Ailuropoda melanoleuca (giant panda): 100481196 Help Entry 100481196         CDS       T01329                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism aml  Ailuropoda melanoleuca (giant panda) Pathway aml04020   Calcium signaling pathway aml04371   Apelin signaling pathway aml04713   Circadian entrainment aml04921   Oxytocin signaling pathway aml04970   Salivary secretion aml05010   Alzheimer disease aml05012   Parkinson disease aml05020   Prion disease aml05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:aml00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100481196 (RYR3)    04020 Calcium signaling pathway     100481196 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100481196 (RYR3)   09154 Digestive system    04970 Salivary secretion     100481196 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     100481196 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100481196 (RYR3)    05012 Parkinson disease     100481196 (RYR3)    05020 Prion disease     100481196 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     100481196 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:aml04040]     100481196 (RYR3) Ion channels [BR:aml04040]  Voltage-gated cation channels   Ryanodine receptor    100481196 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_1 EF-hand_7 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  100481196 NCBI-ProteinID:  XP_034517097 Ensembl:  ENSAMEG00000015734 LinkDB All DBs Position 5:70029839..70571634 Genome browser AA seq 4870 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDAQHRRIFYETGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHVAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPVTLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNMVRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKETLNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQSLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCRIAHVNPAAEEELKKVKLPKNYTMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIELSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLADASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPRDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNAGMIYCRLSMPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLHSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMQFHYH TLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNQYLPGLLRSGFYDLLISVHLASAKE RKLLMKNEYIIPITSSTRKIRLYPDETKRHGLPGVGPRTCLKPGFRFSTPCFVVTGEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSAETEDGAEKKEVTQVGEKAVEAGRKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWTGKLRALVYKIKGPPKPETEQPTEEEERSPTTLKELISQTMIRWAQEDQIQDAELVR MMFSVLRRQYDSIGELLQALRKTYTISQASVSDTVSLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDSEDEEIVHMG NAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSL NKDGSVCEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTV SLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKAQ RDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPS GWGSYGLAVEEELHLTEKLFWGIFDSLSRKKYDPDLFRMALPCLSAIVGALPPDYLDTRI SATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYGI SLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALVQQRENE KLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGS HPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFLK KILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSP LKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTAMVSCLHILAQTLDTRTVM KSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTAALLPILT SIFEHVAQHQFGVDLLLGDVQLSCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAI PVAFLEPTLNHYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISDLAESGA RYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPGTGPWCTKVTSEHLSVILGNILKIINN NLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTRG DTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPGADSDQLFRMVAEVFILW CKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERRKTKRRGDLYSI QTSLIVAALKKMLPIGLNMCTPGDQELISLAKARYGSRDTDEEVKEHLRNNLHLQEKSDD PAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQ RKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEE EEEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKE KTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNA GVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRER GEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESI SDFYWYYSGKDIIDESGQHNFSKALAVTKQIFHSLTEYIQGPCIGNQQSLAHSRLWDAVV GFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVE SSTNVEMILKFFDMFLKLKDLTSSDTFKVYDPDGKGIISKKEFQKAMEGQKQYTQSETDF LLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESV LNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEK MELFVNFCEDTIFEMQLASQISESDSADRPDDEEEGGEDSSYLLEIEGGEQDDKSFESAS AFAMACASVKRNVANFLRKATLRNLRKQCRKVKKLTVKELVKEFFSFFWMLFVGLFRLFF TILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHEDTLDAERVEVTEPGV PPELIHFVKGEKGDAEAMSELFGFRPKKEGGLKHRPEGGLGDLSEIIGKDEPPTLESTVR KKRRAQAAEMKAAHEAEGKVEPEKTDLEDGEKEVMAKEEEQAKALWTDVTKKKKRRRGQK VEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPMLRALAVIHTVISLVCVVGYYCLKV PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN KYGDLYGAERIAELLGLDRNALDFSPVEESKAEASSLVSWLSSIDMKYHIWKLGVVFTDN SFLYLAWYTSMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC FRKQYEDQLG NT seq 14613 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcttgcggactgaagatgag gtggttctccagtgcatcgcaaacattcacaaggagcaaaggaagttctgcctggcagcc gagggccttgggaaccgcctgtgcttcctggagcccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaattttgtgctggaacagtccctctctgtgagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggcagcacaagggggcggccac aggaccctgctatatggccacgcaattctcctgcggcactccttcagtggaatgtatcta acgtgtttgaccacatcgagatcccagacagacaaacttgcatttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagagatct gagggagagaaggttcgaattggtgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctcagtatcaaatgggaatatacaagtggacgcctcttttatgcagaca ctctggaacgtgcatcctacgtgctcaggaagtagcattgaggaaggatacctactcggt ggacacgtagtacgtctcttccacggtcacgatgagtgtttgacgataccatctacagac cagaatgatgcccagcacaggaggatattctatgaaactgggggagctgggacacgagcc agatctctgtggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggccaggctttccgcctccggcatctcaccacaggccactatctggccttgacggaggac caaggccttatactgcaggaccgggcgaagtcagacaccaagtccacagccttctctttc cgggcttctaaggagatcaaggagaaattggattccagtcacaagcgagatatagaaggc atgggcgttccagaaatcaagtatggcgattccgtctgctttgtgcagcatgtagccagt ggtctatgggtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaa agaaaggtcatactccatcaggaaggccacatggacgacgggttaacactacagagatgc cagcgcgaggagtcgcaggctgctcggatcattcggaacacgacagctttattcagccag tttgtaagtggaaacaatcgcacggctgccccagtcaccctgccgatcgaagaggtcctg cagaccttacaggacttgattgcctactttcagcccccagaggaggagatgcggcatgaa gacaaacagaacatggtccgctcactcaagaacaggcagaatcttttcaaggaagaagga atgttggcccttgtgttaaactgcatcgaccgcttgaatatctacaacagcgtagcgcac ttcgcagggatcgcaagggaggagagcggcatggcttggaaagagaccctgaacctcctg tacaaactgctggctgctctcattcgtggaaacaggaacaactgcgctcaattctctaat aaccttgattggctaatcagcaaattggaccgactagaatcttcctcaggtatcttggaa gttttgcactgtatcttgattgaaagcccagaagccttaaatctgatagccgagggccac atcaagtccatcatctccctgttggataagcatgggcggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgcagtcagagccaaccagaatctgatttgt gacaacttgctgccccggagaaacctgctcctgcagacccggctgattaatgatgtgacc agcattcggcccaacatcttcctgggagtcgccgagggctcggcgcagtacaagaagtgg tactttgagctgatcatcgaccaggtggaccccttcctaacagccgagcccacacacctg cgggtgggctgggcctcttcctcaggctatgctccgtaccctggcggaggggaaggatgg ggaggcaacggtgtcggcgatgacctgtactcctatggctttgatggacttcacctttgg tcaggccgcatacccagagccgtagcctccatcaaccagcacctcctgagatcagatgac gtggtgagctgttgccttgacctcggagtgcccagcatctccttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctacgccccttgctatgaagccttacttccaaaagagaagatgaga ttggagcctgtcaaagaatataaacgtgacgctgaaggcgttagagatcttctgggtacc acccagtccctctcccaagcctctttcatcccatgccccatagacaccagtcaggttgtt ttgccccctcacctagaaaagatccgagacagactggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaactgaaaccttaaaaaccctcctggcgctggggtgccgcattgctcatgtg aatccggctgctgaggaggagctcaagaaggtcaaattgcccaaaaactatacgatgtcc aatggctataagccagcccctttggatctgtctgatgtgaagctgttgcctcctcaagaa attttagtggataagcttgcagaaaatgcacataacgtttgggccaaagacagaataaaa caaggatggacttatggcatccaacaggatttgaagaacaagagaaatccccggctggtg ccatatgcattactggatgagcgtaccaagaagtccaatagggacagcctccgcgaagct gttcgcacatttgttggttatggctacaacattgagctgtcggaccaagaactggctgac ccagctgtggagaaagtcagcattgacaagatccgatttttccgggtagagcggtcttat gcagtgagatccggaaaatggtattttgagtttgaggtggtgaccggaggagacatgcgc gttggctgggccaggccgggctgtcggcctgacattgagctgggtgccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcgctggcatcaaggcagtgggtattttggacgt acgtggcagccaggagatgtggttggatgtatgattaacctggctgatgcttcgatgatc ttcacgctgaacggggagctgctgatcaccaacaaaggctctgaactcgccttcgctgat tacgagattgagaatggctttgtgcccatctgctctctgggactgtctcaaatcggccgc atgaatctcgggatggatgccagtaccttcaagttttataccatgtgcggactccaagag ggctttgagccttttgccgtcaacatgaaccgcgacgtggcgatgtggttcagcaagcgc ctcccgacgttcgtcaatgtgccaagggatcacccccatatagaggtggtgaggatcgat ggcaccatggacagcccgccatgcctcaaggtgacgcacaagacgttcggcacacagaac agcaatgccggcatgatctactgccgcttgagcatgcccgtcgagtgccactcctccttc agccacagcccctgtctggacagtgacgctttccagaaaaggaaacagatgcaagaaata ctgtctcatacaacaacacagtgctactatgcaatccgcatctttgctggacaggaccct tcctgcgtctgggttggatgggtgacgccagactatcacttacacagtgaaaaatttgac ctgaataaaaactgtacggtgactgttactctaggggatgaaagaggccgggtccacgaa agtgtgaaacgcagcaactgctacatggtctggggcggggatattgtggccacctcccaa agatcaagtcggagcaacgtggacctggagatcggctgcctggtggatctggccatgggc atgttgtccttctcggccaatgggcgagaactcggcacctgctaccaggtggagcccaat accaaagtgtttccagcagtcttcctgcagcccacgagcacttccttgtttcagtttgaa cttgggaagctgaagaacgcgatgcccctgtcggcggccatatttaagagtgaagagaag aacccagttccgcagtgtccacctcggctggatgtccagaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacggagcgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggccctccacatccccgaggagaac aggtgtgtggatgtcctggagctctgtgagcaggaggacctgatgcagttccattaccac actctacgactctacagtgccgtgtgcgccctgggaaacagccgggtggcctacgccctg tgcggccacgtggacctctcccagctcttctatgccatcgacaaccagtacctccctggc ctcctccgctctggtttctatgacctgctcatcagcgtccacctggccagcgctaaggag aggaagttactgatgaagaacgagtacatcattcccatcaccagcagcaccaggaagatc cgcctgtacccagacgagaccaagaggcacgggctgccaggggtgggcccgagaacgtgc ctcaagccagggttcaggttctccaccccttgctttgtggtgaccggcgaggagcaccag aagcagagccctgagatccccttggagattctcaagacgaaggcactgagcatgctgacg gaggccgtgcagcacagcggggctcacatccgggaccctgtgggcgggtctgtggagttc cagtttgtgcccgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgatgat gacgacgtccggcagatcctcctcctgatcgacccctctgtgtttggggagcacagtgcg gagacagaggacggagccgagaagaaggaagtgacccaggtgggggagaaggcagtggag gctgggagaaaggccagcaaggaggctccagtcaaaggcttgttgcagacccgactgcca gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcag catcgagtggaagccattgtcgcatttggcgacatttatgtctccaaactccaggcaaat cagaagttccgctacaatgagctcatgcaggccttgaacatgtccgcagcgctgactgcc cggaagaccagggagttccgctcccccccacaggagcagatcaacatgcttcttaatttt caactgggagagaattgcccctgcccagaggagatccgggaggagctctatgacttccat gaggaccttcttattcactgtggcgtccccctggaggaggaggaagaggaggaggaggac acctcctggactgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcct gagacggaacagccaacagaagaggaagagagatcccctacaaccttgaaggagctcatc tcacagaccatgatccgctgggcccaggaggaccagatccaggatgcggagctggtccgg atgatgttcagcgtcctccggagacagtacgacagcatcggggagctgctgcaggccctg cggaagacctacaccatcagtcaggcctccgtgagcgacaccgtcagcctgctggccgcg ctgggccagatccgctgcctgctcagtgtcaggatgggcaaggaggaggagctgctcatg atcaacgggctgggagacattatgaacaacaaggtgttctatcagcatcccaacctcatg cgagtccttggcatgcacgagacggtgatggaggtgatggtgaacgtgttgggcacggag aagtctcagattgcttttccaaaaatggttgctagctgttgccgcttcctctgctatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagttacctgttggag aatagcagtgttggcctagcttccccttcgatgagaggatctaccccactggatgtggcg gcttcctctgtgatggacaacaacgagttagcgctgggcttagaggaaccagacctcgag aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaa ggataccctgatgtcggctggaaccctattgaaggggaacgttatctgtccttcctgagg tttgccgtctttgtgaacagcgaaagcgtggaagaaaatgcaagtgttgtggtcaagctg ctcattagacgcccggagtgcttcggcccagccctgcggggtgaaggaggaaacggtcta ttggcagccatgcagggcgccattaagatctctgagaacccagccctcgacctcccttcc cagggatacaagagagaagtcacggaggacagtgaagatgaagagatcgtgcacatgggc aacgcaattatgtctttttattcagctctcatagatctgctgggccgctgtgcgcctgaa atgcacctcatccagacaggaaagggggaagccatccggatcaggtcaatcctgcgctcc ctggtccccaccgaggacctggtcgggatcatcagcatccccttgaagctgccctccctg aacaaagatgggtctgtctgtgagccagatatggcagccaacttctgccctgaccacaag gcacccatggtgctgttcttggatcgtgtttatggcattaaggatcaaacttttctgctc cacttgctagaggttggatttttacccgacttaagagcctctgcctctctagatacggtt tccctgagcaccacagaggctgcgcttgccctcaataggtatctatgttctgccgtgctc ccactcctcacaaggtgcgcccctctctttgccggaacagaacactacacgtctctgatc gactctacactacagacaatatacagactttccaagggacgttccctcaccaaagctcag agggacaccatagaggaatgtttgcttgccatttgcaatcacttgaggccttccatgtta cagcaactcttgcgacgtctggtgtttgacgtaccgcagctcaacgagtattgcaaaatg cctcttaagctcctgacaaatcactatgaacagtgctggaagtattactgtctgccttca ggatgggggagctacgggctggctgtggaagaagagttgcatctgacggagaaactcttc tgggggatttttgactccctctcccgtaagaagtatgacccagaccttttccgaatggcc cttccttgtctcagtgctatagtgggggccctgccaccagattatttagataccagaatc tcagccacattggagaaacagatctcagtggatgcagatggcaactttgaccccaaaccc atcaacaccatgaatttctccttgcctgaaaaatgggaatacatcgtcaccaagtacgcg gagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatggaatt tcactggatgaaaatgtaaagacccatccactgatccggcctttcaagacattaacggaa aaggagaaggaaatctaccgctggcctgccagggagtccctaaaaaccatgctggctgtg ggctggtctgtggagaggaccaaagagggagaggccctggttcaacagcgggaaaacgaa aagcttcggagcgtgtcccaggccagccagggcaacagctacagccctgctcccctagac ctctccaacgtggtgctctccagggagctccagggaatggtggaggtcgtggctgaaaac tatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggtggtggcagt caccctctgttggtgccatatgacaccttgacagccaaggagaagttcagggaccgagag aaggcacaggacctgtttaaattcctccaagtgaatggcatcgtggtttcgagaggtatg aaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttgaag aagatcctgaaatatgttgattccgcccaagagtttattgcccatttggaagccattgtc agcagtgggaaaacggaaaagtctccccacgaccaggagatcaaattctttgccaaagtt ctcctcccactggttgaccagtacttcaccaaccaccgcctctacttcctgtcatcccca ctgaagccccttagcagcagcggctatgcctctcataaggagaaagaaatggtggccagc ctcttctgcaaactcgccgctcttgttcgacacaggatttccctctttgggagcgattct actgcaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatg aagtcaggctcagagctggtcaaggccgggttacgagcgttctttgaaaatgctgcagaa gacttagagaagacttcagaaaacctgaagctggggaagtttacccattccaggacgcag attaaaggcgtgtctcagaatatcaactataccacggcggccctgctccccatcctgacg tccatctttgagcacgttgcccagcaccagttcggggtggatttactcttaggcgatgtg cagctttcgtgctaccacatcctgtgcagcctctactcccttgggaccggaaagaatatc tatgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgccatc ccagtggcattcctggagcccacccttaaccactacaatccactctcagtcttcaacacc aaaacccccagggagaggtctattctgggcatgccggacacagtggaagagatgtgtcct gacatcccgcagctggaaggcctgatgaaggagatcagcgacctggccgagtcaggggcc cggtacacggagatgcctcacgtcatcgaggtgatcttgcccatgctgtgcaactacctg tcttactggtgggagcgggggcctgagcacctgccacccggcactgggccctggtgcacc aaggtcacctctgaacacctcagtgtcatcctgggaaacattctgaaaatcatcaacaac aacctgggcatcgacgaggcgtcctggatgaagcgcatcgcagtgtacgcccagccgatc atcagcaaagcccggcctgacctgctgaaaagccacttcatccccactttggagaagctg aagaaaaaggctgtcaagaccgtgcaggaggaggagcagctgaaagccgacaccagagga gacactcaggaggcagagctcctcatcctggacgagtttgcagtcctctgcagagacctc tacgccttctaccccatgctgatccgctacgtggacaacaacagatctaactggcttaaa agccccggtgctgactctgaccagctcttccgcatggtggcagaggtcttcatcctgtgg tgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaattaat aatttggcatttttaactggcgacagcaaaagcaagatgtcaaaagccatgcaagtaaag tccggagggcaggaccaggagcgcaggaagacaaagcggaggggagacctgtactccatc cagacctctctcatcgtggccgcgctcaagaagatgctgcccatcggtttgaatatgtgc acgccgggcgatcaggagctcatctccctggccaaggcccgatacggctccagggacaca gatgaagaggtgaaagaacatctgcggaataacctgcacctgcaggagaagtccgatgac ccagcagtaaagtggcaactgaacctctacaaagatgttttaaagagtgaagaacctttc aatccagaaaagaccgtagagcgtgtacagagaatttcggcagctgtcttccacctggag caggtggaacagcctttgaggtccaagaaggcggtctggcacaaactgttgtcaaagcag cggaaacgggcagtggtggcctgtttcaggatggcccctctctacaacctgcccaggcac cgctccattaacctcttcctccatggctatcagagattttggatagaaacagaggagtat tcctttgaagagaaactagtacaggacttggctaaatcccccaaggtggaagaggaggag gaggaggaggagacggaaaagcagccagatccacttcatcagatcattctccattttagc cgcaatgctctcacggagaggagcaaattggaagacgaccccttgtacacgtcctattcc agcatgatggccaagagttgtcagagtggggaagacgaagaagaggaggaagacaaggaa aaaacatttgaagagaaagaaatggaaaagcagaaaaccctctaccaacaagcgaggctg catgagcgtggagccgcagagatggtccttcagatgataagcgccagcaaaggtgagatg agccccatggtggttgagactctgaagctggggatcgccattctaaatgggggcaacgct ggtgtacaacagaaaatgctagattacctgaaggagaaaaaggatgccggattctttcaa agcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcattcgaaaggcag aataaagctgaaggcctggggatggttactgaggaaggaacactcattgttcgtgagcgt ggtgaaaaagtacttcagaatgacgagtttacacgagatctcttcagattcctgcagtta ctttgtgaaggacataacagtgactttcagaacttcctgcggactcagatgggcaatacc accaccgtaaacgtcatcatcagtaccgtggactacctcctgcgtctgcaggaatcaatc agtgatttctactggtattattcagggaaggacatcattgacgaatctggacagcacaat ttttccaaagctctggcagtcacgaagcagattttccattctcttacggaatacatccag ggcccttgcattgggaaccaacagagcctggctcacagcaggctgtgggacgcggtggtc ggcttcctccatgtgtttgctaacatgcagatgaaactctctcaggattccagtcagatc gagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctc ctggaagggaatgtggtaaatggaactatcggcaagcagatggttgacacactggtagag tcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagac ctaaccagctcagacaccttcaaagtatatgacccagacggtaaagggattatctccaaa aaagagttccagaaggccatggaagggcaaaaacagtacacacagtcagagactgacttt ctcctttcgtgtgcagaagctgatgagaacgatatgtttaattacatcgattttgtagac cggttccatgagccggccaaggacatagggtttaatgtggcggtgttactgacaaatctc tccgaacatatgccaaatgattctcgcctgaagtgtctgttggacccagcagaaagcgta ctgaattactttgagccctacctgggacgtattgagatcatgggtggggccaagaaaatt gagcgcgtttatttcgagatcagtgaatccagtcgaactcaatgggagaagccccaagtg aaggaatcgaaacggcagttcatcttcgatgtggtcaatgaaggcggagagcaagaaaag atggaactgttcgtgaacttctgtgaggataccatctttgaaatgcagttagcctctcag atctctgaatctgactcagcggacaggcctgacgacgaggaggaaggaggtgaagattca tcttacttgttagaaattgagggtggagagcaggatgacaagtcttttgaatctgcctct gcgtttgccatggcctgcgcctccgtgaagaggaacgtcgccaactttctgaggaaggcc accctgaggaacctgcggaagcagtgcaggaaggtgaagaagctgaccgtgaaggagctg gtgaaggagttcttctctttcttctggatgttgtttgtggggctcttccggttgttcttc accatattgggaggaatctttcagatcctctggaacacggtgtttggagggggcctagtg gaaggggcaaagaacatcagagtgaccaagatcttgggggacatgcctgaccccacccag ttcgggatccatgaggacactctggatgcggagcgggtggaggtgactgagccaggtgtg cccccagaactgattcacttcgtgaagggtgagaagggagacgcagaagctatgtcagag ctctttggattccgcccaaagaaagaaggcggcttaaagcacaggcccgaagggggtttg ggtgacctctcggagattattggcaaggatgaacccccaacgctagagagtactgtacgg aagaaaaggagagcacaggcagcagagatgaaagcagcacatgaagcagaagggaaagtg gagccagagaagacagacctggaagacggggagaaggaggttatggccaaagaggaagag caagccaaggccctgtggacagacgtgacaaagaagaagaagcgacggcggggccagaaa gtcgagaagcctgaagccttcatggctaatttcttcaaagggctggaaatctatcagaca aagttactgcactacctggccaggaatttctacaacctgaggttcctcgctctgtttgta gccttcgcgatcaacttcatcctgcttttttacaaggtcactgaagaacctttagaagaa gagacggaggatgttgcaaacctgtggaactcctttaacgacgaggaagaggaggaggcg atggtgttcttcgtcctgcaggagagcactgggtacatggcgccgatgttgcgggccttg gccgtcatccacaccgtcatctctttagtctgcgtggtgggctattactgcctgaaggtc cctctggtggtattcaaaagggaaaaagaaattgccaggaagctggagttcgatggcctg tatatcactgaacagccatctgaagatgacatcaaagggcagtgggaccgcctggtaatc aacacaccatcttttcctaataactactgggacaagtttgtcaagagaaaggtgatcaac aagtacggagatctctacggagcagaacgcattgctgagctcctgggtttggacagaaat gcccttgatttcagcccggtcgaagagagcaaagcagaggcgtcctctctggtgtcatgg ctgagttccatcgacatgaagtaccatatctggaaactgggagtcgtttttaccgacaac tcctttctctaccttgcctggtatacaagcatgtccgtcctgggccactacaacaacttc ttcttcgccgctcatctgctggacatcgcgatgggcttcaagacgctgaggactattctg tcatctgtaactcacaatggcaagcagctggttctgactgttgggctcctggccgtggtg gtttacctttacaccgtggtggccttcaacttcttccgaaagttctacaacaaaagtgaa gatgacgatgagcccgatatgaagtgtgacgacatgatgacgtgttacctgttccacatg tacgtgggagtgagagctggaggtggcattggcgatgaaatcgaagaccctgctggtgac ccttatgagatgtaccgcattgtctttgacattaccttcttcttctttgtcattgtcatc ttgctggccatcattcaaggtctcattatcgatgcttttggagagctaagagaccagcag gaacaagtgcgagaagatatggagactaaatgtttcatctgtgggattggcaatgactat tttgacacgacgcctcatggctttgagacacataccttacaagagcacaacttagccaac tatttgttcttcctgatgtatctcattaataaagatgaaacagaacacacgggacaggaa tcttatgtctggaagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgc tttcggaaacaatatgaagatcagcttggataa

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