KEGG   Ailuropoda melanoleuca (giant panda): 100480414
Entry
100480414         CDS       T01329                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml01521  EGFR tyrosine kinase inhibitor resistance
aml01522  Endocrine resistance
aml01524  Platinum drug resistance
aml04010  MAPK signaling pathway
aml04012  ErbB signaling pathway
aml04014  Ras signaling pathway
aml04015  Rap1 signaling pathway
aml04022  cGMP-PKG signaling pathway
aml04024  cAMP signaling pathway
aml04062  Chemokine signaling pathway
aml04066  HIF-1 signaling pathway
aml04068  FoxO signaling pathway
aml04071  Sphingolipid signaling pathway
aml04072  Phospholipase D signaling pathway
aml04140  Autophagy - animal
aml04150  mTOR signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04152  AMPK signaling pathway
aml04210  Apoptosis
aml04211  Longevity regulating pathway
aml04213  Longevity regulating pathway - multiple species
aml04218  Cellular senescence
aml04261  Adrenergic signaling in cardiomyocytes
aml04370  VEGF signaling pathway
aml04371  Apelin signaling pathway
aml04380  Osteoclast differentiation
aml04510  Focal adhesion
aml04550  Signaling pathways regulating pluripotency of stem cells
aml04611  Platelet activation
aml04613  Neutrophil extracellular trap formation
aml04620  Toll-like receptor signaling pathway
aml04625  C-type lectin receptor signaling pathway
aml04630  JAK-STAT signaling pathway
aml04660  T cell receptor signaling pathway
aml04662  B cell receptor signaling pathway
aml04664  Fc epsilon RI signaling pathway
aml04666  Fc gamma R-mediated phagocytosis
aml04668  TNF signaling pathway
aml04722  Neurotrophin signaling pathway
aml04725  Cholinergic synapse
aml04728  Dopaminergic synapse
aml04810  Regulation of actin cytoskeleton
aml04910  Insulin signaling pathway
aml04914  Progesterone-mediated oocyte maturation
aml04915  Estrogen signaling pathway
aml04917  Prolactin signaling pathway
aml04919  Thyroid hormone signaling pathway
aml04920  Adipocytokine signaling pathway
aml04922  Glucagon signaling pathway
aml04923  Regulation of lipolysis in adipocytes
aml04926  Relaxin signaling pathway
aml04929  GnRH secretion
aml04931  Insulin resistance
aml04932  Non-alcoholic fatty liver disease
aml04933  AGE-RAGE signaling pathway in diabetic complications
aml04935  Growth hormone synthesis, secretion and action
aml04936  Alcoholic liver disease
aml04973  Carbohydrate digestion and absorption
aml05010  Alzheimer disease
aml05017  Spinocerebellar ataxia
aml05132  Salmonella infection
aml05135  Yersinia infection
aml05142  Chagas disease
aml05145  Toxoplasmosis
aml05152  Tuberculosis
aml05160  Hepatitis C
aml05161  Hepatitis B
aml05162  Measles
aml05163  Human cytomegalovirus infection
aml05164  Influenza A
aml05165  Human papillomavirus infection
aml05166  Human T-cell leukemia virus 1 infection
aml05167  Kaposi sarcoma-associated herpesvirus infection
aml05168  Herpes simplex virus 1 infection
aml05169  Epstein-Barr virus infection
aml05170  Human immunodeficiency virus 1 infection
aml05200  Pathways in cancer
aml05205  Proteoglycans in cancer
aml05207  Chemical carcinogenesis - receptor activation
aml05208  Chemical carcinogenesis - reactive oxygen species
aml05210  Colorectal cancer
aml05211  Renal cell carcinoma
aml05212  Pancreatic cancer
aml05213  Endometrial cancer
aml05214  Glioma
aml05215  Prostate cancer
aml05218  Melanoma
aml05220  Chronic myeloid leukemia
aml05221  Acute myeloid leukemia
aml05222  Small cell lung cancer
aml05223  Non-small cell lung cancer
aml05224  Breast cancer
aml05225  Hepatocellular carcinoma
aml05226  Gastric cancer
aml05230  Central carbon metabolism in cancer
aml05231  Choline metabolism in cancer
aml05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
aml05415  Diabetic cardiomyopathy
aml05417  Lipid and atherosclerosis
aml05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:aml00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100480414 (AKT3)
   04012 ErbB signaling pathway
    100480414 (AKT3)
   04014 Ras signaling pathway
    100480414 (AKT3)
   04015 Rap1 signaling pathway
    100480414 (AKT3)
   04370 VEGF signaling pathway
    100480414 (AKT3)
   04371 Apelin signaling pathway
    100480414 (AKT3)
   04630 JAK-STAT signaling pathway
    100480414 (AKT3)
   04668 TNF signaling pathway
    100480414 (AKT3)
   04066 HIF-1 signaling pathway
    100480414 (AKT3)
   04068 FoxO signaling pathway
    100480414 (AKT3)
   04072 Phospholipase D signaling pathway
    100480414 (AKT3)
   04071 Sphingolipid signaling pathway
    100480414 (AKT3)
   04024 cAMP signaling pathway
    100480414 (AKT3)
   04022 cGMP-PKG signaling pathway
    100480414 (AKT3)
   04151 PI3K-Akt signaling pathway
    100480414 (AKT3)
   04152 AMPK signaling pathway
    100480414 (AKT3)
   04150 mTOR signaling pathway
    100480414 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100480414 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    100480414 (AKT3)
   04218 Cellular senescence
    100480414 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100480414 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    100480414 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100480414 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100480414 (AKT3)
   04613 Neutrophil extracellular trap formation
    100480414 (AKT3)
   04620 Toll-like receptor signaling pathway
    100480414 (AKT3)
   04625 C-type lectin receptor signaling pathway
    100480414 (AKT3)
   04660 T cell receptor signaling pathway
    100480414 (AKT3)
   04662 B cell receptor signaling pathway
    100480414 (AKT3)
   04664 Fc epsilon RI signaling pathway
    100480414 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    100480414 (AKT3)
   04062 Chemokine signaling pathway
    100480414 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100480414 (AKT3)
   04922 Glucagon signaling pathway
    100480414 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    100480414 (AKT3)
   04920 Adipocytokine signaling pathway
    100480414 (AKT3)
   04929 GnRH secretion
    100480414 (AKT3)
   04915 Estrogen signaling pathway
    100480414 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    100480414 (AKT3)
   04917 Prolactin signaling pathway
    100480414 (AKT3)
   04926 Relaxin signaling pathway
    100480414 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    100480414 (AKT3)
   04919 Thyroid hormone signaling pathway
    100480414 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100480414 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100480414 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    100480414 (AKT3)
   04728 Dopaminergic synapse
    100480414 (AKT3)
   04722 Neurotrophin signaling pathway
    100480414 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100480414 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    100480414 (AKT3)
   04213 Longevity regulating pathway - multiple species
    100480414 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100480414 (AKT3)
   05205 Proteoglycans in cancer
    100480414 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    100480414 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    100480414 (AKT3)
   05230 Central carbon metabolism in cancer
    100480414 (AKT3)
   05231 Choline metabolism in cancer
    100480414 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100480414 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100480414 (AKT3)
   05212 Pancreatic cancer
    100480414 (AKT3)
   05225 Hepatocellular carcinoma
    100480414 (AKT3)
   05226 Gastric cancer
    100480414 (AKT3)
   05214 Glioma
    100480414 (AKT3)
   05221 Acute myeloid leukemia
    100480414 (AKT3)
   05220 Chronic myeloid leukemia
    100480414 (AKT3)
   05218 Melanoma
    100480414 (AKT3)
   05211 Renal cell carcinoma
    100480414 (AKT3)
   05215 Prostate cancer
    100480414 (AKT3)
   05213 Endometrial cancer
    100480414 (AKT3)
   05224 Breast cancer
    100480414 (AKT3)
   05222 Small cell lung cancer
    100480414 (AKT3)
   05223 Non-small cell lung cancer
    100480414 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100480414 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    100480414 (AKT3)
   05161 Hepatitis B
    100480414 (AKT3)
   05160 Hepatitis C
    100480414 (AKT3)
   05164 Influenza A
    100480414 (AKT3)
   05162 Measles
    100480414 (AKT3)
   05168 Herpes simplex virus 1 infection
    100480414 (AKT3)
   05163 Human cytomegalovirus infection
    100480414 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100480414 (AKT3)
   05169 Epstein-Barr virus infection
    100480414 (AKT3)
   05165 Human papillomavirus infection
    100480414 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100480414 (AKT3)
   05135 Yersinia infection
    100480414 (AKT3)
   05152 Tuberculosis
    100480414 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100480414 (AKT3)
   05142 Chagas disease
    100480414 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100480414 (AKT3)
   05017 Spinocerebellar ataxia
    100480414 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100480414 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    100480414 (AKT3)
   05415 Diabetic cardiomyopathy
    100480414 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100480414 (AKT3)
   04932 Non-alcoholic fatty liver disease
    100480414 (AKT3)
   04931 Insulin resistance
    100480414 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100480414 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100480414 (AKT3)
   01524 Platinum drug resistance
    100480414 (AKT3)
   01522 Endocrine resistance
    100480414 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:aml01001]
    100480414 (AKT3)
Enzymes [BR:aml01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100480414 (AKT3)
Protein kinases [BR:aml01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   100480414 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 ABC1 PH_11
Other DBs
NCBI-GeneID: 100480414
NCBI-ProteinID: XP_011221869
Ensembl: ENSAMEG00000009273
UniProt: G1LRV9
LinkDB
Position
8:68379969..68678624
AA seq 479 aa
MSDVTVVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCVDNERRPHFPQFSYSASGRE
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgagcgatgttaccgtcgtgaaagaaggctgggttcagaagaggggagaatatataaaa
aactggaggccaagatatttccttttgaagacagatggctcattcataggatataaagag
aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttattatcagatgtctccagtggacc
actgttatagagagaacgtttcatgtagatacaccagaggaaagggaagagtggacagaa
gctattcaggctgtagcagacagacttcagagacaagaagaggagagaatgaattgtagt
ccaacttcacaaattgataatataggggaagaagagatggatgcttccacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactgctaggtaaaggcacttttggg
aaagttattttggttcgagagaaggcaagtgggaaatactatgctatgaagattctgaag
aaagaagttattattgcaaaggatgaagtggcacatactctaactgaaagcagagtatta
aagaacactagacatccctttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgtaaatgggggagagctgtttttccatttgtcgagagag
cgggtgttctccgaggaccgcacacgtttctatggtgcagaaattgtctctgctttggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatttgatgctggat
aaagatggccacataaaaatcacggactttgggctttgcaaagaagggatcacggacgcg
gccaccatgaagacgttctgtggcacaccggagtacctggcacccgaggtattagaagac
aacgactatggccgagccgtggattggtggggcctgggggtcgtcatgtatgagatgatg
tgtgggaggctacctttctacaaccaggatcatgagaaactttttgaactaatactaatg
gaagacattaaatttcctcgaacactctcttcagatgcaaaatcactgctttcagggctc
ttgataaaggatccaaataagcgccttggcgggggcccagatgatgcaaaagaaattatg
aggcacagtttcttctctggagtcaactggcaagatgtatacgataaaaagcttgtacct
ccttttaagcctcaagtaacatctgagacagataccaggtattttgatgaagaatttaca
gctcagactattacaataacgccacctgaaaaatatgacgaggacggcatggactgcgtg
gacaacgagcggcggccgcacttccctcagttctcctactccgccagtggccgcgagtaa

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