Anas platyrhynchos (mallard): 101793907 Help Entry 101793907         CDS       T02816                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2 isoform X4   KO K04962   ryanodine receptor 2 Organism apla  Anas platyrhynchos (mallard) Pathway apla04020   Calcium signaling pathway apla04260   Cardiac muscle contraction apla04261   Adrenergic signaling in cardiomyocytes apla04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:apla00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101793907 (RYR2)    04020 Calcium signaling pathway     101793907 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     101793907 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     101793907 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:apla04040]     101793907 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:apla04990]     101793907 (RYR2) Ion channels [BR:apla04040]  Voltage-gated cation channels   Ryanodine receptor    101793907 (RYR2) Domain-containing proteins not elsewhere classified [BR:apla04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    101793907 (RYR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  101793907 NCBI-ProteinID:  XP_027309582 LinkDB All DBs Position 3:26008388..26414761 Genome browser AA seq 4983 aa AA seqDB search MAEGGEGEDEIQFLRTNYSLTIGTTSRTWEARFVVDDEVVLQCTATVHKEQQKLCLAAEG FGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFM MKSAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWT IHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGS EVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSIHARSLWRLETLR VAWSGSHIRWGQPFRLRHITTGKYLSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDIG TRKEVDGMGAPEIKYGDSICFIQHVDTGLWLTYQSADAKSVRMGSVQRKAIMHHEGHMDD GLTLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKSSAVDLPIESVSLSLQDLIG YFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLNVYSSAAHFADVAGRE AGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVE SPEALNIIKEGHIKSIICLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRD LLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWYYELMVDHLEPFVTAESTHLRVGWASTE GYSPYPGGGAEWGGNGVGDDLYSYGFDGLHLWSGCVARTVNSPNQHLLRTDDVISCCLDL SAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAP CFEAVLPKEKLKVEHSREYKQDRSYTRDLLGPTLSLSQAAFTPVPVDTSQIVLPPHLERI REKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLK TLLALGCHVGIADEHAEEKVKKMKLPKNYQLLSGYKPAPMDLSFIKLTPSQEAMVDKLAE NAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYG YNLEAPDQDHATRLDVCNGIMEKFRIFRTEKTYAVKAGKWYFEFEAVTAGDMRVGWTRPG CLPDQELGSDDEAFVFDGFKAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEI LLDDSGSELAFKDFEVGDGFLPVCSLGPSQVGRMNFGKDVSTLKFFTICGLQEGYEPFAV NTNRDITIWLSKRLPQFLPVPQNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMF FRLSMPIECAEVFSRTAAGGLPGTGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRAER EKDATKSELNNHKDYVQEKPSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLM QTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTSFDLERVRTVTVTLGDEKGKVHESIK RSNCYMVCAGESMSPGQGRNNNGLEIGCLIDAASGLLTFTANGKELGTYYQVEPSTKLFP AVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVSQCPPRLHVQFLTHVLWSRVPN HFLKVDVSRISERQGWMIQCLNPLQFMALHIPEENRTIDILELTEQEELLKFHYHTLRLY SAVCALGNNRVAHAMCSHVDESQLLYAIENKYMPGLLRAGYYDLLIDIHLNTYATARLMM NNEFIVPMTDETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECFQFSPE FPLEILKAKTIEMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKH ILQLIEPRVFKEAVSQEDESDFSEKELSSDELKPEEGEEETRGEQVPKEGLLQMKLPEPV KLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKT KEFRSPPQEQINMLLNFKDDKNDCPCPEEIRDQLLDFHEDLMTHCGIELDEDGTLDGSSD LTIRGRLLYLMEKVTYLKKKQAEKPVDDDAKTSSTLQQLISDTMVRWAQESVIEDPELVR AMFVLLHRQYDGIGGLVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLM IRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCY FCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDL EKVVRYLAGCGLQSCPLLISKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVR LLIRRPECFGPALRGEGGNGLLAAMEEAIQISEDPTRDGPSPSNGSSKTLEMEEQEDDTI HMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHM PTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASL DTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLT KAQRDSIEECLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYC LPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYME SNYVNMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGWT YGETYSESAKVQPLMKQYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYN RTRRISQTSQISVDAAHGYSPRAIDMSNVTLSRDVHAMAEMMAENYHNIWAKKKKMELEA KVGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYIVSRGFKDLELDTPSIEKRF AYSFLQQLIRYVDEAHQYILEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLY FLSAASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLD ARTVMKTGLESVKMALRAFLDNAAEDLEKTMENLKQGQFTHSRNQPKGVTQIINYTTVAL LPVLSSLFEHIGQHQFGEDLILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAA FSGAFPVAFLETHLNKHNIYSIYNTKNARERAVLNLPTSVEEVCPNIPSLVKLMEEIVEL AESGIRYTQMPHIMEVILPMLCSYMSHWWEHGPENNPDKAEMCCTALTSEHMNTLLGNIL KIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPLMDKLKKKAAVVVSDEEHLR AEGRGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNSEAEELFRMVAE VFIYWSKSHNFKREEQNFVVQNEINNMSFLISDTKSKMSKAAVSDQERKKMKRKGDRYSM QTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNLHLQGKLED PAIRWQMALYKDLPNRNEDSSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSK QRKRAVVACFRMAPLYNLPRHRAVNLFLQGYDKSWIETEEHYFEDKLIEDLAKPGEEPTE EDENLKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKS FEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAI LNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGS GEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESI SDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVV GFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVE SSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGIISKRDFHKAMESHKHYTQSETEF LLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESV LNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEK MELFVNFCEDTIFEMQLAAQISESDLNERSANKEENEKDKPEEQDPGMGFFSLVTMKLAL VALKYNLMTLMKMLSMKSLKKQMKKVKKMTMKDMVMALFSSYWSILMGLLHFACSVFRGF FRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKPTETALPAEDLTD LRTLSDESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLAPMPEEQEKIQEQM KEDEKEEKEETKSEPEKAEGEDGEKEEKPKEDKGKQKLRQLHTHRYGEPEVQESAFWKKI IAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKEVPVVSTGESMKL NSLESDSQRVIAVHYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREK EVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRD RISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSVDVKYQMWKLGVVFTDNSFLYLAW YMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVV AFNFFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRI IFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHG FETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYED QLN NT seq 14952 nt NT seq  +upstreamnt  +downstreamnt atggccgaggggggcgagggcgaggacgagatccagttcctgcgaactaattacagtttg acaattggaaccacatctagaacttgggaagcgcgctttgttgtagatgatgaagtggtt ctgcagtgcactgcaacagttcacaaggagcaacagaaactgtgtcttgctgcagaagga tttggcaacaggctttgctttttggaatccacatcaaattctaagaatgtgccacctgat ttgtccatctgtaccttcgtgctggagcagtctctgtcagtacgagccctccaggaaatg ctggctaacacagaggaaaaggcagaagggctagttgatgtggaaaaatggaaatttatg atgaagtctgcacaaggtggtggtcatcgaacactactctatgggcatgcaatcctgctg cgccattcctacagtggcatgtatctatgctgcctgtctacatctagatcttcaatggac aaactggcatttgatgtaggattgcaagaggatacaacaggtgaggcatgctggtggacc atccatcctgcttccaagcagcgatcagaaggagaaaaagtgcgtgttggagatgatctt attttagtcagcgtctcttcagaaagatacctgcatctctcttatggcaatggtagctta catgttgatgcagccttccagcaaacgctctggagtgtagcaccaatcagttcaggaagt gaagttgcccaaggatatctgataggaggggatgttctgaggttgttgcatggtcacatg gatgaatgcttgacagtcccttcaggtgaacatggagaagaacaaagaagaactgtccat tacgaaggtggtgctgtctcaattcatgcacgttctctttggcgattagagactctaaga gttgcgtggagtggcagccacataagatggggacagccattcagattaaggcatataaca acaggaaaatatttaagtctcctggatgacaagagtcttcttcttacagataaagagaaa gcagatgtaaaatctacggcgttctgttttcgttcttccaaggaaaagttggacataggg acaagaaaagaggtggatggaatgggagcacctgaaattaaatatggagattcaatatgc ttcatacaacatgtagacactggcttgtggctcacgtaccagtccgctgatgcaaagtct gtaagaatgggttctgtgcagcgcaaggcaataatgcaccatgaaggtcacatggatgat ggtttaacattgtccagatctcagcatgaagaatcccgcacagcacgtgtcattcgtagt acagtcttccttttcaacaggtttataaggggccttgatgctctcagcaagaaagtgaag tcttccgcagtagatttacctattgagtcggtcagtctgagccttcaagacttgattggc tattttcatcctcctgatgaacatttagagcatgaagacaaacaaaacaggctccgagca ctgaagaatcgccagaacctcttccaggaagagggtatgatcaaccttgttctcgaatgt attgatcgcttgaatgtatacagcagtgctgctcattttgcagatgtagctgggagggaa gctggagaagcatggaaatctattctgaattctttgtatgaattactagcggctctgatt cgagggaatcgtaaaaactgtgctcagttttctggatctcttgattggttgatcagcaga ttagaaagactggaagcctcttctggaattctagaggttttacactgtgtgttggtggaa agccccgaagctctaaacataattaaagaaggacatattaaatcaatcatctgtcttttg gataaacatggaagaaaccataaggttttggatgtcttgtgttctctctgtgtatgtcat ggagtagctgtgcggtctaatcaacatctaatctgtgataatctccttcctggaagagat ctgctattacagacacgcctagtcaaccatgttagcagcatgcggcccaatatctttttg gggattagtgaaggctctgcccagtacagaaaatggtactatgaacttatggtggaccat ctagagccatttgtgactgcagaatcaactcatctacgagtgggctgggcttcaacagaa ggctactcaccatatccagggggaggagcagaatggggaggaaatggtgttggtgatgac ttgtattcctatggcttcgatggtctacatctgtggtcaggttgtgtagcacgaacggta aattctcccaaccaacatctgttaagaactgatgatgttattagctgctgtttggatctg agtgctcccagcatctcttttcggataaatggtcagccagttcaaggaatgtttgaaaat ttcaacatagatggcctcttcttcccagttgtgagcttctctgcaggaataaaggtacgt ttcttgcttggaggtcgccatggagagttcaagttccttcctccacctggatatgcccct tgctttgaagctgtcctaccaaaagagaaacttaaagtggagcatagccgagagtacaag caggatcgcagctacacaagagacctactgggtcccactctttctctctcacaagcagct tttaccccagttcctgtggatactagccagattgttttgcctcctcacctggaaaggatt agagaaaaattagcagagaacattcatgaactttgggttatgaataagattgaacttggc tggcagtatggaccagttagagatgacaacaaaaggcagcacccatgcttagtggaattt tcaaaattgccagagcaagagagaaattataacctgcaaatgtcacttgaaacattgaaa accctgctggcattaggctgccatgttggaattgctgatgaacatgctgaagaaaaagtg aaaaaaatgaaacttccaaagaactaccagttgttaagtgggtataagcctgctcccatg gatctgagttttatcaaactgaccccctctcaagaagctatggtggataaactagcagag aatgctcacaatgtgtgggcaagggaccgtatcaggcaaggctggacctatggtatccag caggatgtgaaaaatcgacgaaatcctcgccttgtaccttatgctcttttggatgatcgg acaaagaagtcaaacaaagacagccttcgtgaagcagttcgtacccttttaggctatggt tacaacctggaagctcctgaccaagatcatgcaacaagactggatgtatgcaatgggata atggaaaaatttaggatcttccgcacagagaagacttatgcagtgaaggctgggaagtgg tacttcgagtttgaggcagttacagcaggagacatgagagttggctggacaaggccgggt tgcttgccagatcaggaacttggctcagatgatgaagcttttgtttttgatggctttaag gcacagcggtggcatcagggtaatgagcattttggccgctcatggctagcaggagatgtt gttggatgtatggttgacatgaatgaacacactatgatgttcaccttaaatggtgaaatc cttctcgatgactcaggttcagaacttgcattcaaggactttgaagttggtgatggattt ctgcctgtgtgcagcctgggcccatctcaagtgggaagaatgaactttggaaaagatgtc agcactctaaaatttttcactatctgtggcttacaggaagggtacgaaccctttgctgtt aatacaaacagagacatcaccatttggctgagtaaaagactccctcagtttctaccagta ccacaaaatcatgaacatattgaggtgatgagaattgatggcaccatagacagctgcccc tgcctgaaggtcacgcagaagtcctttggttcacagaacagtaaaacagacgtcatgttt tttcgattaagtatgcctattgaatgtgctgaggtgttctccagaacagctgcaggaggg ttaccaggcactggtctttttggcccaaagaatgatttggaggattatgatgctgattcc gattttgaggttctaatgaaaactgctcatggtcatctagtgcctgaccgggcagaaaga gaaaaagatgccacaaaatcagagttaaataaccataaagattatgttcaagaaaagcct tcacgtcttaaacaaagatttatgctcaggaggacaaagccagattatagcacaagccat tctgcacggcttaccgaggatgtgctagcagatgatagggatgactatgattatttgatg caaacttcaacgtattattattcagtgagaatatttcctggccaagaacctgctaatgtc tgggtaggctggattacctctgactttcatcagtatgacacaagctttgacttggagaga gtgcgtacagtcacagtgacactgggagatgaaaaggggaaggttcatgagagtataaag cgcagcaactgctatatggtgtgtgcaggagagagcatgagccctggacaaggacgtaat aataatggtctggagattggttgcttaattgatgctgccagtggcctgctgaccttcaca gctaatggcaaggaactgggcacgtactatcaggttgaacctagtacgaagttatttcct gctgtatttgctcaagctacaagccccaatgttttccaatttgaattgggtagaataaag aatgtaatgccattgtctgctggattattcaaaagtgaacacaaaaacccagtgtctcaa tgtcctccacgtctccatgtccagtttctgactcatgtgctttggagcagagtgccaaac cacttcttgaaggttgatgtctctcggatcagtgaacgtcaaggctggatgatacagtgc ctgaatcctttgcagttcatggcccttcacattcctgaagaaaacagaacgattgatatt ttagagctgacggaacaagaagaactgctgaaatttcactaccataccctccgattatat tcagctgtttgtgctttagggaacaaccgagtggcccatgctatgtgtagccatgtggat gaatctcagctcctatatgctattgagaataaatatatgccaggattattacgtgcagga tattatgacttacttattgacatccatctcaatacttatgcaactgccaggttaatgatg aataatgaatttattgttccaatgacagatgagaccaagagtattaccttgtttcctgat gaaaacaaaaaacatggccttcctggtataggacttagcacttccttgagaccaagaatg cagttttcctcgccaagttttgtaagcattagcagtgaatgctttcagttcagtcctgaa ttccctcttgaaatcctaaaagccaaaacaatagagatgctaactgaagctgttcaggag ggcagcctccatgtcagggatccagttggaggttctacagaatttctatttgtccctctc atcaagctcttttacactctcctaattatgggaatcttccacaatggggatctgaaacac atcttgcagttgattgagcccagggttttcaaagaagctgtgagccaggaggatgaaagt gatttctcagagaaggagctgagttcggatgagctcaagccagaagaaggagaggaagaa accagaggggagcaggtgccaaaggaaggactgcttcagatgaaacttcctgaacctgtt aaactacagatgtgtcatctactccagtacctgtgtgattgccaggtacgacaccggata gaagccattgtggcattttcagatgattttgtggccaagcttcaagagaatcagcgcttc cggtacaatgaggtgatgcaggccttgaacatgtctgctgccttgacagctagaaaaaca aaggaatttcgatcaccacctcaggagcagattaacatgctgctgaactttaaggatgat aaaaatgattgtccttgtcctgaagaaattcgggaccagctcttggatttccatgaagac ctaatgacacactgtggaattgagctagatgaagatggaaccttggatggaagcagtgat ttaaccattaggggtcgcctcctataccttatggaaaaagttacatatctgaagaagaag caagctgagaagccagttgatgatgatgctaagacatcctctactcttcaacagttgatt tcagacacaatggtgcgctgggcccaggaatcagtaatagaagacccagagttagtcagg gccatgtttgtactgcttcatcgccagtatgatggtattggtggcttggttcgagccctg ccaaagacctatactataaatagtgtgtctgtggaagacacaatcaatcttctggcatcc ctcggccaaatacgttccttgctcagtgtcaggatgggaaaagaggaagagaaacttatg attcgtggattaggagacatcatgaataacaaagtattttaccaacatccaaatctcatg agagctttaggcatgcatgagactgtcatggaagtgatggtaaatgtgcttggtggagga gaatccaaggaaatcactttccccaaaatggtggcaaattgctgtcgtttcctgtgttat ttttgccgcatcagcaggcagaatcaaaaagctatgtttgatcatcttagctatttgttg gaaaatagcagtgttggccttgcttctccttctatgagaggatcaactcctttagatgtt gcagcagcatctgtgatggataacaatgaacttgcactagctttaagggagcctgatttg gagaaggtggttcgctacttggctggttgtggattgcagagttgccctttgctgatttct aaaggctatccagacattggatggaatccagttgaaggagagcgatatttggattttctt cgttttgctgtattctgcaatggagagagtgtggaggagaacgctaatgttgttgtcaga ctgcttattcgtcgaccagaatgttttggtccagctctaagaggagaaggaggcaatggt ctacttgctgccatggaggaagcaatacaaatatcagaagatccaacaagagatggacct tcgccaagtaatggatctagtaaaactcttgaaatggaagaacaagaagatgacactatt catatgggaaatgcaatcatgaccttttatgctgctttgattgatctcttaggacgttgt gcccctgaaatgcatttgatccatgctggtaaaggggaagccattagaatcaggtcaatt ctaaggtctttgattccactagaagatttggtgggcgtaattagtattcctttccacatg ccgaccatagctaaagatggaactgtggtggaacctgacatgtctgcggggttttgccca gatcacaaggcagccatggttttgttccttgacagggtctatggaattgaggatcaggat ttccttcttcaccttcttgaagttggctttctgccagatctccgtgctgctgcttcttta gatacagctgccttaagtgctacggatatggctttggctctgaatcgatacctttgcaca gcagttttgcctctgttgaccagatgtgctcctctttttgctggcacagagcaccatgct tccctcattgattccttattacatacggtgtacagactatcaaagggctgctctcttacc aaagctcagcgagattctattgaagagtgtttactgtctatttgtgggcaactgaggcct tccatgatgcagcatttgctgagaagattggtatttgatgttcccctattaaacgaacat gcaaagatgcctctcaagttgctgacgaatcattatgaaagatgctggaagtattattgt ttgccaggtggatggggtaattttggtgctgcctcagaagaagaacttcatttatccagg aagttgttctggggtatttttgatgctttgtctcaaaagaaatatgaacaagaattgttc aaactggctttgccttgtttgagtgcagttgcaggggccttacctccagactatatggaa tcaaattatgtaaatatgatggaaaaacagtcttcaatggattcagaaggaaactttaat cctcaacctgttgatacatccaacatcacgatccctgaaaagctagaatatttcattaac aaatatgcagaacattctcatgataaatggtcaatggaaaagtttgccaatgggtggaca tatggtgaaacatactctgaatctgcaaaagtgcaaccattaatgaaacaatacaaatta ctctctgaaaaggagaaagaaatttatcgatggccaatcaaagaatcactgaaaaccatg ctggcatggggatggcggattgaaagaacacgggaaggagattccatggcactgtataat cggacacgccgcatatctcaaactagtcaaatctcagtagatgcagcccatggttacagt cctcgagcaattgacatgagcaatgtcaccctctccagagatgtacatgctatggcagag atgatggctgaaaactaccataacatatgggcaaagaaaaagaaaatggagcttgaagca aaagtaggaggaggcaaccatcctcttcttgttccttatgacactctcacagccaaagaa aaagccaaggacagagaaaaagcacaggatattcttaaatttcttcagattaatggatat attgtctccagaggttttaaggacctggaattggacacaccttccattgagaaacgcttt gcctacagtttccttcagcaacttataagatatgtggatgaagcccatcagtatattttg gagtttgatggtggcagcagaggcaaaggagagcactttccatacgaacaagaaatcaag ttttttgccaaagttgtgctccctttgattgatcagtatttcaaaaatcatcgcctgtat ttcttgtctgcagcaagtagacctctcagcagtggaggccatgcctctaataaggagaag gaaatggtgaccagcctgttctgcaaacttggagttcttgtcaggcataggatttcactg tttggaaatgatgcaacatcaatagtcaactgtcttcacatactgggccagaccttggat gcgaggactgtgatgaaaactggtctggagtctgttaagatggcactgagagcttttttg gacaatgctgccgaggatctggagaaaacaatggaaaatctgaaacaaggccagtttaca cacagcagaaaccagcccaagggagttacacaaatcattaattataccacagtggctctc ctgccagtgctatcttcattatttgagcatattggacagcaccagtttggggaagatttg atattggaagatgttcaggtctcctgttacagaatattggccagtttgtatgctctggga accagcaagagtatttatgtagaacggcaacgatcagcactaggagaatgcttggctgcc ttctcaggtgcctttccagtggcttttttggaaactcatttgaacaaacataatatctac tcaatttacaataccaagaatgcaagagagagagcagttctcaatttgcctactagcgta gaagaggtttgcccaaatattccttccttggtgaagctaatggaagaaattgtggaactg gcagagtctggcattcgttacacacaaatgccacatataatggaagtgatactgcctatg ctatgtagctacatgtcacactggtgggagcatgggccagaaaacaatcctgacaaggct gaaatgtgttgtacagccttgacatcagagcacatgaacactctgttgggtaacatattg aaaatcatctataacaaccttggtattgatgaaggagcctggatgaagaggttagcagtg ttttcccagcccatcataagcaaagcgaaaccacagctcttaaagacacacttcctgcca ctgatggataagctaaagaaaaaagcagcagtggttgtatcggatgaagaacatctaaga gcagaaggcagaggtgacatgtcggaggctgaactgctcatcctagatgagttcaccact ttggcacgggacctctatgccttctaccctttgttgattagatttgtggactataacagg gcaaaatggctgaaagagcccaacagtgaagctgaggaattgtttcgcatggtggctgaa gtcttcatttactggtcaaagtcccataatttcaaaagggaagagcagaactttgtggta caaaatgaaatcaataacatgtctttccttatcagtgacaccaaatctaagatgtccaag gcagcagtttctgaccaagagaggaagaagatgaagcggaaaggtgaccggtactctatg cagacctctctcattgtggcagcactgaagagattacttcccattggcctaaatatttgt gcccctggagatcaagaactaattgcactggccaaaaaccgattcagcatgaaagatact gaggatgaagtacgagacatcatacgcagtaatcttcatctccagggcaagcttgaggat cccgccattagatggcagatggcactttacaaagatttaccaaacaggaatgaagattcc tcagatccagagaagacagtggaaagagttcttgatatagctaatgtactttttcatctg gaacaggttgaacatcctcagcggtccaaaaaagcagtgtggcataagctgctgtctaaa cagaggaaaagagcagtggttgcctgctttagaatggcaccattatataatctgccaagg catcgagctgtcaatctctttcttcaaggctatgataaatcatggattgagacagaagaa cactattttgaagacaaactgatagaagatttagcaaaacctggagaggaaccaacagaa gaagatgaaaaccttaaaagagttgatcctttacatcaacttattctgctattcagtcga acagccttaactgaaaaatgcaaattggaggaagattttctctatatggcttatgctgac attatggcaaagagttgccatgatgaagaagatgatgatggtgaagaagaagtgaaaagt tttgaagtcacaggatcccaacgcagcaaggaaaaagaaatggaaaagcaaaaacttctg tatcagcaagccagactgcatgaccgaggtgctgctgagatggttcttcagacaatcagt gctagtaaaggtgagatggggccaatggttgcagctaccctaaagctagggattgccatc ttaaatggaggaaattctactgttcaacagaaaatgcttgactacctcaaggataagaaa gatgtgggtttctttcagagtcttgctggtcttatgcagtcctgtagtgttcttgaccta aatgcattcgaacgtcagaacaaagcagaaggccttggcatggtgaccgaagagggatca ggagaaaaggtgatgcaggatgatgagtttacctgtgatctcttccgctttcttcaacta ctttgtgaaggacataactcagattttcaaaattacctgagaactcagactggtaacaac acaactgttaatattatcatttccactgtggattacttattgagagttcaggagtccatt agtgatttctattggtattattctgggaaggacgttattgatgagcaaggacaacgaaat ttttccaaagccatccaggttgcaaaacaggttttcaatactctcacagagtatatccag gggccatgtactgggaatcagcaaagtctggcacacagtaggctatgggatgctgtagtt ggttttcttcatgtgtttgcccacatgcagatgaagctctcccaggattccagtcaaatt gaattactgaaagaattaatggatcttcaaaaggatatggttgtcatgttgctgtctatg ctggaaggtaatgttgtgaatggaactattggcaagcagatggttgatatgcttgtggaa tcgtccaacaatgtggagatgattctgaagttctttgatatgttcttaaaactgaaggat ttgacttcctctgatgcattcaaagagtatgacccagatggtaaaggcataatttcaaaa agggatttccacaaagcaatggaaagccataaacattacacgcagtctgaaacagagttt ctgctatcctgtgctgaaactgatgagaatgagactctggactacgaggagtttgtgaaa cggtttcatgaacctgccaaagacattggtttcaatgttgctgttctcctgaccaacctc tcagaacacatgccccatgatacccgcttgcaaacttttcttgaactgtcagagagtgtg ctgaattattttcagcctttccttggacgcatagaaatcatgggtagtgcaaagcgcatt gaacgagtatattttgaaataagtgagtccagtcggactcagtgggagaaacctcaggta aaagagtcaaagagacaatttatatttgatgttgtaaatgaaggtggggagaaagaaaag atggagctttttgttaatttctgtgaggataccatctttgaaatgcaactggctgctcag atttctgagtcagatctgaatgaaaggtcagctaataaagaggaaaatgagaaagataag cctgaggagcaggatcctggaatgggtttcttctctcttgtaactatgaagttagcatta gtagctctcaagtataatttaatgactcttatgaaaatgcttagcatgaaaagcctgaag aaacagatgaaaaaagtgaagaaaatgaccatgaaggacatggttatggctttgttttct tcctactggagcattttgatgggcttactgcattttgcttgtagtgtcttccgtggcttc tttcgcatcatatgcagtttgctgcttggaggaagcctagtagaaggagcaaagaagatc aaggtggctgaactattagctaatatgccagatcccacccaggatgaggtgcgtggggaa ggagaagagggggagaggaagcccacagaaactgcattgcctgcagaagacttgacagat ttgagaactttatcagacgagagtgatctactatcagatatatttggtttggatttgaaa cgggaaggtggacagtataaattgatccctcataatccaaatgctggtttgagcgatttg ctgagcactccttcgttagctccaatgcctgaggaacaggaaaaaatccaggaacaaatg aaagaagatgaaaaggaagagaaggaggaaacaaaatctgaacctgaaaaagcagaagga gaggatggagaaaaagaagagaaacccaaggaagacaaagggaaacagaaattaagacag cttcatactcatagatacggagaaccggaagttcaggaatcggctttctggaagaaaata attgcatatcaacaaaagcttcttaactattttgctcgaaacttttataacatgaggatg ttggcattgtttgttgcttttgccatcaactttatccttcttttctataaggtctccacc tctgctgtgacagaagaaaaggaagttcctgtggtgtctactggagaaagtatgaagttg aacagcttggagagtgacagccagagggtcattgcagttcattatgtcctagaagaaagt agtggctacatggagcccacgctgcggattttggccatcttacacacaatcatctctttc ttctgcatcatcgggtattattgtttgaaagttccactggttatttttaagagggaaaag gaagtagcaaggaaattggaatttgatgggctgtatataaccgaacagccctcagaagat gatattaaagggcaatgggatagacttgtaatcaacacacagtcttttccaaacaactac tgggacaaatttgtgaaaagaaaggtcatggataaatatggtgagttttatggccgtgac agaatcagtgagttactaggaatggacaaagctgctcttgattttagtgatgctcgagaa aagaagaaaccaaagaaggatagctccttatctgctgtgctaaactctgttgatgttaag tatcagatgtggaaattaggagttgttttcactgataattctttcctttacctagcttgg tacatgaccatgtcagtccttggccattacaacaattttttctttgctgctcatcttctt gacattgcaatgggattcaagacgttacgaactatcctgtcatcagtgacccacaatggt aaacagcttgtcctaacagtgggattactggcagtagtggtatacttgtacacagtagtg gcattcaatttttttcgcaagttctacaacaagagtgaagatggtgatatgccagacatg aaatgtgatgatatgttaacatgctacatgtttcacatgtatgttggagtacgtgcaggt ggaggaattggtgatgaaatagaggatccagcaggagacgaatatgaaatctatcggatt atctttgatatcactttcttcttctttgtgattgtcatcctgcttgccattattcaaggt ttaattattgatgcttttggtgagttaagagatcaacaagaacaagttaaagaagacatg gagacaaagtgctttatctgtggaataggaaatgattactttgatacagtgccccatggc tttgaaacacacacactgcaggagcacaacttggccaattatttgtttttcctgatgtat cttattaataaagatgaaacagagcatacaggacaggaatcctatgtatggaaaatgtat caagaacggtgctgggagttttttcctgctggtgattgcttccgaaaacagtatgaagac cagctcaactaa

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