Amycolatopsis mediterranei S699: AMES_7014
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Entry
AMES_7014 CDS
T02190
Symbol
bkdA
Name
(GenBank) 2-oxoisovalerate dehydrogenase E1 component
KO
K11381
2-oxoisovalerate dehydrogenase E1 component [EC:
1.2.4.4
]
Organism
amm
Amycolatopsis mediterranei S699
Pathway
amm00280
Valine, leucine and isoleucine degradation
amm00640
Propanoate metabolism
amm00785
Lipoic acid metabolism
amm01100
Metabolic pathways
amm01110
Biosynthesis of secondary metabolites
amm01210
2-Oxocarboxylic acid metabolism
Module
amm_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
amm00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
AMES_7014 (bkdA)
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
AMES_7014 (bkdA)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
AMES_7014 (bkdA)
Enzymes [BR:
amm01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
AMES_7014 (bkdA)
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Motif
Pfam:
E1_dh
Transket_pyr
Transketolase_C
TPP_enzyme_C
DXP_synthase_N
BLH_phosphatase
Transketolase_N
Motif
Other DBs
NCBI-ProteinID:
AFO80549
UniProt:
A0A9R0P3W4
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Position
7873369..7875339
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AA seq
656 aa
AA seq
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MTATVATELSADPTALFELYRRMRLIRQFEDRASRLYRTNEIPGFLHLSIGQEASAVGAC
WPLDDRDVVTSTHRGHGHCIAKGLDVTGMFAELMGRRTGTCQGRGGSMHIADPRKGIFGA
NGIVAAGLPIATGAATAAQLRGRGGVVLAFFGDGAVAQGMFHEAVNLAAVWQLPVIFCCE
NNHYAEFSAAADQHRATLADRARGYGVEYAHVDGNDVVAVADTVTALVADLRAGAGPVLL
EAETYRWHGHYEGDPERYREPEELAAWKERDPLPRLAARLDPGRIAEIDHEIDILIEKAV
AEAKAAEEPAPETLHHYVGVPREPVAEPPEPTGEIFRTMDAVHEALDYELGSDEGVFVAG
IDVGAGGNVFGLTRGLAEKYPGRVRDTPISESAVVGVGVGAAMAGMRPVVELMYMDFIGV
CLDQLMNQAAKLRFMTGGAVTLPLVVRTQFGAGKSSGSQHSQSLEALLAHIPGLTVVMPS
TPADTYGLLRAAIRDPNPVVFVENRLLYGRKGPRPEPGHLIPLGKAAIRREGTDVTLVSY
SKLVHDCVTVAEQLAGEGISVEVIDLRTIAPLDAETVLRSLAKTGRLVIAHQAVEQFGVG
AELAALAADEGFWTLDAPVIRVGAAATPAPYAPSLEREWLPSPDRIAAAVRRSAAA
NT seq
1971 nt
NT seq
+upstream
nt +downstream
nt
atgactgccactgttgccaccgagctttccgcggatccgacggcgctcttcgagctgtac
cggcgaatgcgcttgatccggcagttcgaagaccgggcgtcgcggctgtaccgcaccaac
gagatccccggtttcctgcacttgtccatcggccaggaggcatccgcggtaggtgcttgc
tggcccctcgacgaccgcgatgtcgtgacctcgacccaccgcgggcacgggcactgcatc
gccaaaggcctcgacgtcaccggcatgttcgccgagctgatgggccggcgcaccggaacc
tgccagggccgcggcggctcgatgcacatcgccgacccccgcaaggggatcttcggggcg
aacgggatcgtcgcggcaggcctgcccatcgcgaccggagccgccaccgccgcgcagctg
cggggacgcggcggagtcgtgcttgcgttcttcggcgacggcgcggtcgcgcagggcatg
ttccacgaggccgtcaacctggccgcggtgtggcagctgccggtgatcttctgctgtgag
aacaaccactacgccgagttctcggccgccgcggaccagcaccgcgcgacgctggccgac
cgcgcccgtggttacggcgtcgaatacgcccacgtggacggcaatgacgtcgtggcggtc
gccgacacagtgaccgcactcgtcgccgacctgcgtgcgggtgccggaccggtactgctg
gaggccgagacctaccgctggcacggacactacgagggcgaccccgagcgctaccgcgag
cccgaggaactggccgcgtggaaggaacgcgacccgctgccgcggctggccgcgcggctc
gaccccggccggatcgcggagatcgaccacgagatcgacatcctgatcgagaaggccgtc
gccgaggccaaggcggccgaagaacccgcgccggagacgctgcaccactacgtcggtgtg
cctcgcgagccggtggccgagccgccggagccgaccggcgagatcttccgcacgatggac
gccgtccacgaggcgctggactacgaactcggctccgacgagggcgtcttcgtcgccggg
atcgacgtcggtgccggaggcaacgtcttcggcctgacccgcgggctcgcggagaagtac
ccgggacgcgtgcgcgacactcccatctccgaaagcgcggtcgtcggtgtcggcgtgggc
gccgcgatggccgggatgcggccggtggtcgagctgatgtacatggacttcatcggcgtc
tgcctggaccagctgatgaaccaagccgcgaagctgcgcttcatgaccggcggcgcggtg
accctcccgctggtggtgcgcacgcagttcggcgcgggcaagtcatcgggcagccagcac
tcgcagagcctggaggcgctgctggcgcacatccccgggctcaccgtcgtaatgccctcg
acaccggccgacacctacgggctgctgcgggccgcgatccgcgaccccaatcccgtcgtg
ttcgtcgagaaccggctgctttacggccggaaaggaccgcgaccggagccggggcacctg
atccccctggggaaggccgcgatccgccgggagggcaccgacgtcacgctggtctcgtac
tcgaagctggtgcacgactgcgtgacggtcgcggagcagctggccggcgagggcatcagc
gtggaggtcatcgacctgcggaccatcgcaccgctggacgccgagaccgtcctgcgctcg
ctggccaagactggccggctcgtcatcgcgcaccaggccgtcgaacagttcggggtcggg
gcggaactggccgcgctcgccgcggacgagggcttctggacgctcgatgccccggtgatc
cgcgtcggcgcggctgcgacgccggcgccgtatgcgccctcgctggaacgcgagtggctg
ccgagtccggaccgcatcgccgccgcggtgcgccggtcggcggccgcctga
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