagacctacgat ttcgactacatcagtaatttgcttggcatggaaaagacatcgtttagtcaacaggaagaa gaaggttctggtttgatacacttcatcgttaatatcgattggaggtatcaagtatggaaa gctggagttaccatcacggataacgcattcttgtacagtttatggtactttacattttca atacttggcaattataacaatttcttcttcgctgctcatttactcgacgtcgcagttggt ttcaaaactctgagaacgatcttacagtctgtgacacacaatggcaaacaattggtgttg acagtaatgttactgactattgtcgtctacatatatacggtcattgctttcaatttcttc agaaaattctatattcaagaagaagacgatgaagtggacaaaaaatgccacgacatgtta acatgcttcgtattccatttgtacaaaggtgtcagagctggtggtggtattggtgacgaa attggtgaacctgatggcgatgattatgaagtttaccgtatcatgtttgatatcactttc ttctttttcgtcattgttatcctgttggccattattcaaggtttgattatcgatgcgttc ggtgaacttcgagatcaacttgagaacgtgaaaacgaatatggaaagcaattgtttcatt tgtggtttaggaaaagaatatttcgatacggtaccacatggtttcgatactcatgtccaa caggagcacaatcttgctaattatatgttcttcctcatgcacttaatcaataaaccagac accgaatacaccggtcaagaaacgtacgtgtggaacatgtatcagcaaaggtgttgggat ttcttcccggtcggtgattgcttccgcaagcagaacgaggcggtggaggaagaggcaaag aaaaaataa

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