Ahaetulla prasina (Asian vine snake): 131198286 Help Entry 131198286         CDS       T09329                                  Symbol OBSCN Name (RefSeq) obscurin   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism apri  Ahaetulla prasina (Asian vine snake) Pathway apri04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:apri00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     131198286 (OBSCN)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:apri01001]     131198286 (OBSCN)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:apri04131]     131198286 (OBSCN) Enzymes [BR:apri01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      131198286 (OBSCN) Protein kinases [BR:apri01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    131198286 (OBSCN) Membrane trafficking [BR:apri04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     131198286 (OBSCN) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase Ig_5 V-set_CD47 Ig_4 PK_Tyr_Ser-Thr Izumo-Ig Ig_6 C1-set SOS1_NGEF_PH C2-set_2 fn3 RhoGEF Adeno_E3_CR1 PH FN3_DSCAM-DSCAML_C IQ RHG20_PH Motif Other DBs NCBI-GeneID:  131198286 NCBI-ProteinID:  XP_058038755 LinkDB All DBs Position 4:complement(146291893..146558086) Genome browser AA seq 10179 aa AA seqDB search MDYISYSGVPRFLTRPKAFVVSMGKDATLSCQIIGNPIPLVSWEKDKLPIQTGGRFKMVE DDDLYRLTIYNLSLEDSGQYICRAKNTIGEAFAAVSIKVGEQTTVTESAPYFIQKPTSIR VIMGEDAMFKCIVQGSPPLAINWEKDGKHLGKSSDSNRIRIESQGEKNALKIQSTHLGDS GTYTCRAENPLGSSSAAAALMVDLPDSYSPGSTRHSIDDIGSKTSPLLSHMQKRREEIRK SDLSKVDSLISTEGRSKLGLSLSLDYERAASLTSKGLRGDGGSYYRVTTRSFTVTEGKHA KMSCYVTGEPKPETVWKKDGEVILESRRHIIYEDEQENFVLKILFCKQVDNGLYTCTASN LAGQTYSSVLVTVKEPRIPFKTKLQDLEVREKDSAIFLCEVPHSDVETTWFKEETRLQQN DKYKIEEDGLCRKLTVQNVTMDDDAVYICEMKEGSRTIAELSVQGNIIKKLPRKTAVSIK DTAVFCVELEQKCEKFRWLKNKEELKPSGRISISSADREYTMIIRDCQMEDGGEIVFVAD ECRTSTQFTVSAPKKPPSHPPADPVVKNKTETSVTLAWSLRKTDRPVPIDGYLVERKKLT GFAWLRCHQALVSQTEFMVNNMTEEADYQFRVSAVNKYGQSDYLEFPGVWHLEPTLAVKT PLRNVEVAPGRDAVFTVDLTTPSPGSWYINGNLVQNSDKYIITRTKASHSLIIKRVTSAF KEAEVKFVAKDIESIGRVTLKDEVATFVNDSAPGISVNLHEKFELVCEVSSATDAVLWRK GKKDIKPDQRVTFSVQGKQRKLIVQNAIKEDEGVYTCESNDDRLTFQVEVKEPAEVFFGK EKVQKEIRAILSENAFLSCEVAQPSMEVRWFKDGKLITPSKKFKIETEGKSRWLIIRQVD RKDGGQYTCEADGQKLAFKVIVTDREVEEIFVNQKKVQKDIRTVASENVSLSCEVAQTKT DVKWFKDGQLITDTKKFKIEEQGESRRLVVQQVEKKDAGEYTCEADGQKLTFKVTVADEK IKEVFVNKEKVQKDIKAVASDNISLSCEVAQAKTEVKWLKDGKLITSNKKFKVEAEDRSH HLVVQQVEKKDAGEYTCEADGQMLNFQVTVTDREAEEVFANKEKVQEDIKAVASENVSLS CEVAQVKTEVKWFKDGKLITSSKKFKVEAEGRSRRLVIQQVEKKDGGEYTCEADGQKLTF KITVADREAEEMFTNKEKIQEDIKVVASENLSLSCEVAQVKTDVKWFKDGKLITASKKFK LETDGRSRCLVVQQVEKKDAGEYTCEADGQKLNFKVTVADREAEEVFASKEKVQKDIKVV ASENLSLSCEVAQVKTDVKWFKDGKLITASKKFKLETDGRSRCLVVQQVEKKDAGEYTCE ADGQKLNFKVTVADREAEEVFASKEKVQKDIKAVASENVSLRCEVAQAKTEVKWFKDGKL ITSSKKFKVEAEGRSRRLVIQQVEKKDGGEYTCEADGEKLTFKVTVTDKEVEEVFANKEK IQEDIKTVPSETVSLSCEVAQAKTDVKWFKDGKPITASKKVKIETDGRSRRLVVQQVEKK DAGEYTCEADGQKLNFKVTVAENVSLRCEVAQAKTEVKWFKDGKLITASKKFKVEAEGRS RRLVIQQVEKKDAGEYTCEADGQKLNFKVTVADREAEEVFASKEKVQKDIKVVASENVSL SCEVAQAKTDVKWFKDGKPITASKKVKIETDGRSRRLVVQQVEKKDAGEYTCEADGQKLN FKVTVADAKVEEMFVNKEKVQKDIKAVASENVSLSCEVAQAKTDVKWFKDGKLITSSKKF KVEAEGRSRRLVVQQVEKKDGGEYTCEADGQKLTFNVAIADEKVTEVFVNKEKVQKDIKT VSSENVSLSCEVAQSKAEVKWFKDGKLITVSKKVKVEAQGRSRRLIVQQVEKKDAGEYTC ESDGQKLTFKVTVADREAEEMFTNKEKVQNNIKAVASETVSLSCEVTQAETEVKWFKDGK LITSNKKFKVEAEGRSRRLVIQQVEKKDGGEYICEAGGQKLTFKVTVTEAEEMFANKEMF EKDIKAVATETISLSCEVAQAKTDVKWFKDGKLITSNKKFKVEAEGRSRRLVVQQVEKKD AGEYICEAEKQKLTYKVVVEEAPDVFINKDKIKKEVKAVLKENAILTCQVATSDTQVKWY KDGQPVPISKHIKMESDGNTRKLYLEQVASKDVGQYTCEAGGQKVTFKVEITEPEVKLQR KAAQEETIVAQEHKEAAFSTVVSPEDAEVKWFKDGVEIHDGKNYEVKKDKAARILIVKMA ETKDAGLYTCEVKSEKQQFQLKVEEVPVKFAKKLEPIKAELGKALSLSCELCQPEGMVVW RKDGTVLKASKRYLMQEIGAKRVLIISSLRAEDKGEYSCETRNDQCTIQVTPTAPRIVKF VKGLSKVVAEEGKEAVFECTVSPSDASVKWSHRGAPIEASKKYVISHRDVHHSLTLTELT VQDSGEVKAEAEGEESQAHLRVEEAPVLFVKKLEPKVVEEKQTIVLEVELSKPTPEVKWT KNASVLHPTANLEIQAQGTKHCLVIKSASCDDRGFYSCETLHDKTQAKVTVDMRPIKLIK GLQPTDVHEKESVTFNVELSHEDVEGVWMKDGLRLKSQDNCQISIQGKKHSLTLSSLTLE DSALISFKAEGIHTTGRLNVKESPVKIITPLKDLKVQNKDDVTLECELSRPNAEVKWRKN GVEIRASKRMAIASRGTKRSLIIHTCEYEDQGTYMCDAVDDKSSAVLEIHARDIKIVKPL EDVEVNEKESASFLCEISHDDVQTQWFSNKNKIRAGENIKLRQEGKSHTLVYRSVELQDS AEIKFVAETAESRAQLKVKELPVKIIKPLRVKIAIERHRGFMECQVSRPNAIVKWFKGDR ELHPGEKYEMVSDGIYRKLIINETEFEDEGIYTCDAVDDKSSAQFYVEEQTINIVKELRD VEVMEPAEARFECEISIHSVKPPKWSLRGEVLQKGPNVIIEQEGKIHRLILRKTNVDMTG TIQFAIGKSKSLADLVVKDIPVTFTRPLEDRTVLETHSVVLSCDFKPSPKEVEWYRNHTL LEPSEKFKMKREKFTAELKILRLTVGDTGVYRCKAGSAETKATLTILERKVEITKHLQDV EVDEESLATFSCELSEDCEDVEWFLNDTHLFPNNFNEIKHLGKSHSLTLKHVTPEDSGTV SIKVQKKISESARLKVKEKPAVFMKSLDDVVAEERSTITLECEVSKPKVKPVWKKEGVEL TPGDKFEMLQSGKTLGLTIRDLGKDDAGWYTCDLGTDVTKSKVIIQELNIGITKRLKSVE VQEGESCSFECVLSHESLEGCQWLVNGNEVSRDARFRAFNKGRKYTLTIKKTLVTDAGEV VFSVRDLKSKASLAVKELNIGITKRLKSVEVQEGESCSFECVLSHESLEGCQWLVNGNEV SRDARFRAFNKGRKYTLTIKKTLVTDAGEVVFSVRDLKSKASLAVKEKPAEFTKQLENKS TLVGCEVSLSCDLSRWDNNLKWKKDGKEIRRSQKYDLRQEGSRAILIIHDTTVKDGGEYT CETEFSKTKATLSVEEAGNCFLKDLEDLKVEENKNATLTCETKKPTSSVTWRKGIVDLQA SKKYEISQKGTVLQLLVRDLKENDSDIYTCDIGDSQSSAKLVVQGLPVVFNQELQNKEAQ EGNKVRLTCELNKPDVPVQWMKGNVVLEAGDKYEFKQRGPVAELVIRDAKTSDAGEYICK SGDLKTSARVEVTAAPAVFKEELKDVEKKEGETVALRCVLAAPEVTVAWKKGATLLRASE KYKMKQDGCVAELLIHHAQPEDAGQYTCEAGEKQSTAQIKVHATPVSFKEKLKKAEALEG GVATLHCELNKPAPVEWVKGQKTLRPGSKYRMKKEGAIVELTIHDLDLKDAGDYTCISGD QQTTAVLTVNAVAAHFKTQLKNQEVTESGTATLHCELTKAADLVVWMKDEKVLKPSEKYR MRLEGRFAELSIQDLEVPDAGSYTCMCGDQKTKATLKVNALPVFFQEDLKNKEVTEGEST SFQCKLNKAASVEWYKGSRLLKPDGKFQLKQEGSCVELVIQGLDITDSGDYTCKCGAQKT TAKLTINALPVLFTKSLKDIEAMEGKVATFQCELNKISAPIEWKKGHKILKSGSKYKMKH EGKIAELVIQNLEVTDSGTYACISGEQQTTATLEVKALPVLFKEGLKNREAVEDATTTFH CEMSKAGAEVQWKKGSQILKPSDKYRMREEGPVAELLIRDLKVVDTGDYSCLCGDQKTTA VLTVHALPVRFQEELKSQEILEGRTAVLHCALNKTAVVDWRKDAQMLQPSAKYKIKQKEN VAELTIQDVTEEDAGEYSCICGDQTTSASVTVQALPPRFKVDLKNLEAAEDDAATLRCEL TKTPALVKWWKGSEILKPSDKYKMKLEGVVAELVVHRLQLADTGEYSCIVGDSKTSAFLR VNAIPARFKKGLEDQEATEGGTIALRCELTKTATVEWKKKHKTLRANDKYNLKQEGPVVE CVIHNLDLRDAGEYSCVCGDQKTTGALAVHALPPQFKQELKDVVATENETATLHCELTKA APVEWMKEGNKLKGDKYQFRQEAAVAKLVIRGLEVEDTGRYTCVCGDQKTSAALTVKVLK PEFTQRLKDEKADEGSTVRLRCEVTVPKAPVEWRKDGARIPPSPRYDIRQDGGIRDLLIH NLEPQDSGEYSCIAGDQTTSATLSVQVLKPEFTQRLKDEKADEGSTVRLRCEVTVPKAQV EWRKDGARIHASPKYDIRQDGGIRDLLIHHLEPQDSGEYSCIAGDHTTSATLSVQVLKPE FTQWLKDEKADEGSTVRLRCEVTVPKAPVEWRKDGARIHASPKYDIRQDGGIRNLLIHNL EPQDSGEYSCIAGDQTTSATLSVQVLKPEFTQRLKDEKADEGSTVRLRCEVTVPKAPVEW RKDGARIHTSPKYDIRQDGGIRDLIIHNLEPQDSGEYSCIGGDQTTSATLSVQALKPEFT QRLKDEKADEGSKARFRCEVTVPKAPVEWRKDGVRIHASPKYDIRQDGGIHDLLIHNLES QDSGKYSCVVGDQTTSATLSVQVIKVEFMQRLKDEKADEGSTARLHCEVTVTKTPVEWRK DGAGIHASPKYDIQQDGGIHELLIHNLQLQDSGEYSCSIGGQTTSATLSVHEVDITIIRG LKSAEVLEEEEVTFECEVSHDNAKDVEWKLQDLSLQSNQMNEISVERGRVHKLTLRNVTQ QDSGTVTFRVGPYISTARLRVDAPHPDFQQELSNLELQEGSAAFLKCEVSMLNVSPIWKK GSEVITPSTKYEISQQGTTHILKIYGVTRRDSGKYICDIGHGRSMGTLSVEALSARPVLF QVQLENQEVKEGATITLATALTKPDVPVQWMKGSAQLQPSHKYEMRQKASYVELLIHDAQ LEDAGHYTCQTEDQQTTASVVVKEIPATIEEELKDLTVLEGEDAVFRCVVSHEKAKNLQW SLAGVPLQSNEMNQIGVEGKTHTLVLRKVTLEDSGTVSFQVGQNSTQAQLLVQAAPVTFL KKLENAEVTENGMATFRCELSKSGVPVEWRKGSSLIQPSQKFEVKIEGNAYVLIIHDVVP EDSGEYICSAAGKKTTAKLKVKALPVLFKRGLQNKEVEVGNTVSLCCELSKPMSPVVWKK GNTKLQSSEKYEIRQEGNFAELLIYDLEIQDDGDYTCDSGDQQTTATVRVKVLPVFFEEG LQNIESETGGKAVLCGKISNPNTPVEWRKGSLILQPSAKYEMKQKGPMVELIIYDLEPED CGSYTCSTGDELSIASVYVQEEEIQIVSGLKNTDIFAGESATFTCELSRSGTQNAQWWLD GSPLHNSTANEISVQDGTIHKLILKDLGLNDSGTVTFRAGSLISSAKLLIKDPTIEVVSP MQDLTLEEDEAAEFICQYSRPVQAIWKKDDQPLREDGQRVVVEQDWNVAKLKIKPAFPCD TGIYSCEAGGTKVVAMLDVQAKNTVIQGLENVDAMEGGEALFECYLSKPEIYNYNWLIDD VPAKTSENVELVYFENGLRHLLLLKNLKVQDSCRVTFQASDVVTSAFLTVKGWRLEFLQP LKDVTVRAGEQAVFSCVLSEAVPIYEIAWYLNDVDIQPDENWRIEVEENTYKLILKKAEL LHSGEITFAARDAIVSAKLTIIEPVEVSQPLVDQSATQGEKAKLQCELSSETQEVIWVKG KEPIQPGGRYEILSEGKKQTLIIQDFKSEDQGLYTCIASPEIKTSASLSIDVSPVSMLKE IVEEAPISKEPMKVADEEVQPSLPPEAAQEGDLHLLWEALAKKRRMSREPTLDSISELPE EDDKLQKRKKEEVEITQYYSEEYSTCDESAKAGEADFSITSSDDESRSGTPSLITYLKKA GSTTVTVSHKAVEKVPQDQQKFSEEPSPPAESTEMEITEGDLEDPSMSQAAVKIQAAFKG YKVRKEIKQQERPVFAETFKDFVGKIGDTLHLECMAHSKTDMTVSWLKDGNVIKDGRHYH IDNYNDGTCSLIIAGLEMSDKGSYACEASNKFGKVTHSAKVTIQPQTPSRKPKTAKKLPD SESESSSGSELDDAFRKAGRRLHKLFKSKISTEISDVDEELFVSADEGEIEAVDRQTYRE DERYIYIKFEVHMEAKTAAGRFREMFAAMGIPVEIDILDQGPKKIELRIGKATSPPAGQL RTSVQRPPPTLLTSDTAPVFITELQNQEVQDGYPVSFDCVVIGKPMPTVRWFKDGRVLEE DDHYMINEDQEGCHQLIITAVVPLDMGVYRCVAENSMGVSSTKAELRVDLTSTDYDTAGD ATETSSYYSAKGYLSSREQDGVESTTEEEQLPQITDELHDIHVAPEAPIAKFHLKVKGFP EPRLYWFKDGQPLHTSDRLQRTDSHEFHALEILQVTKEDDGQYSVFITNSAGSAYSTARL IVKGAGEDRKPEKDIYEQLVPPRFLERFTNKKVKRGVSITLSVKVEGTPSPSVTWLKEES HGEDILWIRSDTPGYKLASSNMQHSLILLDVDKTYSGNYTCIASNQAGQSICSASLDVLD VKEAESLTQERVMVTEAIMTSIGAQVSEAGKGEHMEGETARSQISLTEVGTEEFLQKLTS QITEIVSAKISQASLRIPGADSDDESKTPSASPRHGRSRPSSTAQESSSESDEGDARGEI FDIYMVIADYTPMGADRETITLKEGQYVEVLDSAHPLKWLVRTKPTKSSPSRQGWVSPAY LDKKLKLSAEWGIPDVPEFHGESVSEDEYRKKLSLIIQDLLGTEEEYVKDLLFLQTHHIQ FTETCPAVPVAVSNQKPVIFRNITDISHFHSNTFFPELQKCDTDDDVAMCFLKNEAEFDK YITYLVGRVQAESIVVSKAVQEFYKRYTEGTLASEDPSLPPIFPLQHYLERPINRIQKYQ TAIKDMIRNKARNTQNCALLEQAYAIVSALNRRAENNLHISLIENYPGTLEILGEPIRQG QFIVWEGAPGARMAWKGHKRHVFLFKGYLLVCKPKRDTKMDTYSYLFKNMMKLSHIDVND LIEGDDRAFEIWHEREDSVRKYLFQARTVIIKNSWVKEICSIQQRISLPVWDAPDFEEEL ADCTAELGETIKLACRVTGTPKPGITWYKDGKPVEVDPHHIIIEDPDGSCTLILDNLTGV DSGQYLCYASSPAGSASTLGKILVQVPPRFVNKMKHAYYTNGEDAQFTCTIEGAPYPQIR WYKDGNLLTDPNKHQSFSEPRSGVIVLVIKNACEDDGGLYECELINRLGTAKGSAHLYHQ TTTALAPEKRPEQAITIEVTEQETKVPKKTIIIEETITTVVKNPRTKRKPSPARPSSSYA PRSPGSEFATSEPIYVSKVRQPGPRHDLEGVGKTAIPTLFVTDPQERQGVAGRSISVETP LEEQRKWVEVEEIIEFNVQKPTQMSRKRGASPARSEKDEFASGYSRPTTKPRPSSEDDPN VNNSNNKRVEQVESPISRDVQRSGEPSENQNESSHVELEGKAHLHESKSWIDSSGTTTIE TSQMGLQHPRVENYVVEESSPEDETLPDQKTTVDDPDRGDLSDLGNREVKILTRNGKALT LEDLEDYVPEEGETYRCSHLNSEEDKPCEIAVLQTEINKPTIGKPVLLNVGRPVASKPRQ TFFSKLEGHHPGSMFMSASRVTEMQPRDPTNVSFQIGESHRPTFCTQVQLSPDSGASNFK TEVSTRSYNTAVGETVTFHIKKDDPSQTELQAPAGKTRENDILSREADIIPQDRSMCEGA DLSSKVLEMMAEVPWFKNERTEDILDLAGEGVAERTRVDKKGEKSVTSPPYMQVPLEDVQ VRCGEMAKFQAVIEGDPQPVVGWFKGVSLLLDSERIHQSKEGTSYSLILYNARAEDGGVY ACMAKNPGGEVVCKAELVVQEDKKSQEAKKRSPRRKLHSFYEVKQEIGRGSFSVLKRVIH KANRVACAAKFIPLRSRTREQAYRERDILVQLSHDRITQLLDQFETRKTLILILELCSNE DLLDRLYKKNMVTEVEVKFYIKQLLEGILYLHSNEILHLDIKPSNILMVHPDRDDIKICD FGFAQRINPSEPQHSTYGSPEFVPPEVLSRSSVSTASDIWPVGVISYLSLTCKSPFAGEN DRATLLNIQNGVVSWNSSDWDHLSKEAKGFIEKILQPAPGTRPSAMECLSHPWFSHKSPP EEGHFIETKPLNFFVSRSKWQRSLMSYKSLLVMRPIPEILEKHHKNTSLGVSRQLVEESS SSSTSGSSSDNEILVSSGKKPFGTIPEVRLSVLEGSNDQDDEVFEDEFKLPDDSMPPIKT RRLKEPAAKGHPVREREISKADPHGRTIFELASLQDQTGLLPPEEGNIERSPGCVPRHSV IKSTFYSHPSENLTDFPSSPGKGQKKQLEKAKRSYRKAGYSKSALTGLREPLLERFELGR EGGPLADAELGKEREGSYGPVITKSASFDTAQKSPKVTFQVSTRSRSLDDYRIRARSFAE EQEIVEEDLDTMVQTSPAEKTRVRDEKTTAAKARDGFSVEHPMLVQPGDKERSKLGLQQD KKTLILAQSSEKEEGLPQKTKVPHFVGKSPQGRENQQSGFASGLVSKSDIEEEQTSMSSP HRDGRTIFPKEETSVLRVPPSESPNLVSQDSKKATPTSPKSIEGRQLQQGESLHLLKAVP LHISHVQAEKQLAGAPDKSPKDLQTVSVCEDQKPLHQLPVAHLERKLPVAKTEGPVHPEI VALGGSQHPSQQESPLYRRPYPTTPRSAAALMQAASQPGPTSVPILHGETQMASLPKSSA YPERESLLREVQRTPQAQADLTSFFEAEKYELYHHLPSAPGEALQGPTPTIAGYSLAKMR PFATSGEKVSITQTKRPHSIGEGRSHQQRLYSDSEAHVLENLAEEMAYRSKATLPWSESP QDEMLQQTSPGQVVRPKSRYLVRRGKREGGIGLADPSEADIIYPGEEDYFSLQSYLSKKA RMSAPYEGSDYPGSSQQMYEIALVQIQDLSEMPRPDSKTSKFDITEVEPAFLNLHELYDI VYSPFEFLSFRKAPENLPTKRPPGSKLLSQQEKKICLREDNLPEVALKEPSGEEETGALK MEVAPEPAIAPRIGKRSDSEGDLPMGSQYDLPSDPTRKRKSSLQSALGLFKPVVRSQSME QVELSLRKRMKASVAQFSKMLTRKLSSEDTRTASEEVKSEQAERTSLTEPSPTSKKKRMF SAFTLPSLKTKDKGPSFTEELTDQTVAIGQSLTLSCRTSSHSFSGVEWFKDGAAICSTDR ILISSTLKRFQLLTVLSATMADFGVYTCKATSSHGSVSTSCTIRKAEAPSNIPAPDILEV LEDGVQLAWEAMELSNPVTYTVLCKKDDGEWKTLAGDIPDCCYTVEHLPRGLVYSFRIAC VSPAGVGPYSYPTPKVKIGEEDQAAFQAQEEEDRMAAPPTHQTYAFQTEIKRGRFSIIKQ CREKFSGNPLAAKIIPYQPEEKDAILQEYQILRKLHHTNVGQLQGAYVSPRHLVLIVELC VGPELLHALAGRSSYSEVQVRDYLWQILSAVEYLHKQDIVHLDLRSENMVIVEPNLLKLL DFGNARFYTPDQIITVDGCTDYVETMASELLSEKGAIPQTDIWAIGVTAFIMLSAEYPIS SEGACDFGRLVRRDKIRLNKCYAGLSGGAINFLQSTLSLNPWRRPTATECLQSLWLQETG LDEHQQATVSFSTTKLRNFVAERERKRALLCSKYGVMAV NT seq 30540 nt NT seq  +upstreamnt  +downstreamnt atggattacatttcctacagcggtgtcccgaggttcttgacaaggcccaaagccttcgtg gtctccatgggcaaagatgccaccctgagctgccagatcattggcaaccccatcccgttg gtgagctgggagaaggacaaactccccatccagacgggaggacgcttcaagatggtggag gatgatgacctttatcgtctcaccatctacaacttgagcctggaggacagcggtcagtac atctgccgggccaagaacaccattggggaagccttcgccgccgtcagtatcaaagtcggt gagcagaccaccgtgacagaatcggccccgtacttcatccagaagcccacatccatccga gtgatcatgggtgaagatgccatgttcaagtgcatcgtccaaggtagtcctccccttgcc atcaactgggagaaggacgggaagcatctgggcaaatcatctgactccaaccggatccgg attgaatcccagggcgagaagaacgctctgaagatccaaagtacccatctgggagacagc gggacctacacttgccgtgcagagaatcctttaggatcctccagcgcagccgctgcattg atggtagatcttccagattcgtacagcccaggcagcacgagacacagtatagatgacatc ggtagcaagacctctccactgttatcccacatgcagaaaagacgagaagaaatccggaag agcgatttgtccaaagtagactccctgatctccaccgaaggacggtccaaactcggattg agcttgtccttggattacgaacgggctgctagcttgacctccaagggactccgaggcgat ggaggttcatattatcgagtcaccacccggagcttcactgtcaccgaggggaagcatgcc aaaatgagctgctacgtaaccggagaacccaaaccggagacggtttggaagaaggatgga gaggtgatcctggagagccggagacacataatttacgaggacgagcaagagaattttgtc ttgaagatcctcttctgcaaacaggttgataacggcctctacacctgcacagcttcaaat ctggcgggtcagacctacagttctgtgttggtaactgttaaagaaccgagaatacctttc aagacaaaactccaagatttggaagttcgggagaaagactctgcgattttcttgtgtgaa gttccccattctgatgtggagaccacttggttcaaagaggagaccagacttcaacagaat gacaagtacaagattgaagaagatgggctgtgccgcaagctcacagtccaaaatgtcacc atggatgatgatgctgtctacatttgcgagatgaaggaaggcagcagaaccatcgccgaa ttgagcgttcaaggcaatattatcaagaaactgccaaggaaaacagctgtcagtataaaa gacactgcagtgttctgcgtggaactggagcagaagtgcgagaagttccgatggttgaag aataaggaagaattaaaacccagtggtcgcatttcaatctcatccgcagatagagaatat accatgatcatccgggattgtcaaatggaagatggaggagaaattgtctttgtggctgat gaatgtagaacatccacgcaatttactgtctctgctccgaagaagcccccatcacatcct ccagctgacccagtggtgaaaaataaaacagaaacctcagtgacgttagcctggtctctt cggaagacagaccggcctgtcccaattgatggctaccttgttgaacgtaagaagctgact ggattcgcatggctgaggtgccaccaagctttggtgtcccaaactgagttcatggttaac aacatgaccgaagaggctgactaccagttccgagtttctgcagtcaacaaatatggccaa agtgattatctggaatttcctggagtctggcatcttgaacctaccctggcagtgaaaacc cctctgagaaatgttgaagttgcaccagggagagatgcagtcttcactgtggacctcacc acccctagtcccggctcatggtacatcaatggcaaccttgtgcagaacagtgacaaatac ataattacgagaaccaaagcaagccacagtttaataattaagcgggtcaccagtgctttc aaggaggcagaggtgaaatttgtagccaaagatattgaaagcatcggaagagtcaccttg aaagatgaagtggccacatttgtcaatgactcagcccccgggatttcagtcaaccttcat gagaagtttgagctggtttgtgaagtgtcctcagccacggatgcggtcttgtggagaaag gggaagaaggacatcaagccagatcaaagggtgacattttctgttcagggaaaacagcga aaacttattgtccaaaacgccatcaaggaagacgaaggggtttatacctgcgaatcaaac gatgacagactaaccttccaggtggaggtcaaagagcctgcagaggtcttttttggcaag gagaaagtccagaaagaaatcagagctattctttctgaaaacgcctttctcagttgcgaa gtagcccagccctcaatggaagtgagatggttcaaggatgggaaactcatcaccccaagc aagaaattcaagattgaaacagaagggaaatctcgctggctgattattcgacaagttgac aggaaggatggaggtcaatacacctgcgaagcagatggccagaaactggccttcaaagtt attgtaacagatagagaggttgaagagatatttgtcaaccagaagaaggtccagaaggac ataaggactgtggcttcagagaatgtctctctcagctgtgaggtggcccagaccaagaca gatgtcaagtggttcaaagatggacagctgatcaccgacaccaagaagttcaaaatagaa gaacaaggtgaatcccggcgtctggttgttcaacaggtggagaagaaagatgcaggtgaa tatacctgtgaagctgatggccagaagctcaccttcaaagtcacagttgcagatgaaaaa attaaagaagtctttgtcaacaaggagaaggtccagaaggacatcaaggctgtagcttca gacaacatttctctcagctgtgaggtggcccaggccaagacagaagttaaatggctcaag gatggaaaattgatcacctccaacaagaaattcaaggtagaagcagaagatagatcccat catctggttgtccagcaggtggagaagaaagatgcaggtgaatacacctgtgaagctgat ggtcagatgctgaatttccaagtaacagtaacagacagagaagctgaggaggtgtttgcc aacaaggagaaggtccaggaggacatcaaggctgtggcttcagagaatgtctctctcagc tgtgaggtggcccaagtcaagacagaagtcaaatggttcaaggatggaaaactgatcacc tccagcaagaaattcaaggtggaagctgaaggcagatcccggcgtctggttattcaacag gtggaaaagaaagatggaggcgaatacacctgtgaagcagatggtcagaaactcaccttc aaaattacagttgcagatagagaagctgaggagatgtttaccaacaaggagaaaatccag gaggacatcaaggttgtagcttcagagaatctctctctcagctgtgaggtggcccaggtc aagacagacgtcaagtggttcaaggatgggaaactgatcactgccagtaaaaaattcaag ttagaaacagacggtagatcccggtgtctggttgtacaacaggtggagaagaaagatgca ggtgaatacacctgtgaagctgatggccagaaactgaacttcaaagtcacagttgcagac agagaagctgaggaggtatttgccagcaaggagaaggtccagaaggacatcaaggttgta gcttcagagaatctctctctcagctgtgaggtggcccaggtcaagacagacgtcaagtgg ttcaaggatgggaaactgatcactgccagtaaaaaattcaagttagaaacagacggtaga tcccggtgtctggttgtacaacaggtggagaagaaagatgcaggtgaatacacctgtgaa gctgatggccagaaactgaacttcaaagtcacagttgcagacagagaagctgaggaggta tttgccagcaaggagaaggtccagaaggacatcaaggctgtggcttcagagaatgtctct ctcaggtgtgaggtggctcaggccaagacagaagtcaagtggttcaaggatggaaaactg atcacctccagcaagaaattcaaggtggaagctgaaggcagatcccggcgtctggttatt caacaggtggaaaagaaagatggaggcgaatacacctgtgaagctgatggcgagaagctc accttcaaagtcacagttacagataaagaagttgaggaggtgtttgccaacaaggagaag atccaggaggacatcaagactgttccttcagagaccgtctctctcagctgtgaggtggcc caggccaagacagatgtcaaatggttcaaggatgggaaaccgatcactgccagcaagaaa gtcaagatagaaacagacggtagatcccggcgtcttgttgttcagcaggtggagaagaaa gatgctggtgaatacacctgcgaagctgatggccagaaactgaacttcaaagtcacagtt gcagagaatgtctctctcaggtgtgaggtggcccaggccaagacagaagtcaagtggttc aaggatggaaaactgatcactgccagcaagaaattcaaggtggaagctgaaggcagatcc cggcgtctggttattcaacaggtggagaagaaagatgctggtgaatacacctgtgaagct gatggccagaaactgaacttcaaagtcacagttgcagacagagaagctgaggaggtattt gccagcaaggagaaggtccagaaggacatcaaggttgtagcttcagagaatgtctctctc agctgtgaggtggcccaggccaagacagatgtcaaatggttcaaggatgggaaaccgatc actgccagcaagaaagtcaagatagaaacagacggtagatcccggcgtcttgttgttcag caggtggagaagaaagatgctggtgaatacacctgcgaagctgatggccagaaactgaac ttcaaagtcacagttgcagatgcaaaagttgaggagatgtttgtcaacaaggagaaggtc cagaaggacatcaaggctgtggcttcagagaatgtctctctcagctgtgaggtggcccag gccaagacagatgtcaagtggttcaaggatggaaaactgatcacctctagcaagaaattc aaggtggaagctgaaggcagatcccggcgtctagttgttcagcaggtggagaagaaagat ggtggtgaatacacctgtgaagctgatggccagaaactcaccttcaatgtcgcaattgca gatgaaaaagttaccgaggtgtttgtcaacaaagagaaggtacagaaagatatcaaaact gtgtcttcagagaatgtctctctcagttgtgaggtggctcagtccaaggcagaagtgaaa tggttcaaggatgggaaactgatcactgtgagcaagaaagtcaaagtagaagcacaaggt agatcacgtcgtctcattgtgcaacaggtggagaagaaagatgcaggtgaatacacctgc gaatctgatggccagaaactaactttcaaagtcacagttgcagatagagaagctgaggag atgtttaccaacaaggagaaggttcagaacaatatcaaggctgtggcttcagagaccgtc tctctcagctgtgaggtgacccaagccgagacagaagtcaaatggttcaaggatggaaaa ttgatcacctccaacaagaaattcaaggtggaagcagaaggcagatcccggcgtctagtt atccaacaggtggagaagaaagatggaggtgaatacatctgtgaagctggtggccagaag ctcactttcaaagtcactgtaacagaagctgaggagatgtttgccaacaaggagatgttt gagaaggacatcaaggctgtggctacagagaccatctctctcagttgtgaggtggcccag gcaaagacagatgtcaagtggttcaaggatgggaaattgatcacctccaacaaaaaattc aaggtggaagctgaaggcagatcccggcgtctagttgtccaacaggtggagaagaaagat gccggtgaatacatctgtgaagctgaaaaacagaagttgacctacaaagttgttgttgaa gaagctcctgatgtctttattaataaagacaaaataaagaaggaagtcaaggcagtcctg aaggagaatgccattttgacctgccaggtggccacttcggacactcaggtgaaatggtac aaagatggacaacccgtacccatcagcaaacacatcaaaatggagtcagatggaaacacc cgcaaactgtatctggagcaagtggcgagcaaggatgttggacaatatacctgtgaagca ggtggtcagaaagtgaccttcaaggtggaaataacagaaccagaggtcaaactccaaaga aaagctgctcaggaggagactattgttgctcaggagcacaaggaggccgccttctccacc gtggtatcacctgaggatgctgaggtcaagtggttcaaggacggagttgagatccacgat ggtaagaactatgaggtcaagaaggacaaggcggctaggatcttgattgtgaagatggct gaaaccaaagatgctggtctgtacacctgcgaagttaagagtgagaaacagcagttccaa ctcaaggtggaagaagtaccggttaagtttgccaaaaagctggagcccataaaagctgag ctcggaaaggctttgagcttgagttgtgaactttgccagcctgaaggaatggtagtgtgg cgcaaggatggaacagtcctcaaagccagcaagcgctacctgatgcaagaaattggtgcc aagagagtgctgatcatctccagcttgcgggctgaggacaagggagaatattcatgtgag acaaggaatgaccaatgcaccattcaagtcacccccacagcacctcgcattgtgaagttt gtcaagggcctctccaaggttgtggcagaagaaggcaaagaggcggtttttgaatgcacc gtctcccccagcgacgcatccgtaaagtggagccaccgcggcgccccaattgaagccagc aagaaatacgtcatttctcatcgggatgtccatcatagcctcaccctcaccgaactgacg gtccaagacagtggggaagtcaaagctgaagccgagggagaagagagccaggcccacctc cgagtggaagaagcgccggtgttattcgtgaagaagttggagcccaaagttgtagaagag aaacagacaattgtgctcgaagttgaactatccaagccgaccccagaggtgaagtggaca aagaacgcgagtgtccttcacccaacagcaaatctggagattcaggcccaggggacaaag cactgcctggtgatcaagagcgcatcctgtgacgatcgtgggttttattcttgcgagacc ctccatgacaagacgcaagccaaggtcactgtagacatgagacccatcaaactgatcaaa ggcttgcagccgacagatgttcatgagaaggaatcggtcacttttaatgtggaattgtcc cacgaagacgtggaaggagtttggatgaaggatggtctccgtctcaagtcacaggacaac tgccagatatccatccaagggaagaagcactcactgacgctctcatctttgacattggaa gattcagctcttatttccttcaaggccgaaggaattcacaccacaggcaggcttaatgtg aaagaatcccctgtgaaaatcatcacgcctttaaaagacctcaaagttcaaaacaaggat gatgtaaccctcgagtgcgaactttccaggcccaacgcggaagtgaagtggcgcaagaac ggagtggagatccgggcaagtaaaaggatggccattgcttccagaggaacaaagagaagc ctcatcattcatacatgtgaatacgaagaccaaggaacatacatgtgtgatgcggtagat gataagagctcagctgttttggagatccatgcccgggacatcaagattgtaaaaccgttg gaagacgtggaagtgaatgaaaaagaaagtgcttctttcctctgtgagatttcacatgat gatgtccaaacccagtggttcagtaacaaaaacaaaatccgggctggagagaacatcaaa ctacgtcaggaagggaaaagtcacaccctggtttaccgcagtgtggagttgcaggattcc gcagaaataaaatttgtggctgaaactgcagaatcacgagctcaacttaaagtcaaagaa ctaccggtcaaaatcattaaacccctccgggtgaagattgccattgaaagacaccgaggt tttatggagtgccaagtttctcgtccgaatgccatcgttaagtggttcaaaggagaccga gaactccatcccggtgagaagtacgagatggtgagcgatgggatttaccggaaacttatc atcaatgagaccgagtttgaggatgaagggatttacacctgcgatgccgtggatgataag agcagtgctcagttctatgtagaagaacaaaccatcaacatcgtgaaggagctgagagac gtggaggtgatggaaccagccgaagcccgctttgagtgcgaaatctctatccactcagtg aagccccccaaatggtctctccgtggggaagtactacagaagggcccaaatgtcatcata gaacaagaggggaaaatccaccggctaatcttgaggaaaaccaatgtggacatgacaggc accatccaatttgccattggcaagtccaaatccttggctgatctggtggtcaaagatatt ccagtgaccttcaccagacctctagaagacaggacggtcctggaaacccattcggtggtc ctctcttgtgacttcaagccatccccaaaggaggttgagtggtataggaatcacacattg ctggaaccttctgagaaatttaagatgaagagggagaagttcacagctgagctcaaaatc ttgaggttgaccgtcggggatacaggtgtctaccgatgcaaagccggaagcgcagagacg aaagccacattgaccattttggaacgcaaagtggagatcaccaaacatctgcaggatgtg gaggttgacgaagagagcttggccaccttctcctgcgagttgtctgaagattgtgaggat gttgaatggttcctcaacgatacccatctcttccccaacaacttcaatgaaataaagcat ttgggcaagtcccatagcctgacgctgaagcatgtcacgccagaagacagtgggacagtg tccatcaaagttcagaagaaaatttctgagagcgcccggctgaaggtgaaagagaagccg gcagtcttcatgaaatctctggatgacgtggttgctgaggaacgaagcactatcacactg gagtgtgaagtctcaaaaccaaaagtgaaaccagtgtggaagaaggaaggagtggaactg accccaggagataaatttgagatgctgcaatccgggaagaccctgggactcaccatccga gatctcggaaaggatgatgctggatggtacacgtgtgaccttgggacggatgtcaccaag tctaaagtcatcattcaagagctgaacattggtattacaaagcgtctaaagagcgttgaa gtgcaggaaggagagagttgtagctttgaatgtgtcctctcacatgagagtctggagggt tgtcagtggctggtcaatgggaacgaagtcagccgtgatgcccgattccgagccttcaac aaaggaagaaaatacaccctcacaatcaagaaaaccttagttaccgatgctggtgaagtt gtgttttccgtgcgtgatttaaaatccaaagcatctcttgcggtgaaagagctgaacatt ggtattacaaagcgtctaaagagcgttgaagtgcaggaaggagagagttgtagctttgaa tgtgtcctctcacacgagagtctggagggttgtcagtggctggtcaatgggaacgaagtc agccgtgatgcccgattccgagccttcaacaaaggaagaaaatacaccctcacaatcaag aaaaccttagttaccgatgctggtgaagttgtgttttccgtgcgtgatttaaaatccaaa gcatctcttgcggtgaaagaaaaacctgccgaattcacaaaacagctggagaacaagtcc accttggtgggatgtgaagtcagcctgagttgtgacttgtccagatgggacaacaacctg aagtggaagaaggatggcaaggagattcggaggagtcaaaaatacgacctgcgtcaggaa ggctcccgggcaattttaatcatccatgacaccacagtgaaagatggtggagaatatacc tgtgagaccgaattctccaaaacgaaagccacgctatcggtggaagaagctggaaactgc tttttgaaggatcttgaggacttgaaggtggaggagaacaagaatgccaccctcacttgt gaaaccaagaaaccaacttcttctgtgacgtggagaaaaggcattgttgaccttcaagcc agcaagaaatatgagatcagccagaaaggaactgtcttgcaactcctcgtgagggacctt aaagaaaatgatagtgacatctacacttgtgacattggtgacagccagtccagtgcaaag ctagtggtacaaggcctgccagtagtttttaaccaagaactgcaaaacaaggaagcccag gaagggaataaagtccgtcttacttgtgagcttaacaaaccagacgtgcccgtgcagtgg atgaagggcaatgtagtcctggaagcaggggataaatacgaattcaagcaacggggtcct gtggctgagcttgttatccgggacgcaaagacatcggatgcaggggaatatatttgcaaa agtggagacctgaagacctctgcgcgagtggaggtgacagcagcccctgccgtttttaag gaagagcttaaggatgtggaaaagaaagagggtgagacggtcgctttgcgctgcgtcctc gccgcgccagaggtcacagtggcatggaagaaaggtgcgactctccttcgggcgagcgag aagtacaagatgaaacaggacggctgtgtggctgagctgctgattcaccatgcacaacca gaggatgcaggacaatatacttgtgaagcaggagaaaagcagagcacagctcagatcaaa gtccacgctacacccgtcagttttaaagaaaaactgaagaaggccgaagctctggaaggt ggagtagctactctccattgtgagttaaataaacccgctccggtggagtgggtgaaagga caaaaaactttacggccaggcagcaaataccgaatgaagaaagaaggcgccatcgttgag ttgacaatccatgatctggacctgaaagatgctggagattatacctgcatttctggagac caacagacgactgcagtcttaaccgtgaatgccgtggctgcgcatttcaaaactcaactg aagaaccaggaggtgaccgaaagtggaaccgccactctgcattgcgagttgaccaaagct gcggatttggttgtgtggatgaaggatgaaaaagtactgaaaccgagtgagaagtaccga atgaggttagaaggacgctttgctgagctgtccatccaagatctggaagtcccagatgct ggaagttacacttgcatgtgtggggatcagaagaccaaagcaactttgaaagtgaatgca ctgcctgtgtttttccaagaagacctaaaaaataaggaagtgaccgaaggggaatcgacc tctttccagtgtaagctgaataaagcagcaagtgtagaatggtacaagggatctaggctg ctgaaaccagatggaaaattccaattaaaacaggaaggttcttgtgttgaactggtgatc caaggcttggacatcactgattctggagattatacttgcaaatgtggagcccagaagact acagctaaactgaccataaatgccctgccggtcctcttcaccaaatccttaaaagacata gaagctatggaaggcaaagttgccactttccagtgtgagctgaacaaaatctctgctcct atagagtggaagaaaggacacaagatccttaagtcaggaagcaagtataaaatgaaacac gaaggaaaaattgctgaactggtgatccagaacttggaagtaacagattctggaacttat gcttgtatatctggagaacagcaaaccacagcaactttagaagtcaaggctctgcccgtt cttttcaaagaagggctgaagaaccgggaagctgttgaagatgccaccactactttccat tgtgagatgtctaaagctggggctgaagtacagtggaagaaaggatcacaaattcttaag ccaagtgataaatacagaatgagggaggagggtcctgttgctgaattgttgattcgagat ctgaaggtggtagacacgggagattactcctgtttgtgtggagatcagaagaccacagcc gtcttgacggttcatgctctacctgtgcgtttccaagaagaactcaaaagccaagagatc ctggaaggaagaacggctgttctgcactgtgcattaaataaaactgctgtggtggattgg agaaaagatgcacagatgctccagccaagtgcaaaatacaaaatcaaacagaaagaaaat gtcgcagaactcacaatccaggacgtgaccgaagaggatgcgggggaatattcctgtatt tgtggagatcaaaccacatcagcttctgtcacagtgcaggccttacctccacgtttcaaa gtcgatctgaagaatctcgaagctgccgaagatgacgctgctactctgcggtgcgagctg accaaaactcctgctcttgtgaagtggtggaagggcagcgagattctgaagcccagcgat aaatacaaaatgaaactggaaggtgtggttgctgaactggtggtccaccgcttgcaactg gccgatactggggaatacagttgtattgttggcgattcgaagacttcagctttcttaagg gtgaatgccattcctgcaaggttcaagaaaggtctggaagaccaagaagctacagaaggt ggaactattgctctccggtgtgagctgacaaaaacagctacggtggagtggaaaaagaaa cacaagacactgcgagcaaatgacaaatacaatctgaagcaggaaggccctgtggtagag tgtgtgatccataaccttgatcttagagatgccggagaatactcttgtgtctgcggtgac cagaaaaccactggagctctggcagtccatgccctacctccccaattcaaacaggaactg aaggatgtggtagccaccgaaaatgaaacagccacgttgcattgtgagctcaccaaagct gctcctgtggaatggatgaaggaaggaaacaaattaaaaggagacaagtaccaattcaga caggaagcagctgttgccaagttggtgatccgtggtttagaagttgaggacactggacgt tacacctgtgtttgtggagatcagaaaacttcagctgctttgactgttaaagttctcaag cctgaatttacgcagcggctgaaggatgagaaagcggatgagggcagcacggtcagatta cgttgtgaagtgacagtccccaaagccccagtagaatggcgcaaagacggtgcaagaatc ccccctagccccagatatgacatcagacaggatgggggcatccgtgacttactcattcat aacttagaaccccaagacagtggagagtattcatgcatcgctggagatcagaccacgtct gccacattatctgtgcaagtcctgaaacctgaattcacacaacggctgaaggatgagaaa gcggatgagggcagcacagtcagattacgctgtgaagtgacagtccctaaagcccaagta gaatggcgcaaagacggtgcaagaatccacgctagccccaaatatgacatcagacaggat gggggcatccgcgatttgctcattcatcacttagaaccccaagacagcggagagtattcg tgcatcgctggagatcataccacgtctgccacgttatctgtgcaagtcctgaaacctgaa ttcacgcagtggctgaaggatgagaaagcggatgagggcagcacggtcagattacgctgt gaagtgacagtccctaaagccccagtagaatggcgcaaagacggtgcaagaatccacgct agccccaaatatgacatcagacaggatgggggcatccgcaatttgctcattcataactta gaaccccaagacagcggagagtattcgtgcatcgctggagatcaaaccacgtctgccacg ttatctgtccaagtcctgaaacctgaatttacgcagcggctgaaggatgagaaagcggat gagggcagcacggtcagattacgctgtgaagtgacagtccccaaagccccagtagaatgg cgcaaagacggtgcaagaatccacactagccccaaatatgacatcagacaggatgggggc atccgcgatttgatcattcataacttagaaccccaagacagcggagagtattcgtgcatc ggtggagatcagaccacgtctgccacgttatctgtgcaagccctcaagcctgaattcacg cagcggctgaaggatgaaaaagcagatgagggcagcaaagccagatttcgctgtgaagtg acagtccctaaagccccagtagaatggcgcaaagatggtgtaaggattcatgctagtccc aaatatgacatcagacaagatggtggcatccatgatctactcattcataacttggaatcc caagacagtggcaagtattcgtgcgttgttggagaccaaaccacgtctgccacgttatct gtgcaagttatcaaagttgaattcatgcaacggttgaaggatgagaaagcggacgaggga agcacagccagattacattgcgaggtcacagtcactaaaacccctgtggaatggcgcaaa gacggtgcaggaatccacgctagccccaaatatgatatccaacaagatgggggcatccat gagttactcattcataacttgcaactccaagacagcggcgaatattcgtgtagcattggt ggccaaaccacatctgccacattatctgtgcatgaagtggacatcaccatcatccgggga ctgaaaagtgcggaggttttggaagaggaagaagtcaccttcgagtgcgaagtctcccac gacaacgcaaaagatgtggaatggaaattgcaagatttgtcgcttcaaagcaaccagatg aacgagatctcagtcgagagaggacgggtccacaagctgacgctccgcaacgtcacccag caggattctggcacggtcaccttccgggtcggaccgtacatctccacagcgaggctcaga gtggacgccccacatcctgactttcaacaagagctgagtaacctagaattgcaagaaggc agcgcagctttcctcaaatgcgaagtatctatgctcaacgtctctcccatatggaaaaag ggctcggaagtcatcactccgagcaccaagtacgaaatcagtcagcagggaacgacccat attttaaagatttacggtgtaactcgaagagattctggaaaatatatttgcgacattggc catgggagaagcatgggcacgttatcagtggaagccctctcagctcgtccagttcttttt caagtccagctggagaaccaagaagtcaaggaaggggcaacgatcaccctggccactgcg ctcacaaaacccgatgtgcctgtccagtggatgaaaggctctgcccaactgcagccaagt cacaagtatgagatgagacaaaaggcatcttatgtggagctgctaatccatgatgcgcag ttggaggatgcaggccactatacctgtcaaaccgaggaccagcagaccaccgcatctgtg gttgtcaaagaaataccggctaccatagaagaagaattgaaagacctcactgtccttgaa ggagaggatgctgtgtttcgctgtgtggtttctcatgagaaggccaaaaacctgcaatgg agtttggcaggtgtgcctctgcaatccaacgaaatgaaccaaattggcgtggaaggcaaa actcacaccctcgttctccgaaaagtcacccttgaagattccggcactgtcagtttccaa gttggtcagaattcaacacaggctcagttattggtgcaagctgcaccggtaaccttccta aaaaagctggagaatgcagaagtaactgaaaatggcatggcaaccttccgctgtgagctt tccaaatctggggtcccagtggagtggagaaagggatcatccctgatccagcccagccag aagtttgaagtcaagattgaaggcaatgcctacgttttgatcatccatgatgtggtccca gaagactcaggagaatatatctgcagtgcagctggcaagaaaaccactgccaaactaaaa gttaaagctctgccagtgctcttcaagcgaggtctgcagaacaaggaggttgaagtagga aacactgtgtcattgtgttgtgagctgtccaagccgatgtcacctgtggtgtggaaaaaa ggaaacacgaagcttcagtcgagtgagaagtacgagatcagacaagaagggaactttgct gagcttctcatttatgatctggaaattcaggacgatggcgactatacctgtgattcagga gaccagcagaccactgccacggtcagggtcaaagtgttacctgtcttctttgaagaagga ttgcaaaacattgagtcagaaaccggagggaaagctgtcctgtgtggcaagatctcaaat cccaacactcccgtcgagtggcggaaaggatccctcattctgcagcccagtgccaagtac gagatgaagcagaaaggccccatggttgagctgatcatctatgacttggaaccggaggat tgtggatcgtatacatgcagcactggagacgagctgtccatagcctcagtatatgtacaa gaagaggaaatacagatagtttctggtttaaagaacacggatatttttgccggggaatca gctacttttacctgcgagctctcccgatccggaacacaaaatgcacagtggtggctggac ggctcccctcttcacaacagcactgcaaatgaaatctcggtgcaagatgggaccattcac aagctgatcttaaaagacctgggtctcaatgattcaggaacagtgaccttccgagcgggt tctctgatatcctcggctaaattattaatcaaagatccgaccattgaggtggtcagcccc atgcaggacctaactctggaagaagatgaggccgcggaattcatctgccagtattctcgg ccagtgcaggccatctggaagaaggatgatcaacctcttcgggaagatggccagcgagtt gtggttgagcaggactggaacgtggccaaattgaaaatcaagccggcttttccttgcgac acggggatttactcttgtgaagcaggaggcaccaaagtggtggccatgcttgacgttcaa gccaagaacacagttatccagggcctcgagaacgtggatgcgatggaaggaggggaagcc ctctttgagtgttatctttccaaaccagaaatctacaattataactggctgatcgatgac gtcccagcaaaaacgtcagaaaacgtggaactggtttattttgaaaatggccttcgccat cttctgcttctgaagaacctcaaagtccaagacagctgcagggtgacctttcaagcgagc gatgtggttacgtctgctttcttgaccgtaaaaggatggagactggaattcttgcagcca ctgaaggatgtcaccgtccgtgccggggagcaagccgtcttcagctgtgtgctaagtgaa gcagtaccaatctatgagattgcctggtatcttaatgatgtagacatccaaccggatgaa aactggagaattgaagttgaagaaaatacctacaaactcatcctaaagaaagctgagctt ctccactctggggagataaccttcgccgccagagatgctattgtgtctgcaaaattgacc atcatagaacctgttgaagtgtctcagcctttggttgaccagtctgccacacaaggagag aaggccaagttgcagtgcgaattgtccagcgagacccaagaggtgatttgggtcaaaggg aaagaaccgatccaacctggaggacgatatgaaatcctctccgaaggcaaaaaacagaca ctcatcatacaagattttaaatctgaagatcaaggattgtacacctgcatcgcctcgcct gaaatcaaaacttctgccagtctttcgattgatgtttctccagtgtccatgttaaaagaa attgttgaggaagcaccaatctctaaagagccaatgaaggtagcggatgaagaggttcaa cccagcttgccacccgaagctgctcaggaaggtgacctccaccttctgtgggaagctctg gccaagaagcggaggatgagtcgcgagccgaccttggattcaatcagtgaactgcccgaa gaagatgacaagcttcagaagaggaagaaggaggaagtggagataacccaatactactcc gaggaatactctacttgtgatgaatctgcaaaagctggagaagcagatttctccatcaca agttcagatgatgaatccagatctgggacaccttccttaatcacttaccttaagaaggct ggatcaaccacagtgactgtcagtcacaaagccgtggagaaagtacctcaagatcagcag aagttcagtgaagaaccatctcctcctgcagagtcaactgaaatggagattaccgaaggt gacttggaggatccttctatgtctcaagctgctgtcaaaatccaagctgccttcaaaggt tacaaagtgagaaaggaaatcaaacagcaggaacgtccggtctttgctgagaccttcaag gactttgttggcaagataggagacaccctccatctggagtgcatggcccacagcaaaaca gacatgacggtcagttggctgaaagatgggaatgtaattaaggatgggcggcattatcac atagacaattacaacgatgggacctgttccttaatcattgctggtctggaaatgagcgac aagggcagttacgcctgcgaagcctccaataaatttggcaaggtcacccacagtgccaag gtgaccatccaacctcaaacaccttctcgcaaaccgaaaactgccaagaagcttcctgac agcgaatcagagagctcgtctgggagtgaattggacgacgctttccgtaaagccggacgg aggctccacaagctgttcaagtccaaaatctccaccgagatatctgacgttgacgaggaa ctgtttgtcagcgcggacgagggagagatcgaggcagtggatcgtcagacctaccgggaa gacgaacgctacatctacatcaagtttgaagttcacatggaggccaaaacagctgcaggc cggtttcgggagatgtttgccgctatgggtattcctgttgagattgacattttggaccag ggtcctaaaaagatagagttgcgtattgggaaagccacttcacctcctgcgggacagttg cggacttcggttcaacggccaccacctactttactgacctctgatactgctccagtcttc atcaccgagcttcaaaatcaagaggtgcaggatggttacccggtcagttttgattgtgtg gtgattggcaagccaatgccgactgtccggtggtttaaagatggccgtgttcttgaagag gatgaccattacatgatcaatgaggaccaggaaggatgtcatcagctgatcatcacggcg gtggtccctcttgatatgggggtctaccgttgtgtggctgagaacagcatgggcgtgtct tcaacaaaagccgagctacgagtggacctaaccagcacagactatgatacagccggagat gcaacggagacctcctcatactacagcgccaaaggttacctgtccagccgggaacaagat ggagtggagtcaacaacagaagaggaacagttgcctcaaatcacggatgaacttcatgat attcacgtggcacctgaagcccctattgccaaattccatttaaaagtgaaaggtttcccc gagcctcgtctctactggttcaaagacggtcagccgttacatacaagtgatcgtctccaa aggacagacagccatgaatttcatgctctggaaattctccaggtcaccaaagaggacgat ggccagtattctgtcttcatcactaactctgctgggtctgcttattcgacagccaggctc atagtcaaaggagctggtgaggacagaaaaccagaaaaagacatttatgagcagctggtg ccaccaagattcctggaaagatttaccaacaagaaagtgaagagaggggtcagcattacc ctttcagtgaaggtggaagggactccatcaccctcagtaacgtggttgaaggaagaatct cacggtgaagacatcctctggatcaggtcggacactccaggttataaactggccagttcc aatatgcaacacagtctgatcttattagatgtggataaaacctacagtggaaactatact tgtatcgcctccaatcaggctggtcagtctatctgcagtgcttcattggacgttttggat gtgaaagaggctgagtctctgacccaggagcgtgtgatggtgacagaggccatcatgaca tcaattggagctcaagtttctgaagctggaaaaggagagcacatggaaggagaaacagct cggagtcagatttctctaaccgaagtgggaactgaggaatttctgcagaaactgacatct cagatcacggaaattgtatctgcgaagataagtcaagcttccctccgaattcctggagct gacagtgatgatgaatcaaaaacaccatcagcatctccacgtcacggcaggtccagacct tcctcaactgctcaggaatcttcctccgaatccgatgaaggggatgcaaggggggagatt tttgacatctacatggtcattgctgactataccccaatgggggcagaccgtgaaaccatc actctgaaggaaggccaatacgtggaggttttagactccgctcatcctttgaagtggctg gtcaggaccaaacccaccaagtcaagcccatcgagacaaggttgggtttctccagcctac ttggataagaagttaaagttgtctgcagagtggggtatccccgatgttccagagttccat ggagaatctgtttcagaggatgaataccggaagaaattaagccttatcattcaagacctg ttgggcacggaagaggaatatgtcaaggatcttctgttcctccaaacacaccacatccag ttcacagagacttgtcctgccgttcctgttgctgtgtccaaccagaagcctgttattttc agaaatattactgacatatcgcactttcattccaacaccttcttcccagagcttcagaag tgtgacacagatgacgatgtggccatgtgcttccttaaaaatgaagccgaatttgacaaa tacatcacctacttggtaggccgggttcaagctgagtccattgtggtcagcaaagcagtc caggagttttataagcgatacacagaagggacattggctagtgaggatccttccctgcca ccgatattccctctgcaacattatctagagagacccataaaccggatccagaaatatcaa acagcaatcaaggacatgatccgaaacaaagcaaggaacacccaaaactgcgcccttctg gaacaggcctacgccattgtttctgcactcaacaggcgagcagaaaacaaccttcatatt tctctcattgagaactaccctggaactctggaaatattaggggaacccatccggcaggga cagttcattgtgtgggaaggtgctccaggggcgcggatggcatggaagggacataagcgc cacgtcttcctcttcaagggttacttgctggtgtgcaaaccaaaacgagacacgaagatg gatacttacagctatctgttcaagaacatgatgaagctatctcacatcgatgtgaatgac ctgattgaaggagatgaccgggcatttgagatctggcacgaacgggaagattcggtccgg aagtatctcttccaggcgcgcaccgtcatcatcaaaaactcatgggtgaaagagatctgt agtattcagcaacggatcagtctccctgtatgggatgcacctgattttgaagaggaactg gcagattgtacagcagaactgggcgaaacgatcaagctagcatgccgagtcacaggaacc cctaaaccaggcatcacctggtataaagatgggaaaccagttgaagtggatcctcaccac atcatcatagaagatcccgatggatcctgcactttgatccttgataatctgactggagtg gattcagggcaatatctgtgctatgcgtctagtccagctggcagtgccagcacccttgga aaaattctcgtccaagtgccgcctcggtttgtgaacaagatgaaacatgcctattacacc aatggcgaagatgcacagtttacttgcaccatcgaaggggcaccatacccccaaatcagg tggtataaagatgggaacctccttaccgacccaaacaaacaccagagcttcagtgagcca cgaagtggcgtgattgtcctggttatcaaaaatgcctgtgaggatgatggaggtctctat gagtgtgagttgataaataggttggggaccgcgaagggaagtgcccacctttatcatcaa accacaacagccttggctccagagaagagacctgagcaagcgatcacaatagaagtcact gaacaagaaactaaagtgcctaagaaaaccatcatcatagaggagaccatcaccaccgtc gtgaaaaacccaagaaccaaacggaagccatctcccgcccgtccgtcttccagctacgct cctcgctctccaggctcggagttcgcaacatcagaaccaatttatgtcagcaaggttagg caacctggtcccaggcatgacctcgaaggagtagggaagaccgccattccaactcttttt gtgacagaccctcaggagaggcaaggagttgcaggcaggagtatcagtgtagagactcct ctggaagaacagcgtaaatgggtggaagtggaagaaataattgagtttaatgtgcagaaa ccaacccagatgtcaaggaagagaggcgcatcccctgcgcgttccgagaaggatgaattt gcatcaggttattctcggcccaccacgaaacccaggccttcctctgaagatgacccaaat gtgaataattccaacaacaaacgagttgagcaagttgaatctcccatctcccgagatgtt caaagatctggagaaccatcggagaaccaaaatgaaagttctcatgtggagctagaagga aaggcacatcttcatgaatccaaaagctggattgactcatctgggactaccacaattgaa acatctcagatgggccttcagcatccccgggttgagaactatgttgtggaggagtcttct ccagaagacgagactcttccagatcaaaaaacgacagtagatgaccccgatcggggagac ctctctgatcttggcaaccgcgaagtaaaaatccttacccggaacgggaaagcattaact ttggaggaccttgaagattatgtccctgaagaaggagagacctacaggtgcagccatctt aattccgaagaagataaaccttgcgagatagctgttctccagaccgagatcaacaaaccc accattggcaaaccagtattactgaacgtcggtaggcctgtggcttctaaacccaggcaa accttcttcagcaaacttgaaggccatcaccctggaagtatgttcatgtcggcatccaga gtgaccgagatgcaacctagagatcccaccaacgtttctttccagattggcgagtcccac cgaccaactttctgcacgcaggtccagttgtccccagacagtggcgcatccaatttcaaa accgaagtgtccacccgaagctacaacactgctgtcggagaaaccgtcacgttccacatc aagaaggacgatccttcccaaactgaactccaggcgcctgctggcaaaaccagagaaaat gacatattgtctagggaagcagacatcattccccaagacagaagcatgtgtgaaggtgct gatctctcttccaaggtcctcgaaatgatggcggaggtgccgtggttcaagaatgaaaga acagaggacattttggatttagccggtgagggcgtcgcagagagaacccgtgtcgataaa aagggagaaaagagtgtcacaagtccaccatacatgcaggtgccccttgaggatgtccag gttcggtgtggggaaatggccaagttccaggccgtcattgaaggcgatcctcagccggtt gtcggatggtttaagggagtttccttgttgctggacagcgaaaggatccaccagtcgaag gaagggactagctactctctgatcctctacaacgctcgggccgaagatggaggggtctac gcttgcatggctaaaaaccctggaggggaggtggtctgcaaagcggagctggtggtgcag gaagacaagaaaagtcaagaggcgaagaagcgaagcccacgaaggaaacttcattctttc tacgaggttaaacaggaaataggaaggggctccttcagtgttctcaagagagtcatccat aaagctaaccgtgtggcttgtgcagcaaaattcatccccttgcgaagtcgaacgagggaa caggcttatcgggaaagagatattctagtccaactttcccatgatcgaattactcaatta ctggaccagtttgaaacacggaaaaccttaattcttattttggaactatgttccaacgaa gaccttctggaccgcttgtacaagaagaacatggtgacagaagtagaggtcaaattctat atcaagcaacttctagaagggatcctgtatcttcacagcaatgaaatattacacttggac atcaagccctcaaacattttgatggtccaccctgacagggatgacattaagatctgcgat tttggctttgcccaaaggataaatccgtcggagcctcagcacagcacttatggatctcca gaatttgtcccaccagaagtactgtccaggtcctcagtgtcgacggcatcggacatctgg ccagttggggttattagctatttaagtttgacctgcaaatctccctttgctggggaaaat gaccgagcaaccctgcttaacatccagaatggagtcgtgtcatggaatagctctgattgg gatcatttgagcaaagaagccaagggttttatcgaaaagatccttcagccagctcctgga accaggccaagtgcgatggagtgcctctctcatccatggttttctcacaaatcaccacct gaagagggtcattttatcgagacaaaaccgctcaacttttttgtatcccgaagcaaatgg cagcggtctcttatgagctacaagtcgttgcttgtgatgagaccaatcccagaaattctg gaaaagcatcacaagaacacctcgcttggagtctcccgacaactggtcgaagagagcagt tcctccagcaccagtggatcgtcttcggacaacgagattttggtctcctctggaaaaaag ccttttgggaccatcccggaggttcgtctgtctgtgctggaaggctcaaacgatcaagat gatgaagtatttgaagatgagttcaaacttcctgatgactccatgcctcccatcaaaacc agaaggttgaaggaacctgcagcgaagggacatcctgtccgagaacgagaaatctccaaa gctgacccccatggaagaacaatatttgagctggcttcgttgcaagatcaaactggattg ttgcctccagaagaaggaaatatagaacgatctccaggttgtgtcccgagacatagcgtc atcaaaagcactttttacagccacccatcagaaaatctgaccgactttccttcctcgcca ggaaaagggcaaaagaaacagttagaaaaagctaagagatcttacaggaaagccggatac tcaaagtccgctttaacaggtctacgggaacccttgctagaacggtttgaacttggtaga gaaggaggaccgttggcagatgcagaattggggaaggaacgagaaggaagttatggaccc gtaatcaccaaatcagcttcttttgataccgctcagaaatcacccaaggtgactttccag gtatccaccaggagccgttctttggatgactacagaataagagctcggagctttgctgag gagcaggagattgtagaagaagacctggacaccatggtgcagactagtccggcagaaaaa actcgtgtgagggatgaaaaaacgacagcagcaaaagctagggatggtttttctgtagaa cacccaatgttagtacaaccgggtgacaaggaaagatccaagttgggccttcagcaggac aagaagactttgattttggcacagagctctgaaaaagaggagggtttacctcagaaaacg aaggtaccacattttgtgggaaaatctcctcaaggcagagaaaatcagcaatctggtttt gcttcagggttggtttcaaaaagtgacattgaggaggagcagacatccatgtcttctcct cacagggatggacgaaccatttttccaaaggaggaaacctctgttttgagagtgccacca tcagagagcccaaatttggtgtcccaggatagcaagaaggcaaccccaacttctcccaag agtattgaaggacgtcaacttcaacaaggagaaagtcttcatcttctgaaagctgttcct ttgcacatctcccatgttcaggctgagaaacagctggctggtgctccagacaagagtccc aaagacctacagactgtgtcagtgtgtgaagaccagaaacctttgcatcagttgcctgtt gcacatctggaaaggaagctacctgttgcaaaaactgaaggtcctgttcatccagagata gttgctctgggaggaagccagcacccatcacaacaagagtctcctctttacagaagacca tatcctactaccccaagaagtgctgctgctctgatgcaagcagcttcccaaccggggccc acctcagtacccatacttcatggagaaacccagatggcctcacttccgaagtcctctgct tacccagaaagagagtctcttctcagagaggttcagcgtactcctcaagctcaagcagat ctgacgtccttttttgaagctgaaaagtatgagctctaccaccacctgccatctgctcct ggtgaggccctccagggtccaacccccaccatagcaggctattctctagcgaaaatgaga ccgtttgcaacctctggagaaaaagtctccataactcaaacgaaaagaccacattccatt ggggaaggcagaagccaccagcagagactttacagtgactcagaggctcacgttctggag aacttagcagaggagatggcttaccgatcgaaagcaacacttccttggtcagagtcaccc caggatgagatgctccagcaaacgtcacctggccaagtggtgagaccgaaaagtcggtat ctggtgcgcagaggcaagagagaaggtggcattggcctagcagatccttcagaagctgat atcatctatcctggagaagaagactatttcagtcttcagtcttacctgagcaagaaagcc aggatgtctgctccttatgaaggctcggattatccaggaagcagccaacaaatgtatgaa attgcccttgtgcagatccaggatctctcagagatgcctcgtcctgacagcaagacctcc aaatttgatatcacggaggtagaaccagctttccttaaccttcatgaactctatgacatt gtctattctccgttcgagttcctgagtttcaggaaagcccctgagaatttgcccactaaa aggccacctggatccaaactcctttctcagcaggagaaaaaaatatgtctcagggaggat aatttgcctgaggtggccctcaaggaaccttctggagaagaagaaacaggtgccctcaaa atggaggtggctcctgaaccggccatagcaccacggatagggaagaggtctgactcggaa ggtgatctaccaatggggtcccagtatgatctcccatcagatccaacaaggaagaggaag agttctctccagagtgccttaggacttttcaagccggttgtccgctctcagtccatggag caggtggaactcagtctgaggaagaggatgaaggcatccgtagctcagttctcaaagatg ttgaccagaaaactttccagtgaagacaccagaacagcctctgaggaagtcaagagtgag caagccgagaggacctccttgacggagccttccccaacttccaaaaagaaacggatgttc tctgcattcactttgccaagcctcaagaccaaagacaaaggaccttctttcacagaagag ctcaccgatcagaccgttgccatcggacaatctctgaccctctcctgccggacatcgtcc cattccttctccggcgtcgaatggttcaaagacggagcagcaatttgtagcacagatcgg atcctgatttcttcgactctaaaacggttccagcttttaaccgtcttatcggctacgatg gcggactttggcgtgtacacctgtaaggctaccagttcccacggttccgtttccacttcc tgcaccatacggaaagcagaagcaccttcaaatatacctgcccccgatatccttgaagtt cttgaagacggcgtacaactggcctgggaagcgatggaactcagcaacccagtcacttac accgttctgtgcaagaaggacgatggagagtggaaaaccctggccggtgacatcccggat tgctgttacacagttgaacatcttcctcggggtttggtctactcctttcgcattgcttgt gtgagcccagccggcgtgggtccatacagctacccaactcccaaagtgaaaattggcgaa gaagatcaagcagcatttcaagctcaggaagaagaggacaggatggcagctccaccaaca caccagacctacgccttccagaccgagattaaaaggggccgtttcagcatcatcaaacaa tgccgagaaaaattcagcgggaatccgttggctgccaaaattataccctatcagccggaa gagaaagacgccatcctacaggaataccagatcctaaggaaactgcaccacaccaatgta gggcagctgcagggcgcctatgtgagtccacgtcaccttgtactgattgtcgaactctgc gtgggccccgaactgctccatgccttagctggaaggtcttcgtattcagaggtgcaggtc agggattacctgtggcagattctcagtgcggtcgagtaccttcacaaacaggacatcgtg catctggacctgcggtctgaaaacatggtgattgttgagcccaacctgttgaaacttctg gactttggcaatgcccggttctacacgcccgaccaaatcataaccgtggatggatgcacg gattatgtagaaaccatggcttcagaactcctatcggagaagggagccatcccacagacg gacatttgggcaattggcgtgacagctttcatcatgctaagcgctgaatatcccatcagc tccgagggtgcctgtgacttcggaaggctggtcaggcgggacaagatacgactcaacaaa tgttacgccggcctttcagggggagccatcaactttctccagagcacactttccttgaat ccatggaggagacccacagccacagaatgcctccagtctttgtggctacaggagaccggc ttggacgaacaccagcaagccacggtttctttctccaccaccaagctgagaaattttgtg gctgaacgcgagcggaaaagagcactcctctgttcaaagtatggagtgatggctgtgtag

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