Ailuropoda melanoleuca (giant panda): 100472815 Help Entry 100472815         CDS       T01329                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4 isoform X1   KO K10160   toll-like receptor 4 Organism aml  Ailuropoda melanoleuca (giant panda) Pathway aml04064   NF-kappa B signaling pathway aml04066   HIF-1 signaling pathway aml04145   Phagosome aml04151   PI3K-Akt signaling pathway aml04217   Necroptosis aml04613   Neutrophil extracellular trap formation aml04620   Toll-like receptor signaling pathway aml04621   NOD-like receptor signaling pathway aml04936   Alcoholic liver disease aml05132   Salmonella infection aml05133   Pertussis aml05134   Legionellosis aml05135   Yersinia infection aml05140   Leishmaniasis aml05142   Chagas disease aml05144   Malaria aml05145   Toxoplasmosis aml05146   Amoebiasis aml05152   Tuberculosis aml05161   Hepatitis B aml05162   Measles aml05164   Influenza A aml05170   Human immunodeficiency virus 1 infection aml05171   Coronavirus disease - COVID-19 aml05205   Proteoglycans in cancer aml05235   PD-L1 expression and PD-1 checkpoint pathway in cancer aml05321   Inflammatory bowel disease aml05323   Rheumatoid arthritis aml05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:aml00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     100472815 (TLR4)    04066 HIF-1 signaling pathway     100472815 (TLR4)    04151 PI3K-Akt signaling pathway     100472815 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     100472815 (TLR4)   09143 Cell growth and death    04217 Necroptosis     100472815 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     100472815 (TLR4)    04620 Toll-like receptor signaling pathway     100472815 (TLR4)    04621 NOD-like receptor signaling pathway     100472815 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     100472815 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100472815 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     100472815 (TLR4)    05161 Hepatitis B     100472815 (TLR4)    05171 Coronavirus disease - COVID-19     100472815 (TLR4)    05164 Influenza A     100472815 (TLR4)    05162 Measles     100472815 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     100472815 (TLR4)    05135 Yersinia infection     100472815 (TLR4)    05133 Pertussis     100472815 (TLR4)    05134 Legionellosis     100472815 (TLR4)    05152 Tuberculosis     100472815 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     100472815 (TLR4)    05144 Malaria     100472815 (TLR4)    05145 Toxoplasmosis     100472815 (TLR4)    05140 Leishmaniasis     100472815 (TLR4)    05142 Chagas disease     100472815 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     100472815 (TLR4)    05321 Inflammatory bowel disease     100472815 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     100472815 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     100472815 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:aml04131]     100472815 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:aml04054]     100472815 (TLR4)    04090 CD molecules [BR:aml04090]     100472815 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:aml00536]     100472815 (TLR4) Membrane trafficking [BR:aml04131]  Endocytosis   Phagocytosis    Toll-like receptors     100472815 (TLR4) Pattern recognition receptors [BR:aml04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    100472815 (TLR4) CD molecules [BR:aml04090]  Proteins   100472815 (TLR4) Glycosaminoglycan binding proteins [BR:aml00536]  Hyaluronan   Cell surface receptors    100472815 (TLR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 LRR_4 TIR LRR_1 TIR_2 LRR_5 LRR_9 LRR_NXF1-5 LRR_EndoS LRR_6 LRR_Zer-1 ThsB_TIR LRR_R13L1-DRL21 Motif Other DBs NCBI-GeneID:  100472815 NCBI-ProteinID:  XP_002929935 Ensembl:  ENSAMEG00000031378 LinkDB All DBs Position 7:44359116..44378730 Genome browser AA seq 833 aa AA seqDB search MMSPTRRAGMLIPAMAFLSFLRPESWEPCEQVVPNITYKCMELNLNKIPNNIPTSTKKLD LSFNPLRHLNSRSFSSFPELQVLDLSRCEIRIIEDDAYQGLNNLSILILTGNPIQELFPG AFSGLSNLQTLVVVETNVQSLEDFPIGHLKTLKELNVAHNLIHSFKLPEYFSNMPNLEYL DLSNNKIQNIYHKDLQVLRQMPLLNLSLDLSLNPLYFIQPGAFKEIKLHELTLRSNFNST HVMKTCIQGLAGLKIHQLVLGEFKNERKLESFDKSLLEGLCDLTIEKFRIAYFDEFSKDT TDLFNCLGNVSTISLVHLFLNRPRYLPKNLRWQRLEMVKCGFEEFPTWGLDSLKEFVFTA NKGVNTFTEMNPNSLEFLDLSRNGLSFKGCCSHSELGTTRLKHLDLSFNDIITMSSNFLG LEQLEYLDFQHSNLKQASDFSVFLSLRNLRYLDISYTHTQVVFQGIFDGLVSLQVLKMAG NSFQDNFLPNIFKDLTNLTILDLSKCQLERVSQIAFGSLPKLQLINMSHNNLLSLDTLPY EPLLSLQILDCSFNRIVASKERERQHFPSNLVSLNLTQNDFACVCEHQNFLQWVKDHRQL LVEVEEMVCAKPLDMQGMPVLSFRNATCQRSKTIITVSVFTVLMVSLVAVLVYKFYFHLM LLAGCKKYSKGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKSLL RQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKPWSPEGAADAENS NT seq 2502 nt NT seq  +upstreamnt  +downstreamnt atgatgtctcctacccgccgggcggggatgctgatcccagccatggccttcctctccttc ctgagacccgagagctgggaaccttgtgagcaggtggttcctaacattacttacaaatgc atggaactgaatctcaacaaaattcccaacaatatccccacgtcaaccaagaaactggac ctgagctttaaccccctgaggcatttaaacagccgtagcttctccagcttcccagaactg caggtgttggatttatccaggtgtgaaattcggataattgaagatgatgcatatcagggc ctaaacaacctctccatcttgatattgacaggaaaccctatccaggagttattcccagga gccttttctggactctcaaatttacagacgctggtggtcgtggagacaaatgttcagtct ctagaggacttccccattggacatctcaaaaccttgaaggagcttaatgtggcccacaat cttatccattccttcaagttacctgaatatttttctaacatgcccaacctggagtacttg gatctttccaataacaagatccaaaatatttatcataaagacttgcaggttctgcgtcaa atgcctctactcaacctttctttagacttgtccctgaaccctttatactttatccaacca ggtgcctttaaagaaattaaactccatgaactgactttgagaagtaattttaatagtaca catgtaatgaaaacttgtattcaaggtctggctggtttaaagatccatcagttggttctg ggagaatttaaaaatgaaaggaagttggaaagctttgacaaatctctcctggagggactg tgtgatttgaccattgaaaaattccggatagcatactttgatgagttctcaaaggatact actgacttatttaattgtttgggaaatgtttctacaatttctctggtgcatctgttttta aataggccaagataccttcctaaaaatctcagatggcaacggttggaaatggttaagtgt ggatttgaagaatttcccacatgggggttggactctctcaaggagtttgttttcactgcc aacaaaggtgtgaacacttttactgagatgaacccaaacagccttgagtttctagatctc agtagaaatggcctgagttttaagggttgctgttctcactctgaattggggacaaccaga ctgaagcatttagatctgagcttcaatgacattattaccatgagttcaaacttcttgggc ttagaacaactagaatatctagatttccagcattccaatttgaaacaggccagtgatttt tcagtattcctatccctcagaaacctccgttaccttgatatttcttatactcacacccaa gttgtcttccagggcatttttgatggcctggtcagcctccaagtcttgaaaatggctggt aattcttttcaggacaacttccttccaaatattttcaaagacctaactaacttgaccatt ctagacctttctaagtgtcagctggaacgggtgtcccagatagcatttggttcacttccg aaacttcagttgataaatatgagtcacaacaacctcctgtcattggatacactcccttat gagcctctcctctccctccaaattctggattgcagttttaatcgaatagtggcctccaaa gagcgagaacgacaacattttccaagtaatctagtttccttaaatcttactcagaatgac tttgcttgtgtttgtgaacaccagaacttcctgcagtgggtcaaggaccacaggcagctc ttggtggaagttgaagaaatggtgtgtgcaaaacctttagacatgcagggcatgcctgtg ctgagttttaggaatgccacctgtcagaggagtaagactatcattactgtgtcggtgttc actgtactcatggtttctctggtagcagttttggtgtataagttctatttccacctgatg cttcttgctggctgcaaaaagtacagcaaaggcgaaagcacctatgatgccttcgttatc tactcaagtcaagatgaagactgggtaaggaatgaactagtaaagaacttggaagagggg gtgcccccctttcagctctgccttcattatagagactttattcctggtgtggccatcgcc gccaacatcatccaggaaggtttccacaaaagccggaaggttattgttgtggtgtcccaa cacttcatccagagtcgatggtgtatctttgagtatgagattgcccagacctggcagttt cttagtagtcgtgccggcatcatcttcattgttctgcagaaggtggagaagtccctgctg cggcagcaggtggagctgtatcggcttcttagcaggaacacttacctggagtgggaagac agtgtcctggggcggcacatcttctggagacgactccgaaaagccttgctggatggtaaa ccgtggagtccagaaggagcagcagatgcagaaaacagctag

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