KEGG   Ailuropoda melanoleuca (giant panda): 100463775
Entry
100463775         CDS       T01329                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml00562  Inositol phosphate metabolism
aml01100  Metabolic pathways
aml01521  EGFR tyrosine kinase inhibitor resistance
aml01522  Endocrine resistance
aml01524  Platinum drug resistance
aml04012  ErbB signaling pathway
aml04014  Ras signaling pathway
aml04015  Rap1 signaling pathway
aml04024  cAMP signaling pathway
aml04062  Chemokine signaling pathway
aml04066  HIF-1 signaling pathway
aml04068  FoxO signaling pathway
aml04070  Phosphatidylinositol signaling system
aml04071  Sphingolipid signaling pathway
aml04072  Phospholipase D signaling pathway
aml04081  Hormone signaling
aml04140  Autophagy - animal
aml04150  mTOR signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04152  AMPK signaling pathway
aml04210  Apoptosis
aml04211  Longevity regulating pathway
aml04213  Longevity regulating pathway - multiple species
aml04218  Cellular senescence
aml04360  Axon guidance
aml04370  VEGF signaling pathway
aml04380  Osteoclast differentiation
aml04510  Focal adhesion
aml04550  Signaling pathways regulating pluripotency of stem cells
aml04611  Platelet activation
aml04613  Neutrophil extracellular trap formation
aml04620  Toll-like receptor signaling pathway
aml04625  C-type lectin receptor signaling pathway
aml04630  JAK-STAT signaling pathway
aml04650  Natural killer cell mediated cytotoxicity
aml04660  T cell receptor signaling pathway
aml04662  B cell receptor signaling pathway
aml04664  Fc epsilon RI signaling pathway
aml04666  Fc gamma R-mediated phagocytosis
aml04668  TNF signaling pathway
aml04670  Leukocyte transendothelial migration
aml04722  Neurotrophin signaling pathway
aml04725  Cholinergic synapse
aml04750  Inflammatory mediator regulation of TRP channels
aml04810  Regulation of actin cytoskeleton
aml04910  Insulin signaling pathway
aml04914  Progesterone-mediated oocyte maturation
aml04915  Estrogen signaling pathway
aml04917  Prolactin signaling pathway
aml04919  Thyroid hormone signaling pathway
aml04923  Regulation of lipolysis in adipocytes
aml04926  Relaxin signaling pathway
aml04929  GnRH secretion
aml04930  Type II diabetes mellitus
aml04931  Insulin resistance
aml04932  Non-alcoholic fatty liver disease
aml04933  AGE-RAGE signaling pathway in diabetic complications
aml04935  Growth hormone synthesis, secretion and action
aml04960  Aldosterone-regulated sodium reabsorption
aml04973  Carbohydrate digestion and absorption
aml05010  Alzheimer disease
aml05017  Spinocerebellar ataxia
aml05020  Prion disease
aml05100  Bacterial invasion of epithelial cells
aml05132  Salmonella infection
aml05135  Yersinia infection
aml05142  Chagas disease
aml05146  Amoebiasis
aml05160  Hepatitis C
aml05161  Hepatitis B
aml05162  Measles
aml05163  Human cytomegalovirus infection
aml05164  Influenza A
aml05165  Human papillomavirus infection
aml05166  Human T-cell leukemia virus 1 infection
aml05167  Kaposi sarcoma-associated herpesvirus infection
aml05168  Herpes simplex virus 1 infection
aml05169  Epstein-Barr virus infection
aml05170  Human immunodeficiency virus 1 infection
aml05171  Coronavirus disease - COVID-19
aml05200  Pathways in cancer
aml05203  Viral carcinogenesis
aml05205  Proteoglycans in cancer
aml05206  MicroRNAs in cancer
aml05207  Chemical carcinogenesis - receptor activation
aml05208  Chemical carcinogenesis - reactive oxygen species
aml05210  Colorectal cancer
aml05211  Renal cell carcinoma
aml05212  Pancreatic cancer
aml05213  Endometrial cancer
aml05214  Glioma
aml05215  Prostate cancer
aml05218  Melanoma
aml05220  Chronic myeloid leukemia
aml05221  Acute myeloid leukemia
aml05222  Small cell lung cancer
aml05223  Non-small cell lung cancer
aml05224  Breast cancer
aml05225  Hepatocellular carcinoma
aml05226  Gastric cancer
aml05230  Central carbon metabolism in cancer
aml05231  Choline metabolism in cancer
aml05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
aml05415  Diabetic cardiomyopathy
aml05417  Lipid and atherosclerosis
aml05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:aml00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100463775 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100463775 (PIK3CB)
   04014 Ras signaling pathway
    100463775 (PIK3CB)
   04015 Rap1 signaling pathway
    100463775 (PIK3CB)
   04370 VEGF signaling pathway
    100463775 (PIK3CB)
   04630 JAK-STAT signaling pathway
    100463775 (PIK3CB)
   04668 TNF signaling pathway
    100463775 (PIK3CB)
   04066 HIF-1 signaling pathway
    100463775 (PIK3CB)
   04068 FoxO signaling pathway
    100463775 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100463775 (PIK3CB)
   04072 Phospholipase D signaling pathway
    100463775 (PIK3CB)
   04071 Sphingolipid signaling pathway
    100463775 (PIK3CB)
   04024 cAMP signaling pathway
    100463775 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100463775 (PIK3CB)
   04152 AMPK signaling pathway
    100463775 (PIK3CB)
   04150 mTOR signaling pathway
    100463775 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100463775 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100463775 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    100463775 (PIK3CB)
   04218 Cellular senescence
    100463775 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100463775 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    100463775 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100463775 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100463775 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    100463775 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100463775 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    100463775 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100463775 (PIK3CB)
   04660 T cell receptor signaling pathway
    100463775 (PIK3CB)
   04662 B cell receptor signaling pathway
    100463775 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100463775 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100463775 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100463775 (PIK3CB)
   04062 Chemokine signaling pathway
    100463775 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100463775 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    100463775 (PIK3CB)
   04929 GnRH secretion
    100463775 (PIK3CB)
   04915 Estrogen signaling pathway
    100463775 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100463775 (PIK3CB)
   04917 Prolactin signaling pathway
    100463775 (PIK3CB)
   04926 Relaxin signaling pathway
    100463775 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    100463775 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100463775 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100463775 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100463775 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    100463775 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100463775 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100463775 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    100463775 (PIK3CB)
   04380 Osteoclast differentiation
    100463775 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    100463775 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    100463775 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100463775 (PIK3CB)
   05206 MicroRNAs in cancer
    100463775 (PIK3CB)
   05205 Proteoglycans in cancer
    100463775 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    100463775 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    100463775 (PIK3CB)
   05203 Viral carcinogenesis
    100463775 (PIK3CB)
   05230 Central carbon metabolism in cancer
    100463775 (PIK3CB)
   05231 Choline metabolism in cancer
    100463775 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100463775 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100463775 (PIK3CB)
   05212 Pancreatic cancer
    100463775 (PIK3CB)
   05225 Hepatocellular carcinoma
    100463775 (PIK3CB)
   05226 Gastric cancer
    100463775 (PIK3CB)
   05214 Glioma
    100463775 (PIK3CB)
   05221 Acute myeloid leukemia
    100463775 (PIK3CB)
   05220 Chronic myeloid leukemia
    100463775 (PIK3CB)
   05218 Melanoma
    100463775 (PIK3CB)
   05211 Renal cell carcinoma
    100463775 (PIK3CB)
   05215 Prostate cancer
    100463775 (PIK3CB)
   05213 Endometrial cancer
    100463775 (PIK3CB)
   05224 Breast cancer
    100463775 (PIK3CB)
   05222 Small cell lung cancer
    100463775 (PIK3CB)
   05223 Non-small cell lung cancer
    100463775 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100463775 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    100463775 (PIK3CB)
   05161 Hepatitis B
    100463775 (PIK3CB)
   05160 Hepatitis C
    100463775 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    100463775 (PIK3CB)
   05164 Influenza A
    100463775 (PIK3CB)
   05162 Measles
    100463775 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    100463775 (PIK3CB)
   05163 Human cytomegalovirus infection
    100463775 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100463775 (PIK3CB)
   05169 Epstein-Barr virus infection
    100463775 (PIK3CB)
   05165 Human papillomavirus infection
    100463775 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100463775 (PIK3CB)
   05135 Yersinia infection
    100463775 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    100463775 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100463775 (PIK3CB)
   05142 Chagas disease
    100463775 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100463775 (PIK3CB)
   05017 Spinocerebellar ataxia
    100463775 (PIK3CB)
   05020 Prion disease
    100463775 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100463775 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    100463775 (PIK3CB)
   05415 Diabetic cardiomyopathy
    100463775 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100463775 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    100463775 (PIK3CB)
   04931 Insulin resistance
    100463775 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100463775 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100463775 (PIK3CB)
   01524 Platinum drug resistance
    100463775 (PIK3CB)
   01522 Endocrine resistance
    100463775 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aml04131]
    100463775 (PIK3CB)
Enzymes [BR:aml01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100463775 (PIK3CB)
Membrane trafficking [BR:aml04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100463775 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_C2
Other DBs
NCBI-GeneID: 100463775
NCBI-ProteinID: XP_034517804
LinkDB
Position
6:10139129..10219712
AA seq 797 aa
MNRTLPHFMLVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKMRIISHVWENNNPF
QIVLVKGNKLNTEESVKVHVRAGLFHGTELLCKTIVSSEISGKNDHIWNEPLEFDINTCD
LPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLR
SGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHIKFPETKKQPYYYPPFDKIIE
KAAEIASSDSANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDCRENFPQSL
PKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDE
ELSQYLLQLVQVLKYEPFLDCALSRFLLERALANRRIGQFLFWHLRSEVHIPAVSVQFGV
ILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYRE
ALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQD
MLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAA
AAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQL
FHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLIL
RRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESW
TTKVNWMAHTVRKDYRS
NT seq 2394 nt   +upstreamnt  +downstreamnt
atgaacaggaccttgccccattttatgcttgtggaatgttgcaagatcaagaagatgtat
gaacaggaaatgattgccatagaggctgccataaatcgaaattcatcaaaccttcctctt
cctttaccaccaaagaaaatgcgaattatttctcatgtttgggaaaataacaaccctttc
caaattgtgttggttaagggaaataaacttaacacagaagaaagtgtaaaagttcatgtc
agggctggcctttttcatggtactgaactcctctgtaaaaccatcgtaagctcagagata
tcagggaaaaatgatcacatttggaatgaaccactggaatttgatataaatacttgtgac
ctgccacgaatggctcgattatgttttgctgtttatgcagttttggataaagtgaaaacg
aaaaagtcgactaaaactattaatccctctaaatatcagaccatccggaaatctgggaaa
gtgcattatcctgtagcatgggtaaatacgatggtttttgactttaaaggacagttgaga
tccggagacataatattgcacagctggtcttcatttcctgatgaacttgaagaaatgttg
aatccaatgggaactgttcaaacaaatccatatactgaaaatgcaacagctttgcatatc
aaattcccagagactaaaaaacaaccttactattatcctcccttcgataagataatcgag
aaggcagctgagattgcaagcagtgacagtgctaatgtatccagtcgaggtggaaaaaag
tttcttgctgtactgaaagaaatcttggacagggatcccttgtctcagttgtgtgagaat
gaaatggatcttatttggactttgcgacaagattgcagagagaatttcccacagtcactg
ccaaaattactgctgtcaatcaagtggaataaacttgaggatgttgctcagcttcaggca
ctacttcagatttggcctaaactgcccccccgggaggccttagagcttctagatttcaac
tatccagatcagtacgtgcgagaatatgctgtgggctgcctgcgacagatgagtgatgaa
gaactctctcaatatcttttacaactggtgcaagttttaaaatatgagccttttcttgat
tgtgccctctctagattcctattagaaagagcactggctaatcggaggatagggcaattt
ctattttggcaccttaggtcagaagtgcatattcctgctgtctcagtacagtttggtgtc
atccttgaagcatactgccggggaagtgtagggcacatgaaagtgctttctaagcaggtt
gaagcactcaataagttaaaaactttaaatagtttaatcaaactgaatgcaatgaagcta
aacagagccaaagggaaggaggccatgcatacttgtttaaaacagaacgcttaccgggaa
gccctctctgacctgcagtcgcctctgaatccatgtgttatcctctcagaactctatgtt
gaaaagtgtaaatacatggattccaaaatgaagcctttgtggctcgtgtacaataacaaa
gtgttcggtgaggattcagttggagtgatttttaaaaatggtgatgatttacgacaagat
atgttgacactccaaatgctgcgcttgatggatttactttggaaagaagctggtctggat
cttcggatgctgccttatggctgtttagcaacaggagaccgctctggcctcattgaagtt
gtgagcacctctgaaacaattgctgacattcagctgaacagtagcaacgtggctgctgca
gcagccttcaacaaagatgcccttctgaactggcttaaagaatacaattctggggatgac
ctagaccgagccattgaggagtttaccttgtcctgtgccggctactgtgtagcttcttat
gtccttgggattggtgatagacatagtgacaacatcatggtcaaaaaaaccggccagctc
ttccacattgactttggacatattcttggaaatttcaagtctaaatttggcattaaaagg
gaacgggtgccttttattcttacctatgatttcattcatgtgattcaacaaggaaaaaca
ggaaacacagagaagtttggccgcttccgccagtgttgtgaggatgcatatctgattcta
cgacggcacgggaatctcttcatcactctttttgcactgatgctgactgcagggcttcct
gagctcacatcagtcaaggatatacagtatcttaaggactctcttgccttagggaagagt
gaagaagaagcactcaagcagtttaagcaaaaatttgatgaggcactcagggaaagctgg
actactaaagtaaactggatggcccacacagttcggaaagactacagatcttaa

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