| Entry |
|
|---|
| Symbol |
ARAF
|
|---|
| Name |
(RefSeq) serine/threonine-protein kinase A-Raf
|
|---|
| KO |
| K08845 | A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] |
|
|---|
| Organism |
aml Ailuropoda melanoleuca (giant panda)
|
|---|
| Pathway |
| aml01521 | EGFR tyrosine kinase inhibitor resistance |
| aml04270 | Vascular smooth muscle contraction |
| aml04650 | Natural killer cell mediated cytotoxicity |
| aml04810 | Regulation of actin cytoskeleton |
| aml04914 | Progesterone-mediated oocyte maturation |
| aml04928 | Parathyroid hormone synthesis, secretion and action |
| aml05022 | Pathways of neurodegeneration - multiple diseases |
| aml05208 | Chemical carcinogenesis - reactive oxygen species |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:aml00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100475955 (ARAF)
04012 ErbB signaling pathway
100475955 (ARAF)
04068 FoxO signaling pathway
100475955 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
100475955 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
100475955 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
100475955 (ARAF)
04914 Progesterone-mediated oocyte maturation
100475955 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
100475955 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100475955 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
100475955 (ARAF)
04720 Long-term potentiation
100475955 (ARAF)
04730 Long-term depression
100475955 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100475955 (ARAF)
05205 Proteoglycans in cancer
100475955 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
100475955 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
100475955 (ARAF)
05212 Pancreatic cancer
100475955 (ARAF)
05225 Hepatocellular carcinoma
100475955 (ARAF)
05226 Gastric cancer
100475955 (ARAF)
05214 Glioma
100475955 (ARAF)
05221 Acute myeloid leukemia
100475955 (ARAF)
05220 Chronic myeloid leukemia
100475955 (ARAF)
05218 Melanoma
100475955 (ARAF)
05211 Renal cell carcinoma
100475955 (ARAF)
05219 Bladder cancer
100475955 (ARAF)
05215 Prostate cancer
100475955 (ARAF)
05213 Endometrial cancer
100475955 (ARAF)
05224 Breast cancer
100475955 (ARAF)
05223 Non-small cell lung cancer
100475955 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
100475955 (ARAF)
05160 Hepatitis C
100475955 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
100475955 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
100475955 (ARAF)
09165 Substance dependence
05034 Alcoholism
100475955 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100475955 (ARAF)
01522 Endocrine resistance
100475955 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:aml01001]
100475955 (ARAF)
Enzymes [BR:aml01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100475955 (ARAF)
Protein kinases [BR:aml01001]
Serine/threonine kinases: TKL group
RAF family [OT]
100475955 (ARAF)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| Position |
X:40603516..40614295
|
|---|
| AA seq |
606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEAPSNRPLNEPL
TPQGPSSCTLHRDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTAAPMDSGLIQLTAQSFS
TDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSVADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP |
|---|
| NT seq |
1821 nt +upstreamnt +downstreamnt
atggagccaccacggggcccccctgccaacggggctgagccgtcccgggcagtgggcact
gtcaaagtatacctgcccaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtccggggtctcaatcaggattgctgcgtg
gtctaccggctcatcaaggggcgaaagacagtcaccgcctgggacacagccattgccccc
ctggatggagaggagctcatcgtagaggtccttgaagacgtcccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcgttctgcgacttctgccttaagtttctgttc
cacggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaagtc
cccacagtctgtgttgacatgagcaccaactgccgacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaggctccctcgaaccgccccctgaatgagccgcta
acccctcagggtcccagctcctgcaccctgcaccgcgaccctgagcactttcccttccct
gcccctgccaacgccccactccagcgcatccgctccacgtccactcccaacgtccacatg
gtcagcaccgcagcccccatggactccggcctcatccagctcactgcccagagtttcagc
actgatgctgctggcagtagaggtggtggcgatggagccccccgggggagccccagcccg
gccagcgtgtcctcggggaggaagtccccccactccaagtctccatcggagcagcgggag
cggaagtccgtggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tactactgggaggtgccacccagcgaggtgcagctgctgaagaggatcgggacgggctcg
ttcggcactgtgtttcgcgggcggtggcatggtgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcatgtcaacatcctgctgttcatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccaccacctgcatgtggctgacacacgc
ttcgacatggtccagctcatcgatgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagattggtgactttggcctggccacggtgaagacacggtggagtggggcc
cagcccttggagcagccctcaggctccgtgctgtggatggcggctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcggatgtctacgcctatggggttgtgttgtat
gagctcatgaccggctcgctgccttacagccacattggcagccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctctctgactgcctcaagttccagcgggaggaacgtcccctattc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcaccgcacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag |
|---|
