Anopheles merus: 121599611 Help Entry 121599611         CDS       T08889                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism amer  Anopheles merus Brite KEGG Orthology (KO) [BR:amer00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:amer04040]     121599611    04990 Domain-containing proteins not elsewhere classified [BR:amer04990]     121599611 Ion channels [BR:amer04040]  Voltage-gated cation channels   Ryanodine receptor    121599611 Domain-containing proteins not elsewhere classified [BR:amer04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    121599611 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR Ins145_P3_rec SPRY MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 GET2 TPR_TTI1_C Motif Other DBs NCBI-GeneID:  121599611 NCBI-ProteinID:  XP_041783469 LinkDB All DBs Position 3L:8937831..8979131 Genome browser AA seq 5120 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETGNDSVGKGTGSGHRTLLYGNAILLRHNNSDMYLA CLSTSSSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTW SLDSGQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWSHPMRIRHLTTGRYLGVNEN NELILMSRDQATTSQTAFVLRLEKDDQKVVLEDKDLEIIGAPIIKYGDSTVIMQHYESGL WVSYKSYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTKF ISGLETLQENRRHSIFLQTVNLGEMVMCLEDLINYFAQPEDDMEHEEKQNRLRALRNRQD LFQEEGVLNLILEAIDKINVISSQGFLASFLASDESGQSWDMISGYLYQLLAAIIKGNHT NCAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLE KHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTGLVDHVASIRPNIFVG RVEGSAIYQKWYFEVTMDHIEQMTHMTPHLRIGWANTAGYVPYPGGGEKWGGNGVGDDLF SYGFDGVYFWSAGRRTCVVPREVTEPFIKKGDVIGCTLDLSVPVIRFTFNGEPVQGCFTD FNLDGMFFPVMSCSSKLSCRFLFGGDNGRLKFNPPPGFSPLVQCLMPHQNLSLDPCFYFG NLNKNVLAGPWLVEDDSAFVPKPVDTSIVTLPSSVETIKDKLAENIHEMWALNKIEAGWT WGERRDDVYRIHPCLTSFEKLPAAEKRYDCQLAVQTLKTILALGYYISMDKPPARIRPIR LPNDPYMQGNGYKPAPLDLSAAVLTPKMEELVDQLAENTHNLWAKERIQQGWTYGLNEDS ENLRSPHLVPYSKVDEAIKKANRDTASETVRTLLIYGYNLDPPTGEANEALAAEALRQKF AAYRTYRVERTYAVTSGKWYFEFEVLTAGPMRVGWARADCNPGTMLGSDDASWAFDGYNE EKVSGGATESFGKQWVPGDIVGVFLDLVDHTISFSLNGELLMDALGGETTFADVNAPDGV GFVPACTIGIGQKARVVYGQDVDSLKWFTTCGLQEGYEPFCVNMKRPVTHWYTKDQPIFE NTDEIPECKIDVTRIPGGADTPPCMKISHNTFETMEKANWEFLRLSLPVTCANTFITEQE KMRRWEEIRIRQHRLMTEVDHSAPAHFDHIMRSGFTMNDIKGLHRNYSEDAAEADEMMRN GPRRPSRHQGRGGLSPPGIEINGEATSDGELNAYSDNELEGGDDRKKRGRSPFRLFGKKR DQSKDKLKDRRTPEPEPRKSNLKVTQRGQATRMSNSDLRAQAPLTPERKGMGSPQVESFG NEVYDADCLRLINEYFYGVRIFPGQDPTHVYVGWVTTQYHVHSKEFSQNKVRHAAIYVED ENEKTIEIVNRQSCYMVRADELFNEVTQDSSGKGASQGMFVGCFVDTATGTIRFTCEGKE TSHVFLMEPDTKLFPAIFVEATSKEILQIELGRTPTTLPLSAAVLPTSDKHINPQFPPRL KVQCLKPHQWARVPNTALQVHALKLSDIRGWSMLCEDPVSMLALHIPEEDRCIDILELIE IDRLLQFHAHTLTLYSALCYQSNYRAAHALCSHVDQKQLLYAIQSEYMSGPLRLGFYDLL ISLHLESHATTMEVCKNEYIIPLGSELRELYIDPEMCHSLRSLQTLSVRPEMNMTEIAPT PSQSNMPTIVAPDSSSEPIPAIDSLYSPRFPLEVVREFVMSALQEAVQINQVHNRDPIGG SNENLFLPLIKLIDRLLLVGVITNEDVEKLLIMIDPETWDPSFEKEGRDEHRKGLLTMKM AEGAKLQMCYLLHHLYDVQLRHRVESIIAFAHNYVGDLQQDQLRRYIEIKQSDLPSAVAA KKTREFRCPPREQMNAILGYKNLEEDDLENASCGPELRNRLIEFHEKLMGKVSLNALQEP EEPEADKLEEGRPGALKKLYNFINAVKELEEDPKEPVEEEKKTPEEVFRKVLIKQLVSWA EESQIENPKLVREMFGLLVRQYDTIGELIKALNKTYVINSKTKGDVANMWIGLSQIRALL PVQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRILRVHENVMAVMMNTLGRRAQAQSDAP VQTADGEESAPKEKDTSHQMVVACCRFLCYFCRTGRMNQKAMFDHFDFLLENSNILLSRP SLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRCGLQSNSELIERGYPDLGWDP VEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEGEGLLKAIVDANKM SERISERRKMQDEAEGTITGLNFSHPLPEGDDDEDYIDTGAAILCFYCTLVDLLGRCAPD AAVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLTNPALGEDRPKSDMPSGLVPGHK QSIVLFLERVYGIETQELFYRLLEDAFLPDLRAATMLDRSDGSESDMALSMNRYIGNSIL PLLIKHSKFYNEAENYASLLDATLHTVYRMSKNRMLTKGQREAVSDFLVALTSAMHPAML LKLLRKLTIDVSKLSEYTTVALRLLTLHYERCAKYYGTTGGGQASQFGASSDEEKRLTML LFSNIFDSLSNMDYDPELFGKALPCLIAIGCALPPDYSLSKNSDDDLYGKPTGGGPDQPH YNPQPIDTTAVQLTNDLNQIVQKFSEHYHDAWASRKLENGWTYGDQWSDANKTHPRLKPY NTLSEYERERYREPVRESLKALLALHWRIEHSEGDVPLSNRGSMRRQSKPNLELQGDTGS PFNYNPHPVDMTNLTLSREMQNMAERLAENSHDIWAKKKNEELDQCGGAIHAQLVPYDLL TDKEKRKDRERSQEFLKYLQYQGLKLHKPSRGQTEEPGMSTAAIELRFAYSLLEKLISYS DRATINMKLLKPSSTFSRRSSFKTCSRDIKFFSKVVLPLMEKYFSSNRNYFIAIATATNN VGAASLKEKEMVAGLFCKLASLLRHRLAAFGADVRITVRCLQVLVKSIDAKSLVKNCPEF IRTSMLTFFNNTADDLGQTIVNLTEGKYDRLRGTHLKTSTSLAYVNQVILPVLTSLFDHL AACDYGSDLLLDEIQVASYKILSALYTLGTDMSLTRDRKYLKTELERHKPALGSCLGAFS SCFPVAFLEPHANKHNPFSLLNRIADTSLEAQDIMSKMECCMPTLESILSEVDQFVESEK TYQEAQHIIDVILPLLCSYLPFWWNQGPDNVSPQSGNHVTMVTADHMNHLLKNVLKMIRK NIANENAPWMTRIATYTQQIIINSSEELLKDVFLPLAERVKKRCDSMFHKEESLRGFLKS STDDTSQIEAQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLKDNVAEAEELYNYVAEIF NVWSKSQYFLKEEQNFISANEIDNMTLIMPTATRRSAAVSGDMPASGGKVKKKKRSRDKK RDKDKEIQSSLMVACLKRLLPVGLNLFAGKEQELVQHCKDRYLKKMPEYEVIEFARTQLT LPDKLDPADEMSWQHYLYSKLGKKEQIVQDTLEKSDKKPENKIEDTVERIVAMAKVLYGL HMIDHPQQQSKNVYRSCVSIQRKRAVIACFRQVSLHSLPRHRACNIFARSYSELWLEDEN TGQEVMIEDLTQTFEDAEKKKKDEEEEEGKPDPLTQLVTTFCRGAMTERSGALQEDPLYM SYASIVARSCGEEEEEGGDEEEGAGEDEGGASIHTMEKLMEQEMEKQKLLFHQARLANRG VAEMVLLHISASKGVPSEMVMRTLELGIAVLRGGNIDIQMGMLNHLKEKKDVGFFTSIAG LMNSCSVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQ NYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQ VFNTLTEVIQGPCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQ KDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLKDLTSTPSFMEI DSNGDGWIMPKDFREKMEQQKSYTPEEIDFLLACCETNHDGKIDYIGFVDRFHEPAKEIG FNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFESFLGRIEIMGSSKRIERVYFEIKEA NIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMASDDDGGT VRRDQAFTYISEEEEERAARDPIKRTIQAVKDGLSYSMYMISPSNIKHQITVLQSKSFPE IIVGFFKMIFYAFYYSGFGVSVVIKYLVNILMSLMRGPAQEEEEPIPEAEPSLRALPPLP LEEPPGTVQAFGLDISKEENGQYRMAPHESPALSPSSSIEETGESSPEDGAAELTGEGVP PGEQMTLVDLLGGEAAKRAAQERTEAQKAQEATLASIEAESKKASTETKEPAAVHQIDFS KYTKKCVSYLARNFYNLKYVALVLAFCINFMLLFYKVTTLGDEEDGEGGSGESLMGLGSG LGSGLGILETGSGGGEGGSGDGEGEEEDPPEKVHVDEDFFYMEHVLRIAAILHSLVSLCM LIAYYHLKVPLAIFKREKEIARRLEFDGLFIAEQPEDDDIKSHWDKLVISAKTFPVNYWD KFVKKKVRQKYSETYDFDSISNLLGMEKTAFAAQEANEGGGFFHFITNIDWRYQIWKAGV TITDNSFLYSLWYFSFSVMGNFNQFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVM LLTIIVYIYTVIAFNFFRKFYVQEDDDGEEGDRKCHDMATCFVFHLYKGVRAGGGIGDEI GDPDGDEYEVYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQLESVKEDMESNCFIC GIGKDYFDKVPHGFDTHVAQEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDF FPVGDCFRKQYEDELGGGGS NT seq 15363 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcagagggaggatccgagcaggatgatgtttcattcttgcgtacggaagac atggtctgcctgtcctgtacggcaaccggcgaacgcgtgtgtctggcggccgagggtttc ggcaaccggcactgcttcctggagaacatcgcagacaagaacatcccgccggacctatcg cagtgcgtgttcgtcatagagcaggcgctgtcggtgcgtgcgctgcaggagcttgtcacg gccgccggttcggaaaccggaaacgattcggtaggaaagggtaccggatccggtcatcgt acgctgctttatggcaatgctatcctgttgcgtcacaacaacagtgacatgtatcttgcc tgtctgtcaacgtcgtcctccaacgataagctgtcgtttgacgtcggtctgcaagagcac agccaaggtgaggcctgctggtggaccgtacacccagccagcaaacaacgttcggagggt gagaaggtccgtgtcggtgacgatctgattctggtgtccgtcgctaccgagcgatatctg cacacgaccaaagaaaacgatctgtcgatcgtaaatgctagcttccatgtgacgcactgg agcgtgcagccgtacggaaccggtatctcgcgcatgaagtatgtcggctacgtgttcggc ggcgacgtgcttcggttcttccacggcggtgacgaatgtctaacgattccgagtacctgg agcttggactcgggtcagaacattgtcgtgtacgagggcggttctgtaatgtcgcaggcc cgctcgctgtggcgactcgagctggcccgcaccaagtgggccggtggtttcatcaactgg tcccatccgatgcgtattcgccatcttaccaccggccggtatctcggtgtgaacgaaaac aacgaactgatcctgatgagccgcgaccaagcgaccacctcgcagacggcctttgtgcta cgcctcgagaaggacgaccaaaaggtggtgctggaggacaaggatttggaaattatcggt gccccgatcatcaagtacggcgactcgaccgtaatcatgcagcactacgagtcgggcctg tgggtcagctacaagagctacgaaacgaaaaagaagggcgtcggcaaggtggaggaaaag caggcgatactgcatgaggaaggcaagatggacgatgggttggacttttcgcgttcgcag gaggaggaatcgcgcacggctcgcgtcatccgcaagtgtagcagcttgttcaccaagttt attagtggccttgaaacgttgcaagaaaatcgtcgtcactcgattttcctgcagactgtc aacctgggtgagatggtcatgtgcctggaggatctgatcaactacttcgcccagcccgag gacgacatggaacacgaggagaagcagaaccgtctgcgtgcgctgcgcaatcggcaggat ctgttccaggaggagggcgtgttgaatctgatcctcgaagcgatcgacaagattaacgtc atctcgtcgcagggctttttggcgtcgttcctggcgagcgacgaaagcggacagagctgg gacatgatctccggctatctgtatcagctgcttgccgccatcatcaagggaaaccacacg aactgtgcccagtttgccaactcgaaccgtttgaactggttgttctcgcgacttggttcg caggcatcgagcgaaggttccggcatgctggatgtgttgcactgtgtgctgattgactcg cccgaagcgctgaacatgatgcgggacgagcacattaaagtgatcatttcactgctggag aagcacggccgtgaccccaaggtactggacgtgctgtgctcgctgtgcgttggtaacggc gttgcggtgcgctcgtcgcagaacaacatctgcgactttctgctgccgggcaagaatctg ctcctgcagaccgggctcgtcgaccatgtggccagcatccggccgaacatttttgtgggg cgcgtggaaggatccgccatctaccagaagtggtacttcgaggtgacgatggatcacatc gagcagatgacgcacatgacgccgcatctgcgcatcggctgggctaatacggctgggtac gtgccgtatccaggcggaggtgaaaagtggggcggcaacggtgtcggtgatgatctgttc tcgtacgggtttgacggtgtgtacttctggtccgctggacgacgcacctgcgtagtgccg agggaagtaacggaacctttcatcaagaaaggggacgtgattggctgtacgctcgatttg agtgtaccggtgattcggtttacctttaacggcgaaccggtgcagggttgcttcaccgac ttcaatctggacggtatgttcttccccgtgatgagctgctcgtccaagctaagctgtcgc ttcctgttcggcggtgacaatggaaggcttaagtttaatccaccacccggcttttcgccg ctagttcagtgccttatgccacatcaaaaccttagcctggatccgtgcttttatttcggt aatctgaacaagaacgttctcgccggcccatggttggtagaggacgattcggcgttcgtg ccgaaaccagtggatacctcgatcgtcacgttgccatcgtcggtggaaacgatcaaggac aagctggcggaaaacatccacgaaatgtgggcactgaacaagatcgaagccggctggacg tggggtgaacgaagagacgatgtgtaccgcatccatccgtgtctgacgtcgttcgagaag ctgccggcggcggaaaagcgctacgactgtcagctcgccgttcagacgctcaaaaccatc ctggcgctgggatactacatctcgatggacaagccaccggcacgcattcgtcccattcgc ctgccaaacgatccgtacatgcagggcaacggatacaaaccggccccgcttgatctgagt gccgccgtgctgacgcccaagatggaggagctggtcgatcagctggcagaaaacacgcac aacctgtgggcaaaggagcgcatccagcagggctggacgtacgggttgaacgaggattcg gagaatctgcgtagccctcatctcgtaccgtactcgaaggtggacgaagcgatcaagaag gcaaaccgcgataccgcttccgaaacggtgcgcaccctgctcatctacggctacaatctg gatccgccgaccggtgaagcgaacgaggcgctggcagcggaagcgttgcgccagaagttt gccgcctaccgtacgtaccgcgtcgagcgaacgtatgcggtcacctctggcaagtggtac tttgagttcgaggtgcttactgccggtccgatgagggttggttgggcacgggctgactgt aatcccggaacgatgctaggaagtgacgatgcctcgtgggcattcgatggatacaatgaa gagaaagtgtccggaggtgcaacggagtcgttcggcaaacagtgggtaccaggcgatatt gtcggtgtatttcttgacttagtggatcatacgatcagtttctcgctaaacggtgaactg ctgatggatgctctcggtggtgaaactacctttgctgatgtcaacgcaccggacggtgtt ggctttgtgccagcctgtactattggtatcggtcagaaagcgcgtgttgtgtacggtcag gatgtcgactctctcaagtggtttacaacctgtggtttgcaggaaggttacgagccattc tgcgtcaacatgaagcgtcccgttacccactggtacacgaaggatcaaccgatcttcgag aatacggacgagattccggagtgcaagattgacgtgacgcgtatcccgggcggtgccgat acgccaccctgcatgaagatctcgcacaacacgttcgagacgatggagaaggccaactgg gaatttttacgtttgtcgctccccgtaacatgcgccaataccttcatcactgaacaggag aagatgcgccgctgggaagagatacgcatccgtcagcatcgtctaatgacggaggttgat cattcggctccggcacacttcgaccatatcatgcgtagtggcttcaccatgaacgatatc aagggtctgcatcgtaactattcggaagatgcggccgaagccgacgagatgatgcgtaac gggccaagacgtccgtcgagacaccagggacgcggtggacttagcccaccgggcattgaa atcaatggtgaagctacgagcgacggcgagcttaatgcgtactcggacaacgagctggag ggtggtgacgatcgcaaaaagcgtggccgcagtccgttccgactgttcggcaagaagcgg gaccagagcaaggacaagctgaaggatcgtcgcacaccggagccagaaccgcgcaagagc aatctgaaggttactcagcgcggtcaggctacgcgcatgtcgaacagcgatctgcgtgcc caagcaccgttgacgccggagcgtaagggtatgggaagtccgcaggtggaatctttcggc aacgaagtttacgatgcagattgtctgcgcttaatcaatgaatacttctacggggtgcgc attttccccggtcaagacccgacccacgtgtatgttggatgggtgacgacgcagtaccat gtgcatagcaaagagttcagccagaacaaggtgcgccacgcagcgatctacgtcgaggac gagaatgaaaaaaccattgagatcgttaatcgtcaatcgtgctatatggtacgcgcggat gaactattcaacgaagtcacccaagattcgtctggtaagggcgcatcgcagggcatgttt gttggatgtttcgtcgataccgctaccggcacgatccggtttacgtgcgagggcaaggaa acgtcccacgtgtttctgatggagccggataccaagctgttcccggctatcttcgttgag gcgacgagcaaggaaattcttcagattgagctcggtcgcacaccgacgacgctgcctctg tcggctgccgtactgccaaccagcgacaagcatatcaacccacagttcccaccgagactg aaggtccaatgtttgaagccccaccagtgggcacgcgtaccgaatactgctttgcaggtg cacgccctgaagctgtcggacatccgcggttggtcgatgttgtgcgaggacccagtgtcg atgctggcactgcacatccccgaggaggatcgttgtatcgatattctcgagctgatcgaa atcgatcgtctgttgcagttccatgcacatacgctgacgctttattcggcactgtgctat cagtcgaactatcgtgccgcacatgcgctttgctcgcacgtcgaccagaagcagctgttg tacgcgatccagtcggagtacatgagtggtccgctgcgtcttggattctatgatctattg atttcactgcatctagaatcgcatgccactacaatggaggtttgtaagaatgagtacatc attccgctaggctccgaactgcgcgagctatacattgatccagaaatgtgccactcgctc cgttcattgcaaacgctttccgttcgaccggaaatgaacatgaccgaaatagcacccaca ccctcacaatcgaatatgccgacaatagtagcaccagattcttccagtgaacccataccg gcaattgactcgttatattcgccaagattcccactcgaagtggtgagggagttcgtgatg agcgcactgcaggaagcagtacagatcaatcaagtacacaaccgcgatcccatcggtggg tccaacgagaaccttttcctgcccttgatcaagctgatcgatcgtttgctgttggtcggt gttatcactaacgaagatgtagagaagctactgatcatgattgatcccgagacgtgggat ccatctttcgaaaaggaaggtagggacgaacaccgtaagggactgttgacgatgaagatg gctgaaggtgccaagctgcagatgtgctacctgctgcaccatctgtacgatgtgcagctg agacatcgcgtagagagcattattgcattcgcacacaactatgtcggagatttgcagcag gatcagttgcgcagatacatcgagatcaaacaatctgatctgccaagtgccgtcgctgcc aagaagacgcgtgagttccgctgtccaccacgcgagcagatgaacgccatccttggatac aagaatctcgaggaagatgatcttgagaatgcgtcttgcggtcccgagcttcgcaaccgt ttgatcgagttccacgagaagctaatgggcaaggtgtctcttaatgctttgcaagagcca gaggagcccgaggcggacaagctggaagagggtcgaccaggtgctctgaagaagttgtac aatttcatcaacgccgtgaaagagctggaagaagatcccaaggaaccggtcgaagaggaa aagaaaacgcccgaggaagtgttccgcaaggtgctgatcaagcagctcgtatcctgggcc gaagagtcccagattgagaatcccaagcttgtgcgtgagatgtttgggctgcttgtacgc cagtacgacaccatcggtgagctgatcaaggctctgaacaagacctacgtcatcaactct aaaacgaagggtgatgtagcgaacatgtggattgggctgagtcaaattcgtgccttgctc ccagtacagatgagccaggaggaggaagagctgatgcgcaagcgtctgtggaagcttgtc aacaatcataccttcttccagcatcccgatctgattcgcattctacgcgttcacgagaac gtgatggcggtcatgatgaacacgctcggacgccgtgcccaggcacagagcgatgcaccg gtgcagacggccgatggagaagagtcggcaccgaaggagaaggacacatcccaccagatg gtggtcgcatgctgtcgctttttgtgctacttctgtcgtacgggtcgtatgaatcagaag gccatgttcgatcatttcgatttcttgttggaaaattccaacattctcctatcgcgacca agtctgcgcggatcgacgccattggatgtggcgtactcgagtttgatggagaacacggag ttggcgttggcactgcgtgagcactacttggaaaagattgccatttacctatctcgctgt gggttgcagagtaattccgagctgatcgagcgcggctaccccgatctcggctgggatcca gtggaaggcgaacgttatctcgatttcctgcgcttctgcgtttgggttaacggggaaagt gtagaggagaatgccaatcttgtcattcgtttgctcattcgtcgtcccgagtgtcttggc ccggctttgcgtggtgaaggtgagggtctgctgaaggccattgttgacgccaacaaaatg tccgaacgtatctcggagcgcagaaagatgcaggacgaagcggaaggtaccatcactggg ctgaacttctcacatccactgcccgagggtgacgatgatgaggattatatcgacaccgga gctgccatcctgtgcttctactgtacgctggtcgatctgctgggacgctgtgctccggat gcggccgtcatcgagcagggcaagaatgagtctctgcgtgcgcgtgctattttacgttcg ctggtaccgctggaagatttgcagggagtattgagtttgaagtttacgctgaccaatcca gcactgggtgaagataggcccaagtcggacatgccgtctggattggtgcctggccacaag cagagcatcgtactgttcctggagcgtgtttacggaattgaaacgcaggagctgttctac cgcttgctggaagacgctttcctgcccgatcttcgtgcggcaaccatgttggaccgtagc gatgggtcggaaagtgatatggctctgtcgatgaatcggtacattggcaattcaatcctt ccactgctgatcaaacactctaagttctacaacgaagccgaaaactatgccagcttgctc gatgccacactgcacacggtctatcgcatgtcgaagaaccgtatgctaaccaagggacag cgtgaagccgtgtctgatttcctggtcgcactgacgtcggccatgcacccggctatgtta ttgaagctgctccgcaagcttactatcgacgtgtcgaagctgtctgaatatacgaccgtt gcactgcgcctcttaaccctgcactatgaacgatgtgccaagtactacggcactaccggt ggcggtcaagcctcccagttcggagcatcgtcggatgaggagaagcgtcttacgatgttg ctgttctccaacattttcgactcgctcagcaacatggactacgatccggaactattcggt aaggcgctgccgtgcttgattgcaatcggttgcgcactgccaccggactacagcttgtcc aagaactcggatgacgatctgtacggtaaaccgacgggtggtggtcccgatcagccacac tacaatccgcagccgatcgatacgacggcagttcagcttacgaacgatctgaaccagatt gtgcagaagttcagcgagcattatcatgacgcttgggctagccgtaagctcgagaacgga tggacgtacggtgaccaatggtcagatgcaaacaagactcatccacgtttgaagccgtac aacactctcagtgaatacgagcgtgaacgctatcgcgaaccagtacgggaaagcttgaag gcactgctggcgttgcactggagaatcgaacactcggagggtgatgtgccactgtcgaac cgtggttcgatgcgtcgccaatcgaagcctaatctggaattacagggcgatactggttca ccgttcaactacaatccgcacccggttgacatgaccaacctgacgttgagcagagagatg cagaatatggccgaacgtttggcggagaattcgcacgacatatgggccaagaagaagaac gaagagctggaccagtgtggtggagctatccacgcccagctggtaccgtacgatctgctt accgacaaggagaagcgcaaggatcgcgagcgttcgcaagaattcttgaagtatctccag taccagggactcaaactgcacaaaccatcgcgtggacaaactgaggagccgggcatgagc acggccgcgatcgagctgcgctttgcctattcactgctggagaagctgatctcctacagc gaccgtgctacgatcaacatgaagctgctgaaaccatcatctactttcagccgtcgctcg tccttcaagacctgctcacgcgacatcaagttcttctccaaggtggtactgccgctgatg gagaaatatttctcgagcaatcgtaattacttcattgcaatcgctaccgccaccaataac gttggtgcggcttcactgaaggagaaggaaatggtggctggactgttctgtaagcttgcc agcctgttgcgtcaccggttggcagcattcggtgcggacgttcgcatcaccgtgcgctgt ctgcaggtgctggtgaagagtatcgatgccaaatctttggtgaagaactgtcccgagttt attcgtacgtcgatgttgacgttcttcaacaacaccgcggacgatttgggccagacgatc gtcaatctgacggaaggcaaatatgatcgtctgcgtggaacgcatctgaagacgtccact tcgttggcgtacgtcaatcaggtgatcttgccagtgttgacttcactgttcgatcatttg gcagcgtgcgactatggaagtgatttgttgttggacgaaattcaggtcgcatcgtacaag atcctgtctgcgctctacacactcggcactgacatgtctttgacgcgcgatcgtaaatat cttaagaccgagctggaacgtcacaagcccgcacttggatcttgtctcggtgcgttcagt tcctgcttcccggtggctttccttgagccgcacgctaacaagcacaacccgttctcgcta ctgaaccgtattgcggatacctcactcgaggcgcaagacatcatgagcaagatggaatgc tgcatgccaacgctcgagtcgatcctgtccgaggtcgaccagtttgtcgagtcggaaaag acgtaccaggaagcacagcacatcatagatgtcattctgccgctgctctgttcctatttg ccgttctggtggaatcagggcccagacaacgttagcccgcagtcgggcaatcacgtcacg atggttacggccgatcacatgaaccatctgctgaagaacgtactcaagatgattcgtaag aacattgccaacgagaacgcgccctggatgacgcgtatcgctacgtacacgcagcagatc attatcaacagctcggaggaactgctcaaggatgtcttcctaccgttggccgagcgggtc aagaaacgttgcgacagcatgttccacaaggaggaaagcttgcgtggtttcctcaagtct tccaccgatgatacctcccagattgaagcccaaatccaggaggactggcaactgctggtc cgcgatatctactcgttctatcccctgctgatcaagtacgtcgatctgcagcgtaaccat tggctcaaggataacgttgccgaggcggaggagctctacaactatgtggcggagatcttt aacgtttggtcgaagagccagtacttcctgaaggaagagcagaacttcatctcggcgaac gagattgacaatatgacattgatcatgcctacggcaacgcgccgctcggctgccgtctcg ggtgatatgcccgcgtccggcggtaaggtgaagaagaagaagcgcagccgcgataagaag cgtgacaaggataaggaaattcagtccagcttgatggtggcctgtctgaagcgtctgctg ccggttggtttgaatctgttcgccggtaaggaacaagagctggtgcagcactgcaaggat cgctacctaaagaaaatgcctgagtacgaggtgattgagtttgcgcgcacgcaactcacc ctgcccgacaagctcgatccagcggacgagatgtcctggcagcactatctctactcgaag ctcggcaaaaaggagcaaattgtgcaggacacactggaaaagtcagacaagaagccggaa aacaagatcgaagacacggtcgaacgcatcgtcgccatggctaaggttctttatggactt cacatgatcgaccatccacaacaacaaagcaaaaatgtttacagaagttgcgtctcgata cagagaaaacgagcggtcattgcctgtttcagacaagtttccttacattcactgccaaga catcgtgcttgcaacatttttgcccgaagttactcggagctgtggctggaggatgaaaat acgggccaagaggtcatgattgaggacctcacgcaaacatttgaggatgctgaaaaaaag aagaaggacgaggaagaggaggaaggcaaaccagatccacttacgcagctcgtgacaacg ttctgccgcggtgcgatgactgaacgcagtggcgctttgcaagaagatcctctgtacatg tcctacgctagcatcgttgcacgatcctgcggtgaagaggaggaggaaggtggcgacgaa gaggaaggagcaggagaggacgaaggaggtgctagtattcatactatggaaaagctaatg gaacaagaaatggaaaagcagaagctcctgttccaccaggcacgtctggccaaccgtggc gtcgcggagatggtgctgctacacatttccgcctcgaagggcgtcccgtcggagatggtg atgcgtacgctcgagctcggaattgccgtgctgcggggtggtaacatcgacatccagatg ggaatgttgaaccatttgaaggaaaagaaggatgtcggattctttacctcgattgccggt ttgatgaactcctgcagcgtgctagatttagatgcgttcgagcgtaacaccaaggcggaa ggtcttggcgtcggttcggaaggcgcagccggtgagaagaacatgcacgatgccgaattt acgtgcgcactgttccgcttcattcagctgacctgcgagggtcacaacctcgactggcag aactatctgcgtacgcaggccggtaacacgaccacggttaacgtggtcatctgcacggtc gattatctgctgcgactgcaggaatcgatcatggacttttactggcactactccagcaag gagctgatcgatccggccggcaaggcaaacttcttcaaggcaatcggtgtcgctagccag gtcttcaacacgctcactgaagtcatccagggtccgtgtacgcagaaccagcaggcgctg gcccactcgcgtctttgggatgcggtcggtggtttcctcttcctgttctcgcacatgcag gacaagctgtcgaaacactctagccaggtggatctgctgaaggagctactcaatctgcag aaggacatgattaccatgatgctctccatgcttgagggtaacgtggtgaacggtacgatc ggtaagcagatggtggatacgctggtcgagtcggcctcgaacgtcgagctgattctgaag tacttcgacatgttcctgaagctaaaggatctgacctccacgccaagcttcatggagatt gacagcaacggggacggttggattatgccgaaagatttccgcgaaaagatggaacagcag aagagctacacgccggaggagatcgacttcctgctcgcttgctgcgagaccaaccatgac ggtaagatcgactacatcggtttcgtcgatcggttccacgagccggccaaggagattggt ttcaatctggccgtcctgctgacgaacctgtccgagcacatgccgaacgaaccgcggttg gcccggttcctcgagacggccggttccgtgctgaactacttcgagtcgttcttgggccgt atcgaaatcatgggctcgtccaagcgcatcgagcgcgtgtacttcgaaatcaaggaagcg aacatcgaacaatgggagaagccacagatcaaggaatcgaagcgtgccttcttctactcg atcgtcacggaaggtggcgataaggagaagctggaagccttcgtcaacttctgcgaggat gccatctttgaaatgacgcacgcgtccggactgatggcgagcgatgacgacggtggcacc gtgagacgcgatcaagccttcacgtacatcagcgaggaggaggaggagcgtgccgcccgc gatccgatcaagcgcaccatccaggccgtcaaggacggtctgtcctactcgatgtacatg atcagcccgtccaacatcaagcaccagattaccgtactgcagtcgaaatcattccccgag attatagtcggattcttcaagatgatcttctacgcgttctactactctggatttggcgtg tcggttgtgattaagtacttggtgaacatcctgatgtcgctcatgcgcggcccggcccag gaggaggaagaaccgatcccggaggcggaaccatccctgcgtgcactgccaccactacca ctggaggaaccgccaggtacggtgcaggcgtttggtttggacatcagcaaggaagagaat ggacagtaccgcatggcaccgcacgagtcgcccgctctcagcccgtcgtcctcgatcgag gaaacgggtgagtccagccccgaggatggagcggccgagctgacgggcgaaggtgtacca ccgggtgaacagatgacgctggtcgatctgctcggcggtgaagccgccaagcgtgccgcc caggaacgcacggaagcacaaaaggcacaggaagctacgctcgccagcattgaggcggag tcaaagaaggcttcaaccgaaacgaaggaacccgcggccgtccaccagatcgatttctcc aagtacacgaagaagtgcgtcagctatctggcgcgtaacttctacaacttgaagtacgta gcgctggtgctggctttctgcatcaactttatgctgctgttctacaaggtgacgacgctc ggcgacgaggaggatggcgagggcggttcgggagaaagtttgatgggactcggttcgggc ctgggatcgggacttggcattttggaaacgggctcgggcggcggtgaaggtggaagcggc gatggcgaaggcgaagaggaagacccaccggagaaggtacatgtggatgaggacttcttc tacatggagcacgtgctacgtatcgctgccatcctgcacagtctggtgtcgctctgcatg ctgatcgcttactaccatctgaaggtaccgctggccatcttcaagcgcgagaaggaaatc gctcgtcggctcgagtttgacggactgttcattgctgagcagccggaggacgacgatatc aaatcgcactgggacaagctggtgatatccgccaaaacgttcccggttaactactgggac aagttcgtaaagaagaaggtccgccagaagtacagcgaaacgtacgacttcgactcgatc tcgaacctgcttggcatggaaaagacggcatttgcggcacaggaagcgaacgagggcggt ggcttcttccacttcattacgaacatcgactggcgctaccagatctggaaggcgggcgtg acgatcacggacaactcgttcctgtactcgctctggtacttctcgttctcggtgatgggc aacttcaaccagttcttcttcgccgcccatctgctcgatgtggcggtcggcttcaagacg ctgcgcaccattctgcagtcggtaacgcacaacggcaagcagctggtgctgacggtgatg ctgctcacgatcatcgtgtacatctacacggtcatcgcgtttaacttcttccgcaagttc tacgtgcaggaggatgacgacggggaggagggcgaccgcaagtgtcacgatatggcgacc tgcttcgtgttccatctgtacaagggtgtgcgggcgggtggtggtatcggtgacgagatc ggtgatccggacggtgacgagtacgaggtgtaccgtatcctgttcgacatcacgttcttc ttcttcgtcatcgttatcctgctggccatcatccagggtttgatcatcgatgcgttcggt gagcttcgtgatcagctcgaatcggtcaaggaggatatggagtccaactgcttcatctgt ggcataggcaaagactactttgataaggtacctcacgggttcgatacgcacgtcgcccag gagcacaatctcgccaactacatgttcttcctgatgcatttaatcaacaaaccggacacg gagtacaccggtcaggagacgtacgtgtggaacatgtatcagcagcgatgctgggacttc ttccccgtcggtgactgcttcagaaagcagtacgaagatgagctgggcggtggcggtagc taa

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