Actinobacillus pleuropneumoniae L20 (serotype 5b): APL_0250
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Entry
APL_0250 CDS
T00476
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase/homoserine dehydrogenase
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
apl
Actinobacillus pleuropneumoniae L20 (serotype 5b)
Pathway
apl00260
Glycine, serine and threonine metabolism
apl00261
Monobactam biosynthesis
apl00270
Cysteine and methionine metabolism
apl00300
Lysine biosynthesis
apl01100
Metabolic pathways
apl01110
Biosynthesis of secondary metabolites
apl01120
Microbial metabolism in diverse environments
apl01230
Biosynthesis of amino acids
Module
apl_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
apl_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
apl_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
apl00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
APL_0250 (thrA)
00270 Cysteine and methionine metabolism
APL_0250 (thrA)
00300 Lysine biosynthesis
APL_0250 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
APL_0250 (thrA)
Enzymes [BR:
apl01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
APL_0250 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
APL_0250 (thrA)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
ACT_9
AA_kinase
NAD_binding_3
ACT_7
ACT
Sacchrp_dh_NADP
DapB_N
DUF1131
Motif
Other DBs
NCBI-ProteinID:
ABN73358
UniProt:
A3MYX2
LinkDB
All DBs
Position
complement(271317..273773)
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AA seq
818 aa
AA seq
DB search
MRVLKFGGTSLANPERFIQAADIIEKAHLKDQAAGVLSAPAKITNHLVAIVDKAIAGESF
ESNLKEATEIFHNIINGLYAINNKVDREGLLALVEAELAQIQSVASEAAKSKSLPDSVAA
TIHCRGEKLSIAMMQAWFEAKGYEVTRIDPVEKLLAHGSYLESSVDIAESTKRVDANSIP
KKNVVLMAGFTAGNENGELVLLGRNGSDYSAACLAACLKADCCEIWTDVDGVYTCDPRLV
PEAICLESMSYQEAMELSYFGAKVIHPRTIGPLVPLNIPCLIKNTANPDAKGTLIDGNVA
TDGLKVKGITNLDNVAMFNVSGAGMQGMVGMAARVFSTMSKAGISVILITQSSSEYSISF
CVPAKFEEKATACLNAEFAQELSKGDLDPIDMIRELSIISVVGDGMRTAKGIAARFFSSL
AQANISIVAIAQGSSERSISAVVPMNKAIEAVKATHQGLFSNKKSIEVFLVGVGGVGSEL
IDQIKQQKEFLAKKDIEIRVCALANADKMLLNENGLNLDNWKSDLETATQPSDFDVLLSF
IKLHHVVNPVFVDCTAAQSVANLYTRALKEGFHVVTPNKKANTGSYRYYQELREAARQGQ
HKFLYETNVGAGLPVIENLQNLLAAGDEVEKFEGILSGSLSFIFGKLDEGLSLSEATLIA
KEKGFTEPDPRDDLSGADVARKLLILARETGLALEFDDIEVEGVLPKGFSDGMSKEEFLK
VLPEIDAQFNERVQAAKAEGKVLRYVGSITGDKCRVAIEAVDENHPLYKVKDGENALAFL
TRYYSPIPLLLRGYGAGTDVTAAGIFADILRTLHGGSN
NT seq
2457 nt
NT seq
+upstream
nt +downstream
nt
atgcgagttcttaaatttggcggtacatcccttgcaaacccggagcgttttatccaagcg
gcggatattattgaaaaggcgcatttgaaagatcaagccgcaggcgtactttccgcaccg
gcaaaaatcaccaaccaccttgttgcaattgtcgataaagcgattgcaggcgaatcattc
gaatccaacctaaaagaagccaccgaaattttccacaatatcatcaacggattatacgca
atcaataataaggttgatcgtgaaggcttattagctttagtagaagcggaactcgcacaa
attcaaagtgtggcaagtgaagcggcaaaaagcaaatcattaccggatagtgttgcggcg
acgattcactgccgtggcgaaaaactatcgattgcaatgatgcaagcgtggtttgaagca
aaaggttatgaagttactcgtattgatcctgtcgaaaaattattagcgcacggcagttat
ttagaatcctccgtcgatattgccgaatcaaccaaacgtgtcgatgctaattcgattcca
aagaaaaatgtcgtattaatggcaggttttaccgctggtaatgaaaacggtgaactggtc
ttactcggtcgtaacggttccgactattcggcagcatgtttagccgcttgtttaaaagcg
gattgttgcgaaatttggacggatgtggacggtgtttatacttgtgaccctcgcttagtg
cctgaagcgatttgtttagaatcaatgagttatcaagaagcgatggagctttcttacttc
ggtgcgaaagtcattcaccctcgtactatcggtccgttagtgccgttaaatattccatgt
ttaattaaaaataccgcaaatcctgatgcgaaaggcacattaatcgacggcaacgtagcg
actgacggtttaaaagtaaaaggcattactaatcttgataatgttgcaatgtttaacgta
tccggtgccggtatgcaaggtatggtcggtatggcggctcgcgtattctcgactatgtcg
aaagccggcatttcggtcattctaattactcaatcttcttccgaatacagtatcagtttc
tgcgtacctgcaaaatttgaggaaaaagcgaccgcttgcttaaatgcggaatttgctcaa
gagttaagtaaaggcgatttggatccgattgatatgatccgtgagctttctatcatctcg
gtagtcggtgacggtatgcgtaccgcaaagggaattgccgctcgtttcttctcttcactg
gcacaagccaatatcagcatcgttgccattgcacaaggttcgtccgagcgttcaatttca
gcggtagtgccgatgaataaagcgattgaagcggttaaagcgacccatcaaggtttattc
agcaataaaaaatcgattgaagtctttctagtcggtgtaggcggagtcggaagcgaactt
atcgatcaaatcaaacaacaaaaagaatttttagcaaagaaggatattgaaatccgtgta
tgcgcattggcgaatgcggataaaatgctcctcaacgaaaacggtttaaatttagataat
tggaaaagcgatttagaaacggcaacccaaccgtccgatttcgacgttttactctcgttt
attaagttacaccacgtagtaaatccggtatttgtcgattgtaccgcggcgcaatcggta
gcaaacctttatacccgagcgttaaaagaaggtttccacgttgttaccccaaacaagaaa
gccaataccggtagttaccgatattaccaagaattacgtgaagctgctcgccaaggtcag
cataaattcttatacgaaacgaacgtaggcgcaggcttaccggttattgaaaacttacaa
aacttgttggctgccggtgacgaagtggaaaaattcgaggggattttatccggctcgctt
tcatttattttcggtaaattagacgaaggtttaagcctttcggaagcaacgttaatcgca
aaagaaaaaggctttaccgagccggatccgcgtgatgacctttcaggtgcggatgtcgct
cgtaaactattgattcttgcgcgcgaaaccggtttggcactggaattcgacgatattgaa
gtggaaggcgtactaccgaagggcttctcggacggtatgagtaaagaagaattcttaaaa
gtcttgccggaaatcgacgcacagtttaatgaacgagttcaagcggctaaagcggaaggt
aaagtattacgctatgtcggttcgattaccggcgataaatgtcgtgttgctattgaagcg
gtagatgaaaatcacccgctttataaagtaaaagacggtgaaaatgcgctggcattctta
acccgttactatagcccgattccgctcttattaagaggttacggtgcaggtacggacgta
actgccgccggtatttttgccgatattctgcgtacattacacggaggttcaaactaa
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