KEGG   Aotus nancymaae (Ma's night monkey): 105710740
Entry
105710740         CDS       T10127                                 
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase 3 isoform X1
  KO
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
Organism
anan  Aotus nancymaae (Ma's night monkey)
Pathway
anan00220  Arginine biosynthesis
anan00330  Arginine and proline metabolism
anan01100  Metabolic pathways
anan04020  Calcium signaling pathway
anan04022  cGMP-PKG signaling pathway
anan04066  HIF-1 signaling pathway
anan04071  Sphingolipid signaling pathway
anan04151  PI3K-Akt signaling pathway
anan04370  VEGF signaling pathway
anan04371  Apelin signaling pathway
anan04611  Platelet activation
anan04915  Estrogen signaling pathway
anan04921  Oxytocin signaling pathway
anan04926  Relaxin signaling pathway
anan04931  Insulin resistance
anan04933  AGE-RAGE signaling pathway in diabetic complications
anan05415  Diabetic cardiomyopathy
anan05417  Lipid and atherosclerosis
anan05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:anan00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    105710740 (NOS3)
   00330 Arginine and proline metabolism
    105710740 (NOS3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    105710740 (NOS3)
   04371 Apelin signaling pathway
    105710740 (NOS3)
   04066 HIF-1 signaling pathway
    105710740 (NOS3)
   04020 Calcium signaling pathway
    105710740 (NOS3)
   04071 Sphingolipid signaling pathway
    105710740 (NOS3)
   04022 cGMP-PKG signaling pathway
    105710740 (NOS3)
   04151 PI3K-Akt signaling pathway
    105710740 (NOS3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105710740 (NOS3)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    105710740 (NOS3)
   04921 Oxytocin signaling pathway
    105710740 (NOS3)
   04926 Relaxin signaling pathway
    105710740 (NOS3)
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105710740 (NOS3)
   05418 Fluid shear stress and atherosclerosis
    105710740 (NOS3)
   05415 Diabetic cardiomyopathy
    105710740 (NOS3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    105710740 (NOS3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105710740 (NOS3)
Enzymes [BR:anan01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     105710740 (NOS3)
SSDB
Motif
Pfam: NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1
Other DBs
NCBI-GeneID: 105710740
NCBI-ProteinID: XP_021520893
Ensembl: ENSANAG00000036230
LinkDB
Position
Unknown
AA seq 1203 aa
MGNLKSVAQESGPPCGLGLGLGLGLCGKQSPATPAPEPSRAPASPPPPAPEHSPPSSPLT
QPPEGPRFPRVKNWEVGSIAYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQGRPSPGPTAP
EQLLSQARAFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCVQHGWTPGSGRFDVLPLLLQAPDEPP
ELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW
KGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILFGSETGRAQGYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSVSCSDPLVSSWRRRRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSAQTEGLQLLPGLIHVHRRKMFQATILSVENLQSSKSTRATIL
VRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALSQDPRRY
EEWKWFRCPTLLEVLEQFPSVAPPAPLLLTQLPLLQPRYYSVSSAPSIHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAP
FRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSRE
PDNPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWAFDPPASDT
NGP
NT seq 3612 nt   +upstreamnt  +downstreamnt
atgggcaacttgaagagcgtggcccaggagtctgggccaccttgcggcctggggctgggg
ctgggcctcgggctgtgcggcaagcagagcccagccaccccagcccctgagcccagccga
gccccagcatcccctcccccgccagcgccagaacacagccccccgagctccccgctaacc
cagccaccggaggggcccaggttccctcgagtgaagaactgggaggtggggagcatcgcc
tatgataccctcagcgcccaggcacagcaggatgggccctgcaccccaagacgctgcctg
ggctccctggtatttccaaggaaactgcagggccggccctcccccggccccacagcccct
gagcagctgctgagtcaggcccgggccttcatcaaccagtactacagctccatcaagagg
agcggctcccaggcccacgagcagcggcttcaggaggtggaagccgaggtggcagccaca
ggcacctaccagcttagggagagcgagctggtgttcggggccaagcaggcctggcgcaac
gctccccgctgtgtgggccggatccagtgggggaagctgcaggtgttcgatgcccgggac
tgcaggtctgcacaggagatgttcacctacatctgcaaccacatcaagtatgccaccaac
cggggcaaccttcgctcggccatcacagtgttcccgcagcgctgccctggccgcggagac
ttccgaatctggaacagccagctggtgcgctacgcgggctaccggcagcaggatggctct
gtgcggggggacccggccaacgtggagatcactgagctctgcgtccagcacggctggacc
ccaggaagcggccgcttcgacgtgctgcccctgctgctgcaggccccagacgagccccca
gaactcttccttctgccccctgagctggtccttgaggtgcccctggagcaccccacgctg
gagtggttcgcagccctgggcctgcgctggtacgccctcccggcggtgtccaacatgctg
ctggaaattgggggtctggagttccccgcagcccccttcagtggctggtacatgagcact
gagattggcaccaggaacctgtgtgacccccaccgctacaacatcctggaggacgtggct
gtctgcatggacctggatacccggacgacctcgtccctgtggaaggacaaggcagcggta
gaaatcaacttggctgtgctgcacagttaccagctggccaaagtgaccatcgtggaccac
cacgctgccacagcctccttcatgaagcacctggagaatgagcagaaggccagggggggc
tgccctgcagactgggcctggatcgtgccccccatctcaggcagcctcactcctgtcttc
catcaggagatggtcaactatttcctgtcccctgccttccgctaccagccagacccctgg
aaggggagtgcggccaagggcaccggcatcaccaggaagaagacctttaaggaagtggcc
aacgctgtgaagatctccgcctcgctcatgggcaccgtgatggcgaagcgagtgaaggca
acaatcctgtttggctctgagaccggccgggcccagggctacgcacagcagttggggaga
ctcttccggaaggcttttgacccccgggtcctgtgtatggatgagtatgacgtggtgtcc
ctcgaacacgagacgctggtgctggtggtaaccagcacatttgggaatggggatcccccg
gagaatggagagagctttgcagccgccctgatggagatgtccggcccctacaacagctcc
ccaaggccggagcagcacaagagttataagatccgcttcaacagcgtctcctgctcagac
ccactggtgtcctcgtggcggcggaggaggaaggagtccagtaacacagacagtgcaggg
gccctgggcaccctcaggttctgtgtgttcgggctgggctcccgggcgtacccccacttc
tgcgcctttgctcgagcggtggacacgcggctggaggaactgggcggggagcggctgctg
cagctgggccagggcgacgagctgtgtggccaggaggaggccttccgaggctgggcccag
gccgccttccaggccgcctgtgagactttctgtgtgggagaggatgccaaagctgccgcc
cgagacatcttcagccccaaacggagctggaagcgccagaggtaccggctgagcgcccag
accgagggcctgcagttgctgccaggtctgatccacgtgcacaggcggaagatgttccag
gctacaatcctttcagtggaaaacctgcaaagcagcaagtccacgcgggccaccatcctg
gtgcgcctggacactggaggccaggaggggctgcagtaccagccgggggaccacataggc
gtctgcccacccaaccggcccggccttgtggaggcactgctgagccgcgtggaggacccg
ccggcaccaactgagcctgtggcagtagagcagctggagaagggcagccctggtggccct
ccccccggctgggtgcgggacccccggctgcccccgtgcacactgcgccaggctctcacc
ttcttcctggacatcacctccccacccagtcctcagctcttgcggctgctcagcaccctg
gcagaagagcccagggaacagcaggagctggaggccctcagccaggatccccggcgctac
gaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttcccgtcg
gtggccccgcctgccccactgctcctcacccagctgcctctgctgcagccccggtactac
tcagtcagctcagcacccagcatccaccccggagagatccacctcaccgtagctgtgctg
gcatacaggacccaggatgggctgggccccctgcactatggagtctgctccacgtggcta
agccaactcaagcctggagaccctgtgccctgcttcatccggggggctccctccttccgg
ctgccgcccgatcccagcctgccctgcatcctggtgggcccaggcactggcattgccccc
ttccggggattctggcaggagcggctgcacgacattgagagcaaagggctgcagcccgcc
cccatgactttggtgttcggctgccgatgctcccaacttgaccatctctaccgcgacgag
gtgcaggacgcccagcagcgcggggtgtttggccgagtcctcaccgccttctcccgggaa
cccgataatcccaagacctacgtgcaggacatcctaaggacggagctggctgcggaggtg
caccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgatgtcaccatggca
accaacgtcctgcagaccgtgcagcgcatcctggcgaccgagggcgacatggagctggac
gaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaagacattttt
gggctcacgctgcgcacccaggaggtgacaagccgcatacgcacccagagtttttccttg
caggagcggcagttgcggggcgcagtgccctgggcgttcgacccgcccgcctcagacacc
aatggcccctga

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