Amycolatopsis sp. TNS106: CVV72_05730
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Entry
CVV72_05730 CDS
T10876
Name
(GenBank) non-ribosomal peptide synthetase
Organism
amys Amycolatopsis sp. TNS106
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Condensation
AMP-binding
PP-binding
AMP-binding_C
PapA_C
Motif
Other DBs
NCBI-ProteinID:
QXV56568
LinkDB
All DBs
Position
1271996..1289560
Genome browser
AA seq
5854 aa
AA seq
DB search
MTVLDTTDAPEAERAVALPELFAAMVRSIPDAVAVDGHGGQLTYAELADRAARLAARLTR
LGVRAEDRVGLLIERSAELVVAELAIVLAGGVYVPLDRRAPDDRARLVLTTAGVSVLITD
EPERTARVHSGRIVVAGRSLPAPDVAPPRVDADQLAYLMHTSGSTGTPKGVAVRHRDVAA
LAADSRFAGGPHRRVLLHSPAAFDASTYELWVPLLNGGTVVIAPPGDLDVEALREVVRQY
AVTSLWLTAGLFRVVAQEAPDCFLGVEEVWTGGDVVPAAAVRRVLDACPGLTVTDGYGPT
ETTTFATAYPMSTRDGVPDSVPIGRPLDGVRAHVLDDALNAVPAGQAGELHLAGAGLARG
YWGEPGATANRFVADPGVPGGRMYRTGDLVRYNDEGELEFLGRTDDQVKVRGFRVEPGEI
EAVLAAVPGVGEVVVVAREQRPGVKRLVAYVVARQGEVLGDLAESAAAVLPDYMVPSAFV
ALDELPLNANGKVDRRALPAPPEESRSDTGPGSETERAVAEVLAGVLGTEDVASEDDFFA
LGGDSILAVQALSRLRRTFGVALSARAVFDAPTVTGLARLIDEARPAGNDPIPAAPPSQV
VPLSPAQRRLWFLDELTGDSAEYNTAVGLRLSGPLDLDALRGALAALCARHESLRTTFDG
GFQRIADTAEIPLRVEDTAADDATLAAEVSVPFDLRTGPLTRATLYRQAPEEHLLVLCQH
HIVTDGRSIGILTGELLDFYAGATPPPLESGYRDYTLWRRQSDDDAQLGYWREALEGLEP
LAFPTDRPRPAQRGTAGAVHRHDLPADLVRGLTTAGRPHGATLFMTLTAAVQLLLSAYGG
QRDIAVGTAVAGRDRPEWEPLTGFFVNTLVLRSRIDRTRPFPEFLAGFRETVLEAFAHAD
VPFDRVVEAAQPERDPARTPLVQAVVVLQSPLVRPCEVAGLRVSEFDLPRPSARFDLVIE
FWPTEDGLRVTVEYATALFDGATIERLTESLEALLAGIAAEPGRLVGELPLLTEADRRLL
PSPDPAPSMTITRLFDHHAGQHPHAPAVLFGEARLGYGELRAEADRLAGRLIELGVRPED
RVGVLMDRSADLVVALLAILKAGAAYLPLDLRAPADRLRLLLDGTALLLTDETWHETAAT
VHKGRILTVPVTGDAATVTVEPANLAYVEYTSGSSGVPKGVAVRHTDVVALATDPRFTGG
AHERVLLHSPLAFDASTYELWVPLLNGGTVVVAPPGDVDAEVVRELTARHGVTAFWLTAG
LFRLFAGDAPECFRGLREIWTGGDVVPPEAVRRVLESCPGVTVVDGYGPTETTTFATSFR
MTSAEAVPETIPIGTPLTGMGVYVLDDGLRPVPRGALGEICVAGPGLARGYADRPGATAD
RFVACPYGAPGERMYRTGDRGRWRADGTLEFAGRADDQLKIRGFRVEPGEVERALTARPE
VVEAVVTARTGSGRKHLVAYVVAADDSTVDTEVLRESLGRNLPDYLVPSAFVVLDALPLN
ANGKVDRRALPEPSFEPAASGGTAPRTEREAVLAGIWADVLGLDRVGVEDNFFALGGDSI
LGIQVSARARKVGLAITTADLFRHQTIAALAPALTEVSSVPDRGPVSGDVVATPIQRWFF
DTIQEPGRFDQAIAVELAHGTDETVLAAAIDAVIEHHDALRTTFTRDGDRWRLRITAVED
GHSLLRWSVSGPPERRVLHLSAHHLAVDGVSWRILLDDLDQACRMADLGPRTSSFQDWAA
RLADHAEAGGFDDELEHWRSIPEVTPIPVDGVGANTVDQARAVTVRLTAEETRSLLRHVP
EVYRTQVNDLLLTALGRTLRDWTGRVPVIDLEGHGREDLFDGVDLSRTVGWFTSLFPVAL
DVPNEWGAAIKAVKERLRSVPRRGIGYGALRYLSGTAPRIDPQISFNYLGQFELTGELYT
GSPGELSLVADPVGVRPHLLDVVGQVTGDTLEFTWHYAEGVHEAATVTRLADGMLENLRG
LLGHCAEPGAGGRTPSDFPLAGLDQSTVDELVGDGRDVEDVYPLTPMQAGMVFHSLAQPG
DRNYFEQITFTVDDVPDPRALVAAWRRVVARTPVLRSRIVWDGVPRPLQVVRRSAEIPVS
CPDWSTMDAEEALRLRLAEDLAEGLDLTRAPLTRLVVAKESATSVRVIWTFHHVLLDGWS
VFGVLSDVLAVLRGGEPPVRRPFRDYAGWLAAQDDEAAEAHWRAELDGVTPTPLPGVHGA
RAHAASSSARVPVDFDDATTARITAFARRHHLTLNTIVQGAWAALLSRYSGEAEVCFGAT
VSGRPVELPGADDIPGLFIDTLPVRVRLDTGHGLVDWLRELQAAQAESRRFGHVGLPRLQ
SWSDTGGSLFDSIIVFENYPVADVAGVRDVRAAERTNYPLGVVAYPGRRMSLMLTHDPEL
IGPELARQLAGHLETLIRGFVDSPYEPVTRVPMLSDPEIRHLLRDRDATTRPIPEGTVPE
LFEARARRNPGAVALVTDAETVTYGELDVRANRLANRLRELGVRAENRVALLMDRSPALV
VAELATLKAGGAYLPLDLRAPAERLRLLLSEAGADVLVTDQAWLSTAEEIHDGVIVTDTG
DAPETSPGVTTDPEQLAYVIYTSGSTGKPKGVAARHRDVLALAADRRFAAHDRVLLHSPQ
AFDASTYELWVPLLNGGTVVLAPPGELDVHTLGRVITTHAVTGVFMTTGLFRLVAQEAPE
MFAGVREVWTGGDAVPAVALRRVRAACPRTLVADVYGPTETTTFATVHPLPDEVPDVVPI
GAPLANTRGYVLDDGLNLAPPGAPGELHIAGAGLARGYLGRPGLTADRFVADPFGPPGER
MYRTGDVVRWNDEEALEFVGRVDEQVKIRGFRVEPSEIEAALGEHPGVEQAAVLARADGG
VKRLVAYVVGETEGLGEFLGRTLPDYMVPAAFVRLAEFPVNVNGKLDRTALPAPDFGARD
HVVPRTERELVLAGIWAEVLGVERVGATDDFFELGGDSILSIQVVSKARRAGLELLPGDL
FAHRTPAALAAAARTATEAVHRGPVSGEVPLTPIQRWFFATQTADPEHFHQFVRLGPERI
EQAVARKAVDALLEHHDALRMRFTHDDGWKQENGPVGAGTPLIRLDISERGVTLAVHHLV
VDGVSWRVLAEDFDRGYAQALRGEAIDLGPRTTSFREWAIRLAEHTADGGFDDELPYWQG
IPENTSIPVDGEGQATGASMREVTVRLPEAETEALLRDVPAVYRTQVNDVLLTALGRVLR
DWTGKVPVVDLEGHGREDLFDDVDLSRTVGWFTSVFPVALDVPEDWGTALKSVKEQLRAV
PRRGVGYGALRHLAGTAPSIDPAVSFNYLGRFTSGRLESDESELSARAHLLDVVGRVESG
ELELTWYYTEGVHRESTVDRLAGAMLAALREIIAHCAAPEAGGRTPSDFPLLALDQATVD
TLAGDGRTIEDIYPLTPMQAGMVFHSLSQREERLYFQQVGFVVEGVEDVDALAEAWQHVV
DRTPVLRTKIAWEGVPEPVQVVRRRVTVPVTRLDWRAHTPAGQERFWQEVLSADRAEGLD
LDGEALLRLTLARLSETEVRVLWTFHHVLLDGWSVFGVLSDVFTAYSGGEPPERPPFRDY
VAWLSRQDDTEAERHWRRELGDFTASARLTAGDHTSRSAEWLRVPVESSARLGEAARKAG
LTMNTVLQGAWALVLSRLTGERDVCFGTTVSGRPVDLTGADDITGIFINTLPVRVTTDRS
PVAKWLVALQDRQVESRRYGHLPLTKLQAWSGSGGSLFDSIVVFENYPIDSATRDGLRLR
DVDAAETTNYPISVVASPGERLSLDVGYDPDLFDAATAEWITDQLVGVLDAFAEDLNRPL
DGIDLLTDAERLQILGDWNDTAYPLPEGSLAELFGRQVAQAPGAVALVGDGVRLTYAELD
ERADRLARRLVSLGAGPETVVGVLMDRSPDLVVAELAVIKAGAAYLPLDTRAPAPRLTTL
LDGVPILVTDRARSESMVHNGQIVVPDGRTADVALPEASPDNLAYVMYTSGSTGRPKGVA
VRQRDVVALAADRRFASHERVLLHASPAFDASTYELWVPLLNGGTVVVAPPGDLDVDTLR
RIIAEYEVHGAFFTAGLFRLLAQEAPETFRGMREVWAGGDVVPAAAVRRVREACPGTVVV
DGYGPTETTTFATSYPIPAEVPDAVPIGKPLDNMRTYVLDAELRLVPQGVSGELYIAGAG
LARGYSGDPALTADRFVPDPFGPPGERMYRTGDLVRWTPRGELEYTGRADEQVKIRGFRI
EPAEIEAALTAHPGVGQAAVLTREDHGVKRLVAYHTGDADGLAEFLGRTLPDYMVPAAFV
RLDRFPLNANGKIDRHALPAPDFGGKTAGTAPATEAERALAAIWSDVLGVADVGAEANFF
ELGGDSILSIQVVSRARRAGLSLLPHDVFRHPTLAALAAHAGGDAGPRAEQGPVTGAAPL
TPIQHWYFDTLPDRFDQRVVLEFTEDVDEAALRRALETVWAQHDGLRLRFGRDGSQYGEP
VWQADLLTDEIAFDPGRGPLLAAVLDGRRLTVAAHHLVVDGVSWRILLEDLETAYRGGEL
GPKTTSYLEWARRLAEHAESGGFDDELAYWRGIPAPAPVAGPATVADTGEVTVRLTAEET
RALLQDVPEVYRTQVNDVLLAALGRVLRDWTGRIPVIDLEGHGREDLFDDVDLSRTVGWF
TSMFPVALDVPDDWGAALKAVKEQLRAVPRRGIGYGALRYLTGTAPVIDPEVGFNYLGRF
DDAEAGAFRTGALGADVDPAAPAGHTLDIVGHVLAGSLELSWAYVTTRHDRGVVEELAER
MLAALREIIAHCGSPEAGGRTPSDFPLAALDQSTVDTLVGDGRTVEDVYPVTPMQGGMLF
HGLSQTAQGMYVEQATFVLDGVTDLDRLAAAWQRVVDRTPVLRTAFVWAGVDEPLQVVHR
EVRLPVRVLDGTGHDLRRLLAEDREQGLDLAEAPLMRVALVRSSATEVQVLWTFHHALLD
GWSVFHVLSDVCGAYAGQSLPSRPPFRDYLAWLGGLDRTDAERFWRRTLSGIDGPTPVPG
DRAPAAGHIACSSEWLPVRLDEAATSGLDEFVKRHGLTHNAVLQGAWALLLSAYSGHDDV
VFGSTVSGRPPEVTGVDAITGIFINTLPVRIGIDRGARVADWLAGLQSSQAEARRHGHLP
LALVQGWAELPGGVNLCESLVVFENYPITGAEAGHGLTVRDLSARETTNFPLTVVASPGR
ELNVDLGYDPALFDAETVSRLAGHLLTLLRELTVDGARAITDVSMLTPRDELLLAEWTKI
GAAAPARSLPELFAEQVRARPDAVAAVLDGEPVTYAELNRRANRLANRLIGLGLRPEEPV
GLVTSRAGTVVAELAVVKAGGAYLPVDTRAPAERRQALLDGVRFVVSDREYPHAIRLSSV
DDEPDGDPVLVVDPDRLAYVMYTSGSTGTPKGVAVRHRDVAALAADSRFRGGAHERVLLH
SPAAFDATTYELWVPLLTGGRVVTAPDGDLDAHRLRTLIREHGLTGMWVTTGLFRVLAQE
SPDCFTGLREVWTGGDVVPAEAVRRVLGACRGLRVVDGYGPTETTTFATAHPMDETVPDR
VPIGTPLDGMVARVLDPDLRPVPPGVPGELYLAGSGLARGYRDRPGLTADRFLAAPGGQR
MYRTGDVVRWTGVGTLEFLGRADDQVKLRGFRVEPGEAEAMLARHPAVAQAAVIVREDQP
GLKQLVAYVVSEAGQDTLRDFLAERLPEYLVPSAFVALDRIPVSANGKLDRKALPAPAER
ESGYVEPETETELALAGIWAEVLGVERIGVEDNFFALGGDSLRSLHIAAKAGALFAVRLT
PADVLTARTVAGLAGTVEELILGELESLASETEA
NT seq
17565 nt
NT seq
+upstream
nt +downstream
nt
atgaccgtgctcgacacgacggacgcccccgaagccgaacgagccgtcgccctgccggaa
ctgttcgccgcgatggtgcgttccatccccgacgcggtcgccgtggacggccacggtgga
cagctgacctacgccgaactcgccgaccgggccgcacgcctcgccgcccggttgacccgg
ctcggagtgcgtgccgaggaccgggtcgggctgctgatcgaacggtccgccgaactcgtc
gtcgccgaactggcgatcgtgctggcgggtggggtctacgtgccgctcgaccggcgcgcc
cccgacgaccgcgcgcggctggtgctgaccaccgcgggggtctcggtgctgatcaccgac
gagccggaacggacggcgcgggtccacagtggacgaatcgtggtcgcgggacgatccctt
ccggcgccggacgtggcgccaccgcgcgtcgacgcggatcagctggcgtatctcatgcac
acgtcaggctcgaccgggacaccgaagggagtcgcggtccggcatcgggacgtcgcggcg
ctggcagccgacagccggttcgcgggtggtccgcaccgccgggtcctgctgcattccccg
gccgccttcgacgcgtcgacctacgagctgtgggtaccgctgctcaacggcgggacggtg
gtgatcgcgcctccgggcgacctggacgtggaggcgctgcgcgaggtcgtccgccagtac
gcggtcacctcgctttggctgaccgccgggctgttccgggtggtggcgcaggaggcgccg
gactgtttcctcggtgtggaagaagtatggacgggcggcgacgtggtcccggcggccgct
gtccgccgtgtgctggacgcctgccccggcctcaccgtgaccgatggctacggccccacc
gaaaccaccaccttcgccaccgcatatccgatgtccacaagggacggtgtgccggactcc
gtgccgatcggccgtccactcgacggagtccgagcccacgtcctcgacgacgcgttgaac
gccgtcccagccggacaggcgggggagttacatctggccggggccggcctggcccgtggt
tactggggcgaaccgggtgcgaccgcgaaccgcttcgtcgccgatcccggcgtacccggc
ggccggatgtaccggaccggcgatctggtgcggtacaacgacgagggcgaactggagttc
ctcggccggaccgacgaccaggtcaaggtccgcggtttccgggtcgagcccggcgagatc
gaagcggtgctcgccgccgtgccgggggtgggcgaggtcgtggtcgtcgcccgtgagcaa
cggccgggcgtcaagcggttggtcgcctacgtcgtggcccggcagggcgaggtgctcggc
gacctggcggagtcggcggcggcggtgttgccggactacatggtgccgtcggcgttcgtc
gccctcgacgagcttcccctcaacgccaacgggaaggtcgatcgccgcgctctgcccgcg
ccgccggaagagagccggtcggacaccggaccgggttcggaaaccgaacgtgccgtcgcc
gaggtgctcgccggcgtgctcggaacggaggatgtcgcgagcgaagacgacttcttcgcc
ctgggtggcgactcgatccttgcggtacaggcgttgtcccggctgcgcaggaccttcggc
gtggccttgtcggctcgcgcggtgttcgacgcgcccaccgtgaccgggctggcccggctg
atcgacgaggcgcggcctgccgggaacgacccgatcccggccgcaccgccgtcccaggtg
gtcccgctttcgcccgcccagcggcgcctgtggttcctcgacgagctgaccggggacagc
gccgaatacaacaccgcggtcggtctccggctctccgggccgctggacctcgacgccctg
cgcggcgcactggccgcgctctgcgcccgccacgaatccctgcgcaccaccttcgacggg
ggtttccagcgcatcgccgacacggccgagataccgctgcgcgtcgaggataccgccgcg
gacgacgcgacgttggcggcggaagtgagcgtgccgttcgacctgcgcaccggcccgctg
acgagggccacgctctatcgtcaggcgccggaggagcacctgctcgtcctgtgccagcac
cacatcgtcaccgacggccggtcgatcggcatcctgaccggcgagcttctggacttctac
gccggtgcgaccccgccgccgctggagtcgggctaccgcgattacacgctctggcgtcgt
caatccgacgacgacgcccagctcggctactggcgtgaagcgctcgagggactcgaaccg
ctcgctttcccgaccgatcgtccgagaccggcccagcgcggtacggcgggtgcggtacac
cgtcacgatctgcccgcggacctggtccgcggccttaccaccgcgggacgtccgcacggg
gcgacgttgttcatgactctcaccgcggccgtgcaactcctcctgtcggcttatggaggt
cagcgcgacatcgccgtgggcaccgcggtcgccggacgggaccggcccgagtgggagccg
ctgacggggttcttcgtgaacaccctcgtgctgcgctcccggatcgatcgcacgcggccg
ttcccggagttcctggccgggttccgggagacggtgctggaggcgttcgcgcacgccgac
gtccccttcgaccgcgtcgtcgaagcggcacagccggagcgggatccggcacggacaccg
ctggtgcaggcggtggtcgtcctgcagagcccgctggtccgcccgtgcgaggtcgccggc
ctgcgggtttcggagttcgacctgccccggccgtcggcccggttcgacctggtcatcgag
ttctggccgacggaagacggcctgcgggtcaccgtcgagtacgccaccgcgctcttcgac
ggcgcgacgatcgagcggctgaccgagagcctggaagcgctcctcgccgggatcgccgcc
gaacccggccgcctggtgggcgagcttccgctgctcaccgaggccgatcgccggctcctg
ccgtcgccggatcccgcgccgtcgatgaccatcacgcgcctgttcgaccatcacgccggg
cagcatccgcatgcccccgcggtgctcttcggtgaggcgcgcctcggttacggcgaactg
cgtgccgaggccgaccggttggcggggcggctgatcgagctcggcgtgcgcccggaggac
cgggtcggcgtgctgatggaccgctcggccgacctcgtggtggcgctgctggcgatcctc
aaggccggtgccgcgtacctgccgctcgatctgcgtgctccggccgatcgcctgcgcctg
ctgctcgacggcacagcgctgctgctcaccgacgagacatggcacgaaaccgccgccacc
gtccacaagggacggatactgacggtgcccgtcaccggggacgcggccacggtcacggtc
gaaccggcgaatctggcctatgtcgaatacacctccggctccagcggcgtaccgaagggc
gtggcggtccggcacaccgacgtggtcgcgctggccaccgacccccgcttcaccggcggc
gcgcacgagcgcgtgctgctgcactcgccgctggcgttcgacgcctccacctacgagctg
tgggtcccgctcctgaacggcggcaccgtggtcgtcgcgccgccgggggacgtcgacgcg
gaggtcgtccgtgagctgaccgcgcggcacggtgtcaccgccttctggctcaccgccggt
ctcttccggctcttcgccggtgacgcccccgagtgcttccgcggcctgcgggagatctgg
accggtggcgacgtcgtgccgcccgaagccgtgcgccgcgtgctggagagctgccccggc
gtcacggtcgtcgacggctacggaccgaccgagaccaccacgttcgcgacctcgttccgc
atgacgtccgcggaggcggttcccgagaccatcccgatcgggaccccgctgacgggaatg
ggtgtctacgtgctcgacgacggactgcggccggtcccgcgcggcgcgctcggcgaaatc
tgcgtcgcgggcccagggctcgcccgcgggtatgccgaccggccgggtgcgacggcggat
cggttcgtcgcctgcccctacggcgcgcccggcgagcgcatgtaccgcaccggcgaccgc
ggccggtggcgggccgacgggaccctcgagttcgccggccgggccgacgaccagctcaag
atccgcggcttccgggtcgaacccggcgaggtggaacgcgccctcaccgcccggcccgag
gtcgtggaggcggtggtgacggcgcgtaccgggtccggtcgcaagcacctggtcgcctat
gtggtggccgcggatgactccacagtggacactgaggtgctgcgcgaatccctcggccgg
aacctgccggactatctcgtgccgtcggcgttcgtcgtcctcgacgcgcttcccctcaac
gccaacgggaaggtcgaccggcgcgctctgccggagccgagcttcgagcccgccgcgagc
gggggcacggcgccgcggaccgagcgggaagcggtgctcgcggggatctgggcggatgtg
ctcggtctcgaccgggtgggtgtcgaggacaacttcttcgccctcggcggcgactcgatc
ctcggcatccaggtcagcgcgcgggccaggaaggtggggctggcgatcacgacggcggac
ctgttccgacatcagaccatcgccgcgctcgccccggccttgaccgaagtctcctcggta
ccggaccgcggtcccgtctccggggacgtcgtggcgaccccgattcaacgctggttcttc
gacacgatccaagagcctggccggttcgatcaggccatcgcggtcgaactggcgcacggc
accgacgagaccgtgctcgccgccgcgatcgacgcggtgatcgagcaccacgacgcgttg
cggacgaccttcacccgcgacggagaccggtggcggctgcgcatcaccgcagtcgaggac
gggcattcgctgctgcgctggagcgtgtccggacctccggagcggcgcgtgctgcacctg
tccgcgcaccatctcgccgtcgacggcgtgtcctggcggatcctgctcgacgacctcgac
caggcctgtcggatggccgatctcgggccgaggacgagctcgttccaggactgggcggca
cgcctcgcggaccatgccgaagcgggtggattcgacgacgaactggagcactggcgctcg
atccccgaggtcacgccgatcccggtcgacggggtcggtgcgaacacggtggaccaagcc
cgcgcggtgacggtccggctgaccgcggaggagacgcggtcgctcctacggcacgtcccc
gaggtctaccggacgcaggtcaacgaccttctgctcaccgcgctcggccggacgttgcgg
gactggaccggccgggtcccggtgatcgacctggagggccacggccgtgaggacctgttc
gacggcgtggatctgtcgcgcacggtgggctggttcaccagcctgttcccggtggcgctg
gacgtcccgaacgaatggggcgcggcgatcaaagccgtgaaggagcggctgcgctcggtc
cctcgacgtggcatcggctacggcgcgctgcgctatctctccggcacggccccgcgcatc
gacccccagatcagcttcaactacctcgggcagttcgagctcaccggggagctctacacc
ggctcgcccggcgaactgtccctggtcgccgaccccgtcggcgtccgcccccatctgctc
gacgtggtcggccaggtcaccggcgacacgctggagttcacgtggcactacgcggaaggc
gtgcacgaagcggcgaccgtgacccggttggccgacggcatgctggagaacctgcgtgga
ctcctcgggcactgcgccgaacccggcgcgggcgggcggacgccgtcggacttcccgctg
gcgggcctcgaccagtccactgtggacgagctggtcggcgacggccgggacgtggaggac
gtgtacccgctgacgccgatgcaggcgggcatggtgttccacagcctggcccagcccggc
gatcgcaactacttcgaacagatcaccttcaccgtcgacgacgtccccgacccgcgggca
ctcgtcgcggcctggcggcgggtggtggcccggaccccggtcctgcgcagccggatcgtc
tgggacggggtaccacgtccgctgcaggtcgtgcggcgttcggcggagatcccggtgagc
tgtccggactggtccacaatggacgccgaggaagccttgcggctccggttggccgaagac
ctcgccgaagggctcgacctgacccgcgccccgctgacgcggctggtcgtcgccaaggag
tcggcgacctcggtgcgggtgatctggaccttccatcacgtactactggacggctggagc
gtcttcggtgtcctgtccgacgtcctcgccgtgctgcgcggtggagaaccgccggtgcgg
cgcccgttccgcgactacgccgggtggctcgccgctcaggacgacgaggccgccgaagcc
cactggcgggccgaactcgacggagtgacgccgacgccgcttcctggagttcacggcgcc
cgggcacacgccgccagctcgtccgcccgggtgccggtggacttcgacgacgccacgacc
gcccggatcaccgcgttcgcgcggcggcaccacctgacgctcaacacgatcgtccagggc
gcctgggcggcgttgctgtcccgctacagcggcgaagccgaggtctgtttcggcgcgacg
gtgtcgggcaggccggtcgagttgccgggagcggacgacatcccgggcctgttcatcgac
accctgccggtgcgggtcaggctcgataccgggcacggcctcgtcgactggcttcgggaa
ctgcaggcggcgcaagcggaatcccgccggttcggccatgtcggcctgccgcggttgcag
tcctggagcgacaccggcggcagcctgttcgacagcatcatcgtcttcgagaactatccg
gtggcggacgtcgcgggagtgcgggacgtccgcgcggccgaacgcaccaactacccgctc
ggcgtcgtcgcgtatccgggccgccggatgtcgctgatgctgacccacgaccccgagctg
atcggaccggagctcgcccggcagctcgccgggcatctcgaaacgctgatccgtggcttc
gtggactcgccgtacgagcccgtgacccgggtgccgatgctgtcggacccggagatccgg
cacctgcttcgcgaccgcgacgccaccacccggccgataccggaagggacggtgcccgag
ctgttcgaggcccgcgcacgccggaatcccggcgccgtcgcgctggtgaccgatgcggag
accgtcacctacggcgaactcgacgtccgggcgaaccggctggcgaaccggctgcgcgag
ctcggcgtccgcgccgaaaaccgggtcgcgctcctgatggaccgttcgcccgccctcgtc
gtggccgagctcgcgaccctgaaggcaggcggggcctatctgccgttggatctgcgcgcg
cccgccgagcggttgcggctgctgctgagcgaagccggagcggacgtcctcgtcaccgat
caggcctggctgtccaccgccgaagagatccacgacggcgtgatcgtcacggacacgggt
gacgccccggagacatcccccggggtgacgaccgaccccgaacaactggcctacgtcatc
tacacctccggctcgaccggcaagccgaagggcgtcgccgcccggcatcgcgacgtcctc
gctctggcggccgaccggcgcttcgcggcccacgaccgggtgctgctgcactcaccgcag
gccttcgacgcgtccacgtacgagctgtgggtgccgttgctgaacggcggcacggtcgtc
ctggccccgccgggggagctcgacgtccacacgctcggccgcgtgatcaccacgcacgcc
gtgacgggagtcttcatgacgaccggcctgttccggctcgtcgcgcaggaggccccggag
atgttcgccggcgtgcgggaagtctggacgggcggtgacgccgttcccgccgtcgcgctg
cgcagggtccgggccgcgtgcccgcggacgctggtcgccgacgtctacggccccaccgag
accacgaccttcgccaccgtgcatccgctgccggacgaggtgcccgacgtcgtgccgatc
ggagcaccgctggccaacacccgcggctatgtcctcgacgacggcctgaacctggcgccc
ccgggtgcgccaggcgagctgcatatcgccggggccgggctcgcgcgcggctacctcgga
cggccggggctgaccgcggaccggttcgtcgcggatccgttcggtccgccgggggagcgg
atgtaccgcaccggcgacgtcgtgcgctggaacgacgaggaggcgctggagttcgtcggc
cgggtggacgagcaggtcaagatccgcggcttccgcgtcgaaccgagcgagatcgaggcc
gcgctgggcgaacaccccggcgtcgagcaggcggccgtactggcccgcgcggacggtggg
gtgaaacggctggtcgcctacgtcgtcggcgagaccgaaggacttggcgaattcctgggg
cggaccctgccggactacatggtcccggccgcgttcgtccggttggcggaattcccggtc
aacgtcaacgggaagctcgaccgcaccgcgctgcccgcgccggatttcggggcccgtgac
cacgtcgtgccgcgcaccgagcgcgaactcgtgctcgccgggatctgggccgaggtgctg
ggtgtcgaacgggtcggtgcgaccgacgacttcttcgaactgggcggcgactcgatcctc
agcatccaggtggtgtccaaggcccggcgcgccgggctggaactgctgcccggcgacctg
ttcgcccatcggaccccggcggcgctcgccgccgcggcgcgcaccgccaccgaggccgtc
caccgcggcccggtcagcggcgaggtgccgctcaccccgatccagcggtggttcttcgcg
acccagaccgccgatccggagcacttccaccagttcgtccggttaggacctgagcggatc
gagcaggccgtggcgcgcaaggccgtggacgcgctgctggagcaccacgacgcgctgcgg
atgcgattcacccacgacgacggctggaagcaggagaacggtcctgtcggggccgggaca
ccgctgatccgcctcgacatctccgagcgcggcgtcaccctcgccgtgcaccacctcgtc
gtcgacggtgtctcgtggcgggtgctcgccgaggacttcgaccgcggttacgcccaggcg
ctgcgaggcgaggcgatcgatctcgggccgcgcaccacctcctttcgggagtgggcgatc
aggctcgccgagcacaccgccgacggtggattcgacgacgaactgccctactggcaaggg
attcccgagaacacctcgatcccggtcgacggtgagggccaggccacgggcgcctcgatg
cgtgaggtcaccgtgcggcttcccgaggcggagaccgaggcgctgctgagggacgtgccc
gccgtctatcgcacgcaggtcaacgacgtgctgctgaccgcgctgggccgggtgctgcgg
gactggacgggcaaggtaccggtcgtcgatctggaaggacacgggcgcgaggacctgttc
gacgacgtcgacctgtcccgcacggtgggctggttcaccagcgtcttcccggtcgcgctg
gacgtccccgaagactggggtacggccctgaaatcggtgaaagagcagctccgggccgtg
ccccggcgcggggtcgggtacggcgccctgcgtcacctcgccgggaccgcgccgtcgatc
gacccggcggtgagtttcaactacctcggccgcttcacctcgggcaggctggaatccgac
gagagcgagctttcggcgcgagcgcatctgctcgacgtggtcggccgcgtcgagtccggc
gaactcgaactgacctggtactacaccgagggtgtccatcgcgagtccacagtggacagg
ctcgccggggcgatgctcgccgccctgcgggagatcatcgcgcactgtgcggcaccggag
gcgggtgggcggactccgtccgacttcccgctgctcgcgctcgatcaagccacagtggac
accctcgccggcgacggcaggacgatcgaggacatctacccgctcacgccaatgcaggcg
ggcatggtgttccactcgctgtcacagcgggaagaacggctctacttccagcaggtcggg
ttcgtcgtcgaaggtgtcgaggacgtcgacgcgctcgccgaggcctggcagcacgtcgtc
gaccgcacccccgtgctgcgcacgaagatcgcctgggaaggcgtgccggaaccggtgcag
gtggtgcgtcggcgggtgaccgtcccggtcacccggctcgactggcgtgcccacacgccg
gcgggacaggagcggttctggcaggaggtcctgtccgcggaccgtgccgaggggctggac
ctggacggcgaagccctgctgcggctgaccctggcgcggctttcggaaacggaagtccgg
gtgctgtggacgttccaccatgtcctgctcgacggctggagcgtcttcggagtgctgtcc
gacgtgttcaccgcctattccgggggcgaaccgccggagcggccgccgttccgggactac
gtcgcgtggctgagccgtcaggacgacaccgaggcggaacgccactggcgccgcgagctc
ggcgacttcaccgcgtccgcccggctcacggcgggggaccacacgagccggtcggccgag
tggctgcgggtcccggtcgagagctccgcgcggctcggggaagccgcgcgcaaggcgggt
ctcacgatgaacaccgtcctgcagggagcgtgggcgctggtgctttcccggctgaccggg
gaacgcgacgtctgcttcggcaccaccgtgtccggtcgcccggtcgacctgaccggcgcc
gacgacatcaccgggatcttcatcaacacgctcccggtacgtgtcaccaccgaccggtcg
ccggtcgcgaaatggctggtggcgctgcaggaccggcaagtggagtcgcgcaggtacgga
catctgccgctgacgaagctgcaggcgtggagcggatccggtggcagcctcttcgacagc
atcgtcgtcttcgagaactatccgatcgactcggcgacgcgtgacggactgcggttgcga
gacgtcgacgccgccgaaacgacgaactacccgatcagtgtcgtcgcgtcgccgggggaa
cggttgagtctcgacgtcggctacgaccccgatctgttcgacgccgcgacggccgagtgg
atcacggaccagctcgtcggcgtgctcgacgccttcgccgaagacctgaaccgtccgctc
gacggtatcgacctgctcaccgacgccgaacggctccagatcctcggtgactggaacgac
accgcgtatccgctgccggagggaagcctcgccgagctcttcgggcgacaggtcgcgcag
gctcccggcgcggtcgccctcgtcggcgacggcgtccgcctgacgtacgcggaactggac
gagcgcgcggaccggctcgcccggcggctggtgtcgctcggcgccggtcccgaaaccgtg
gtcggcgtgctcatggaccgttccccggacctggtcgtcgccgaactcgccgtgatcaag
gcgggggcggcgtatctcccgctggacacgagggcgcccgcgccacggttgacgaccctg
ctggacggggtgccgatcctcgtcaccgaccgggcccgctccgaatcgatggtccataat
ggacagattgtcgtgcccgacggccggacggcggacgtggcgctgcccgaggcgtcgccg
gacaacctcgcgtacgtgatgtacacgtccggttcgacgggcaggccgaagggcgtggcc
gtacgccagcgtgacgtcgtcgccctcgccgccgaccggaggttcgcctcgcacgagcgg
gtgctgctgcacgcttcgcccgccttcgacgcctccacttacgagctgtgggttccgctt
ctcaacggcggcaccgtcgtcgtggcgcccccgggcgacctcgacgtggacaccctccgg
cggatcatcgccgagtacgaggtccacggggcgttcttcaccgccgggctgttccggctg
ctcgcgcaggaggccccggagaccttccgggggatgcgcgaggtgtgggcgggcggcgac
gtcgtcccggccgccgcggtccggcgggtgcgagaggcgtgcccgggcacggtcgtcgtc
gacggctacggcccgaccgagacgacgaccttcgccacctcgtatccgatcccggccgaa
gttcccgatgccgtcccgatcgggaaaccgctcgacaacatgcggacctacgtcctcgac
gccgagctgcggctcgtgccgcagggcgtgtccggcgagctgtacatcgccggggccgga
ctcgctcgcgggtactccggtgatccggcgctgaccgccgaccggttcgtgcccgacccg
ttcggcccgccgggggagcggatgtaccgcaccggtgaccttgtccgctggaccccgcgc
ggggaactggagtacaccgggcgcgccgacgagcaggtcaagatccgcggtttccggatc
gaaccggcggagatcgaggccgcgctgaccgcgcatccgggcgtcggccaggccgcggtg
ctgaccagggaggatcacggcgtcaaacggctcgtcgcctaccacaccggcgacgcggac
ggcctcgccgaattcctcggccgcactctgcccgactacatggtgcccgccgcgttcgtc
cggctcgaccgcttccccttgaacgccaacgggaagatcgaccgtcacgccctgcccgcg
ccggacttcggcggcaagacggccgggaccgcgcccgcgaccgaggccgaacgcgcgctc
gccgcgatctggtccgacgtgctcggcgtcgcagacgtcggcgccgaggccaacttcttc
gaactgggcggcgactcgatcctcagcatccaggtcgtgtcgcgtgcccgccgcgccggg
ctgagcctgctgccccacgacgtcttccggcatccgaccctcgccgcgctggccgcgcac
gccggtggcgacgccgggccgcgcgccgaacaggggccggtgaccggggcggcgccgctc
acccccatccagcactggtacttcgacaccctgccggaccggttcgaccagcgagtggtg
ctggaattcaccgaggacgtcgacgaagccgcgctgcgccgcgcgctggaaaccgtttgg
gcgcagcacgacgggctgcggctgcggttcgggcgcgacgggagccagtacggcgaaccg
gtgtggcaggcggaccttctcaccgacgagatcgccttcgatcccggacgcggtcccttg
ctggcggcggtgctcgacgggcggcggctgaccgtggccgcgcaccacttggtcgtcgac
ggcgtttcctggcgaatcctgctcgaggatctggaaaccgcctaccgcggcggcgaactc
gggcccaagaccacgtcctacctggagtgggccaggcggctggcggagcatgccgagtcc
ggcggattcgacgacgaactggcgtactggcgggggatcccggcgccggcgccggtcgcc
ggaccggccacggtcgccgacacgggcgaggtgacggtccggctcaccgccgaggagacc
cgggcacttctccaggacgttcccgaggtctaccgcacgcaggtcaacgacgtgctgctc
gccgcgctgggccgtgtcctccgggactggaccgggcggatcccggtgatcgacctggag
ggccacgggcgcgaggacctgttcgacgacgtcgacctctctcgcaccgtcggctggttc
accagcatgttcccggtggcactcgacgtcccggacgactggggtgccgcgctcaaagcg
gtgaaggaacagctccgggcggtgccgcggcgggggatcgggtacggcgccctgcggtac
ctcaccggcaccgcgccggtcatcgatcccgaggtcggcttcaactacctcggccggttc
gacgacgccgaggcgggcgcgttccggaccggcgccctcggcgccgacgtcgacccggcc
gctcccgccggccacacgctcgacatcgtcggccacgtgttggccgggagcctggagctg
agctgggcgtacgtcacgacccggcacgatcgcggcgtcgtcgaagagctggcggagcgg
atgctggccgccctgcgcgagatcatcgcgcactgcgggtcaccggaggcaggcggccgc
acgccgtcggacttcccgctcgccgccctcgatcagtccacagtggacactttggtcggt
gacggccggacggtcgaggacgtctacccggtgacgcccatgcagggcgggatgctgttc
cacggcctttcccagaccgcgcaaggcatgtacgtcgagcaggcgacgttcgtcctcgac
ggtgtcaccgacctcgaccggctcgccgcggcatggcagcgggtcgtggaccggacaccg
gtcctgcggacggcgttcgtctgggccggggtcgatgagccactgcaggtggtgcaccgc
gaggtgcggctgccggtccgagtgctcgacgggaccggtcacgatcttcggcggctcctc
gccgaggaccgcgaacaagggctggacctcgcggaggcaccgctgatgcgcgtggccctc
gtgcggtcgtcggcgaccgaagtccaggtgctgtggacgttccaccacgcgctgctcgac
ggctggagcgtcttccatgtcctctccgacgtctgtggcgcctacgccggccaaagcctg
ccctccaggccaccgttccgggactacctcgcctggctgggcggcctcgaccggaccgac
gccgaacgcttctggcgtcgtaccctctccgggatcgacgggccgacgcccgttcccggc
gaccgggcgcccgcggccgggcacatcgcctgttcgtccgagtggctgcccgtccgcctg
gacgaggcggcgacgagcgggctcgacgagttcgtcaaacgccacggcctcacgcacaac
gcggtcctgcaaggggcctgggccttgctgctgtcggcctacagcggccacgacgacgtc
gtgttcgggtccaccgtctccggccgcccgcccgaagtgaccggcgtggacgcgatcacc
ggcatcttcatcaacacgctgccggtcaggatcgggatcgaccgtggtgcccgcgtcgcc
gactggctcgcgggtcttcagtcgagccaggccgaggcacgccgccacggacatcttccg
ctcgcgctggtccagggctgggcggagctgcccgggggagtgaacctctgcgagagcctg
gtggtgttcgagaactacccgatcaccggcgccgaagccgggcacggcctgaccgtgcga
gacctgtcggcacgcgagacgacgaacttcccgctgacggtcgtcgcgtcgcccggtcgt
gagctgaacgtcgacctgggctacgacccggccttgttcgacgccgaaacggtgagccgg
ctggccggtcacctgctcacgctgctccgggaactgacggtggacggcgctcgggcgatc
accgacgtgtcgatgctgaccccgcgggacgaactgctcctggcggaatggacgaaaatc
ggtgcggcggcccccgcccggtcgctgccggaactcttcgccgagcaggtccgcgcccgg
cccgacgcggtcgcggccgtcctcgatggcgagccggtcacctacgccgagttgaaccgg
cgggcgaaccggctggccaaccgcctgatcgggcttggcctgcgccccgaggaaccggtc
ggcctcgtcacgagcagggcgggcaccgtcgtggcggaactggccgtggtcaaggcgggc
ggcgcgtatctgccggtcgacacgcgcgccccggcggaacggcggcaggcgctgctcgac
ggtgtgcggttcgtcgtgtccgacagggagtatccgcacgccatccggctgtcctcagtg
gacgacgagccggacggcgatcccgtcttggtcgtcgatcccgaccggctggcgtacgtc
atgtacacctccgggtccaccggcaccccgaagggcgtcgcggtgcggcaccgcgacgtc
gccgccttggccgcggacagccggttccgcggcggggcacacgaacgggtcctgctgcat
tccccggcggccttcgacgcgaccacgtacgaactgtgggtaccgctgctcaccggcggc
cgcgtcgtcacggcgccggacggcgatctcgacgcgcaccgcctgcggaccttgatccgc
gagcacggcctgaccgggatgtgggtcacgacggggctgttccgggtgctggcgcaggaa
agcccggactgcttcaccggactgcgggaggtgtggaccggcggcgacgtcgtgcccgcc
gaggcggtgcggcgagtgctgggtgcctgccgggggctgcgtgtcgtcgacggctacggt
ccgaccgagacgaccaccttcgccaccgcccatccgatggacgagacggttccggaccgg
gtccccatcggcacgccgctggacggaatggtcgcccgcgtattggatccggacctgcgc
ccggtacctccgggagtgccgggcgagctgtacctcgccggttcaggcctcgcccgtggc
tatcgcgaccggccgggcctgaccgccgaccggttcctcgcggccccgggcgggcagcgg
atgtatcgcaccggcgacgtggtccgctggaccggggtgggcaccctcgaattcctcgga
cgggcggacgaccaggtgaagctgcgcggcttccgggtcgagcccggtgaggccgaagcc
atgctggcccggcatcccgccgtggcgcaggccgcggtcatcgtccgcgaagaccagccc
ggcctgaagcaactcgtcgcctacgtcgtgtcggaagccggacaggacaccctgcgggac
ttcctggccgaacggctgccggagtacttggtgccgtcggcgttcgtcgcgctggaccgg
atcccggtcagtgccaacggaaagctcgatcgcaaggcattgccggcaccggccgagcgg
gagagcgggtacgtcgagccggaaaccgaaaccgaactggcgctggccgggatctgggcc
gaagtgctcggcgtggagcggatcggcgtcgaggacaacttcttcgccctcggcggggat
tcgctgcggagcctgcacatcgcggccaaggcgggagccttgttcgcggtccggctcacc
ccggccgacgtcctgaccgcgcgcaccgtcgcggggctggccggaacggtcgaagaactc
atcttgggcgagctcgaaagcctcgcctccgaaacggaagcgtga
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