KEGG   Arvicanthis niloticus (African grass rat): 117706649
Entry
117706649         CDS       T08817                                 
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
anu  Arvicanthis niloticus (African grass rat)
Pathway
anu00562  Inositol phosphate metabolism
anu01100  Metabolic pathways
anu01521  EGFR tyrosine kinase inhibitor resistance
anu01522  Endocrine resistance
anu01524  Platinum drug resistance
anu04012  ErbB signaling pathway
anu04014  Ras signaling pathway
anu04015  Rap1 signaling pathway
anu04024  cAMP signaling pathway
anu04062  Chemokine signaling pathway
anu04066  HIF-1 signaling pathway
anu04068  FoxO signaling pathway
anu04070  Phosphatidylinositol signaling system
anu04071  Sphingolipid signaling pathway
anu04072  Phospholipase D signaling pathway
anu04081  Hormone signaling
anu04140  Autophagy - animal
anu04150  mTOR signaling pathway
anu04151  PI3K-Akt signaling pathway
anu04152  AMPK signaling pathway
anu04210  Apoptosis
anu04211  Longevity regulating pathway
anu04213  Longevity regulating pathway - multiple species
anu04218  Cellular senescence
anu04360  Axon guidance
anu04370  VEGF signaling pathway
anu04380  Osteoclast differentiation
anu04510  Focal adhesion
anu04550  Signaling pathways regulating pluripotency of stem cells
anu04611  Platelet activation
anu04613  Neutrophil extracellular trap formation
anu04620  Toll-like receptor signaling pathway
anu04625  C-type lectin receptor signaling pathway
anu04630  JAK-STAT signaling pathway
anu04650  Natural killer cell mediated cytotoxicity
anu04660  T cell receptor signaling pathway
anu04662  B cell receptor signaling pathway
anu04664  Fc epsilon RI signaling pathway
anu04666  Fc gamma R-mediated phagocytosis
anu04668  TNF signaling pathway
anu04670  Leukocyte transendothelial migration
anu04722  Neurotrophin signaling pathway
anu04725  Cholinergic synapse
anu04750  Inflammatory mediator regulation of TRP channels
anu04810  Regulation of actin cytoskeleton
anu04910  Insulin signaling pathway
anu04914  Progesterone-mediated oocyte maturation
anu04915  Estrogen signaling pathway
anu04917  Prolactin signaling pathway
anu04919  Thyroid hormone signaling pathway
anu04923  Regulation of lipolysis in adipocytes
anu04926  Relaxin signaling pathway
anu04929  GnRH secretion
anu04930  Type II diabetes mellitus
anu04931  Insulin resistance
anu04932  Non-alcoholic fatty liver disease
anu04933  AGE-RAGE signaling pathway in diabetic complications
anu04935  Growth hormone synthesis, secretion and action
anu04960  Aldosterone-regulated sodium reabsorption
anu04973  Carbohydrate digestion and absorption
anu05010  Alzheimer disease
anu05017  Spinocerebellar ataxia
anu05020  Prion disease
anu05100  Bacterial invasion of epithelial cells
anu05132  Salmonella infection
anu05135  Yersinia infection
anu05142  Chagas disease
anu05146  Amoebiasis
anu05160  Hepatitis C
anu05161  Hepatitis B
anu05162  Measles
anu05163  Human cytomegalovirus infection
anu05164  Influenza A
anu05165  Human papillomavirus infection
anu05166  Human T-cell leukemia virus 1 infection
anu05167  Kaposi sarcoma-associated herpesvirus infection
anu05168  Herpes simplex virus 1 infection
anu05169  Epstein-Barr virus infection
anu05170  Human immunodeficiency virus 1 infection
anu05171  Coronavirus disease - COVID-19
anu05200  Pathways in cancer
anu05203  Viral carcinogenesis
anu05205  Proteoglycans in cancer
anu05206  MicroRNAs in cancer
anu05207  Chemical carcinogenesis - receptor activation
anu05208  Chemical carcinogenesis - reactive oxygen species
anu05210  Colorectal cancer
anu05211  Renal cell carcinoma
anu05212  Pancreatic cancer
anu05213  Endometrial cancer
anu05214  Glioma
anu05215  Prostate cancer
anu05218  Melanoma
anu05220  Chronic myeloid leukemia
anu05221  Acute myeloid leukemia
anu05222  Small cell lung cancer
anu05223  Non-small cell lung cancer
anu05224  Breast cancer
anu05225  Hepatocellular carcinoma
anu05226  Gastric cancer
anu05230  Central carbon metabolism in cancer
anu05231  Choline metabolism in cancer
anu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
anu05415  Diabetic cardiomyopathy
anu05417  Lipid and atherosclerosis
anu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:anu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    117706649 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    117706649 (Pik3ca)
   04014 Ras signaling pathway
    117706649 (Pik3ca)
   04015 Rap1 signaling pathway
    117706649 (Pik3ca)
   04370 VEGF signaling pathway
    117706649 (Pik3ca)
   04630 JAK-STAT signaling pathway
    117706649 (Pik3ca)
   04668 TNF signaling pathway
    117706649 (Pik3ca)
   04066 HIF-1 signaling pathway
    117706649 (Pik3ca)
   04068 FoxO signaling pathway
    117706649 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    117706649 (Pik3ca)
   04072 Phospholipase D signaling pathway
    117706649 (Pik3ca)
   04071 Sphingolipid signaling pathway
    117706649 (Pik3ca)
   04024 cAMP signaling pathway
    117706649 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    117706649 (Pik3ca)
   04152 AMPK signaling pathway
    117706649 (Pik3ca)
   04150 mTOR signaling pathway
    117706649 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    117706649 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    117706649 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    117706649 (Pik3ca)
   04218 Cellular senescence
    117706649 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    117706649 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    117706649 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    117706649 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    117706649 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    117706649 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    117706649 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    117706649 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    117706649 (Pik3ca)
   04660 T cell receptor signaling pathway
    117706649 (Pik3ca)
   04662 B cell receptor signaling pathway
    117706649 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    117706649 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    117706649 (Pik3ca)
   04670 Leukocyte transendothelial migration
    117706649 (Pik3ca)
   04062 Chemokine signaling pathway
    117706649 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    117706649 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    117706649 (Pik3ca)
   04929 GnRH secretion
    117706649 (Pik3ca)
   04915 Estrogen signaling pathway
    117706649 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    117706649 (Pik3ca)
   04917 Prolactin signaling pathway
    117706649 (Pik3ca)
   04926 Relaxin signaling pathway
    117706649 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    117706649 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    117706649 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    117706649 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    117706649 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    117706649 (Pik3ca)
   04722 Neurotrophin signaling pathway
    117706649 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    117706649 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    117706649 (Pik3ca)
   04380 Osteoclast differentiation
    117706649 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    117706649 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    117706649 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    117706649 (Pik3ca)
   05206 MicroRNAs in cancer
    117706649 (Pik3ca)
   05205 Proteoglycans in cancer
    117706649 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    117706649 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    117706649 (Pik3ca)
   05203 Viral carcinogenesis
    117706649 (Pik3ca)
   05230 Central carbon metabolism in cancer
    117706649 (Pik3ca)
   05231 Choline metabolism in cancer
    117706649 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    117706649 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    117706649 (Pik3ca)
   05212 Pancreatic cancer
    117706649 (Pik3ca)
   05225 Hepatocellular carcinoma
    117706649 (Pik3ca)
   05226 Gastric cancer
    117706649 (Pik3ca)
   05214 Glioma
    117706649 (Pik3ca)
   05221 Acute myeloid leukemia
    117706649 (Pik3ca)
   05220 Chronic myeloid leukemia
    117706649 (Pik3ca)
   05218 Melanoma
    117706649 (Pik3ca)
   05211 Renal cell carcinoma
    117706649 (Pik3ca)
   05215 Prostate cancer
    117706649 (Pik3ca)
   05213 Endometrial cancer
    117706649 (Pik3ca)
   05224 Breast cancer
    117706649 (Pik3ca)
   05222 Small cell lung cancer
    117706649 (Pik3ca)
   05223 Non-small cell lung cancer
    117706649 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    117706649 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    117706649 (Pik3ca)
   05161 Hepatitis B
    117706649 (Pik3ca)
   05160 Hepatitis C
    117706649 (Pik3ca)
   05171 Coronavirus disease - COVID-19
    117706649 (Pik3ca)
   05164 Influenza A
    117706649 (Pik3ca)
   05162 Measles
    117706649 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    117706649 (Pik3ca)
   05163 Human cytomegalovirus infection
    117706649 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    117706649 (Pik3ca)
   05169 Epstein-Barr virus infection
    117706649 (Pik3ca)
   05165 Human papillomavirus infection
    117706649 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    117706649 (Pik3ca)
   05135 Yersinia infection
    117706649 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    117706649 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    117706649 (Pik3ca)
   05142 Chagas disease
    117706649 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    117706649 (Pik3ca)
   05017 Spinocerebellar ataxia
    117706649 (Pik3ca)
   05020 Prion disease
    117706649 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    117706649 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    117706649 (Pik3ca)
   05415 Diabetic cardiomyopathy
    117706649 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    117706649 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    117706649 (Pik3ca)
   04931 Insulin resistance
    117706649 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    117706649 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    117706649 (Pik3ca)
   01524 Platinum drug resistance
    117706649 (Pik3ca)
   01522 Endocrine resistance
    117706649 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:anu04131]
    117706649 (Pik3ca)
Enzymes [BR:anu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     117706649 (Pik3ca)
Membrane trafficking [BR:anu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    117706649 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 117706649
NCBI-ProteinID: XP_034355469
LinkDB
Position
4:17872854..17945529
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDLVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPID
SFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
FHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcttcgggcgaactgtggggcatccacttgatgcccccacgaatc
ctcgtggaatgtttactcccaaatggaatgatagtgactttagagtgcctccgtgaggcc
acgctggtcaccatcaaacatgaactgttcaaagaggccaggaaataccctctccatcag
cttttgcaagatgaatcttcttacatttttgtaagcgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagagaagatcctcaatcgagaaattggtttcgtt
attggcatgccagtgtgtgaatttgatttggttaaagatccagaagtccaagacttccga
aggaacattctgaatgtttgcaaagaagccgtggacctgcgggatctcaactcgcctcac
agcagagcaatgtatgtctaccctccaaatgtcgagtcttccccagaactgccaaagcac
atctacaacaagttagataaaggacaaatcatagtggtgatttgggtaatagtctctcca
aacaatgacaagcagaagtacactctgaagatcaaccatgactgtgtgccagagcaagtc
attgctgaagccatcaggaagaagacccggagcatgttgttgtcctctgagcagctgaag
ctctgtgtcttagaatatcagggcaagtacattctgaaagtgtgtggctgtgatgagtac
ttcctagaaaagtaccctctcagtcagtacaagtacataagaagctgtataatgctggga
aggatgcccaacttgatgttgatggccaaggaaagcctgtactctcagctgccgattgat
agcttcaccatgccatcatattccaggcgcatctccacagctaccccctacatgaatgga
gagacatctacgaaatccctctgggttataaatagcgcgctcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
ttccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgcg
cgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccgttggcctggggaaacataaacttgtttgattatacagacacgctagtgtcaggaaaa
atggctttgaatctctggcctgtaccacatgggttagaagatctgctgaatcctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagaattggagtttgactggttc
agcagtgtggtgaagtttccagacatgtctgtgatcgaagagcatgccaattggtctgtg
tcccgagaagctggcttcagttactctcatacaggactgagtaacagattagccagagac
aatgagttaagagaaaatgacaaggaacagctccgagcactttgcacccgggacccactg
tctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgtgtaact
attcctgaaatcctccccaaattgcttctgtctgtcaagtggaattccagagatgaagtg
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaagccatggaa
ctcctagactgtaactatccagatcccatggttcgaagttttgccgttcggtgcttggaa
aaatacttaacagatgacaaactctctcagtacctcattcagcttgtacaggtcttaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgacaaat
caaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagactgtc
agtcagaggtttggcctgctgttagagtcctactgccgtgcctgtgggatgtatctgaag
cacctgaacagacaagtagaggccatggagaagctcatcaacctcactgacattctcaag
caggagaagaaggatgagacacagaaggtacagatgaagtttttggttgaacagatgaga
cagccagatttcatggatgctttgcagggttttctgtcccctctaaatcctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggcgacgacttacggcaagatatgttaacccttcagatcatccgaatcatg
gagaacatctggcaaaaccaaggccttgaccttcgcatgctgccttatggctgtctgtcc
attggggactgtgtgggtctcatcgaggtggtcagaaactctcacaccatcatgcagatc
cagtgcaaaggaggcctgaagggggcactgcagttcaatagccacacactgcatcagtgg
ctcaaggacaagaacaagggcgagatatatgatgcagctattgacctgttcactcggtcc
tgtgctggttactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaac
atcatggtgaaagatgacggacagctgttccatatagattttgggcactttttggatcac
aagaagaaaaaatttggctataaacgggaacgtgtgccatttgttttgacgcaggatttc
ttaatcgtgattagtaaaggtgcacaagagtacacgaagaccagagagtttgagaggttt
caggagatgtgttacaaggcttacctagcaattcggcagcatgctaatctcttcatcaac
cttttttccatgatgcttggctctggaatgccagaactgcagtcttttgatgacattgcg
tatattcgaaagactctagccttagacaaaactgagcaagaggctttggaatatttcaca
aagcaaatgaatgatgcacatcatggtggctggacgacaaaaatggattggatcttccac
accatcaagcagcatgcattgaactga

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