Agrilus planipennis (emerald ash borer): 108738805 Help Entry 108738805         CDS       T07419                                  Name (RefSeq) protein purity of essence   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism apln  Agrilus planipennis (emerald ash borer) Brite KEGG Orthology (KO) [BR:apln00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:apln04121]     108738805 Enzymes [BR:apln01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      108738805 Ubiquitin system [BR:apln04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     108738805 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  E3_UbLigase_R4 E3_UBR4_N UBR4 zf-UBR Trypan_PARP Motif Other DBs NCBI-GeneID:  108738805 NCBI-ProteinID:  XP_025830452 UniProt:  A0A7F5R3Z4 LinkDB All DBs Position Unknown AA seq 5293 aa AA seqDB search MAASSGGVEWSAVIKTFLSSEFGKGNKADVIELCSAIIKNESEILRYKDSNKSFYNSFVV LAVSLITSNARRLTVSQLEVVNAACRVLLKYLLSTLQGVSREGNPSSLQAEQFLKAIKAL CLGTEFLSSDELSVLTNTMKGDTVTGHSPSGTDKETSNKQDSSKSRTDLSVSIFEQLTMP LRDGHTVTSEASSSQPNVNEPVSTSDPTTEINKLFLVANTESLQALRAGDTLADLCLSLP AIKRARTKVEEALAGKPFSLPTTHSEASIIRSSLPSTMADISLASSAINLPVLEPLTPSK LDKLCSLSMAVLQCAVAQAAANAMLSLGPAVSPKCTSAQAQAVKDEDLDANAVALVEESL NIFTFVGNTIKNSTRAGGHVYQNHLLAGAWVLISGLQSHLNNSMNIASEKGSHAKERDEK GRSPSKTREAGSSRSSLIKFQQSFGVLSVALASKAISLLSELFEDLYLEVCGGGGNTLQV EPAPLAIMGQFTALQRVARLLGAAPLNQLLFYLATVSYRKACTLKRIHPPEGDTYSQSDS TTYYEDMIMCSDESSTEDDDSEPILGQWFEATIAPPEPSEPVKQTATSDNQDNKQAGSSG QHAGERSHSIVPEKGEAHGYISLSTQIFVFLNRHFLCSKSAYVTRYVKGGLSEQQMVILA AIIRDLDRETARTEVGTISVYFGAALGQLYCEFSGALTRFTHNLITHPGLQHLQTSLLTH LGISPWNTDVPHSWPLQVYSRSLAVLAQVLLLRPQNEKEASVISIWHRVVNTLIENVINP PPMLDTDNEDINVEHAQVLLYLFHSLNLMQKKSVVLLMAGGVLRCSEVAGGPLRDFQLLH LSRLLLLFDYIMKHLYDAPAILLEQIQWNLFYSTNLNTDKDKENNMSRMFTPWKEIEDNY RKLAGSDEFSMKPCFYMLTNVEISNQDAPKLDGLACNFVLGTPDKLRYPLLLDALIEILN VTHITSGTGAAKMTFLGLCATQYCFSICWRLLQLLPPSTANMERLSTGETLVAGPQLLHS LVWGPRAGHKNFNRWLKDALVKQGMYTVVAEKLLKAVSEAVNTLKYDVTTAKSCIIALTP DVKKGTVSKESLPPLWHLFILDSVLAKVQISLIDEAETNLADASGVTISGATYVQELLPH VLRLTRAILHCTRWALLHSMVQQSEPAGKYTLQDFESLQEVLAIASSQNTLTCALATELS SLLPSAATTVLQQWSVSTLEECTWTPYLNDVIPSESYILKIVEIHTSTLSMSYPFNVNCS LKRLLQCLVKFICQHAPKIDNTDTKNKAIELLVLVTLDVRTEFLHETVSKTLDKMIGDTE TDEHQKRVYLHFLEHSYKLITRCTQQQLSQQNQDVGYSNISNCNTVVDEKVLHSCLKFYE KLLEKSSGRQALETFFTGDRDLVKVLMSVSSPQISQQYSTKVLNFFNRLFQAAEKSSTDP SLNYLCSSMCKLADVDSDKLQVWLRHVILGPNNMESSTSSSIAHTPTLVPVKSDSTKPTA SASNATTNKPDATASSNVGSGAQWVSTAAPPSTESNVSPTPSDDQKSLVQENSQLLQALT SFIVKQGNSMSEDVALTILKALLPLGSHILSPALEGVGFTDLMVVMTMLADAGSGKGHVH LFPATAEWLEICRQFFARKDVVEKLAGTGGTSSTSTEDCGTNNNRSTIMLDAACCLMDYV GDVVGGLTNQAQGPTIRPLSPPWESEMPLDVDSEWPDETNEDEDSGDDSDEDSLCNKLCT FTITQKEFMNQHWYHCHTCRMLDGVGVCSVCARVCHKGHDLSYAKYGNFFCDCGAKEDGS CQALVKRSPQSNETVGTSGTTTNTMGYAPEQLLSSSLRRRASSPAPTTTTEKSTVLHKDR RKNGNVAKQLEGAKDWLYNYLGSSSIPGVLLELAESLVPVVEKTCARTSAVGCHARALKA VQQLHSAEKKYVHTDQLMVPTLGSQEGAFENVRMSYSGEQGQTIRQLLSAHIIRRVAMCC MSSIHGRRQHLAVSHEKGKITVLQLSALLKQADSSTRKLTLTRLASAPIPFTVLSLSSNQ CNEDYLAVCGLKDCHVLTFTSTGSVSDHLVLHPQLETGNFIIKAIWLPGSQTKLALVTAD FVKIYDLSKDALSPQYYFLVPSGKVRDCTFICDEDVYNILIMSSPGHIYTEFLNEESSAK HGTFYVTNTLEVFHLDVTDVNGQVAGGGVSIYYSHTLGLLFYSYAQGKSFISPIKPKSNC LSVVFPITLSSQTSSSSKSNGSKNPTPQPLCQWTEIPNHPGLICSVMQSSNNPVIIMLKP DTVAIQEIKVVPSKSKIMDMVAIRHVSGNEQRTTLILLCEDGSLKIYMANMEQTDFWMSS NIQPALSLTTAKPRKKKIVKTGKSSGCVSFPVDFFEHCQPMNDVEVGGNDLLQVYNVTQL KHRLNATGLYVVCTKPIGFTVEITNPDNNMVMTGVRVAVGSQDPQRSPSFIEVFGRIITV SCTRSRWYDVPFSREESLQADKKLTMMFGPSQDPETVTMVDSIKVYGKTKEAFGWPEENE DTVANNATTSQSVAVSSNNEAEQLKTPLPLTNLERLVVGILEVLDNSFTLCSSDGKMSLH KPLSIKVTTTLLTLPSSPSLQIHSKALLSTLHSTKQAYHNYKDHALLQHVLTSLTHMTET DPKNYGDIDPESYYRLVMIARGIAVSRPQNLVKFCDSQAFIHDVVLEDPLDIKSTPTKTS KNKHLLLQLMDVLWILHSQRVENVSLAPLVSPGLKHVEQTVHAIVEIVHAFHSSEAHGNV TYGNIVVAVYLQLLLCEDSVIAFSAKQALSRVLKPKTRRRRVFIPSPPHCTTPPAKTSIE MEEDKPPRASTQSSQEDEGQPRALRYDVDSVESIGLLQQGTGAPEHQDNHNINPLEALLG GGAGFPPLLDIPPDADDETMVELAIALSLQEHELGGEIQQAQQELRTLQVSGGGGHAQET GHYSDTTASAAGSDDEGSTAATDGSTLRTSPAEQGGSAGSESGGSGVESITGEHNASGRS SAYGDNIQEATNLISRSDTSSLTNANCQNPEADAIPQEVEQEPEPEPEPEPDPESCSRLH MLRLQLLERLVEYLPKLRNVGGVRVIPFLQVILQLTTELDSHMERDKTCLNALLNAIVNE LQINKPDLENISERTKRREVQMVLMRLLSVLMSRCKTTSTTSTGTPAKPIPGDNSVFVSQ TTATVLYKADIVNYCLKLLQALLEYWRSVSNDDEPPQIGGNLLKEHLTHAPPDMTPFFLK QFVKGHSTDVFQTYPQLLTEMALRLPYQVHKHSEISEPIISVFDNAWYTHLCEYMMTSQE PFVRRQVRKLLLFICGNKDKYRQLRDVHALSTHIKAVKLCCIKGGYDHSNETQHALSMTY DTLVDLIEHLKACLEVAINRTGNWQKFCIHNDDILPFLFQVSCLLDEGVAPTILHLLQCA IVTNGSSGVSSTSTASSSSKKTDANVKTGNASAGGTSRKEREKSDDSTAEAAFEEANCGV LVDHINKQVPPEVFARFIRAFLLETNATNMRWQAHALVLAIYKNSKTTEQEQLLKLLWHL WPLLPAYGRKASQFVDLLGYFSLCFLQKSESSGLISDYVEKAVDVLRTQNELLAHHPNAS LYMQMSQFVELDGYYLESEPCLVCNNPEVPFASIKLSSLKVDSKFTTTTQIVKLLNSHTI SKITLRIGDLKRTKMVRTINIYYNNRSVQAVVELKNKPALWHKAKKVVLQSGQTEVKIEF PLPIVACNLMIEYADFYENIQASSETLQCPRCSAAVPANPGVCANCGENVFQCHKCRAIN YDEKDPFLCHACGFCKYAKFDFTLVAKPCCAVEPIETDEDRKKMISSINNLLEKADRVYK QLMANKPALESLVLKITDHRSDKQEEQQTGSNNANNVSSVQSGGTQVKVNKTIQMLAQQY CNECKTSFEELSKIIQRVLVSRKELVAYDRRHMEMDSPKSQAPLLSSQTESQGMSSISST SSRCYGCSAAATEHCLTLLRALAANSNTKQVLCSKGLIHELVQNNLRKGNVQMQEEVRQL LCILTRDNAEATEELCNLLTERITLSLKGHTSSSDLGTGVRHEIELLAAMVQKEDNCWEL KLRCLMRLFIRACEDSRNPLVMESVILPCLKILQSLMRTNDGGNKKTKVIKLFKNNPNYL FFSVNQEKLNKTLTIRTTSGINVDVYKWLKKDPVHSFSSWKARTPVKTDEGPRGLPSSRE EVRMYYLAEKYGRRWKRKVEKTFSIEPLGLDYSSWLKVVLFNPSSRLARQVTCNIIENMC TSSERKREILLLLTYFLDQLGTAGESSAEFLNLYQNLIQEEPWKQFLTMVGLLEVLAHFI TKEIEQLHRLEETTLTSDLAQGYSLNQLTELLASFLDDPCIRRQYKGRLVGAVLNGYLSL RRLVVQRTRLIDDTQEKLLELLEEMTTGTEEETEAFMAICIETVENCKVQDVLTPVFIFE RLCSIIYPEENDVGEFFLTLEKDPQQEDFLQGRMLGNPYSSLEPGLGPLMRDVKNKICQD CELVALLEDDNGMELLVNNKIMSLDLPVKDVYKKVWLAEGGEAESMRVVYRMRGLLGDAT EEFVETLNNKSQNAVDNEEVYKMANVLADCGGLKVMVKRLNAIQNVWRARPLLQVLLKLF RLSVKVQKVQEVLIDPELRAAAVFLRTLQLCLESESDSNQTALTEQLLEIMETIFSKATS KSKESFDEFARTLGGPEHVRSLLSFTCHPSVRNNQPVLLHLTRVLAALVYGNEEKMRALV AHFEPVFNFYRFDADHSADDQHKFEIFCMLTDGIERNAIGNTLRDFINSIGVVDDALQYI TTNAPCVKPTLLRTDSDELKEFISKPALKYILRFLTGLASGHEKTQLAIAAADTIPIIHR LEQVSSDEHVGSLAENLLEALRTNPSVATRIEEAREFTRSEKKRLAMAMREKQLGQLGMR TNDKGQVTAKSSILQQIEELGEETGLVCCICREGYKYQPAKVLGIYTFTKRCNVDEFEAK PRKTMGYNTVTHFNIVHVDCHMSAVRLARARDEWESAALQNANTKCNGLLPLWGPQVPES AFASCLARHNTYLQESTNHRDIGHVSTIHDLKLLLLRFAFEKPFHEDTGGGGPQSNMHLV PYVVHMALYVINTTRSAKKEEQSLMSYLETDNKEKWIETSYEADGPLFWITMSICLHSRE KWAAVKLLHLRRLLVLAQTRHCSPSSACKTLFDKTVKEYSVYKPYLVLFGLVDGIYNNFF KSLSCPDDQWPSKLADYIRFNDEALLKDSERLLSTYTDELLPCTSFPEFCDVAGLLGDIP DPDSYLENLFKDF NT seq 15882 nt NT seq  +upstreamnt  +downstreamnt atggccgctagcagtggtggagtagaatggtctgctgttataaaaacatttttatcttca gaatttggaaaaggaaataaagcagatgtgattgaattatgttctgcaattataaaaaac gaaagtgagattctacgttacaaagacagtaataaatcattctataattcctttgtggtg ttagccgtatctttaataaccagcaatgcacgccggctaactgtcagtcaactggaagta gtaaatgctgcttgtcgtgttctgcttaaatatttgcttagtactttgcaaggagtgagt cgtgaaggcaatcctagcagtttacaggcagagcaattcttgaaggcaataaaggcattg tgcttaggaactgaatttttatcttctgatgaattatctgtgttaaccaacactatgaaa ggagatacggtcacaggacactctccctcagggacggacaaggaaacttctaataaacag gacagttctaaaagtagaaccgatctatctgtcagtatatttgagcaactcactatgcct ctaagagatggtcatactgtcacctcagaggctagctcaagtcaacctaatgtcaatgaa ccagtctcaactagtgatccaacaacagaaataaataagttattcttggtggcaaataca gaaagtttgcaagctcttagagcaggtgatactttggctgatctgtgtctcagtttgcca gcaattaaacgtgcccgtacaaaagtagaagaggctttggctggaaaaccattcagttta ccaaccacacattctgaggcttctatcattcggagcagtctaccttcgacaatggctgat atatccctggcgtcctcggcaatcaatctacctgtcctggagcctttgacgccgagtaaa ttggacaaactatgcagcttgagtatggcagtgttgcaatgtgcagtcgcgcaagctgca gcaaacgccatgttatcgttaggacctgcagtgtcgcccaaatgtacatctgctcaagca caagccgtcaaagatgaagatcttgatgcgaacgctgttgccctcgttgaagaatctctc aacatattcaccttcgtcggtaataccattaagaattccacgcgagctggaggacatgtt tatcaaaatcatctattagctggggcatgggtattaatatcgggccttcaatcccatctg aataatagcatgaatattgcaagtgagaaggggtcacatgctaaagaacgcgacgaaaaa gggcgtagtcctagtaaaacacgtgaagctggatcttctcggtcaagtttgatcaagttt caacaatcttttggagttctgtcggtggcccttgccagcaaggcgatatccttgctgtct gaactatttgaggacttgtatttggaagtttgtggtggaggaggtaacacattacaggtc gaacctgctcccttagccattatgggccagttcacagcactgcaaagggtggctagactt ttaggcgcggcacccttgaatcagttgcttttttatcttgcaacagttagttacaggaaa gcttgtacactgaaacgaattcatccacctgaaggagacacctacagtcaaagtgattca actacttattacgaagacatgattatgtgttctgacgaaagttccacagaagatgacgat agtgagcctatattgggtcagtggtttgaagcaaccatagccccgccggagccgtcagag cctgtaaagcagacagccacgtctgataatcaagacaacaaacaggctggtagttctggt caacatgccggtgaacggagccattcgatcgtgcctgagaagggcgaagctcatggctac atatcactttcgactcagatatttgtctttcttaatcgacatttcttgtgttcgaagagc gcttatgtaacacgctacgtcaaagggggtttatcagaacagcagatggttattttggct gcgatcattagggacttagatagggaaaccgctaggaccgaagtcggaacaatatcggta tattttggcgcagccttgggacaattgtattgtgaattttccggtgctttgacgcgtttt actcataatctgataacgcatcctggtcttcaacatctccagaccagtttactgactcac ttgggcatatcaccctggaacaccgacgtgccccattcgtggccccttcaggtttattcg cgatctttagctgtgctagctcaggttttgttattgagaccccagaacgagaaagaagca agcgtgattagtatatggcatagagttgttaatactcttattgaaaatgtgataaatcca cctccaatgctggatacagataacgaagatatcaatgttgaacatgctcaagtactgctg tatttatttcactcattaaatttgatgcagaaaaaatctgtggttttgctgatggctggc ggcgtcttacgatgctcggaggtggctggtggtcctctacgtgactttcagctgcttcac ttatcacgactgttacttctttttgattacataatgaaacatctatatgacgctccagca attcttctagaacagatccaatggaatttattttattcgactaatttaaatactgataag gataaagaaaataacatgtcgcgtatgttcacaccatggaaggaaatagaggataattac cgaaagttggccggaagtgatgagttttcgatgaagccctgtttttacatgctgacaaat gtggaaattagtaatcaagacgcaccaaaactcgatggtcttgcgtgcaactttgtctta ggaacccccgacaaattgcggtatcctcttcttttagacgctctcatcgaaattctgaat gtaacgcacattacatcggggacaggggcggctaagatgacctttttaggattatgtgct acacaatattgtttttccatctgttggcggctattgcagttgttgccaccttctactgct aatatggaacggctgtccactggggagacgctagttgccggacctcaattacttcattcg ttggtctggggaccacgagctggacataagaactttaataggtggttgaaagacgctctg gtcaaacaagggatgtacacagttgtcgctgagaagttactaaaggctgtatcggaagcg gttaatactctgaaatacgatgtcaccacagccaaaagttgcattatagctctaacaccg gacgtaaaaaaaggaaccgtttctaaggaaagtttgccccctctgtggcatttgttcatt ttggactcggtcctagccaaagtacagatatcgctgatagacgaagcggaaacgaacctt gcggacgcttctggtgttaccatttccggagcaacatatgttcaagaattattaccccac gtgctaagattaacacgggctatcttacattgcaccagatgggcactactgcacagtatg gttcaacagagcgagccagctggaaagtacacgttgcaggactttgaaagtctacaagaa gtccttgcaattgcctccagtcaaaatactttaacttgtgccctcgccactgaattgagt tcacttttaccatccgctgccaccaccgtactgcaacaatggagcgtttcgacgcttgaa gagtgcacctggactccctacttaaacgatgtgatcccatcagaaagttatatactgaaa atagtagaaatccacacgtccaccctatcaatgagctatcctttcaacgtaaactgttct cttaaacgtctccttcagtgcttggtgaagtttatttgtcagcacgctcctaaaattgat aacactgacaccaaaaataaagccatcgaacttctggtgcttgtcacccttgatgtccgc accgaattccttcacgagactgtttctaaaactttggacaagatgattggagacacagaa acagacgaacatcagaaacgtgtatatcttcactttctagagcattcatacaaacttatt accagatgtactcagcagcagctttcacaacaaaaccaggacgtgggttatagtaatatt tctaattgtaatacggtcgttgacgagaaggtgctgcacagttgtctgaagttctatgag aaattgttagaaaagtcttcgggacgacaggcattggagacgttctttaccggcgacaga gatttggtaaaggtattaatgtcggtcagtagtccccaaatctcgcagcaatacagcacc aaagtgctgaacttctttaatagattgttccaagccgcggagaagagctcaactgatccc agtttaaactatctttgcagtagtatgtgcaagttggcggatgttgacagcgataaattg caggtctggctacgccacgtcattttgggtccaaacaatatggaatcaagcacatcttca tctatagctcacactccgacactcgttcccgtcaaatcagactcaacaaaaccgactgcc tccgcctcaaatgcgacaacaaacaaaccagatgcaacggcttcttctaatgtaggaagt ggcgcccagtgggtgtcaacagcggccccgccgagcaccgaatcgaatgtttctcctact cccagtgacgaccaaaaatctctggttcaagaaaacagccaattgttacaagcccttacg tcatttatcgtgaaacaagggaatagtatgtctgaagatgtagctttaacaatattaaag gcacttttgcctcttggttcacatattttgtccccggcgctcgaaggcgtcggttttacc gatctaatggttgtaatgaccatgttagcggatgcaggatcaggcaaaggtcatgtacat ttattccctgccactgcggaatggctggaaatttgtcggcagtttttcgcacgaaaagac gtagtcgaaaagttggccggaactggaggaacatcttcaacgtcaactgaagactgcggt acgaacaataatagaagtacaatcatgttggacgcggcgtgctgcctgatggattacgtg ggcgatgttgttggaggactgaccaatcaggctcaaggtcccacgattcggccattaagt ccaccatgggagagcgagatgccattggacgtagattccgagtggcctgacgaaaccaac gaggatgaagacagcggcgatgattcggatgaagattcgctctgtaataaactgtgtaca tttacaataacacaaaaagagttcatgaaccaacattggtaccattgtcacacgtgtcgt atgcttgatggcgtcggtgtgtgttcggtttgcgcccgcgtgtgtcacaaaggtcatgac cttagttacgccaaatatggtaactttttttgcgactgcggcgctaaagaagacggctca tgccaggcgttggtgaaaagaagccctcaatcaaacgagacggtaggaaccagcggtacc acaactaacacaatgggttacgcccctgaacaacttttgtctagttcattgcgacgtagg gcgtcgtctcctgcacccacaaccaccacagaaaaaagtaccgttttacataaagaccgc cggaaaaatggtaatgtggcgaagcagcttgaaggtgcgaaggattggttatataattac ttaggaagtagttccatacctggtgtattgttagaactggcggagtctttggttccagtg gtagaaaagacgtgcgcgcgtacatccgctgtcggttgtcacgctcgtgcgcttaaagcc gttcagcagcttcactcggctgaaaagaagtacgtgcacactgatcaactgatggtgccg actttagggtcccaggagggcgcgttcgagaacgttcgcatgagttattcgggcgaacag ggtcaaacaatacgtcaattattgtccgcgcacattataagacgcgttgcgatgtgttgt atgtcatctatacacggtcgtcggcagcatttggctgtgtctcatgaaaaaggaaaaatt acggtcctgcaattatctgctttgctaaaacaagccgattcgtctaccaggaagctaact ttgacccgtctagcttcggctccgattccatttacagtcctctctttatccagtaaccag tgtaacgaggattatttggcagtgtgtggattgaaagactgtcacgtgctgacgtttaca tccacgggttcggtatcagatcacctagtgcttcatccacagcttgaaacaggaaatttt attataaaggccatctggttgccgggatcgcagacgaagctagcacttgtcacggctgat tttgtgaagatctatgacttgtccaaagacgccttaagtccacagtattactttttggta ccgagtggcaaggtacgcgactgtacatttatttgcgacgaagatgtttacaatatattg ataatgtcgtcccctggacacatttataccgaatttttgaacgaagaaagttcagccaag catggtactttttatgtgaccaatactttggaggtgtttcatctggacgttacggacgtg aatggtcaagttgcaggcggaggcgttagtatctattattctcacactttaggcctgctt ttttacagctacgcacaagggaagagctttatttcccccattaaaccaaagagtaattgt ctctctgttgttttccccatcaccttatcatctcagacttcgtcgagttcaaaaagcaat ggcagtaaaaatccaacaccgcaacctttgtgtcagtggacggaaatcccaaatcaccca ggacttatttgttctgttatgcaaagcagtaacaatccggtcattataatgctaaaaccg gatacagtggctattcaggagatcaaagtggtaccttctaagtcaaaaataatggatatg gttgccattcgtcatgtttctggcaatgaacaaagaacaacattgattctactatgcgaa gatggaagcttaaaaatatatatggccaatatggaacaaacagacttttggatgtcttcg aatatacaaccggctttatctttaactacggccaaaccacgtaaaaagaagattgtgaaa actggcaagtcttcaggttgcgtcagctttccagtagactttttcgaacattgtcaaccc atgaacgatgttgaggtcggaggcaatgatcttcttcaggtttataatgtcacccaactg aaacatcgattaaacgcaacgggtctttatgttgtgtgcacgaaacctatcggttttacc gtcgaaattaccaatccggacaataacatggtgatgacaggtgttagggtggcggttggt agccaagatccccaaaggtcgccgtcttttatagaggtatttggccgtattataacggtt agttgcactcgtagcaggtggtatgacgtgcccttttcaagagaagaaagcctgcaggcc gacaaaaaactcaccatgatgttcggtccctcacaagaccctgaaactgttaccatggtg gacagtatcaaagtttatggtaaaacaaaagaggcgtttggttggcccgaagaaaatgaa gacacagtagcgaacaacgcgacaacttctcagtcagtggctgtttcttcgaataatgaa gctgaacagctaaagactccactaccgttgacgaatttagaaagacttgtcgttggcatc ttggaagttttagacaacagctttactctttgttcctctgatggaaagatgtcacttcac aaaccattgtcaattaaagtcactactacccttctaacattaccgtcatcgccttcgctt caaattcattctaaagccctactttcgactctgcactccactaaacaagcttaccataat tataaggatcacgctttattgcaacatgtgctaacaagtttaactcatatgacggaaaca gatcctaaaaattatggggatattgatccagaaagttattaccgtttagtgatgattgca agaggcattgcagtttctaggcctcagaatctcgtcaaattttgcgattcccaggcgttt attcatgatgttgttttagaagacccattagacatcaaatcgactcctactaaaacgtcg aagaacaaacaccttttacttcaattaatggacgtgctgtggattttacattcgcaacga gttgagaatgtctccttggcccccctcgtgtctcctggattaaagcacgtggaacaaacg gttcatgcaatagttgaaattgtacatgcttttcatagtagcgaagcacacggtaatgtc acctacgggaacatcgttgtggccgtttaccttcaactcttgctttgcgaggactctgtg atcgcgttcagcgcaaaacaggcgctcagtagagtgcttaaacccaagacacgacgtcga agagtatttataccgagcccgcctcattgcacaacacctccggcaaaaacaagtatcgag atggaagaggacaaaccgccaagagcttcgactcagtccagccaagaagacgagggccaa ccaagagcgttacgttacgatgtggactctgtagaatcaataggactgttgcaacagggc acaggtgctcctgaacatcaggataaccacaatataaaccctttggaggcacttttgggt ggaggagcaggttttcctccccttttggacatccccccagatgcagatgacgagaccatg gtggaattggctattgcgcttagtcttcaagaacatgaacttggaggagagatacagcaa gctcaacaggaactaagaaccttacaggtatctggcggcggtggtcacgctcaggagacc ggccattacagcgacacaacggcctcggcagccgggtccgatgatgagggcagcaccgcc gccacggacggctctaccctgcgcacctccccagccgaacaaggtggcagcgcaggatca gagagcggaggaagcggcgttgaaagtattacaggagagcacaatgcgtcgggacgcagt tctgcctacggcgacaacatccaggaagcaactaatttaatatcgcgttctgatactagt tcgttaactaatgcgaattgtcagaatccagaagcagacgccataccacaggaagtcgag caggaacccgaacccgaacccgaacccgaacctgatccagagagctgcagtcgccttcac atgcttcgtctgcaattattggaacgtttggtggaatatttgcctaaattgcgaaatgtg ggtggcgttcgtgttattcccttcctacaagtaatacttcaacttacgactgaattagac agtcatatggaacgcgataaaacttgtttgaacgcccttttgaatgccattgttaatgaa ctgcaaataaacaaacccgacttggaaaacatcagtgagaggactaagagacgcgaagtt caaatggttctcatgagattgttaagtgttttgatgtcacgttgtaagacgacatctacc acgagtactggaacccctgcgaagcctattcctggggacaattcggtgtttgtatcccaa acaacagccactgtcctctataaagcggatatcgtcaactattgtctgaaactgttacag gctttattagaatattggcgtagtgtctccaatgacgatgagcctccccaaattggtgga aatttgcttaaagagcatttgactcatgcgcctcccgatatgacaccgtttttccttaaa cagttcgtgaaaggacattctacagatgtgtttcaaacgtaccctcaactcttaacggaa atggctcttcggttgccctatcaagtgcacaaacattcagaaatatcagaaccgataata agcgtgtttgataacgcgtggtacacacatttatgcgaatacatgatgacatcacaagag ccgttcgtacgtcgccaagtgcggaaattgttattatttatttgcggaaacaaagacaaa tataggcaactgagggacgtacacgctctcagtactcacattaaggcggtgaagttatgt tgcataaaaggcggttatgatcattcgaatgaaactcagcatgctctatctatgacctat gatactcttgttgaccttattgaacatctaaaggcttgtctcgaagtagcaatcaatcgg accggaaattggcagaagttttgcatacataacgacgacattttaccttttctcttccaa gttagctgtcttttggatgaaggagtagcaccgacaatcttgcacttgcttcagtgtgct attgtaacgaacggatcgtcgggagtctcgtcaacttctactgcatcttcctcgtcaaag aagacggatgcaaatgtaaaaacgggcaatgctagtgcgggtggaacgtccaggaaagaa cgcgaaaagtccgacgatagcacggccgaagcagccttcgaagaggcaaattgtggcgtt ctcgtcgaccacattaacaaacaagtacctcctgaagtttttgctcgtttcattagggcg ttcctcttggaaacaaatgctacgaacatgcgttggcaggctcacgctctcgttctcgcc atatataaaaattcgaaaactactgaacaggaacaattgttgaagttattgtggcattta tggcctttgctaccagcctatggccgtaaagcttctcagtttgttgatttgcttggttat ttctcgctgtgcttcttgcagaagtcagaatcttcaggactgatatcagattacgtagag aaggctgtggatgttctaaggactcaaaatgaactcctagctcaccatccgaatgctagc ctttatatgcagatgagtcagttcgttgaactagacggttattacctcgaatcggaacct tgcttagtctgcaataatccggaggtgccttttgctagtataaaactgagctcacttaag gtcgattcgaaatttaccactacaacgcaaattgtcaagttactcaatagtcatacaatt agcaagatcaccttgcgtattggagacctcaaacggaccaaaatggttaggacaattaat atttattacaataatcgaagcgtgcaggctgtggttgaacttaaaaataaaccagctttg tggcataaagcaaagaaagtggtgctgcaaagtggtcaaacagaagtgaaaattgaattc cccttaccgatagttgcttgcaatttaatgatcgaatacgcggatttctatgagaatatc caagcaagtagtgaaacgttacagtgtcccagatgtagtgcagccgtccctgcgaaccct ggagtttgtgccaattgtggcgagaatgtgtttcagtgtcataagtgcagagccattaat tacgacgaaaaagatccgttcttgtgtcacgcctgtggtttttgtaaatacgctaaattt gactttacgttggttgcgaagccttgttgtgccgtggaacctatcgagacagatgaggac aggaagaagatgatttcaagtataaacaaccttttggaaaaggccgacagggtttacaaa cagttaatggccaataaaccggcattagagtctctagtattaaaaataacggaccataga agtgataaacaggaggagcaacagacaggctcaaataatgccaacaatgtaagctctgta cagtccggggggacccaggttaaggttaacaaaacaatccaaatgctggctcaacaatat tgtaatgaatgtaaaacatccttcgaagaactaagcaaaatcatccagagggtgttggtg tctcgtaaagaactcgtcgcttacgatcgtagacatatggagatggactcaccgaagtca caagctcctcttttaagttcacagactgaatcgcaaggaatgtccagtataagtagcaca agtagtcgatgctacggatgttccgctgcagccacagaacactgtcttacacttttaaga gctctggctgcgaattccaatactaaacaagtcttatgctcaaaaggactcatacatgaa ttggttcagaacaatttaaggaaaggaaatgtacaaatgcaggaagaggtaagacagtta ttgtgcattttgacgagagacaatgccgaagcaacggaagaactttgcaatttgttaacg gaacggattactttgagccttaaaggacacaccagtagctcagatttaggcacaggagtc cgtcatgagatcgagcttttggctgcaatggtgcagaaagaagacaactgttgggaattg aagttacgctgtttaatgagactcttcataagggcttgcgaggactctcgcaatcctctt gtgatggaatcagtcatactaccctgcttgaagattttgcaaagcttaatgaggactaac gacggtggaaataagaaaacgaaggtaataaaattatttaaaaataatccaaattattta ttcttttctgtgaatcaggaaaaattaaataagactttgaccattcgaacaacgtctgga ataaacgtggacgtgtacaagtggctgaaaaaagatcccgtgcatagtttttctagttgg aaggctcgtacgcctgtaaaaaccgacgaaggaccccgaggacttcctagtagtcgcgaa gaggttcgaatgtattatttggcagaaaaatacggacgtagatggaaaaggaaagtagaa aagacgttttcgatagaacctcttggattagattattcatcctggttgaaagttgtactc tttaatccgagttctcgtttagcacgccaggtcacttgtaatattatagagaacatgtgt acttcttcagaaagaaagagggagattctcctattgctgacctatttcctcgaccaactc ggcactgcaggagagagttctgctgaattcctaaacttgtatcagaatttaatccaggag gagccctggaaacaattcttaaccatggttggccttttggaggtacttgctcattttatt accaaagaaatcgaacaattgcaccgtttggaagaaacaactttaacttcagacttagcc caaggctactctcttaatcaattgactgaacttttggcctcgttccttgacgatccttgc atccgtagacagtacaaaggacgtttagtaggtgctgtattaaatgggtatttgtccctg agaagattagttgtgcaaaggaccagacttattgatgatacacaggaaaaacttctagaa cttttggaagaaatgactacaggcactgaagaagaaacggaagctttcatggctatttgt atcgagacggtggagaattgcaaggttcaagacgtcttgacgcctgtctttatatttgag cgtctttgttctattatttatcccgaagagaacgacgtaggggagttctttttgacgttg gaaaaggatcctcagcaggaggacttcttgcaagggcggatgctgggtaatccatactcc agtcttgagcctggtctggggccgcttatgagagacgttaaaaataaaatttgtcaggat tgcgaattggtcgcccttttagaagacgataatggaatggaattgctggtaaacaacaag attatgagcctggatttaccagttaaagacgtttataagaaggtttggttggcagaagga ggcgaggcggagtcgatgagagttgtatatcgaatgagaggtttgttaggagatgctact gaagagtttgtagaaacgttgaacaataaatcacaaaatgctgttgataacgaagaagtt tataaaatggcaaacgttctagcagattgcggaggcctgaaggtgatggttaaacgttta aacgccattcaaaatgtgtggcgcgcaagaccattgttacaagttcttttgaaattgttt aggctgtctgtaaaagttcagaaggtacaagaagttctcatcgatcctgaactacgagct gcagctgtgtttctacgtactctgcaactttgtctggagagcgaatctgatagcaaccaa actgctttaactgagcaacttttagagataatggaaacaatattttcgaaggctactagt aaatcgaaagagtcatttgatgagtttgcgcgtacccttggaggccccgaacatgttcgt tctcttttgtctttcacttgtcaccctagtgtccgtaacaaccaaccagttctcttgcac ttgacaagagtccttgctgctcttgtatacggcaatgaagaaaaaatgcgagccctcgtt gctcattttgaacctgttttcaacttttatcggtttgacgcggaccacagtgccgacgac cagcacaaattcgaaatattttgtatgctcacagacggtatcgagagaaatgcaattgga aatacgttgcgcgatttcatcaattctatcggtgtagttgacgacgctttacaatatatc accacaaacgcgccctgcgtgaaaccgaccctgctgcgtactgacagtgacgaacttaag gagtttatttcgaagccagccctaaagtatatactcagatttttgactgggttggccagt ggacatgaaaaaacacagttagcaattgctgcagcggatacaataccgataatacatcga ttggagcaagtgtcctcagacgaacacgtcggttccttagctgaaaatctcttagaagca cttagaactaatccttcggttgctacccgcattgaagaagctcgagagttcactagatca gagaaaaagagacttgcaatggccatgagagaaaagcagcttgggcagcttggaatgcgc acaaacgacaaggggcaggttacagcgaagtcctcgattctacagcagatcgaagaacta ggagaagagactggcctggtgtgctgtatttgtcgcgagggatacaagtatcaacctgcc aaggtattgggaatttatacgtttacaaagaggtgcaacgtggacgagttcgaagcaaaa ccaagaaaaacaatgggctacaacaccgttactcatttcaacatagttcatgtcgattgt catatgagtgccgttagactggcgcgagctcgtgacgaatgggaatctgcggctcttcag aatgctaacacgaaatgcaacggtttactaccattatggggtcctcaagtaccggaatca gcgtttgccagttgcttagcccgtcacaacacttatttgcaagaaagcactaaccatcgc gatataggtcatgtatctactatacatgatctcaagttgctcctgctacgtttcgcgttt gagaaacctttccacgaagacacggggggcggaggaccacaaagcaacatgcatcttgtg ccctatgtagtgcatatggctttgtatgttataaacacaacaagaagcgctaaaaaggaa gagcagagccttatgtcatatttagagacagataataaggaaaagtggatcgaaacctcg tacgaagcagatgggcctctcttctggattacgatgtctatctgcttgcacagcagggaa aaatgggcagcagtgaagcttctgcatttgcgtagactgttagtattagcacagacgcga cactgttcaccttcaagtgcatgcaagactctgttcgacaagaccgtaaaggagtactca gtttataagccgtatttggtgctgtttggactcgttgatggaatatataacaatttcttt aagagcttaagctgccccgatgaccagtggccaagcaaattagccgattatattcgtttc aacgacgaagcacttttaaaagattccgaacgcttacttagcacatacactgatgaattg ttgccttgcacttcttttccagagttctgtgatgttgcaggtttacttggtgatattccc gacccagattcatacttagaaaatctctttaaggacttttaa

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