Anopheles marshallii: 128708283 Help Entry 128708283         CDS       T10928                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism amrs  Anopheles marshallii Brite KEGG Orthology (KO) [BR:amrs00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:amrs04040]     128708283    04990 Domain-containing proteins not elsewhere classified [BR:amrs04990]     128708283 Ion channels [BR:amrs04040]  Voltage-gated cation channels   Ryanodine receptor    128708283 Domain-containing proteins not elsewhere classified [BR:amrs04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    128708283 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR Ins145_P3_rec SPRY MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 TPR_TTI1_C GET2 Motif Other DBs NCBI-GeneID:  128708283 NCBI-ProteinID:  XP_053659218 LinkDB All DBs Position 2:82250581..82280165 Genome browser AA seq 5114 aa AA seqDB search MAEAEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETVSMPGKGTGSGHRTLLYGNAILLRHNNSDMYLAC LSTSSSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLH TTKENDLSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTWN LDPGQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWSHPMRIRHLTTGRYLGVNENN ELILMSRDQATTSQTAFVLRLEKDDQKVVLEDKDLEIIGAPIIKYGDSTVIMQHYESGLW VSYKSYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTKFI SGLETLQENRRHSIFLQTVNLGEMVMCLEDLINYFAQPEDDMEHEEKQNRLRALRNRQDL FQEEGVLNLILEAIDKINIISSQGFLASFLASDESGQSWDMISGYLYQLLAAIIKGNHTN CAQFANSNRLNWLFSRLGSQASSEGSGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTGLVDHVASIRPNIFVGR VEGSAIYQKWYFEVTMDHIEQMTHMMPHLRIGWANTAGYVPYPGGGEKWGGNGVGDDLFS YGFDGVHFWSAGRRTCVVPREVTEPYIKKGDVIGCTLDLSVPVIRFTFNGEPVQGCFTDF NLDGMFFPVMSCSSKLSCRFLFGGDNGRLKFSPPTGFSPLVQCLMPHQNLSLDPCFYFGN LNKNVLAGPWLVEDDSAFVPKPVDTSPVTLPSSVETIRDKLAENIHEMWALNKIESGWTW GERRDDVYRIHPCLTSFEKLPAAEKRYDCQLAVQTLKTILALGYYISMDKPPARIRPIRL PNDPYMQGNGYKPAPLDLSAAVLTPKMEELVDQLAENTHNLWAKERIQQGWTYGLNEDSE NLRSPHLVPYSKVDEAIKKANRDTASETVRTLLIYGYNLDPPTGEANEALAAEALRQKFA AYRTYRVERTYAVTSGKWYFEFEVLTAGPMRVGWARADCNPGTMLGSDDASWAFDGYNAR KMHLHTVEDFGRRYKIGDIIGCFVNVHEKSMSFSLNGELLMDALGGETTFADVTAPDGVG FVPACTIGIGQKARVVYGQDVDSLKWFTTCGLQEGYEPFCVNMKRPVTHWYTKDQPIFEN TDEIPEGKIDVTRIPGGADTPPCMKISHNTFETMEKANWEFLRLSLPVTCANTFISEQEK MRRWEEIRIRQHRLMTEVDHSAPAHFDHIMRSGFTMNDIKGLHRNYSEDAAEADEMMRNG PRRPSRHQARGGLSPPGIEINGEATSDGELNAYSDNELEGGDDRKKRGRSPFRLFGKKRD QSKDKLKDRRTPEPEPRKSNLKVTQRGQPTRMSNSDLRSQQPMAPERKGMGSPQVESFGN EVYDAECLRLINEYFYGVRIFPGQDPTHVYVGWVTTQYHVHSKEFGQNKVRHAAIYVEDE NEKTIEIVNRQSCYMVRADELFNEVTQDSSGKGASQGMFVGCFVDTATGTIRFTCEGKET SHVFLMEPDTKLFPAIFVEATSKEILQIELGRTPTTLPLSAAVLPTSDKHINPQFPPRLK VQCLKPHQWARVPNTALQVHALKLSDIRGWSMLCEDPVSMLALHIPEEDRCIDILELIEI DRLLQFHAHTLTLYSALCYQSNYRAAHALCSHVDQKQLLYAIQSEYMSGPLRLGFYDLLI SLHLESHATTMEVCKNEYIIPLGSDLRELYIDPEMCHSLRSLQTLSVRPEMNMTEIAPTP SQSNMPTIVAPDSSSEPIPAIDSLYSPRFPLEVVREFVMSALQEAVQINQVHNRDPIGGS NENLFLPLIKLIDRLLLVGVITNEDVEKLLIMIDPETWDPLFEKEGKDEHRKGLLTMKMA EGAKLQMCYLLHHLYDVQLRHRVESIIAFAFNYVGDLQQDQLRRYIEIKQSDLPSAVAAK KTREFRCPPREQMNAILGYKNLEEEDLENASCGPDLRNKLIEFHEKLMGKVSLNALQEPE EPEADKLEEGKPGALKKLYNFINAVKELEEDPKEPEEEEKKTPEEVFRKVLIKQLVSWAE ESQIENPKLVREMFGLLVRQYDTIGELIKALNKTYVINSKTKGDVANMWIGLSQIRALLP VQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRILRVHENVMAVMMNTLGRRAQAQSDAPV QTAEGEESAPKEKDTSHQMVVACCRFLCYFCRTGRQNQKAMFDHFDFLLENSNILLSRPS LRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRCGLQSNSELIERGYPDLGWDPV EGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEGEGLLKAIIDANKMS ERITERRKMQDEAEGTIAGLNFAHPLPEGDDDEDYIDTGAAILCFYCTLVDLLGRCAPDA AVIEQGKNESLRARAILRSLVPLEDLQGVLSLKFTLTNPAMGEDRPKSDMPSGLVPGHKQ SIVLFLERVYGIETQELFYRLLEDAFLPDLRAATMLDRSDGSESDMALSMNRYIGNSILP LLIKHSKFYNEAENYASLLDATLHTVYRMSKNRMLTKGQREAVSDFLVALTSAMHPAMLL KLLRKLTIDVSKLSEYTTVALRLLTLHYERCAKYYGTTGGGQASQFGASSDEEKRLTMLL FSNIFDSLSNMDYDPELFGKALPCLIAIGCALPPDYSLSKNSDDDLYGKPTGGGPDQPHY NPQPIDTTAVQLTNDLNQIVQKFSEHYHDAWASRKLENGWTYGDQWSDVNKTHPRLKPYN TLSEYERERYREPVRESLKALLALHWRIEHSEGDVPLSNRGSMRRQSKPNLVSTQFKVNT GSPFNYNPHPVDMTNLTLSREMQNMAERLAENSHDIWAKKKNEELNQCGGAIHAQLVPYD LLTDKEKRKDRERSQEFLKYLQYQGLKLHKPSRGQTEEPGMSTAAIELRFAYSLLEKLIS YSDRATINMKLLKPSSTFSRRTSFKTCSRDIKFFSKVVLPLMEKYFSTNRNYFIAIATAT NNVGAASLKEKEMVAALFCKLASLLRYRLAAFGADVRITVRCLQVLVKSIDAKSLVKNCP EFIRTSMLTFFNNTADDLGQTIVNLTEGKYDRLRGTHLKTSTSLAYVNQVILPVLTSLFD HLAACDYGSDLLLDEIQVASYKILSALYTLGTDMSLTRDRKYLKTELERHKPALGSCLGA FSSCFPVAFLEPHANKHNPFSLLNRIADTSLEAQDIMSKMECCMPTLESILSEVDQFVES EKTYQEAQHIIDVILPLLCSYLPFWWNQGPDNVSPQSGNHVTMVTADHMNHLLKNVLKMI RKNIANENAPWMTRIATYTQQIIINSSEELLKDVFLPLAERVKKRCDSMFHKEESLRGFL KSSTDDTSQIEAQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLKDNVSEAEELYNYVAE IFNVWSKSQYFLKEEQNFISANEIDNMALIMPTATRRSAAVSGDMPAAGGKVKKKKRSRD KKRDKDKEIQSSLMVACLKRLLPVGLNLFAGKEQELVQHCKDRYLKKMPEYEVIEFARTQ LTLPDKLDPADEMSWQHYLYSKLGKKEQIVQDALEKTDKKPENKIEDTVERIVAMAKVLY GLHMACRPRAKGLNWTHVLSQARRKMAVACLRAKPMYRLSRHRACNIFARSYSELWLEDE NVGQEVMIEDLTQTFEDAEKKKKDEEEEEGKPDPLTQLVTTFCRGAMTERSGALQEDPLY MSYASIVARSCGEEEEEGGDEEEGAGEDEGGASIHEQEMEKQKLLFHQARLANRGVAEMV LLHISASKGVPSEMVMRTLELGIAVLRGGNIDIQMGMLNHLKEKKDVGFFTSIAGLMNSC SVLDLDAFERNTKAEGLGVGSEGAAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQNYLRT QAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTL TEVIQGPCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMIT MMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLKDLTSTPSFMEIDANGD GWILPKDFREKMEQQKSYTPEEIDFLLACCETNHDGKIDYIGFVDRFHEPAKEIGFNLAV LLTNLSEHMPNEPRLARFLETAGSVLNYFESFLGRIEIMGSSKRIERVYFEIKEANIEQW EKPQIKESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMASDDDGGTVRRDQ SFTYISEEEEERAARDPIKRTIQAVKDGLSYSVYMISPSNIKHQITVLQSKSFPEIIVGF FKMIFYSFYYSAFGVSVVIKYLINILMSLMRGPAQEAEEPMPEAEPSLHALPPLPLEEPP GTVQAFGLDISKEENGQYRMAPHESPALSPSSSIEETGESSPEDGAAELTGEGVPPGEQM TLVDLLGGEAAKRAAQERTEAQKAQEATLASIEAESKKASSETKEPAAVHQIDFSKYTKK CVSYLARNFYNLKYVALVLAFCINFMLLFYKVTTFGDEEEGEGSGESLMGLGSGIGSGLG ILETGSGGGEGGSGDGEGEEEDPLEKVEVDEDFFYMEHVLRVAAILHSLVSLCMLIAYYH LKVPLAIFKREKEIARRLEFDGLFIAEQPEDDDIKSHWDKLVISAKTFPVNYWDKFVKKK VRQKYSETYDFDSISNLLGMEKTAFAAQEANEGGGFFHFIANIDWRYQIWKAGVTITDNS FLYSLWYFSFSVMGNFNQFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIV YIYTVIAFNFFRKFYVQEDDDGEEGDRKCHDMATCFVFHLYKGVRAGGGIGDEIGDPDGD EYEVYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQLESVKEDMESNCFICGIGKDY FDKVPHGFDTHVAQEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDC FRKQYEDELGGGGS NT seq 15345 nt NT seq  +upstreamnt  +downstreamnt atggctgaagcagagggaggatccgagcaggatgatgtttcattcttgcgcacggaagac atggtctgcctgtcctgcacggcaaccggtgagcgcgtgtgtctggcggccgaaggtttc ggcaaccggcactgcttcctggagaacatcgcagacaagaacatcccgccggacctatcg cagtgcgtgttcgtaatagagcaggcgctgtcggtgcgtgcactgcaggagctggtcact gccgccggttcggaaaccgtaagtatgcccggcaaaggtacggggtccggccataggacg ttgctttacggcaatgctattctgttgcgtcacaacaacagtgacatgtaccttgcctgt ctgtcgacttcgtcctccaacgacaagctgtcgttcgacgtcggtctgcaggagcacagc cagggtgaagcctgttggtggaccgtacatccagccagcaagcaacgttcggaaggtgag aaggtccgagtcggtgacgatctgattctggtgtccgtcgctaccgagcgttatctgcac accaccaaggaaaatgatctgtcgatcgtaaacgccagcttccacgtgacgcactggagc gtacagccgtacggaaccggtatctcgcgcatgaagtacgtcggttacgttttcggtggc gacgtacttcggttcttccacggcggtgacgaatgtctaacgatcccaagtacctggaac ttggatccgggtcagaacattgtcgtatacgagggtggctctgtgatgtcacaggcacgt tccctatggcgactggagctagcccgtaccaaatgggccggggggttcatcaattggtcg catccgatgcgtatccggcatttgaccaccggccggtacctcggtgtgaacgaaaacaac gagctgatactgatgagccgcgaccaggccaccacctcgcagaccgcctttgtcctccgt ctcgaaaaggacgaccagaaggtagtgctggaggacaaggatctggaaatcatcggtgca ccgatcatcaagtacggtgactcgaccgtcatcatgcagcactacgaatcgggcctatgg gtcagctacaagagctacgaaacgaagaagaagggcgtcggtaaggtggaggagaagcaa gccatcctccacgaggaaggcaagatggacgatgggttggacttttcgcgctcgcaggaa gaggagtcacgtacggctcgcgtcatccgcaagtgcagcagtttgttcaccaagtttatt agtggccttgaaacgttgcaagaaaatcgtcgtcactcgattttcctgcagacggtcaac ctgggtgagatggtaatgtgcctggaagatttgatcaactatttcgcccagccggaggac gacatggaacacgaggagaagcagaaccggctgcgtgcgttgcgcaaccggcaggacctg ttccaggaggagggcgtgctcaatctgatcctcgaagcgatcgacaagatcaacatcatc tcgtcccaaggcttcctggcgtcgttcctggccagtgacgagagcggccagagctgggat atgatctccggctacctgtaccagctgctggcggccatcatcaagggcaaccacaccaac tgtgcccagtttgccaactcgaaccggttgaactggttgttctcgcgactgggatcgcag gcctccagcgagggttccggcatgctggatgtgttgcactgcgtgctgatcgattcgccg gaagcgctgaacatgatgcgagacgaacacatcaaggtgatcatttcgctgctggagaag cacgggcgcgatccgaaggtgttggacgtgctgtgttcgctgtgcgtcggtaacggtgtt gcggtacgttcctcccagaacaacatctgtgactttctgctgccgggcaagaatttactc ctgcaaaccgggctggtcgaccacgtggctagcatccggccgaacatctttgtcgggcgc gtggaaggatccgccatctaccagaagtggtacttcgaggtgacgatggatcacatcgag cagatgacgcacatgatgccccatctgcgcatcgggtgggccaacacggccggctacgtg ccgtacccgggcggtggtgagaagtggggcggtaacggtgtcggtgacgatctgttctcg tacgggttcgacggtgtgcacttttggtctgccggccggcgcacctgcgtagtgccgcga gaagtgacggaaccctacatcaagaagggtgacgttattgggtgcacgctggatctgagc gttccggtgattcggttcacgttcaacggcgaaccggtgcagggttgcttcaccgacttc aacctggacggtatgttcttccccgtgatgagctgctcgtcgaagctgagctgccgcttc ctgtttggcggtgacaatgggcgtctcaagttcagcccaccgaccggcttctcgcccctc gtacagtgccttatgccacaccaaaaccttagcctggatccgtgcttctacttcggcaat ctgaacaagaacgtgcttgccggtccgtggttagtcgaggacgattccgccttcgtgccg aaaccggtcgatacgtcgccggtcacgctaccctcgtcggtggaaacgatccgggacaag ctggcggaaaacatccacgaaatgtgggcgctgaacaagatcgagtccggctggacgtgg ggtgaacgtcgggacgatgtgtaccgcatccatccgtgcctgacgtcgttcgagaagcta ccggcggcggaaaaacgctacgattgtcagctggccgtccaaacgctcaagaccatcctt gcgctcgggtattacatctcgatggataaaccaccggcacgcatccggccgattcgcctg ccgaacgatccgtacatgcaaggcaacggctataagccggctccgctcgatctgagtgcg gccgtgctaacgcccaagatggaagagctggtcgatcagctcgccgaaaacacgcacaat ctgtgggcgaaggaacgcatccagcagggctggacgtatggactgaacgaagattcggaa aaccttcgcagcccccatctcgtaccatactccaaagtagacgaagcgatcaagaaagcg aaccgcgatactgcctccgaaacggtgcgcactctgctcatctacgggtacaatctggac ccaccgaccggcgaggcgaacgaagccttggccgcggaagcactgcgacagaagtttgcc gcgtaccggacgtaccgggtcgagcggacgtacgccgtaacctccggcaagtggtacttt gagtttgaagttctcaccgctggaccgatgcgggttggttgggcacgagctgattgtaac cccggtacgatgctgggcagtgacgatgcttcctgggcattcgatggatacaacgcgcgt aagatgcatctccatacggtcgaagactttggtagacgctataagatcggggacatcatc ggttgcttcgtaaacgtccacgagaagagcatgagtttctcgctcaacggtgagctgctg atggatgccctcggtggtgagaccacatttgcggatgttaccgcaccggatggtgttgga tttgtgccagcctgcactattggtatcggtcagaaggcgcgcgttgtatatggacaggat gtggattcgctgaagtggttcacaacctgcggtttgcaggaaggttacgaaccattctgc gtcaacatgaagcgccctgtcactcactggtacacgaaggatcagccgatcttcgagaat acggacgagattccggagggtaagatcgatgtgacgcgtatcccgggcggtgcggataca ccgccgtgcatgaagatctcgcacaataccttcgaaacgatggagaaggccaactgggaa tttttgcgtctatcactgccggtaacgtgcgccaataccttcattagtgagcaggagaag atgcgccgctgggaagagatacgcatccgccagcaccgtctcatgacggaggtggatcat tcggcaccggcacactttgaccatatcatgcgcagcggcttcaccatgaacgatatcaag ggtctgcatcgtaactattcagaggatgcagccgaagccgacgagatgatgcgcaacgga ccgagacgtccctcgagacatcaggctcgcggaggactcagtccaccaggcatcgaaatc aacggcgaggctacgagcgacggtgagctgaacgcgtactccgacaacgagctggagggt ggcgacgaccgtaagaagcggggccgtagtccgttccgtctgtttggcaagaagcgcgat cagagcaaggacaagctgaaggatcgtcgcacaccggagccggaaccgcgcaagagcaac ctgaaggtgacgcagcgtggccaacctacgcgtatgtcgaacagcgatctacgctcccaa caaccgatggcacccgaacgcaagggtatgggaagtccacaggtggagtcgttcggtaac gaggtgtacgatgcggaatgtttgcgcctgatcaacgagtacttctacggagtgcgcatt ttccccggtcaggatccgacgcacgtatatgtgggctgggtgacgacacagtaccatgtg cacagcaaggaatttggccagaacaaggtgcgccatgctgcgatctacgtggaggacgag aatgagaaaactatcgaaatcgtgaatcgtcagtcatgctacatggtgcgtgccgacgaa ctgttcaacgaagtgacgcaggactcttccggcaagggtgcctcacagggcatgtttgtg ggatgcttcgtcgataccgctaccggtacgatccggtttacctgcgaaggcaaggaaact tctcacgtgttcctgatggaaccggacaccaaactcttcccggccatcttcgtcgaggcg accagcaaggaaattcttcagatcgagctgggccgcacaccaacaacgctccccttgtcg gcagccgtactgcctaccagcgataagcacatcaacccacagttcccaccgaggctgaag gtgcagtgcctgaagccgcaccagtgggcacgcgtccccaacacggccctgcaggtgcac gccctgaagctgtcggacatccgcggttggtcaatgctgtgcgaagatccggtatcgatg ctggcactgcacatccccgaggaggaccgctgtatcgatattctcgagctgatcgagatc gatcgactgctgcagttccatgcgcatacgctaacgctctattcggcgctttgctaccaa tcgaactaccgtgccgcacatgcgctttgctcgcacgtcgatcagaagcagctactgtac gcgatccaatcggagtatatgagcggtccgctgcgtctcgggttttacgatctgctgatt tcactgcacttggaatcgcacgccaccacaatggaggtttgtaagaatgagtacatcatt ccgcttggatcggacctgagggagctttacatcgatcccgaaatgtgccactcgttgcgt tcgcttcaaacgctctccgtgcgaccggaaatgaacatgaccgaaatagcacccacaccc tcacaatcgaatatgccgacaatagtagcaccagattcttccagtgaacccataccggca attgactcgttatattcgccaagattcccactcgaagtggtgagggagtttgtgatgagc gcactgcaggaggcggtacagatcaatcaggtacacaaccgcgatcctatcggtggatcg aacgagaatctgttcctgcccctgatcaagctgatcgatcgcttactgctggtcggtgtc attacgaacgaagacgtcgagaagctgctgatcatgatcgatcccgaaacgtgggatcca ttgttcgagaaggaaggtaaggatgaacatcggaagggattgttgacgatgaagatggcc gagggtgcgaagctgcaaatgtgctacctgttgcaccatctgtacgatgtgcagttgcga catcgcgtcgaaagcattatcgcattcgctttcaactacgttggcgatttgcagcaggat cagttacgcagatatatcgagatcaaacagtccgatctgccgagtgccgtcgcggctaag aagacgcgtgaattccgttgtccaccacgcgaacagatgaacgccatcctggggtacaaa aatctcgaggaagaagacctggagaatgcctcgtgtggtccggatctacgcaacaagctg atcgagttccacgagaagctgatgggcaaggtgtcgcttaatgctctgcaggaaccggaa gaaccggaagcggacaagcttgaagagggtaaaccgggagcgctgaagaagctgtacaac ttcatcaacgccgtaaaggaactggaagaagatcccaaagaaccggaggaagaggaaaag aaaacgccggaagaagtgttccgcaaggtgctgattaagcagctcgtatcttgggcggag gaatcccagatcgagaatccgaagctcgtgcgcgagatgtttggactgcttgtgcgccag tacgatacgatcggtgagctgatcaaggctctcaacaagacgtacgtcattaactccaaa acgaagggtgatgtggcgaacatgtggatcggcctgagtcaaattcgtgccttgcttccg gtgcagatgagccaggaagaggaggaactgatgcgcaagcggctctggaagctggtcaac aatcacaccttcttccagcatccagatttgattcgtattttgcgcgtgcacgagaacgtt atggcggtcatgatgaacacgcttggacgtcgtgcccaggcacagagtgacgccccggta cagacggccgaaggcgaagagtccgcaccgaaggagaaggatacctcgcatcaaatggtg gtcgcttgctgtcgcttcttgtgttacttctgccgaacgggtcgccagaatcagaaggcc atgtttgatcatttcgacttcctgttggagaactccaacattcttctgtcgcgtccaagt ctacgcggctcgacgccgctggacgtggcgtactccagcttgatggaaaacacggagcta gcgctggccttgcgtgagcactatctggagaagattgccatttacctgtctcgttgcgga cttcagagcaactccgagctgatcgaacgtggctatcccgatctcggctgggacccagtg gaaggtgaacgttatctcgacttcttgcgcttctgtgtttgggtgaatggagaaagtgtc gaggaaaatgctaacctcgttattcgtttgctcatccgtcgaccggagtgtctcggaccg gcgctgcgtggtgaaggcgagggtcttctcaaggccatcattgatgccaacaaaatgtcc gaacgcatcacggaacgtcgaaagatgcaggacgaagcagagggtacgatcgcgggtttg aacttcgcccatccacttcccgagggagatgatgatgaggattacattgacaccggagct gccattctgtgcttctactgtacgctggtcgatttgctgggccgatgtgctccggatgct gcggtcatcgagcagggcaagaatgagtcactgcgtgcgcgtgccattttacgatcgctt gtgccgctggaagatctgcagggtgtgctcagcctgaagttcacactgaccaatccagcg atgggcgaggatagacccaagtccgatatgccatctggactggtgcccggtcacaagcag agcatcgtcctgttcctggagcgtgtctatggaattgaaacgcaggagctgttttaccgc ttgctggaggacgctttcttgcccgatctgcgggcggccacgatgttggatcgtagcgat gggtcggaaagtgatatggcgctgtcgatgaatcggtacataggcaactcgattttgccg ttgcttatcaagcactccaagttctacaatgaggctgaaaactatgccagcttgctggat gccacgctgcacacggtttaccgtatgtccaagaatcgtatgctcaccaagggccagcgt gaagctgtttccgatttcttggtcgcgcttacgtcggcaatgcatccggctatgttgctg aagctactgcgcaagcttaccatcgacgtgtcgaagctgtccgaatatacgaccgttgct ctgcgactgctaaccctgcactacgagcgttgcgccaagtactacggtactaccggcggc ggtcaagcctcacagttcggagcatcttcggacgaagagaagcgtctgacgatgttgctg ttctcgaacatcttcgattcgctcagcaacatggactacgatccggaactgttcggtaaa gcgttaccgtgtctgattgccatcggttgcgccctgccgccggactacagcttgtccaag aactcggacgacgatctgtacggcaagccaacgggcggtggtcccgatcaaccgcactat aacccacaaccgatcgatacgaccgcggtacagcttacgaacgatctcaaccagatcgtg cagaagttcagcgagcattatcatgacgcgtgggctagccgtaagctggagaacggatgg acctacggtgatcagtggtcggatgtgaacaaaactcatccacgcttgaagccgtacaac acgctcagcgaatacgaacgcgaacgctatcgcgaacctgtacgcgaaagcttaaaggca ctgctggcgttgcactggagaattgaacattcggagggtgatgtcccgctgtctaaccgt ggctcgatgcgccgccaatcgaaacccaatcttgtaagtacccagtttaaagtcaatact ggttcaccgttcaactacaatccacacccggtggatatgaccaatctgacgctgagcaga gaaatgcaaaacatggcggaacggttggccgaaaactcgcacgatatctgggcgaagaag aagaacgaagagctcaaccagtgcggcggtgccatacatgcccagctagtgccgtacgat ctgctcacggacaaggagaagcgcaaggatcgcgagcgttcgcaggagttccttaagtac ctccagtaccagggactcaagctgcacaagccatcgcgtggacaaacggaggaaccgggc atgagtactgctgcgatcgagctgcgctttgcctactcgctgctggagaagctgatctcc tacagcgatcgtgctacgatcaacatgaagctgctgaaaccatcgtccacgttcagtcgt cgcacgtccttcaagacctgctcgcgcgacattaagttcttctcgaaggtggtactgcca ctgatggagaaatacttctccaccaatcgcaactacttcattgcgatcgctaccgccaca aacaacgttggtgcggcctcgctgaaggagaaggaaatggtggccgcactgttctgtaag ctggccagtctgctgcgttaccggttggctgcgttcggtgccgatgttcgcatcaccgta cgctgtctgcaggtgctggtgaagagtatcgacgccaagtcgctcgtcaagaactgtccc gagtttattcgcacctcgatgttgacgttcttcaacaacactgccgacgatctcggacag acgatcgtcaacctgacggagggcaaatacgatcgtttgcgtggaacgcatctgaagact tccacttcgttggcgtacgtgaatcaagtgattcttccagtgctgacgtccctgtttgat catttggctgcatgtgactatggaagcgatttgttgttggacgaaatccaggtggcttcg tacaagatcctatcggctctttatactctcggtaccgacatgtcattaacgcgggaccgt aaatatctcaagaccgagctggaacgccacaagccggcgcttggatcctgtctgggcgca ttcagttcctgtttcccggtggcgttcctcgaaccgcacgccaacaaacataatccattc tcgctcctgaaccgcattgccgatacctcgctggaagcgcaagacattatgagcaaaatg gagtgctgcatgccaacgctagaatcgatcctgtccgaggtcgatcagtttgtcgagtcg gaaaagacctaccaggaagcgcagcacatcattgacgttattctgccactgctctgctcg tacctgccgttctggtggaaccagggcccggacaacgtgagcccgcagtcgggcaatcac gtcacgatggttacggccgatcacatgaaccatctgctgaagaacgtgctcaagatgatc cgtaaaaatattgccaacgaaaatgcaccgtggatgacgcgcatcgccacgtacacacag cagatcatcataaacagctcggaggagctgctcaaggatgtcttcctaccgttggccgag cgggtgaagaaacgttgcgacagcatgttccacaaggaggaaagcttgcgtggtttcctc aagtcttccaccgatgatacctcccagattgaagcccaaatccaggaggactggcaactg ctggtccgcgatatctactcgttctacccgctgctgatcaagtacgtcgatctgcagcgt aaccattggctcaaggacaatgtgtccgaggcggaagagctgtacaactacgtggcggag atatttaacgtatggtccaagagccagtacttcctgaaggaagagcaaaacttcatctcg gccaatgagatcgacaatatggcactgattatgccaacggccactcgccgctcggcagcc gtgtcgggtgatatgccggcggccggtggcaaggtgaagaagaagaagcgtagccgtgac aagaagcgcgacaaggataaggaaattcagtccagcttgatggtggcctgtctgaagcgt ctgcttccggttggtttgaatctgttcgccggtaaggaacaggagctggtgcagcattgc aaggatcgctatcttaagaaaatgcccgagtacgaggtgatcgagtttgcccgtacgcag ctcacactgccagacaaactcgaccctgcggatgaaatgtcctggcagcactacctgtac tcgaagctcggcaaaaaggaacagattgtgcaggatgcgctggaaaaaacggacaagaag ccggaaaacaaaatcgaagacacggtcgagcgtatcgtcgctatggcgaaggttctctat ggactgcacatggcatgccgacctagagcaaaaggtcttaattggacacacgttttatca caagcacgacgcaaaatggctgttgcatgtctaagagcaaaaccaatgtatagattgagc agacatcgtgcctgcaacattttcgctcggagctactcggaactgtggctagaggatgaa aacgtgggccaagaggtgatgattgaggatctcactcaaacatttgaggatgcagaaaag aagaagaaggacgaagaagaggaagaaggcaaaccggacccactgacgcagctcgttact acgttctgtcgcggtgcgatgaccgaacgcagcggtgccctccaggaagatccactctac atgtcctatgctagcattgtcgcacgatcctgcggtgaagaagaggaggaaggtggcgac gaggaggaaggagccggagaagatgagggcggcgctagtatacacgaacaagaaatggaa aagcagaagcttctgttccaccaggcacgtctcgctaaccgtggcgttgccgagatggta ctgttgcacatctccgcctccaagggtgtcccgtcggagatggtgatgcgcacgctggag cttggaattgcagtgctgcgtggcggtaacatcgacatccagatgggaatgttgaaccac ctgaaggaaaagaaggatgtcggattcttcacctccattgcggggctgatgaattcctgc agcgtgctcgacttggacgcgttcgagcgtaacacgaaggcggaaggtctgggcgttggg tcggaaggtgccgccggtgagaagaatatgcacgatgccgaatttacctgcgcactgttc cgcttcatacagctaacctgcgagggccacaatctcgactggcagaactatctccgtacg caggcgggcaacacgaccacggtgaatgtcgtcatctgcaccgtcgattacctgctgcga ctgcaggaatcgattatggacttttactggcactactccagcaaggagctgatcgatccg gccggtaaggctaacttcttcaaggcaatcggtgtcgcgagccaggtgttcaacacgctc actgaggtcatccagggtccgtgtacgcagaaccagcaggcactggcgcactcgcgtctg tgggatgcggtcggtggtttcctgttcctgttctcgcacatgcaggacaagctgtcgaaa cactcgagccaggtggatctgctgaaggagctgctcaatctgcagaaggacatgatcacc atgatgctgtccatgcttgagggtaacgtcgtgaacggtaccatcggtaagcagatggtg gacacactggtcgagtcggcatcgaacgtcgagctgattctgaagtacttcgacatgttc ctgaagctgaaggatctcacctctacgccgagcttcatggagatcgatgcgaacggtgac ggttggatcttgccgaaggacttccgcgaaaagatggaacagcagaagagctacacaccg gaagagattgacttcctgctcgcttgttgcgaaacgaaccacgacggcaagatcgattac attggtttcgtcgatcggttccacgaaccggccaaggagatcggtttcaacttggccgtc ctgttgacgaatctttccgagcacatgccgaacgagccccgtttggcacggttcctcgaa acggccggctcggtgctgaactatttcgagtcgttcctgggccgcattgagattatgggc tcgtccaagcgcatcgagcgggtgtacttcgagatcaaggaagcgaacattgaacagtgg gagaagccacagattaaggaatcgaagcgtgccttcttctactcgatcgtcacggagggt ggcgacaaggagaagctcgaggcgttcgtcaacttctgcgaggatgccatctttgaaatg acgcatgcgtccggtttgatggcgagcgatgacgatggtggcacggtgcgtcgcgatcag tccttcacgtacatcagcgaggaggaggaggagcgtgcggcacgcgatccgatcaagcgc accatacaggccgtcaaggacggtctgtcctactcggtgtacatgatcagcccgtccaac atcaagcaccagattaccgtactgcagtcgaaatcattccccgagattatagtcggattc ttcaagatgatcttctactcgttctactactctgccttcggcgtgtcggttgtgattaag tacttgatcaacatcctgatgtcgttgatgcgtggcccggcccaggaagcggaagaaccg atgccggaggcggaaccatcgctgcatgcgttgccaccactgccactggaagaacccccg ggtacggtgcaggcattcgggttggacatcagcaaggaagagaatggacagtaccgcatg gcaccgcacgaatcgcccgccctcagcccatcgtcgtcgattgaggaaacgggcgaaagc agcccggaggatggtgccgccgagctgaccggggaaggtgtgccaccgggtgagcagatg acgctggtcgatctgcttggtggtgaggccgctaagcgtgccgcccaggagcgtaccgaa gcgcagaaggcccaggaggcaacgctggcaagcattgaggcggaatcgaagaaggcgtcg agcgaaacgaaagaaccggctgcggtccaccagatcgatttctccaagtacacgaagaag tgtgtcagctatctggcgcgtaacttctacaacctcaagtacgtcgcactggtgctggcg ttctgcatcaactttatgctgctgttctacaaggtgacgacgttcggcgatgaggaggag ggcgaaggttcgggcgaaagtttgatgggacttggatccggtattggttcgggactgggc attttggaaacgggctccggtggcggcgagggtggcagtggcgatggcgaaggcgaagag gaagacccgctggaaaaggtcgaagtggacgaagatttcttctacatggagcatgtgcta cgggtcgccgccatcttgcacagcttggtgtcgctgtgcatgctgatcgcttactaccat ctgaaggtaccgttggccatcttcaagcgtgagaaggaaattgcccgtcggctagagttt gacggtctgttcattgccgaacagccggaagacgatgatatcaaatcgcactgggacaag ctggtgatatcggccaaaacgttcccggtgaactattgggacaagttcgtgaagaagaag gtccgccagaagtacagcgagacgtacgatttcgactcgatctcgaatctgctgggcatg gaaaagacagcgtttgccgcgcaggaagcgaacgagggcggtgggttcttccactttatc gcaaacattgactggcgctatcagatctggaaggcgggcgttacgatcacggacaactcg ttcctgtactcgctctggtacttctccttcagcgtgatgggtaacttcaatcagttcttc ttcgccgcccatctgctcgatgtggcggttggctttaagacgctgcgcacgatcctgcag tcggtaacgcacaacggcaagcagctggtgttgacggtgatgctgctcacgatcatcgtg tacatctacacggtcattgcgttcaacttcttccggaagttctacgtgcaggaggacgat gacggtgaggagggtgaccgcaagtgtcacgacatggcaacctgcttcgtgttccatctg tacaagggtgtacgggcgggtggtggtattggtgacgagatcggcgatccggacggtgac gagtacgaggtgtaccgcattctgttcgacatcacgttcttcttcttcgtcatcgttatc ctgctggccatcatccagggtttgatcattgacgctttcggtgagcttcgtgatcagctg gaatcggtcaaggaggacatggagtccaactgcttcatctgtggtataggcaaggactac ttcgataaggtaccgcacgggttcgatacgcacgtggcccaggagcacaacctggccaac tacatgttcttcctgatgcatttaatcaacaaaccggacacggagtacaccggccaggag acgtacgtgtggaacatgtaccagcaacgctgctgggacttcttcccggtcggtgactgc ttcagaaagcagtacgaggacgaactgggtggcggtggtagctaa

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