Ailuropoda melanoleuca (giant panda): 100479804
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Entry
100479804 CDS
T01329
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
aml
Ailuropoda melanoleuca (giant panda)
Pathway
aml00790
Folate biosynthesis
aml01100
Metabolic pathways
aml01240
Biosynthesis of cofactors
aml01523
Antifolate resistance
aml04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
aml00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
100479804 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
100479804 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
100479804 (FPGS)
Enzymes [BR:
aml01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
100479804 (FPGS)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
100479804
NCBI-ProteinID:
XP_002915221
Ensembl:
ENSAMEG00000015069
UniProt:
G1M966
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All DBs
Position
7:53055427..53070860
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AA seq
588 aa
AA seq
DB search
MSQARCHLRAALFLAAVSPRGATTGVTAWRGLSAWPAPQEPGMEYQDAVRTLNTLQTNAG
YLEQVKRQRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPVSPELFTKHFWRLYHRLEETKDSSSCVSMPAYFR
FLTLMAFHIFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGISSLGIDHTSLLGDTVEEI
AWQKGGIFKCGVPAFTVLQPDGPLAVLRDRAQHISCPLYLCPPLEALEEGGPPLTLGLEG
EHQRSNAALALQLARCWLQQKGHQGLGELKVSRPSVLRQMPLAPVFQPTSHMRHGLRDTE
WLGRTQVLRRGPLTWYLDGAHTASSVQACVRWFRQALHRSHRPSHGPEVRVLLFNATGDR
DPAALLKLLQPCQFDYAVFCPNLTDVSSAGSADQQNFMVTLDQVLLRCLAHQRHWSHLAE
EQASPDPWSPASPEPGEPTSLLLASRPPRTHSTSSLVFSCISHALQWISQGRDPVFQPPN
PPQGLLAHPVAGSGAGVLQEAAAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq
1767 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcaggcacgctgccacctgcgcgccgctctcttcctggcagcagtttctccgcgc
ggtgcaacgaccggggtcacggcgtggcgagggttgagcgcgtggcccgcgccgcaggag
ccgggcatggagtatcaggatgctgtgcgcacactgaacaccctgcagaccaatgctggc
tacctggagcaggtgaagcgccagcggggtgaccctcagacacagctggaagcgatgaag
ctgtatttggcccggagtgggctgcaggtggaagacttggaccagctgaacatcattcac
gtcactgggaccaaggggaagggttccacttgtgccttcaccgaacgtattctccgcagc
tatggcctgaagacaggattctttagctctccccacctggtgcaggtgcgggagcggatc
cgcatcaacgggcagcccgtaagccccgagctcttcaccaagcacttctggcgcctctac
caccggctggaggagaccaaggacagcagcagctgcgtctccatgcccgcatacttccgc
ttcctcacgctcatggccttccacatcttcctccaagagaaggtggacctggcggtggta
gaagtgggcattggtggcgcttacgactgcaccaacatcatcaggaagcctgtggtgtgt
ggcatctcctctctcggcatcgaccacaccagccttctgggggacacagtggaagagatc
gcgtggcagaaagggggcatcttcaagtgtggcgtccctgctttcacggtgctccagccc
gacggtcccctggcagtgctgcgggaccgtgcccagcacatctcctgtcctctctacctg
tgcccgccactggaagccctggaggaaggggggccgccgctgaccctgggcctggaggga
gagcaccagcggtccaacgccgccttggccttgcagctggctcgctgctggctgcagcaa
aagggccaccagggcctcggggagctgaaggtgtctcggcccagcgtcttgcggcagatg
cccctggcacccgtgttccagcccacgtcccacatgcggcatgggcttcgggacacagag
tggctgggccggacgcaggtgctgcggcgcgggcccctcacctggtacctggacggcgcg
cataccgccagcagcgttcaggcctgcgtgcgttggttccgccaggcgctgcaccgcagc
cacaggccgagccacggccctgaggtgcgcgtcttgctcttcaatgccactggggaccgg
gatcccgcggccctgctgaagctgctgcagccctgtcagtttgactatgctgtcttctgc
cctaacctgacagacgtgtcgtctgctggcagcgcagaccagcagaacttcatggtgacc
ctggaccaggtgctgctccgctgccttgcgcaccagcggcactggagccacctggctgag
gagcaggccagcccggacccctggagccccgccagcccggagcctggtgagcccacatcc
ttgctgctggcttcccgcccaccccgcacccacagcaccagctccctcgtcttcagctgc
atctcccatgccctgcagtggatcagccaaggccgggaccccgtctttcagccacccaat
ccccctcagggcctccttgcccacccggtggcaggcagcggggccggcgtgctccaggag
gccgccgccatccacgtactggtcacgggcagcttgcacctggtgggcggcgtcctgaag
ctgctggagcctgccctgtcccagtag
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