Ailuropoda melanoleuca (giant panda): 100466511
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Entry
100466511 CDS
T01329
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X3
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
aml
Ailuropoda melanoleuca (giant panda)
Pathway
aml05012
Parkinson disease
aml05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
aml00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
100466511 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
100466511 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
aml01001
]
100466511 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
aml04131
]
100466511 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
aml04147
]
100466511 (LRRK2)
Enzymes [BR:
aml01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100466511 (LRRK2)
Protein kinases [BR:
aml01001
]
Serine/threonine kinases: TKL group
LRRK family
100466511 (LRRK2)
Membrane trafficking [BR:
aml04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
100466511 (LRRK2)
Exosome [BR:
aml04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
100466511 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR-B
Ras
COR-A
LRR_14
LRR_9
Beta-prop_RSE1_2nd
LRR_13
Arf
Beta-prop_EML_2
WD40_CDC20-Fz
Beta-prop_WDR36-Utp21_1st
LRR_NXF1-5
AAA_22
T2SSE
Beta-prop_THOC3
WDR55
WD40_WDHD1_1st
nSTAND3
ABC_tran
PduV-EutP
Kdo
G-alpha
SRPRB
MMR_HSR1
GTP_EFTU
Ank_2
AAA_7
TniB
TsaE
AAA_16
Beta-prop_WDR3_1st
LRR_6
Beta-prop_WDR5
NB-ARC
MobB
Septin
AAA_29
NACHT
AAA_23
nSTAND_NTPase5
cobW
TrwB_AAD_bind
WD40_Prp19
AAA_SelU
Motif
Other DBs
NCBI-GeneID:
100466511
NCBI-ProteinID:
XP_002925880
Ensembl:
ENSAMEG00000015799
UniProt:
D2HTG2
LinkDB
All DBs
Position
16:31624039..31762485
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGRDWEVLGVHQLIL
KMLTVHNASVNLLTVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEIQKL
GCKALRMLFERVSEEQLTEFVENKDYMILLNTLKNFKDEEEIVLHVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
RRYSENATLQIAGLSCLALLTETIFLNQDLEEKNENPENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQRHIHSPEVAESGCKMLNHLFEGSSVTLDTT
AAVAPKIITVMKSHEASLSVQLEGLRAVLHFIVPGMPEDSREDIEYQHKLHMVKKQCFKN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIARSPDALEVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLSLTGCLITKKNLCIGTGHLLAKILVSSLQRFKDMAEVQIKGFQTILTILELSV
SFSKLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLAMDDELKSVLLERACDQN
NSIMVECLLLLGADANGTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISMG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIDPSWLGPLFPDKTSNLRKETNIGSTLA
RMVLRYQMKSAVEEGAASGSNGNFPEGVLDKFDEWAFIPDSYVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDCALQRCSPNLQRHSCSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQRCCISGHLEHLEKLELHQ
NALTSFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDISPSVVLDSAV
KCPTLKQFNLSYNQLSSFPENLGDVVEKLEQLILEGNKIPEICSPLSLKELKILNLSKNH
ITSLSEDFLEACPKVESFSARMNYLAAMPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNEIEYLPSPAHWKSLNLRELLFSFNQISILDLSEKAYVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKTKKSDLGVQSATVGIDVKDWPIQI
RGKGRKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKGSLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAGIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDNLNSAELICLMRRITIPKNFSVECMVSTNH
NNKNASIWLGCGHRDKGQLLFLDLNTEKHTSEEVIDSRILCLALVSLPVEKESWIVCGTQ
SGTLLVINTEDGEKRHTLEKMTDSVTCLYCNPFPKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGAVPLKILNIGNVSTPLMCLSESMNSTEKNIMWGGCGTKLFSFSDDFTIQKLIETKT
NQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVRDKKTEKLCELIDCVHFLKEEMVKV
SAESKHKLSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMT
AQLGSLKNVMLVLGYIRKSTESTQHQKEIQSCLSVWDLNLPHEVQNLEKHIEVRKELAEK
MRRISVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagcgtacagcag
gtgggttggtcacttctttgtaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggacctcaagatattggacgtgattgggaagtacttggggttcaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagtcggactgaaggcctta
gatctccttctaacttcaggcaaaatcactttgctgatactggatgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaaatccagaaactt
ggatgcaaagctttacgtatgctgtttgaaagagtttcagaggagcagctgactgaattt
gttgagaataaagattatatgatcttgctcaatacgttaaaaaattttaaagatgaagag
gaaattgtgcttcatgtcctgcactgtttacattccctagcaattccttgcaataatgtt
gaagtcctcatgagtggcaatgtcaggtgttataatattgtggtagaagccatgaaagca
ttccctgtcaatgaaaaaattcaagaagtaagttgctgcttgctccataggcttacatta
ggtaatttttttaatattctggtgttaaatgaggtgcacgagtttgtggtgaaagctgtg
cggcgatactcagagaacgccacgttacagatcgcggggctcagctgcttagcgcttctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatccggagaatgat
gatgaggaggaagataagttgttctggttggaagcttgttacaaagcattaacgtggcat
aggaagaacaagcacgtgcaggaagctgcatgctgggcccttaacaatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctttccatgctgatgcattcctcatcaaaagaagtcttccaggcatctgcaaat
gcattgtcgactctgttagagcaaaacgttaatttcagaaaaatcctgttgtcaaaagga
atatacctgaatgtattggagttaatgcagaggcatatacattctcctgaagttgctgag
agtggctgtaaaatgctaaatcatctctttgaaggaagcagtgtgactctggatacaacg
gcagcagtggcccccaaaataataacagttatgaaaagtcatgaggcatccttatcagtg
cagctggagggactaagagctgttttacatttcatagttccaggcatgccagaagactcc
agggaagatattgaatatcaacataagctacatatggttaagaaacagtgtttcaagaat
gatattcataaactggtcctagcagccttgaacaggttcattggaaatcctgggattcag
aaatgtgggttgaaagtaatttcttctatagcgcgttctcctgatgcgttagaagtatta
tccttggaaggtgctattgattcagtgcttcacacactgcagatgtatccggatgaccaa
gaaattcaatgtctggggttaagtcttacaggatgcttgattacaaagaagaatttatgc
ataggaactggacatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggccgaagtgcagattaaaggatttcagacaatcttgacaatactggagttgtcagtg
tctttttccaagctgctggtacaccattcctttgattccgtgatattccatcagatgtct
tccagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagctatggatgatgagttaaaaagtgtgcttctagagagagcatgtgatcagaat
aacagtatcatggttgaatgcttgcttctcttgggagcggacgccaatggaacaaaggag
gcaacgtctttaatttgtcaggtatgtgagaaagcgagtagtcccaaattggtggaactg
ttactgaacggtggttcccgtgaacaagatgtccggaaagcgctgacgatcagcatgggc
aaaggtgacagccagatcatcagcttacttttaaggaggcttgccctggatctggccaat
aatagcatttgccttggaggattctgtataggaaaaattgacccttcatggcttggtcct
ttatttccggataagacatctaatttaagaaaagaaacaaatataggatccaccctagca
agaatggtgctcagatatcagatgaaaagtgctgtggaagaaggggcagcttcaggcagc
aatgggaattttcctgaaggagtacttgataaatttgatgaatgggccttcattccagac
tcctatgtggacagtgtgtttggtcaaagtgatgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatccaattcaattagcgtaggagaattttaccgagattgt
gccttgcagcgttgttcaccaaatttgcaaaggcattcctgttcgttgggacctattttt
gatcatgaagatttactgaggagaaaaagaaaaatattgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgag
agagaatatattacatcattagacctttcagcgaatgaactaagagacatcgatgcccta
agccagagatgctgtatcagtggtcatttggagcaccttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacaactgtgtgaaaccctgaagtgtttgacacatttg
gacttgcacagtaataaatttacatcatttccctcttacttgttgaaaatgaattgtatt
gccaacctcgatgtctctcgaaacgacatcagcccttcagtagttttggactctgcagtg
aagtgcccaaccttgaaacagtttaacttgtcatacaatcagctgtcttcttttcctgag
aaccttggcgatgtggtagagaaattggaacagctcattttagaaggaaataaaataccg
gaaatatgttcccccttaagcctgaaggaactgaagattttaaaccttagtaaaaatcac
attacatccctgtcagaagacttccttgaggcatgtcctaaagtggagagtttcagtgcc
agaatgaattatcttgctgctatgccttttttgccttcttcgctgacaagcctaaaatta
tctcaaaacagatttacatgtgttccagaagcaattttaaatcttccacacttgcgatcc
ttagatatgagcagcaatgaaattgaatatttgccgagtcctgcacactggaaatctttg
aacttaagggaactcttgttcagttttaatcaaatcagcatcttggacttgagtgaaaaa
gcgtatgtgtggtcaagagtagagaaactacatctttctcataataaactgaaagagatc
cctcctgagattggctgtcttgaaaacctgacctcccttgatgtcagttacaatttggaa
ctgagatcctttcccaatgaaatggggaagttaagcaaaatatgggatcttcctttggat
gaactacggcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcaacagcggttaaaaaaggccgtaccctacaaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaattaacaaaaaccaagaaatcc
gatcttggggtgcaaagcgccacagttggcatagatgtgaaagactggcctatccaaata
agaggcaaagggaggaaagacctcattctaaacgtgtgggattttgcaggtcgtgaggag
ttctatagcactcatccgcatttcatgacccaacgagccctctaccttgccgtctatgac
ctcagcaaagggcaggctgaagtggacgccatgaagccttggctcttcaatataaaggct
cgtgcttcttcttctcctgtgattcttgttggcacacatttggatgtttctgatgaaaag
cagcgtaaagcctgcataagtaaaatcaccaaggaactcttgaacaagcgggggtttcct
gcaataagggattaccacttcgtgaatgccactgaggagtccgatgccttggcaaagctt
cggaaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgttgtcggg
cagctgatcccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccaattgaatttcctgtaatcgaccggaaacgattattacaacttgtaaaagaaaat
cagctgcagttggatgaaaatgagcttcctcatgcagttcacttcctcaatgaatcaggg
gtccttcttcattttcaagacccagcattgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctatccaaaa
catcctaaggggatcatttcacgtagagatgtggagaaatttctttcaaagaaaaagaga
tttccaaagaactacatgtcacagtactttaaactcctagaaaaattccagattgccttg
ccaataggagaagaatatttgcttgttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcattcgactatatgaaatgccttatttt
ccaatgggattttggtcccggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggatgtattcttctgggccaagtt
gtggaccacattgattctctcatggaagaatggtttcctggattactggagattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagacctccta
gtaaatccagatcaaccaaggctaaccatcccaatatctcaaattgctcctgacttaatt
ttggctgacctgcctagaaatattatgttgaataatgatgagttggaatttgaacaagct
ccagagtttctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagattttcaataaacatacatcacttagactgttaagacaggag
ctggtggtcctttgccacctccaccaccccagcttaatatctttgctggcggctgggatt
cgtcctcgcatgttggtgatggagttggcctccaagggttcgctggaccgcttgcttcag
caggacaaaggaagtctcaccagaaccctgcagcacaggattgcgctacatgtggctgat
ggcttgagatacctccactcagccatgattatataccgtgacttgaagccccacaacgtg
ctgctcttcaccctgtatcccaatgcaggcatcatcgcgaagattgcggactatgggatt
gctcagtactgctgtagaatggggataaagacgtcagaaggcacaccagggtttcgtgca
cctgaggttgctagaggaaatgttatttataaccaacaggctgatgtttattcatttggt
ttactactctatgacattttgacaactggagggagaatagcggagggtttgaagtttcca
aatgagtttgatgagctggcaatacaaggaaaattacctgatccagttaaagaatatggc
tgtgccccatggcccatggttgagaagttaattaaaaagtgtttgaaggaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacaatttgaattcagctgagttaatctgtctg
atgagacgtataacaatacctaaaaactttagtgttgaatgcatggtctctacaaatcat
aacaacaagaatgcaagcatctggctgggctgtgggcaccgtgacaaaggacagctctta
tttcttgacttaaatacagaaaaacacacttctgaggaagttattgatagtagaatactg
tgcctggctttggtgtctcttcctgtggaaaaggaaagctggatcgtgtgtgggacacag
tctggcacgctcctggtcatcaataccgaagatggggaaaagaggcatactcttgaaaag
atgactgattccgtgacttgcttgtattgcaatccctttcccaagcaaagcaagcaaaaa
aattttcttctggtgggaactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtaaaggagctgttcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgaatccatgaattcaactgaaaaaaacattatgtggggaggatgtggt
acaaaacttttctcattttctgatgatttcaccattcagaagctcattgagacaaagaca
aatcagctgttttcttatgcagctttcagtgactccaacatcatagcagtggtggtagac
acggctctctacgttgctaagaaaaatagtccatttgtggaagtacgggataagaaaact
gaaaaactttgtgaactaatagactgtgtgcactttttaaaggaggaaatggtaaaagta
agtgcagaatcaaaacacaaactgtcttattctgggagagtaaaaaccctgtgcctccag
aagaacaccgctctctggataggaactggaggaggccatattttactccttgatctttca
actcgtcgaattatacgtataattcacaatttttgtgattctgtcagagtcatgatgaca
gcacaattaggaagccttaaaaatgtcatgctggttttggggtacatccggaaaagtact
gaaagtacacaacaccaaaaagagatacaatcttgtttgtctgtttgggacctcaacctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtgagaaaagaattagctgagaaa
atgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
