Amycolatopsis keratiniphila: AORI_1478 Help Entry AORI_1478         CDS       T02678                                  Name (GenBank) amino acid adenylation   KO K16428   nonribosomal peptide synthetase CepA Organism aoi  Amycolatopsis keratiniphila Pathway aoi01055   Biosynthesis of vancomycin group antibiotics Brite KEGG Orthology (KO) [BR:aoi00001]  09100 Metabolism   09109 Metabolism of terpenoids and polyketides    01055 Biosynthesis of vancomycin group antibiotics     AORI_1478  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:aoi01008]     AORI_1478 Polyketide biosynthesis proteins [BR:aoi01008]  Nonribosomal peptide synthetase (NRPS)   Linear NRPS    Vancomycin synthetase     AORI_1478 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AMP-binding Condensation PP-binding AMP-binding_C Motif Other DBs NCBI-ProteinID:  AGM04066 UniProt:  R4SV84 LinkDB All DBs Position 1540853..1550305 Genome browser AA seq 3150 aa AA seqDB search MNSAARTTRTVLELFASHVDRTPGAVAVVDGDRVLTYRQLDEQASRLAGCLAGRGIRRGD RVAVIMGRSADLVAALLGVWKAGAAYVPVDAAYPAPRVEFMVSDSAAALTVCSAATRSAV PAGVASLEADAVTDEDAGGTPVAAARPGDPAFVMYTSGSTGTPKGVVISQSRVAELVQDP GWEMGPDDAVLMHSPHAFDASLLEIWTPLSSGARVVIAEPGVMDARRLREVAAAGVTRAY LTAGSFRAVAEESPESFAGFREVLTGGDVVPVHAVERVRQACPRARVRHMYGPTEATMCA TWHLLEPGDVLGTVLPIGRPLAGRAVHVLDESLRPVGPGVVGDLYLSGSLAEGYFGKAGL TAERFVADPSTPGQRMYWTGDLAQWTAEGELLFAGRADNQVKVRGFRIEPGEIEAALIAQ PDVQDAVVAAIDGRLIGYVVAGEDVDPALVRERLRAVLPEYLVPVAVLVLDALPLTGNGK VDRAALPAPEFTASATSREPATEAERVLCGLFAEVLRIDRAGVDDGFFELGGDSILAMRL AARAAKAGLLLTPVQIFEETTPARLAAVARDLPADRPADGALLSLTEAEEAELALAAPGA DEIWPLAPLQEGLLFESILDDQGPDIYQVQVILELTGEVDETRLRAAWDTVVRRHDELRL TFHRLESGKTVQAVHGDVTVPWRTVDLTGADDVDTAFEALAMQEQAHRFDLATAPLIRLV LVRVGEDRHRLLVVIHHILVDGWSVAVILNEAFEAYEPGGRLPERREGAGYLDYLAWLER QDKDAAREAWRAELSDLDEPALIASASAATDYDYRVTHLPPALHDGLLEFTREHGLTPST VVHAAWAMVLSRLTRRTDVVFGTMVATRPAELPGIESMPGLLMSAMPVRVTLDGGQAVMD MLTGLYGRQLALMPHQHLGLPEIQKAAGPGATFDTLLVVENYPREYAGRYKYLRTIEGTH YPLTLGITPGDRFKIQLGYWQGQVPDAVADSLLEWFVGAIGALVADPAGPVGRIGVGTAE ARDWRTPLVAGEPLHTLVGRMAAERPDGVALVDGDGELTYARLWDLSVRFAAVLRAHGVG AESRVGLVVGRSSWWTVGMLGVLLAGGTFVPVDPAYPDERKETIFRSADPMLVVCAASTR GTVPAEYADRSLVIDEVELTAATEEELPRVDPRSAAYVIYTSGSTGTPKGVVVTHTGLGN LALAHIERFAVKPSSRVLQFAALGFDTIVSEVMMALLSGATLVVPPERELPPRMAMSETL ARWDITQVKAPPSVLGTVDVLPDRVDTVVAAGELCPPGLVDRMSANHRMINAYGPTETTI CATMSMPLSPGQHPIPFGGPVPGVRAYLLDSFLRPLPPGITGELYLAGIGVARGYLGRPA LTAERFVADPFAPGERMYRTGDLAYWTDQGELVSAGRADDQVKIRGFRVEPREIEFALSA YPGITQATVTVREDRLIAYVTPGDIDTQAVRAQLASRMPQYMVPAAVVALDVLPLTAHGK IDRRALPDPDFVTGTPAREPATETERVLCELFAGVLGLERAGVDDSFFDLGGDSILSMQL AARARRSGLSFTAADVFDGKTPERIAQLAEVSSPPEQAASPKPDGVGDVAWTPVMSLLGD GVTGPGFAQWMVVATPPGLTEKALAAGFSAVVATHDMLRARVVEDGRGRRLVVGERGAVD PAGWITRVGLDGRSPDEAVEDAAREAVGRLDPAAGVMARVVWLDAGPDRAGRLVVVVHHL SVDGVSWRILLSDLRSACEAAAEGRTPALEPVGLSFKRWASLLKEQAVSAERVAELEAWK AILGPVERGPSESRAAGGEVRSRSWVVPKAETRALVGRAPLVFHCGVNDVLLAGLAGAVA RRRGGDAVLVDVEGHGRHPAAGTDLSRTVGWFTSAHPVRLAVADTDLADVLAGGPAAGRL LKLVKEQSRAVPGDGLGYGMLRYLNDVTGPVLAALPSPEIGFNYLGRFATAEKGDVRAWQ PVGDLGSAQEPGMGLPHALEVNAIVQDSPDGPELTLLLEWQEDLLDEAEVERLAQDWLDM LAGLARQADDPAAGGHTASDFELVTLDQAEIEALEAEYADAGGVADVLPLSPLQHGLAFH AGYGGDGVDVYTAQAVLDLSGPLDMLLLRKSVRGLLDRHPNLRAGFRHAAAGPAYQVIPG AVEVPVSFVDATGSADPEAEATAVAEAERARPFELAKPPLLRITVVALSRDSHRLVLTNH HILLDGWSTPLLVDELLTLYRDGAAPSALAPVTPYRDYLAWVGETDRDASITAWREALAG LPEPTLVADDRPVPVQVPGQMWAELDETFAAALTARARECGVTVSTMLQAVWGLVLAATT GRDDVVFGAVVSGRPAELPGIETMVGLFINTVPVRVRTRPEQTFAELVRQIQDEQIALLA HHHVGLADIQQAAGLGRLFDTLVVYENYPRPDETADTEPDRLRVRGMTAADATHYPLALA VVPGDVLRLRLEHQPTLFTTEQAAAVLDRFTRVLEAVVAEPRTPLPAVPILSAAEQRDLL ARNDTAVEVPDRTLPESFAAQAAATPDATAVVFEDLSLSYAELDARANQLARWLIERGAG PEGLVAVLLPRSLELVVTVLAITKTGAAWLPIDPVYPAERVSYMLDDARPSLVITSAALS ASPAGEVVAGRQATVVIDDPVAVGELAARDRAPVTDADRVRPLDPRHPAYLIYTSGSTGR PKAVVVTHRNLANYLFHCGRKYPGLRGRSLMHSSIAFDLTVTALLTPLTVGGTVQVGALE DLIGTVESAPALFLKATPSHVKTLDTGSREIAVAGDLLLGGEQLPVDTIAHWRRTYPNTV VVNEYGPTEATVGCVEFRLEPGQPAPSGEVVPIGTPMTNARAFVLDSWLRPVPPGAVGEL YVAGAGVARGYLGRPGLTATRFVADPSGDGGLMYRTGDLVRWNPDGELMFIGRVDDQVKV RGYRIEPGEIEAALVAQEPVGQAVVLAKDGASGKRLIGYVTAAGESEVDEAAVLAGVAAR LPRYMVPAAVVVLETLPLTANGKVDRDALPDPDFNGRVTGREPVTEAERLLCSLFAEVLG LERAGADDSFFELGGDSILSMQLAARAHRAGIAFGAREVFEQRTPAAIAAVVERAASAPA ASEHATSDVALLELDQDEIDEFEAEFESGR NT seq 9453 nt NT seq  +upstreamnt  +downstreamnt atgaattccgcagcgcggaccacacggacggtgctggagctgttcgcgtcgcacgtggac cggacgcccggcgcggtggccgtggtcgacggtgaccgggtgctgacataccggcagctc gacgagcaagcgagccggttggccggatgcctggcaggccggggaatccgccgtggcgac cgggtcgcggtgatcatgggccggtcggcggacctggtggcggcgctgctcggcgtgtgg aaggcgggggcggcgtatgtgccggtcgacgccgcctatcccgctccgcgcgtggaattc atggtgtcggactcggcggccgcgctgacggtgtgctcggccgccacccgttccgccgta ccggcgggggtggcgtcgctcgaagcggacgccgtcacggacgaggacgcgggcggcact ccggtcgccgcggcgcgcccgggggatccggcgttcgtgatgtacacgtccggctctacg ggcacgccgaagggagtggttatctcccagagccgtgtcgcggagctggtgcaggacccc ggttgggagatggggccggacgacgcggtgctcatgcactcgccgcacgccttcgacgcg tccctgctcgaaatctggacgccgctgtcctcgggggcccgggtggtgatcgccgaaccg ggcgtgatggacgcccggcgcctgcgggaagtggccgccgcgggagtgacgcgcgcgtac ctgaccgcggggagtttccgtgcggtggctgaggaatcgccggaatccttcgccgggttc cgcgaggtgctgaccggcggcgacgtggtgcccgtgcacgcggtggagcgcgtgcggcag gcctgcccccgggcgcgggtccggcatatgtacggaccgaccgaagcgacgatgtgcgcg acgtggcatctgctggagccgggtgacgtgctggggacggtgctgccgatcgggcgtccg ctggcgggccgcgcggtccacgtgctcgacgagtcgctgcggcccgtcgggccgggtgtg gtcggcgacctgtatctctcgggaagcctggcggagggctacttcggcaaggccgggctg acggcggaacggttcgtggcggatccctccacgccgggacagcggatgtactggacgggc gacctcgcccagtggaccgccgagggcgagctgctgttcgcgggccgggccgacaaccag gtgaaggtccgcgggttccggatcgaacccggcgagatcgaggccgcgctcatcgcccag ccggacgtccaggacgccgtggtggcggcgatcgacggacggctcatcggttatgtggtg gcgggtgaggacgtcgaccccgcgctcgtccgcgagcgtctccgtgcggtgctgccggag tacctggtcccggtcgccgtgctcgtgctggacgcgttgccgctgaccggcaacggcaag gtggaccgggcggcgctgcccgcacccgagttcacggcgagcgccacgagccgggagccc gccaccgaggccgagcgtgtcctttgtggactgttcgccgaggtgctccggatcgaccgg gccggtgtcgacgacggattcttcgaactgggcggggattcgatcctcgcgatgcgcctg gcggcgcgcgcggccaaggccggtctgctgctgacgccggtccagatcttcgaggagacc actcccgcgcggctggccgccgtggcgcgggacctgcccgccgaccggcccgccgacggt gccctgctcagcctgaccgaggcggaagaggcggagctggcgctcgccgctcccggcgcc gacgagatctggccgctggccccgctgcaggaggggctgctcttcgaatcgatcctcgac gaccagggccccgacatctaccaggtgcaggtgatcctggagctgaccggcgaggtggac gagacccggctgcgagccgcgtgggacaccgtcgtccggcggcacgacgagctgcggctg accttccaccggctcgaatcgggcaagaccgtgcaggccgtccacggggatgtcaccgtg ccgtggcggacggtggatctgaccggcgccgacgacgtcgacaccgccttcgaagccctg gcgatgcaggagcaggcgcatcggttcgacctcgccacggcgccgctgatccggctggtg ctcgtccgggtcggggaggaccggcaccggctgctggtcgtcatccaccacatcctggtc gacggctggtcggtggcggtcatcctcaacgaggcgttcgaggcctacgagcccggcggg cggctgccggaacggcgggagggcgccggctatctcgactacctggcttggctggagagg caggacaaggacgcggcacgcgaggcctggcgggcggagctgtccgacctcgacgagccc gcgctcatcgcgtcggcgtcggccgcgacggactacgactaccgcgtcacccacctgccg cccgcgctgcacgacggcctcctggaattcacccgtgagcacgggctgacaccgagcacg gtggtgcacgccgcctgggcgatggtgctgtcgcggctcacgcggcggaccgacgtggtg ttcggcaccatggtcgcgacccgccccgcggaactgccgggcatcgagtcgatgccgggc ctgctgatgagcgcgatgccggtccgtgtgacgctggacggcgggcaggcggtcatggac atgctcaccgggctgtacggccgtcagctggccctcatgccgcatcagcacctgggactg ccggagatccagaaggcggccggacccggcgcgaccttcgacacgctgctggtggtcgag aactacccgcgggaatacgccggccggtacaagtacctgcgcacgatcgaagggacccac tatccgctgacgctcggcatcaccccgggggaccggttcaagatccagctcggctactgg cagggccaggtcccggacgccgtcgccgactcgctgctggagtggttcgtcggtgccatc ggcgccctggtcgccgatcccgccggtccggtggggcggatcggggtgggcacggcggag gcacgcgactggcgaacgccactcgtggcgggggaaccgctgcacacgctggtggggcgg atggccgccgagcggccggacggcgtggcgctggtggacggcgacggcgagctgacctac gcgcggttgtgggatctctcggtgcggttcgccgccgtgctgcgcgcccacggcgtcggg gcggagtcccgggtcggcctggtggtgggacggtcgtcctggtggaccgtcggcatgctg ggcgtcctgctcgcgggcggcacgttcgtgccggtggacccggcgtatccggacgagcgc aaggaaacgatcttccgcagcgcggatccgatgctggtggtgtgcgcggcgtcgacccgg gggaccgtgcccgccgagtacgcggaccggtcgctggtgatcgacgaggtcgagctgacg gcggcgacggaggaagagctgccgcgggtggatccgcgtagtgccgcgtacgtgatctac acgtcgggatcgacggggaccccgaagggcgtcgtcgtcacccacaccgggctggggaac ctggcgctggcgcatattgaacggttcgccgtgaagccgtcgtcgcgggttttgcagttc gcggcgctcggcttcgacaccatcgtgtccgaggtgatgatggcgctgctgtcgggagcc acgctggtggtgccgccggagcgggagctgccgccgcggatggcgatgtccgaaacgctg gcacggtgggacatcacgcaggtgaaggcgccgccgtcggtgctgggcacggtcgacgtg ctgccggaccgggtggacaccgtggtcgcggcgggcgaactctgcccgcccggcctggtg gaccggatgtccgcgaaccaccggatgatcaacgcctacgggccgaccgagaccacgatc tgcgcgacgatgagcatgccgttgtcgccgggccagcacccgatcccgttcggcggaccg gttccgggagtgcgcgcctatctgctggactcgttcctgcgcccgttgccgcccggcatc accggtgagctgtatctggcgggcatcggggtggcgcgcggttacctgggccgtccggcg ctgacggccgagcggttcgtcgccgatccgttcgcccccggtgagcggatgtaccggacc ggggacctggcgtactggacggatcagggcgaactggtgtccgccgggcgggccgatgac caggtgaagatccgcggcttccgggtcgaaccgcgcgaaatcgagttcgcgctgtccgcg tacccggggatcacccaggccaccgtgaccgtccgcgaagaccgcctgatcgcctacgtg acgccgggagacatcgacacccaggcggtgcgggcgcagctcgcgtcgcggatgccccag tacatggtgcccgcggcggtggtggcgctggacgtcctgccgctgacggcgcacgggaag atcgaccggcgcgcgttgcccgaccccgatttcgtcaccgggacgcccgccagggagccc gccaccgagaccgagcgggtgctgtgcgagctgttcgccggcgtgctcgggctggagcgg gccggggtggacgacagcttcttcgacctcggcggggactccatcctctcgatgcagctc gcggcgcgggcgcggcgttcgggactgagtttcaccgcggcggacgtcttcgacgggaag accccggagcgcatcgcgcagctggcggaggtgtcttcgccgccggaacaggccgcttcc ccgaagcccgacggtgtcggcgacgtcgcctggacgccggtgatgtcgctgctgggcgac ggcgtcacgggacccggattcgcgcagtggatggtggtcgcgacacctccgggcctgacg gaaaaggctttggcggcgggattctcggccgtggtggcgacgcacgacatgctgcgggcc cgcgtcgtcgaagacgggcgcggacggcggctggtggtcggcgagcgcggggcggtggac ccggccgggtggatcacccgcgtcgggctcgacggccgttcgccggacgaggccgtcgag gacgcggcacgcgaggccgtcggcaggctcgacccggcggcgggggtgatggcgcgggtc gtgtggctcgacgccggaccggaccgggccggccggttggtggtggtcgtccatcacctg tcggtcgacggtgtgtcctggcggatcctgctgtcggatctgcggtccgcctgcgaagcg gcggccgaggggcggaccccggcgctggaaccggtgggcctgtcgttcaaacggtgggcg agcctgctgaaggagcaggcggtctccgcggaacgggtcgcggaactggaggcgtggaaa gcgatcctcggaccggtggagcgcgggccgtccgagagccgggccgcggggggcgaagtg cgctcgcggtcgtgggtggtgccgaaggcggagacacgggccttggtcggccgggctccg ctggtcttccactgcggggtgaacgacgtcctgctcgcggggctggccggagcggtggcc cggcggcgcggtggcgacgcggtgctggtggacgtggaaggccacggccgtcatccggcc gcgggcaccgatctgtcccggacggtgggctggttcaccagcgcgcatccggtacggctg gccgtggcggacaccgatctggcggacgtgctcgccggtggcccggcggccggtcggttg ctgaagctggtcaaggagcagtcgcgggcggtgcccggcgacggcctcggatacggcatg ttgcgctatctcaacgacgtgacggggccggtactggcggcactgccgtcgccggagatc gggttcaactacctcggcaggttcgccaccgccgagaagggcgacgtgcgggcctggcag ccggtcggcgacctcggcagtgcgcaggaacccggaatgggtctgccgcacgcgctcgaa gtcaacgcgatcgtccaggattcgccggacggtcccgaactgacgctcctgctggaatgg caggaagacctgctggacgaagccgaggtcgaacgactggcccaggactggctcgacatg ctggccgggctggcccggcaggcggacgatcccgccgcgggcgggcacaccgcgtccgac ttcgagctcgtcaccttggaccaggccgagatcgaagccctcgaagccgaatacgcggac gccggcggagtggccgacgtgctcccgctttcgccgttgcagcacgggctcgcgttccac gccgggtacggcggtgacggggtcgacgtctacaccgcccaggcggtgctggacctgagc ggtccgctggacatgctgctgctgcggaaatcggtgcgcgggctgctggaccggcacccg aacctgcgcgccggattccggcacgccgccgccgggcccgcctatcaggtgatcccgggc gccgtggaggtgccggtgtcctttgtggacgcgacggggtcggcggatccggaggccgag gcgacggcggtggccgaggccgagcgggctcggccgttcgagctggccaagcctccgctg ctgcggatcacggtggtggccctgagccgggacagccaccgcctggtgctgaccaaccat cacatcctgctcgacggctggtcgacgccgctgctggtggacgaactgctcacgctctac cgcgacggcgcggccccgtccgcgctggcgccggtcaccccgtaccgggattacctggcc tgggtcggcgaaaccgatcgggacgcgtcgatcaccgcgtggcgcgaggcgctggcgggc ctgccggaaccgaccctggtcgcggacgaccggccggtgccggtccaggtgcccggccag atgtgggccgaactggacgagacgttcgccgccgccctgaccgcgcgggcccgcgaatgc ggggtcacggtcagcacgatgctgcaagcggtgtggggcctggtgctggcggcgaccacc ggacgcgacgacgtggtgttcggggcggtggtgtccgggcgaccggccgagctgcccggg atcgagaccatggtcggcctgttcatcaacaccgtgccggtccgggtccggacgcggccg gagcagaccttcgccgagctggtgcggcagatccaggacgagcagatcgcgttgctggcc catcaccacgtcgggctcgccgacatccagcaggccgccgggctgggccggttgttcgac accctcgtcgtctacgagaactaccccaggcccgacgagaccgccgacacggagccggat cggttgcgggtgcggggaatgaccgccgccgacgccacccactacccgctggcgctggcg gtcgtccccggcgacgtcctgcgcctgcggctggagcaccagcccacgctgttcaccacg gagcaggccgccgccgtgctggaccgcttcacgcgggtgctcgaagccgtggtcgccgag ccgcggacgccgctcccggcggtgccgatcctgtccgccgccgaacagcgggacctgctg gcgcgcaacgacaccgcggtggaggtgccggaccggacgctcccggagtcgttcgccgcg caggccgccgccaccccggacgcgaccgcggtggtcttcgaggacctgtcgctgtcctac gccgaactcgacgcccgtgccaatcagctggcgcgctggctcatcgaacggggcgccggg cccgaaggcctggtcgcggtgctgctgccccggtcgctggaactggtcgtcacggtgctg gcgatcaccaagaccggtgctgcctggctgccgatcgatccggtctatccggccgagcgc gtgtcgtacatgctcgacgacgcccggccgtcgctggtgatcacctccgcggcgctgtcg gcgtcgcccgccggtgaggtggtggcgggcaggcaggcgacggtggtgatcgacgatccc gtggccgttggcgagctggctgcccgggatcgcgctccggtcaccgacgcggaccgcgtc cggccgctggatccgcgtcatccggcgtacctcatctacacctcgggctccaccggcagg cccaaggccgtcgtcgtcacccaccggaacctggcgaactacctgttccactgtggacgg aagtacccggggctgcggggacgatcgctgatgcattcgtcgatcgctttcgatctgacg gtgaccgcgctgctcactccgctgaccgtgggcggaacggttcaggtcggtgcgctggaa gacctgatcggcacggtggaaagcgccccggcgctgttcctcaaggccacgccgagccat gtgaagacgctggacaccggttcacgggagatcgcggtcgcgggcgaccttctgctcggt ggcgagcagttgcccgtcgacacgatcgcccactggcgccggacctacccgaacaccgtc gtggtcaacgaatacggcccgaccgaggccaccgtcggctgcgtcgaattccggctcgaa cccgggcagccggcgccgtccggcgaggtggtgccgatcggcactcccatgacgaacgcg cgggcgttcgtgctggattcgtggctgcggccggtgccgccgggcgcggtgggcgaactg tacgtggcgggcgcgggtgtggcacgcggctatctcgggcggccggggctgaccgcgacg cggttcgtggccgacccgtccggggacggcgggctgatgtaccggaccggggacctggtg cggtggaacccggacggggaactgatgttcatcggtcgcgtcgacgaccaggtgaaggtg cggggttaccggatcgagcccggcgagatcgaagcggcactggtggcacaggagccggtg ggacaggccgtggtgctggccaaggacggcgcctccggcaaacggctgatcggttacgtg accgccgccggggagtccgaagtggacgaagccgcggtcctcgcgggcgtggccgcccgg ttgccgcggtacatggtgccggcggcggtggtggtgctggagacgctgccgttgacggcg aacgggaaagtggaccgggacgcgttgccggatcccgatttcaacggacgcgtcaccgga cgggagccggtcacggaggccgagcggctgctgtgttcgctcttcgccgaggtgctcgga ctggagcgggcgggcgcggacgacagtttcttcgaactgggtggcgattcgatcctttcg atgcaactggcggcgcgtgcccaccgggcgggaatagccttcggggcgcgtgaggtgttc gaacagcggacccccgcggcgatcgcggcggtcgtggaacgggcggcgagcgctcccgcc gcgagtgaacacgcgacgtccgacgtcgctcttctcgaactggaccaagacgagatcgac gaattcgaagcggagttcgaaagcggtcgctga

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