KEGG   Arvicanthis niloticus (African grass rat): 143439404
Entry
143439404         CDS       T08817                                 
Symbol
Map2k1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
anu  Arvicanthis niloticus (African grass rat)
Pathway
anu01521  EGFR tyrosine kinase inhibitor resistance
anu01522  Endocrine resistance
anu04010  MAPK signaling pathway
anu04012  ErbB signaling pathway
anu04014  Ras signaling pathway
anu04015  Rap1 signaling pathway
anu04022  cGMP-PKG signaling pathway
anu04024  cAMP signaling pathway
anu04062  Chemokine signaling pathway
anu04066  HIF-1 signaling pathway
anu04068  FoxO signaling pathway
anu04071  Sphingolipid signaling pathway
anu04072  Phospholipase D signaling pathway
anu04114  Oocyte meiosis
anu04140  Autophagy - animal
anu04148  Efferocytosis
anu04150  mTOR signaling pathway
anu04151  PI3K-Akt signaling pathway
anu04210  Apoptosis
anu04218  Cellular senescence
anu04270  Vascular smooth muscle contraction
anu04370  VEGF signaling pathway
anu04371  Apelin signaling pathway
anu04380  Osteoclast differentiation
anu04510  Focal adhesion
anu04517  IgSF CAM signaling
anu04540  Gap junction
anu04550  Signaling pathways regulating pluripotency of stem cells
anu04613  Neutrophil extracellular trap formation
anu04620  Toll-like receptor signaling pathway
anu04650  Natural killer cell mediated cytotoxicity
anu04660  T cell receptor signaling pathway
anu04662  B cell receptor signaling pathway
anu04664  Fc epsilon RI signaling pathway
anu04666  Fc gamma R-mediated phagocytosis
anu04668  TNF signaling pathway
anu04720  Long-term potentiation
anu04722  Neurotrophin signaling pathway
anu04725  Cholinergic synapse
anu04726  Serotonergic synapse
anu04730  Long-term depression
anu04810  Regulation of actin cytoskeleton
anu04910  Insulin signaling pathway
anu04912  GnRH signaling pathway
anu04914  Progesterone-mediated oocyte maturation
anu04915  Estrogen signaling pathway
anu04916  Melanogenesis
anu04917  Prolactin signaling pathway
anu04919  Thyroid hormone signaling pathway
anu04921  Oxytocin signaling pathway
anu04926  Relaxin signaling pathway
anu04928  Parathyroid hormone synthesis, secretion and action
anu04929  GnRH secretion
anu04934  Cushing syndrome
anu04935  Growth hormone synthesis, secretion and action
anu05010  Alzheimer disease
anu05022  Pathways of neurodegeneration - multiple diseases
anu05034  Alcoholism
anu05132  Salmonella infection
anu05135  Yersinia infection
anu05160  Hepatitis C
anu05161  Hepatitis B
anu05163  Human cytomegalovirus infection
anu05164  Influenza A
anu05165  Human papillomavirus infection
anu05166  Human T-cell leukemia virus 1 infection
anu05167  Kaposi sarcoma-associated herpesvirus infection
anu05170  Human immunodeficiency virus 1 infection
anu05200  Pathways in cancer
anu05205  Proteoglycans in cancer
anu05206  MicroRNAs in cancer
anu05207  Chemical carcinogenesis - receptor activation
anu05208  Chemical carcinogenesis - reactive oxygen species
anu05210  Colorectal cancer
anu05211  Renal cell carcinoma
anu05212  Pancreatic cancer
anu05213  Endometrial cancer
anu05214  Glioma
anu05215  Prostate cancer
anu05216  Thyroid cancer
anu05218  Melanoma
anu05219  Bladder cancer
anu05220  Chronic myeloid leukemia
anu05221  Acute myeloid leukemia
anu05223  Non-small cell lung cancer
anu05224  Breast cancer
anu05225  Hepatocellular carcinoma
anu05226  Gastric cancer
anu05230  Central carbon metabolism in cancer
anu05231  Choline metabolism in cancer
anu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:anu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    143439404 (Map2k1)
   04012 ErbB signaling pathway
    143439404 (Map2k1)
   04014 Ras signaling pathway
    143439404 (Map2k1)
   04015 Rap1 signaling pathway
    143439404 (Map2k1)
   04370 VEGF signaling pathway
    143439404 (Map2k1)
   04371 Apelin signaling pathway
    143439404 (Map2k1)
   04668 TNF signaling pathway
    143439404 (Map2k1)
   04066 HIF-1 signaling pathway
    143439404 (Map2k1)
   04068 FoxO signaling pathway
    143439404 (Map2k1)
   04072 Phospholipase D signaling pathway
    143439404 (Map2k1)
   04071 Sphingolipid signaling pathway
    143439404 (Map2k1)
   04024 cAMP signaling pathway
    143439404 (Map2k1)
   04022 cGMP-PKG signaling pathway
    143439404 (Map2k1)
   04151 PI3K-Akt signaling pathway
    143439404 (Map2k1)
   04150 mTOR signaling pathway
    143439404 (Map2k1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    143439404 (Map2k1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    143439404 (Map2k1)
   04148 Efferocytosis
    143439404 (Map2k1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    143439404 (Map2k1)
   04210 Apoptosis
    143439404 (Map2k1)
   04218 Cellular senescence
    143439404 (Map2k1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    143439404 (Map2k1)
   04540 Gap junction
    143439404 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    143439404 (Map2k1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    143439404 (Map2k1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    143439404 (Map2k1)
   04620 Toll-like receptor signaling pathway
    143439404 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    143439404 (Map2k1)
   04660 T cell receptor signaling pathway
    143439404 (Map2k1)
   04662 B cell receptor signaling pathway
    143439404 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    143439404 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    143439404 (Map2k1)
   04062 Chemokine signaling pathway
    143439404 (Map2k1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    143439404 (Map2k1)
   04929 GnRH secretion
    143439404 (Map2k1)
   04912 GnRH signaling pathway
    143439404 (Map2k1)
   04915 Estrogen signaling pathway
    143439404 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    143439404 (Map2k1)
   04917 Prolactin signaling pathway
    143439404 (Map2k1)
   04921 Oxytocin signaling pathway
    143439404 (Map2k1)
   04926 Relaxin signaling pathway
    143439404 (Map2k1)
   04935 Growth hormone synthesis, secretion and action
    143439404 (Map2k1)
   04919 Thyroid hormone signaling pathway
    143439404 (Map2k1)
   04928 Parathyroid hormone synthesis, secretion and action
    143439404 (Map2k1)
   04916 Melanogenesis
    143439404 (Map2k1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    143439404 (Map2k1)
  09156 Nervous system
   04725 Cholinergic synapse
    143439404 (Map2k1)
   04726 Serotonergic synapse
    143439404 (Map2k1)
   04720 Long-term potentiation
    143439404 (Map2k1)
   04730 Long-term depression
    143439404 (Map2k1)
   04722 Neurotrophin signaling pathway
    143439404 (Map2k1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    143439404 (Map2k1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    143439404 (Map2k1)
   05206 MicroRNAs in cancer
    143439404 (Map2k1)
   05205 Proteoglycans in cancer
    143439404 (Map2k1)
   05207 Chemical carcinogenesis - receptor activation
    143439404 (Map2k1)
   05208 Chemical carcinogenesis - reactive oxygen species
    143439404 (Map2k1)
   05230 Central carbon metabolism in cancer
    143439404 (Map2k1)
   05231 Choline metabolism in cancer
    143439404 (Map2k1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    143439404 (Map2k1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    143439404 (Map2k1)
   05212 Pancreatic cancer
    143439404 (Map2k1)
   05225 Hepatocellular carcinoma
    143439404 (Map2k1)
   05226 Gastric cancer
    143439404 (Map2k1)
   05214 Glioma
    143439404 (Map2k1)
   05216 Thyroid cancer
    143439404 (Map2k1)
   05221 Acute myeloid leukemia
    143439404 (Map2k1)
   05220 Chronic myeloid leukemia
    143439404 (Map2k1)
   05218 Melanoma
    143439404 (Map2k1)
   05211 Renal cell carcinoma
    143439404 (Map2k1)
   05219 Bladder cancer
    143439404 (Map2k1)
   05215 Prostate cancer
    143439404 (Map2k1)
   05213 Endometrial cancer
    143439404 (Map2k1)
   05224 Breast cancer
    143439404 (Map2k1)
   05223 Non-small cell lung cancer
    143439404 (Map2k1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    143439404 (Map2k1)
   05170 Human immunodeficiency virus 1 infection
    143439404 (Map2k1)
   05161 Hepatitis B
    143439404 (Map2k1)
   05160 Hepatitis C
    143439404 (Map2k1)
   05164 Influenza A
    143439404 (Map2k1)
   05163 Human cytomegalovirus infection
    143439404 (Map2k1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    143439404 (Map2k1)
   05165 Human papillomavirus infection
    143439404 (Map2k1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    143439404 (Map2k1)
   05135 Yersinia infection
    143439404 (Map2k1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    143439404 (Map2k1)
   05022 Pathways of neurodegeneration - multiple diseases
    143439404 (Map2k1)
  09165 Substance dependence
   05034 Alcoholism
    143439404 (Map2k1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    143439404 (Map2k1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    143439404 (Map2k1)
   01522 Endocrine resistance
    143439404 (Map2k1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:anu01001]
    143439404 (Map2k1)
Enzymes [BR:anu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     143439404 (Map2k1)
Protein kinases [BR:anu01001]
 Serine/threonine kinases: STE group
  STE7 family
   143439404 (Map2k1)
SSDB
Other DBs
NCBI-GeneID: 143439404
NCBI-ProteinID: XP_076781865
LinkDB
Position
26:complement(36658386..36724758)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETSLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgatggctcggcggtt
aacgggaccagctcggccgagaccagcctggaggccttgcagaagaagctggaggagctg
gagctggatgagcagcagcgcaagcgcctggaggccttcctgacgcagaagcagaaggtg
ggggagctgaaggacgacgacttcgagaagattagtgaactgggggctggcaatggtgga
gtggtgttcaaggtctcccacaagccgtctggcctggttatggctagaaagctaattcac
ctggagatcaaacctgcaatccgcaaccagatcatccgggagctgcaggtgctgcacgag
tgtaactccccgtacatcgtgggcttctacggggctttctacagtgacggcgagatcagc
atctgcatggagcacatggatggtgggtccttggatcaagttctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtgataaaaggcctgacgtatctt
cgggagaagcacaagattatgcacagagatgtcaagccttccaacattctagtgaactca
cgtggggagatcaagctctgtgattttggggtcagtgggcagctgattgactccatggcc
aactccttcgtgggcacgaggtcctacatgtcgcccgagagactccaggggacgcactac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttgggaga
taccccattcctcctcccgacgccaaggaactggagctgctgtttggatgccaggtggaa
ggagatgcagccgaaactccacccaggccaaggacccctgggaggcccctcagctcatat
ggaatggacagccgacctccaatggcgatttttgagttgttggattacatcgtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaggattttgtgaataaa
tgcttaataaagaaccctgcagagagagcagatctgaagcagctcatggtacatgctttc
atcaaaagatctgatgctgaggaggtagactttgcaggctggctctgctccaccattggg
cttaaccagcccagcacaccaacgcacgctgccagcatctga

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