Ailuropoda melanoleuca (giant panda): 100466011
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Entry
100466011 CDS
T01329
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate---cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
aml
Ailuropoda melanoleuca (giant panda)
Pathway
aml00270
Cysteine and methionine metabolism
aml00480
Glutathione metabolism
aml01100
Metabolic pathways
aml01240
Biosynthesis of cofactors
aml04216
Ferroptosis
Module
aml_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
aml00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
100466011 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
100466011 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
100466011 (GCLC)
Enzymes [BR:
aml01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
100466011 (GCLC)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
100466011
NCBI-ProteinID:
XP_002923001
Ensembl:
ENSAMEG00000005766
UniProt:
D2HKW5
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All DBs
Position
19
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AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEEVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPNPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPEDEEAAKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGHVSDIDCRWGVI
SASVDDRTREERGLEPLKNSNYRISKSRYDSIDSYLSECGEKYNDIDLTIDKEIYEQLLQ
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNTVVDGYGKAQNSTELAVEEYALMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LILKCNQIANELCECPELLGPAFRKVKYSGSKTDSSN
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagaccaagcgccacgccgac
cacgtgcggcggcacgggattctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtgtcttttgatcat
gaaaataaaaaagtccgattggtcctgtctggagaggaagttcttgaaactctacaagaa
aagggggaaaggacaaacccaaaccatcctaccctgtggagaccagagtatggcagttac
atgattgaaggcacacctggccagccgtacggaggaacgatgtccgagttcaacacagtc
gaagacaacatgaggaaacgccggaaggaagcaacttctttattaggagaaaaccaggct
ctctgcacaataacttcatttcccagattaggctgtcctgggttcacactgccagagttc
aaacccaatccggttgaaggaggagcttccaagtccctcttctttcctgatgaagccata
aataagcacccccgcttcagtaccctaacacgaaatatccgacacaggagaggagaaaag
gttgtcatcaatgtaccaatatttaaggacaagaatacaccgtctccgtttatagaaaca
tttcctgaggatgaggaggcggccaaggcttctaagcctgatcatatttacatggatgcc
atgggatttgggatgggcaattgctgtcttcaggtaacgttccaagcctgcagcatatct
gaggccagatacctttatgatcagttggccactatctgtccaattgtcatggctttgagc
gctgcgtctcctttttaccgaggccatgtgtcggacattgattgtcgctggggagtgatt
tccgcatctgtagatgatagaactcgggaggagagaggactggagccactgaagaacagt
aactataggatcagtaagtcccggtacgattcgatagacagttacttatctgagtgcggt
gagaaatacaatgacatcgacttgacaatagataaggaaatctacgaacaactcctgcag
gaaggcatcgatcatctcctggcccagcatgttgctcatctcttcattagagaccccctg
actctgtttgaagagaaaatacacttggatgatgccaatgaatccgaccattttgagaat
attcagtccacaaattggcagacgatgcgatttaagccccctcctccaaactccgatatt
ggatggagagtagaattccgacccatggaggttcagttaacagactttgagaactctgcc
tatgtggtgtttgtggtgctgcttaccagggtgatcctttcatacaaactggattttctc
attccactatcaaaggttgatgaaaacatgaaagttgcacagaaacgagatgctgtcttg
cagggaatgttttatttcaggaaggatatttgcaaaggtggcaacactgtggtggatggc
tacggcaaggcccagaacagcacggaactggcggtggaggagtacgccctgatgagcata
gacaccatcatcaacgggaaggaaggtgtgtttcctgggctgatcccgattctgaactct
taccttgaaaacatggaagtggatgtggacaccagatgtagtattctgaactacctgaag
ctgattaagaagagggcgtctggagaactaatgacagttgccagatggatgagagagttt
attgcaaaccatcctgactacaagcaagacagtgttataactgatgaaatgaactatagc
cttattttaaagtgtaaccaaattgcaaatgaattatgtgaatgcccagagttacttgga
ccagcatttaggaaagtaaaatatagtggaagtaaaactgactcttccaactag
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