| Entry |
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| Symbol |
ARHGEF12
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| Name |
(RefSeq) rho guanine nucleotide exchange factor 12 isoform X1
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| KO |
| K07532 | Rho guanine nucleotide exchange factor 12 |
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| Organism |
aml Ailuropoda melanoleuca (giant panda)
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| Pathway |
| aml04270 | Vascular smooth muscle contraction |
| aml04625 | C-type lectin receptor signaling pathway |
| aml04810 | Regulation of actin cytoskeleton |
| aml05163 | Human cytomegalovirus infection |
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| Brite |
KEGG Orthology (KO) [BR:aml00001]
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100471078 (ARHGEF12)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
100471078 (ARHGEF12)
04625 C-type lectin receptor signaling pathway
100471078 (ARHGEF12)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100471078 (ARHGEF12)
09158 Development and regeneration
04360 Axon guidance
100471078 (ARHGEF12)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100471078 (ARHGEF12)
05205 Proteoglycans in cancer
100471078 (ARHGEF12)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
100471078 (ARHGEF12)
09171 Infectious disease: bacterial
05135 Yersinia infection
100471078 (ARHGEF12)
05152 Tuberculosis
100471078 (ARHGEF12)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:aml04131]
100471078 (ARHGEF12)
Membrane trafficking [BR:aml04131]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
100471078 (ARHGEF12)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
8:15923227..16077682
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| AA seq |
1543 aa
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERSASHDFDPTDSSSKKTKSSSEE
SRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGT
LVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQ
EAKKHIPQLQEQLSKATGSAQDGAAVTSSKPLGDALTVSEVEADPGDGLSRIDSSSGDAS
RPSSDSADSPKSALKERIYLEENPEKSEVIQDTDTQSLIGSPSPRIAPHIIGAEDDDFGT
EHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKQTNSKETRR
VFLEFHQFFLDRSAHLKVSVPDEISVDLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHL
EDFRQKRSMGLTLAESELTKLDAERDKDRVTLEKERACAEQIVAKIEEVLMTAQAVEEDK
SSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDREGEEKGKRRGFPSI
LGPPRRPSRHDNSAIGRAMELQKQRHPKHLPTPSSVSPEPQDPAKLRQSGLAGEGTDVGY
LPANSMSSVASGATLSQEGGKENDTGSKQLGETPASGDCVDSTPRTPNTVFDFPPPPLDQ
VQEEEWEVERVTEHGTPKPFRKFDSIAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG
LKPSEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQ
LHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEDKLKHAAATFCSNQPFALEMIKS
RQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPMEREKV
KKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSNLKLSEYPNVEELRNLDLTKRKM
IHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVI
KLNTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSAK
PIPLPQSPPCEGDNDEEAAPKLKVGHHSISVPGLQSPDRDLGLESPLMSSKPQSHSLGTS
GKSEVDDLFVAERQFAKEQHADGTLQEAGASYQIPIPDPHLPASEERWALDALRNLGLLK
QLLVQQLGLTEKSTQEDWPHFPRYRTASSGVQTNGGAQNSENSKACPPGEGQMPFRTGTG
DIATCYSPRTSAESSAPRDSVVLAFQDSQASNILVMDHVIMTPEMPPAEPEGSLDESGEH
FFDAREAHSDDNPSEGDGAVQKEEDVTLRISGNYLILDGYEAVQESSTDEDVASLLPPPP
PAGIPSTDSARPHQHSPQRAHSDGAASPFTPEFLLQQRWGAMEDSCFEIQSPPSCADSQS
QIMEYIRKIEADLEHLKKVEESYSMLCQRLAGSALTDKHSDKS |
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| NT seq |
4632 nt +upstreamnt +downstreamnt
atgagtggcacacagtctactatcaccgacaggtttcccctcaaaaaacctataaggcat
gggagtattttgaaccgagagtcaccaacagataagaagcagaaagttgagcgcagtgca
tcacatgattttgatcctacagatagctcctccaagaagacaaagtctagttcagaggag
agtagatccgagatatatggtcttgttcagcgttgtgtgatcatccagaaggatgacaat
ggatttgggctgacggtcagtggagacaatccagtcttcgtacagtctgtcaaagaagat
ggagcagccatgcgggctggggtacagacaggtgatcgaatcatcaaggtgaatggaact
ctggtgactcattcaaaccatttggaagtggtgaagctaatcaaatctggttcctatgta
gctctcactgttcagggacgcccacctgggtcgccccagattccactcgccgattctgaa
gtagagccatcagtcattggacatatgtctcccatcatgacatcccctcattcacctgga
gcatctgggaacatggagagaattactagtcctgtgcttatgggggaggaaaacaatgtg
gttcataaccagaaagtagaaattctgagaaaaatgttacagaaagaacaggaacggctg
cagttattgcaggaagattacaaccgaacacctgcccaaagattgctaaaagagatccaa
gaggccaagaaacacattcctcagctgcaagagcagttatccaaagccacgggctctgct
caggatggagctgcagttacctcctccaagcctttaggtgacgcactgacagtcagtgag
gtggaagctgatcctggtgatggactaagcagaattgactccagcagtggagacgcttct
cggcccagtagtgacagcgcagacagtcccaagagtgccctgaaagagaggatttatcta
gaggaaaacccagagaaaagtgaagtgattcaggacactgatactcagtcactcatcggg
agtccctctccccgtatagcacctcatattattggagcagaggatgatgattttggtact
gaacatgaacagatcaatgggcagtgcagctgtttccagagcatcgagctgctgaaatct
cgccctgctcacctggctgttttcttacaccacgtggtctcacaatttgaccccgcaacg
ctgctctgttatctctattcagacctgtacaagcagaccaattccaaggagactcgtcgt
gtcttccttgagtttcatcagttcttcctggatcgatctgcacacctgaaagtttctgtg
cctgatgaaatatcagtagatctagaaaaaagaagacctgagcttatacccgaggatctg
caccgccactatatccaaactatgcaggaaagagtccacccagaagttcagaggcacttg
gaagattttcggcagaagcgtagcatggggctgaccttggctgaaagtgaactgactaaa
ctcgacgcagagcgagacaaggaccgggtcactttggagaaggaacgggcatgtgcagaa
cagatcgttgccaaaattgaagaagtgttgatgactgctcaggctgtagaagaagataag
agttcaacaatgcagtatgttatccttatgtacatgaagcatttgggggtaaaagtgaaa
gaacctcgaaatttggagcacaagcggggtcggattggattccttccaaaaatcaagcag
agtatgaagaaagatcgagaaggcgaagaaaaagggaagcgcagaggattccccagcatc
ctgggacccccaaggagaccaagccgtcatgacaacagtgcaattggcagggccatggag
ctacagaaacagcggcacccaaagcacttacccacaccctcttctgtgagtccagagcct
caggaccctgctaagttgcgccagagtgggttagcaggtgaaggaacagacgtcggatac
ctgccagccaattccatgtcctctgtggcttcaggggccactctttcccaggaaggaggg
aaagagaatgatacaggatcaaagcaacttggagaaacaccagcatctggagactgcgta
gatagcacccctcggactccgaatactgtctttgatttcccacctcctcctttagaccaa
gtgcaggaggaggaatgggaagtggaaagggtgactgaacatgggacaccaaagcccttt
cgaaagtttgacagcatagcttttggagaaagtcaaagtgaggatgaacagtttgaaaat
gacttagagacagacccaccgaactggcaacagcttgttagtcgagaagtgttactggga
ctaaagccttctgagatcaaaaggcaggaagtaattaatgaattgttctacactgaaaga
gctcatgttcgaacactgaaagttcttgatcaagtattctatcagcgagtgtccagagaa
ggaattctgtcaccttcagaactacggaaaattttttcaaacttggaagatattcttcaa
cttcatattggattgaatgagcaaatgaaggctgttcgaaagaggaatgagacctcagtt
attgatcagattggggaagatttgctgacctggttcagtggaccaggagaggacaagttg
aagcacgccgctgctaccttttgcagtaaccaacctttcgccctggaaatgatcaagtct
cgtcagaaaaaggattctcgattccagacctttgtgcaagatgccgagagtaatcctcta
tgtcgtcgtctgcagctgaaggatatcattcctacccaaatgcagaggcttaccaagtac
cctcttctgttggataatattgccaaatacacagaatggccaatggaaagggagaaggtg
aagaaagctgcagatcactgtcgtcagatcttgaattatgtaaatcaggctgtcaaggag
gcagaaaacaaacagcgtttagaagactatcagcgtcgtctggatacctccaatctgaag
ttgtcggagtacccaaacgtggaagagctcaggaatttggatttaacaaaaaggaagatg
attcatgaagggccattggtctggaaggtgaaccgagataaaactattgatctatacaca
ttgctgctggaagacattcttgtattgttacaaaagcaggatgacagactggtgttaaga
tgtcatagtaagattctggcgtctaccgctgacagcaaacacacatttagccctgtcatt
aagttgaatacagtgttggttcgacaagtggcaacagataacaaagctttatttgtcatc
tccatgtcagacaatggagcccaaatttatgaactggtggcacagacagtttccgaaaag
actgtctggcaagacctaatctgtcggatggccgcatccgtgaaggaacaatccgcaaag
cccatcccgttgccacagtcaccaccttgcgaaggagacaacgatgaagaagcagctcca
aagttaaaggtgggacaccacagcatttcggtccctggtctgcagagtccagacagagat
ttgggattagagtctcccttaatgtcgtcaaaacctcagtctcattcactggggacctct
gggaaatccgaggtagatgatctgtttgtggccgagaggcagtttgctaaggagcagcat
gcagatgggactctgcaggaagccggagcaagttatcagatcccaatcccagacccacac
ttgcctgcctcggaagaacggtgggcgctggatgcactaaggaatttgggcttgctgaag
cagttgctcgtccaacagctgggtttgactgagaagagcactcaggaagactggccacat
ttcccaagatataggacagcgtcttcaggggtgcagacaaacggtggagcccagaactct
gagaatagtaaggcctgtcctcctggtgaaggacagatgccctttagaactggaactggt
gacattgcaacttgttacagtccacggacttcagctgaatcttcggctccgcgggattca
gtggtactggcattccaagatagccaggcaagtaacattttagtaatggaccacgtgatt
atgaccccagagatgcctcctgcggagccagaagggagtctcgatgagagtggagagcac
ttttttgatgcccgtgaagcacatagtgatgataacccatcagaaggtgatggagcagtt
cagaaggaagaggatgttactttgcgcatctcaggaaactatctgattcttgatggctat
gaagcggtgcaggagagctccacggatgaggacgttgcttccttgctccccccgccgccc
ccggcaggcatcccctccacagactctgcccgcccacaccagcactcgccccagcgtgcc
cattccgacggggcggcttcaccgttcacccccgaattcctgctccagcagcgctggggg
gctatggaggattcctgttttgagatccagagtcccccctcttgtgcagactctcagagc
cagattatggagtacattcggaagatcgaggctgaccttgaacacttaaagaaggtggaa
gaaagttacagcatgctttgccaaaggctggctggatcagccctcacagacaagcactca
gataaaagttag |
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