Amphimedon queenslandica (sponge): 100637092 Help Entry 100637092         CDS       T02284                                  Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism aqu  Amphimedon queenslandica (sponge) Brite KEGG Orthology (KO) [BR:aqu00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:aqu04040]     100637092    04990 Domain-containing proteins not elsewhere classified [BR:aqu04990]     100637092 Ion channels [BR:aqu04040]  Voltage-gated cation channels   Ryanodine receptor    100637092 Domain-containing proteins not elsewhere classified [BR:aqu04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    100637092 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_ITPR RYDR_Jsol RyR SPRY RIH_assoc MIR Ion_trans Ins145_P3_rec EF-hand_7 EF-hand_1 EF-hand_5 EF-hand_6 EF-hand_8 Cor1 Motif Other DBs NCBI-GeneID:  100637092 NCBI-ProteinID:  XP_019855347 UniProt:  A0AAN0JF00 LinkDB All DBs Position Unknown AA seq 4753 aa AA seqDB search MHRSTGNTDRPGGASSDNVDSCIYIRTGDSVGFATSTTTGRIVKHYLSTGFGTQYCTVLL EPSDDQEPTVIWRHIFEVFDAISPHAIHGWNEKESQAKGCRVLLYGQAILLRMASGYKYL RCLPHHAGRVGKYKMNDFHSHYLIGSSSPNQKAQVDEYCWFVIRPATNQRSEGEKVKAGD DIHLVNLGTGRYLSLPHERPVAYDTTSTSLSIDFDDDTFTDIPVATFSPWTWIIDIIRSH AANAGLLNGYVNAGDPIQLKVAHRDDELMSIPLSSLEDPLAVNDAKRMVYFEDKSVKLEL RSLWLVMLSGVSYGRAFIEYGQPFRLRHMVSGMYLGVDQNRQLVLVDGKNAQRDPCCFCF VKKGSPVPPINYKREGMGTPTIKMGETEVSLYHISSKLWVTLELMGPSLRRLRTGFSGPP RALLSDEPHGFSFTTLKAMHIALSTVVCNELETVMLAFSEAMRRIQGQSTNDRSIRSIKE SAEEKTLAKLNESLVFLIPPNKEIMDIHTYQDLLMKLRNRQTRLLNHGTANMVFALLRKT VSHYGHDVTSNGLQIQQALCRILANVVKGNRLACRRFANRESIQNMFELINNPSLLHPML EVMDCLLEESPEVLLSLTEENVRHLFTLLYCHGRDHKVMSLLGRLPVCQGVAMREKQLQI CRLLQDSHQLLLHTSLMPKLYSMYANVFLSSKDNVEATKLYFEVQWTRSEAAGTKPYIRI GCVQYLNFLPYPKSKGSMATQGGIGDDGSSVSFDGQHILMNSEKYGLQSIPLAKGQFKKQ SPEDEQDVTVYGCCLDLEKGTLMFTINGQLFPLLVNFHLNENTIAVPAVSFTGGVENARL CFGSGYGDLYFAPPIGYQPLSCFIEQKANGKKEKICLYPFVCVGDSNERILNGPIQYNDS VWFRPSVPDLTNVTIPSRLHQLINDLAVESHDTWAVSQIVLGHSSPNLTAFPHLPKDVQL QRIQEGRNLIATLISLGCRISATDTHPISHQDLPDDPYLQLNGFKPCPLELLDDLPVSLQ PLITQLSEIEHNKWSKERMSKGWKYGVTTRPQVMQDCCLVPYQCLPLDIKKKYELVVKKS LLVLSSLGYTVQSPPIDYLKRDLGHTLVSFRTFRGQFLGYCTGSGKWFFKVKLLKGRMSR IGWAIPRYSSSSLLGSDSFSYAIDGHNVVKWHDGLSENFGHILEEGDEITCLLDLDEGTM SFACNDKLLLSLTHQSGIAFSDLPRNELYVPAVSVFMGEQVQMILTTMKDQETSSSRNIT AGYRSIENDIKVRIPLWYSHVSHQFKDITPSHSYLKITKTKEDELTVNSNEAKLTCLRLN MGVEMTLDKRRDKDDPVDEREGGSEESQNDDDREKYSFSVTLPAGEAPSAVYFGWAREDF LYDPNDFHTHSDDLILNANATIELISDSDSPFGDAMFEEFEETGVKDVFSRGDTMKDGVK RRMNTNSTTSTKKRRSQLESIEEWPIEDDDDDESSSFRVTGKEHVLRKHQCAAYLLKMSA LLKVDESVYLATDTQVDCVINPSTGLMKFSCLSYSKNAVFELRVRAPGRLFPILITRPKY LKIGSFSFGPAKGCQPLVKALLGKYYKDTFPNLLPSMKLMSISDSCWYQMDDRSSLYPTE SCLYIPNMPSYDITHLCLPQEGNVMRLTELIESPSLYSFHVETLRTYRACCMHDNSKAAE MVNKIVSWKELVHSIKSSYWSYQLVAESFNLVNTLYLEHKVLEHQLIRQDSIFASDCVSC STSSPSSSYNAGRRHSSNSLLNRTVTICCNTEKEWLSSCHYYQLSVLKDITFQVLDSVIL ADVMTCRMLSAEYNNCLFLPLLKAVDCFLVLGMLQDSERLLSLLHPSLAPSGHKANFYIL TMPTKDPQIQSVLCDILDHLCDAQLQGRLDHIIEFASGFVEELQEDQRKRVMESDPNQFL SPLVIQEINTPTEKQLNTLLSFSSDSCLTSESLKDSLQSFHADLSLHCNGIPSSINQTAD LSSFQKLAKLVSLVTVRSSSSESENSPDTSSLHKLRDVIISTVLRWSRSTISDIKMAEKT YKLLYRQFNESEMLRKAIQRTYIVEQYSEFSSGEISKFRSALGKMRKMLVVGFGEEEEPV FQELLQELSTCDLFQRHPDLLRFAGVHSLVINVMKSYFSFSETLSSAFPSSFGTESSSGF VGMTQTLKLAVSDEGFADIVEDCCKFLCSFAQTSHQNQIALSEHLQYLLDECLIFSDQVA SNSTNPLDVAIATISNNLQLVMTLSNEGILHKVVQLMHKMMKYEDEASSTANNTISSPIH KMSVLYDAMPMEWLPTGAEKCLKFLQAAVYVNGETIEENAAAIIRLLIQQPDCLGPCYIN QHLSLVKMFSSCFSQINSLKTTKKPKRLTRASSRLTDTIVRLASDTELPQVSQSDYRQRS LHRSSTLNLFYKQLSALTSELTVSFYTLLVRVLGLCAPSIDTRKNFSCTRKVKYSTEHIL PFLRTLIGLEDLRDLLSLPMNVMPPTHKEALMVFLDRVYSKSDKRLVLDLIREAFLPDIK ATIHQAKKTKYDAFVYLRYISCHVLPYLEHQSSTLDLLSEFPLLLNLIHEVYQLIALATD SHRRMIEQFLITMTKTLPPPSILKLLPMIMDDIKDLSKPSFTVALKILTVHHSHHSRYYT TGSVIGQYKLCRPSHKERVYIALLFSLVLKSLCHAKEASIAGIINQCLESLACAILPEIL VPPIAELKALSVETATLSPSHTSTPSSTPSPPLEDEGSSLTRIVNNLSAYIDQIEFSSEY HSHVFEFAKFCHENWVYEMQQVNGWSYDHVSNPDTYHDDRLRPFEYINDELGDRVVDEVK QVLQVLLFYGCVFNEGNGGGQLESIPLKPKLLCLFGANKKKVLRTITDDPDTWYSYEPLV VDLDQIELPLHALIIVSSANTIMNHIVLPTVEERGDTQSDLGTYDPIRLMYYEKTNRRSY GLIEDFLKFMKVKGLTVANPFAAIPGSMQYMLSKTIDSKPFSLQLFECFLTVLRYECCCT AGYTCRCQSHKQEIFPAFCSYLNTHASYFNPNIEGEERRLTFATLDEKIPLIKLFFEVHS YIGSHLDSFLISTSKTATVAPGEATTSKGEISWNTELQAIKERNQKLLNRLLSLSMSLIK VLDVSQFGVLEETKSFFSYVISTLESLEKSLNKINSNQSNQFDKKLFLYVTHCLAPSLTA LFRRCEDIVMSPVNGVVKSRFSDVFSCVFSLVCNEITIFIESDTLSIIGQCLSEVCLADS KFQCSRFENRLAMLLLKRGALLKLSTQKISFVALVIAPVLTNRSIREAKNGSNVEVDKVL KLVLRILSEYQGDKETTWMKDLSCSVCHLASYCSIPVYKTHLIPLLMKMSDRGSRLWQEE QLVTSSLSIKESDLLIKQKQFEKRLKLYGQDLVSVLLFLVFFTEKNPSLVADLRNKTLFH HTALILNHYFTSQKFSSILNSCSTSFIQNVRGRKTERWNILISFAMTIIRHLPSSAFQFL QQLNPLFDQPGKSSADIDQAILDLIKCLAESDSRTGIDVKLNGRNHDEEKREILQILMTY KTAPFVIQSFARVQRLMRQIVTPSLIVRERWRDAMSRKKREGIVACLKAVPFHRLKKHRA MNLFLQEYSSSWLSQCHSFNMENLCEEIIDKEEYYQEKQARSSVISLINDRYVDPLEQLF SLLGMQASTGQWYGNSTDLYDSFANAVIETFQTMIDDAEELEGNSIYDNFESIRYQVVAK QGLLIKKKVPEMILAILTSSNGKLCPLVHITLKLGIVQLEGGNASAQERIMEKVKSLGSE FWTSIAGLISHFGTLDWNIYEKSQIVVQDQNNIGERVFPTSDQVLALFRFLQLLCEGHNE GFQNLLRTQGSNAMSTNIVIATVDYLLKLQDSIRDFYWYHAKQDSLELPARETFLLSFKV AKQLFRTLTEYIQGPCVGNQEALAKSRFWDAMGGFLHVFVALQQKLFCYTSHMELLLELL GLQEEYFILLLAMLEGTTKVSAVGEHMLNMLHESDQFLKELITFYNIFIKLKDVSSSTAF KEYDLNKDGLISYQEFEQAMRAQQFYTKSEIQYLMKLADTNKDGLLDYQEFTERFYQPTH KLGFHLCALIRQLSDTMPGNPKLKEIEKNCLKLSEYFEDNIGCIEMMGKSGNVERVYFHI KTSHALQWNDPAIKESRHNFLHSFDWTSQKEKLGEFMNFCEDTIFQMTYNDRMFNVEQEE REKRTDNLRKSQFPETAQYNTRSMLSSAQTKLLSLGITDPGHIYLKAHSLLSFIWFTLIL GVIVAPLTHLVHYTRVFYDFCFYGGQGPLKYSSSNPSFLKQYFMQYFRPAQFYLPRTMYA SKSLRGHLAHSYYMIKYCLVLTTILINFLILISIQADKNEDSISLYLSIHLHFVLSCLLM VSFWHLKVPLIIFQKEKNIARRLEKHKGSVTSDHFSFFDRLALRSPSFPRRFWDRQIKER VFDKSPSENRTKLASALGIVNKSRFDEVSRYEQLSNAIASLIDVRYQAWRIVMICFSDMT FRYHLGYCLLSLAGIKYNVFFFSLHLLELTLQSKTLVNVLRSLKINMKQLLMTLVVTSVV IYIYSAVAFSFFRKFYVQQVESGYVRDNCGNMLTCFLFHIDHGLRSGGGIADVILSAFED QVYLGRLVFDLTYFFVVIVILLAVFQGLIIDAFGELRKKDDLVLEELKNKCFICGLSLAD FKNPHEFDTHINRHHSLKDYMFFLLHLISKPDTEFTGQESMIWSLYLEQTWDFFPAGTCF QTQERRASDALAN NT seq 14262 nt NT seq  +upstreamnt  +downstreamnt atgcacagaagcacaggcaacactgaccgacccggcggggcctcttcagacaatgtggac tcctgtatatacataagaacaggagacagcgttggttttgcaacgtctaccactactgga agaatagtgaagcattatctttccactggtttcggtacgcagtactgtactgttctcctg gagccgtcagacgatcaggagcctactgtgatttggagacatatttttgaggttttcgat gcaatatctcctcatgctatacacggctggaatgagaaagagagtcaagctaaaggatgc cgtgtactgctttatggacaagccatactgttaagaatggccagtggatataaatattta cgttgcttgccccatcatgcgggcagagttggcaagtataagatgaatgactttcattct cattatttgattggctcttcttcaccgaaccagaaagctcaagttgatgagtattgttgg tttgttattcggccagcaacaaaccagcgctctgagggagagaaggtgaaagctggtgat gatatacatttagttaatcttggaacaggacgatatttgtctctacctcatgaaagacca gtagcatatgataccactagtaccagcttaagcattgactttgatgatgatacttttact gatataccagtagcaacattctctccttggacctggataattgatatcatccgttcccat gcagcaaatgctggattacttaatggttatgtcaatgctggagaccccatacagttgaag gttgctcatcgtgatgatgaactaatgtccataccactctcatctcttgaggacccactg gcagttaacgacgcaaaaagaatggtttatttcgaagataaatcagtcaagctggagttg aggtccctgtggctggtgatgctctctggtgtgagttatgggcgggcattcatagagtat ggtcaaccctttcgcttgcgtcacatggtcagtgggatgtaccttggagtggaccagaac cgacagcttgttttggttgatggaaagaatgctcaaagggacccttgttgcttctgtttt gtaaagaaaggatccccagtccctcctattaattacaagagagaggggatggggactccc accattaaaatgggagaaactgaggtctccctctaccacatctcctcaaagttgtgggtc actcttgagctcatgggtccttccctccggagactcaggacaggattcagtggaccacca agagctcttctctcagacgaacctcatggctttagctttacaacactcaaggcaatgcat atagcactcagtactgtcgtctgtaatgagctggagactgtcatgcttgccttctctgaa gctatgaggaggatccagggtcagtcgactaatgataggtccattagaagtatcaaggaa tcagctgaagagaaaactttagcaaaattgaatgagtctttagtttttttgatacctcca aataaggaaatcatggatattcacacatatcaagatttgttgatgaaattaagaaacaga cagacaagacttctgaatcatggcacagccaacatggtgtttgctctcctcaggaagaca gtctctcattatggtcatgatgtcacttcaaatggactccagatccagcaagctttatgc aggattctagctaatgttgttaaagggaaccgtttggcttgcaggaggtttgctaataga gagagcatacaaaacatgtttgagctgatcaataatcctagtttacttcatccaatgctt gaagtgatggattgtctactggaggagagtcctgaagttttattgtcactaactgaagag aatgtcagacacctcttcacactcctctactgtcatggaagagatcacaaagttatgagt ctattgggaaggctcccagtctgtcaaggtgtagctatgagagagaaacagttacaaata tgtcgcctcttgcaagactctcaccaactgttgctgcatacatcattgatgcctaaacta tacagtatgtatgcgaatgtgtttctatccagtaaagataatgtagaggctactaagttg tattttgaggttcaatggaccagatctgaagcagctggaacaaagccatacattaggatt ggatgtgtgcagtacttaaactttcttccatatccaaagagtaaaggatcaatggctact caaggaggcataggtgatgatggcagctctgtatcatttgatggtcagcatattttgatg aacagtgaaaaatatggccttcaatcaatcccattggccaaaggacaattcaaaaaacaa agtcctgaagatgagcaggatgtaactgtgtacggctgttgtttggatttagagaaaggg acactcatgttcaccatcaatggtcaattgtttccactcctagttaattttcatttaaat gagaacacgattgcagtaccagctgtatcatttactggcggagttgaaaatgcaaggttg tgttttggttctggttatggcgatttatattttgctcctccaattggatatcaacctctt tcttgttttattgaacagaaagcaaatgggaaaaaagagaagatttgtttgtatccgttt gtgtgtgttggtgattctaatgagaggatacttaatggaccaatccagtataatgactcg gtttggttccgtccttcagtacctgacttaactaatgttactataccgtcaaggcttcac cagttgatcaatgaccttgctgttgagtctcacgatacttgggctgtctcacaaatagtc ttgggtcattcctctcctaatctcacggcctttcctcatcttcctaaggacgttcaactg cagaggatacaagagggaaggaacctcattgctacacttatttcccttggctgtaggata tctgctacagacacacaccccatctcccatcaggatcttcctgatgatccttacctacag ttgaatggtttcaagccttgtccattagagctgctggatgatctcccagtctcattgcaa ccactgatcacacagttatcagagatagagcataacaagtggtcaaaggagagaatgagc aaaggatggaaatatggagtcacaactcgcccgcaagtaatgcaggactgctgtcttgtc ccatatcagtgcttaccattggacattaaaaagaaatacgagcttgtagtaaagaagagt ctgttagttttgagttcacttggttacactgtacaatctccacctattgattatcttaaa cgtgatctcggacacactttagtatcttttagaaccttccggggacaatttctaggctat tgcactggtagtggaaaatggttttttaaagtgaagttattgaaaggtaggatgtctcgt attggttgggctattccacgctattcctcttcatctttgcttggatctgatagtttttct tacgccattgatggacacaatgttgtcaagtggcatgatggtctctcagagaattttggt cacatcttagaagaaggagatgagataacttgtctgctagaccttgatgaagggacaatg tcatttgcttgtaatgataaactgctcttaagtctcactcatcagagtggtattgcgttc agtgatctacccaggaatgagctctatgtcccagcagtgtccgtttttatgggagaacaa gttcaaatgatcctaacaactatgaaagatcaagaaacctcttcttctcgcaatataact gctggctaccgctcaattgaaaatgatataaaagttaggataccattatggtactcacac gtatctcaccagttcaaagacatcacaccctctcactcgtacctcaagatcacaaagacc aaagaggatgaactgactgtcaatagcaacgaggcaaaactgacctgcctgcgacttaac atgggagttgagatgaccctagacaagaggagggacaaagatgatccggtggatgagaga gaaggaggctcagaggaaagtcagaatgatgatgatagagagaagtattctttttcagtt actctgccagcaggcgaagcaccatcagctgtatactttggctgggctagagaagatttt ttgtacgatccaaacgactttcatactcattctgatgacctcattcttaatgctaatgcc accatcgaactgatatcagatagtgacagcccttttggagacgcaatgtttgaggaattt gaagaaacaggtgtcaaggatgtcttttctagaggagatacaatgaaagatggcgtaaag agaagaatgaatacaaactcgactactagcactaagaaaagacgtagtcagctagaatcc atcgaagaatggccaatagaagatgatgatgatgatgagagtagctcatttagagttact ggtaaggagcatgtactgagaaagcatcagtgtgcagcttatttactgaaaatgagtgca ttgcttaaagtggatgaatcagtttacttagctactgatactcaggttgactgtgtgatt aatcctagcactggattaatgaagttctcttgtctctcttacagcaagaatgctgtgttt gagcttagagttagagcacctggaagattattcccaatcctaatcactagaccaaaatat cttaaaattggctcgttctcatttggaccagccaaaggatgccagcctctagtcaaggct cttcttggcaaatattacaaggatactttccctaatctgctaccgtcaatgaaactcatg agtatttctgatagctgctggtatcaaatggatgatcgctcttctctgtatcccacagag tcctgtctttatattcctaatatgccttcgtatgacatcactcatttgtgcctgcctcag gaaggtaatgtaatgagactgacggagctgattgagtccccatctctctattcgttccac gtggaaacacttagaacctatcgcgcctgctgcatgcatgataattccaaagctgctgaa atggttaataaaatagttagttggaaggagctggttcattcaataaagtcctcttactgg agctatcaattagttgctgagtcattcaatctcgtcaatacactttaccttgagcacaag gttctggagcaccagctcattagacaagactccatatttgcctcagactgtgtatcatgc tctacctcttctccttcctcctcttataatgcaggaagaagacactcctctaattctttg cttaatcgtacggtcacaatttgttgcaatacagaaaaggagtggctctcgtcctgtcat tattatcaactgagtgtcctcaaggatatcacttttcaagttcttgacagcgtcatttta gcagacgtcatgacctgccggatgctttcagcagaatacaacaactgcctctttcttcct ttgcttaaagctgtcgattgtttcctagtactgggaatgctacaagactctgaaagactt ctctctttactgcacccttcattagccccttctggccacaaggctaatttctacatacta acaatgcctactaaggacccacagatacagtcagtgctgtgtgatatattggatcatttg tgcgatgcacagctccagggaaggctggatcatatcatagagtttgccagtgggtttgtt gaagagctacaagaggatcaaaggaagagagtgatggagagtgatcctaatcagttcctg tctcctctagtaatacaagagattaatactccaactgaaaaacagttaaacactctcttg tcattttcatcagactcgtgtctcactagtgaatctcttaaagactccctccaatcattt cacgctgaccttagcttgcactgcaacggaatcccatcgtccatcaatcagacggcagac ctatcatcgtttcaaaaactagccaaactggtcagtttggttactgttaggagcagctcc agtgagagcgagaatagtccggacacctctagtcttcacaaactgagagatgtcatcata tcgactgtcctcagatggtccaggagcacaatctctgatatcaaaatggcagagaaaacc tacaaactcttgtacagacagttcaatgagtctgagatgctccggaaagctatccagagg acgtacattgttgagcagtacagcgagttctcttccggcgagatttcaaaattcagatct gcactgggtaagatgaggaagatgcttgtggttgggtttggtgaagaggaagagcctgtt ttccaggagctgttgcaggaattgagtacttgtgatctcttccaacgtcatcccgacttg ttgaggtttgccggagtccacagtcttgtcatcaacgtcatgaagagctacttcagcttc agtgagactctctccagtgcattcccatcatcatttggcactgagagcagcagtgggttt gttggcatgactcagacacttaaactagctgtcagtgatgaagggtttgctgatatagtt gaagactgctgcaaattcctttgctcttttgctcagactagtcatcagaatcaaattgca ctctctgagcatcttcagtatctcttggacgaatgtctaatattctctgatcaggtagca agcaatagtaccaatcctcttgatgttgctattgctaccataagcaacaacctccagcta gttatgacactctccaatgagggcatactccacaaggtggtacagttaatgcataagatg atgaagtatgaagatgaggcttccagcactgctaataacactatttcaagtccaattcac aagatgtcagtattgtatgatgccatgcccatggaatggctgcccactggtgctgaaaag tgtctcaagttcttacaagcagcagtttatgttaatggtgaaactattgaagagaatgct gctgcaattattcgtctccttatacagcagcctgactgcctcgggccctgctacatcaac cagcatctctcacttgttaagatgttctcctcctgtttttcacaaatcaactcacttaag accaccaagaaacccaagagactgacgagagctagttccagactcacagataccatcgtt aggcttgcctctgataccgagttacctcaggtctcgcagtctgactatcgtcaaaggtct ctacacaggtcaagcactctcaacttgttctataaacaactcagtgcactaacatccgaa ctgacagtctcgttttacactctactggtccgtgtccttggactctgtgctccctccatt gacacaaggaagaatttcagctgcacccgtaaagtcaaatacagcactgagcatatactc cctttcctaaggacactcataggactagaggacctaagggacttgctttccctccctatg aacgtcatgcctcctacacacaaagaggctttgatggttttccttgatcgtgtctactca aagagtgataagcgtttggtgctagacctcattagagaagcttttctacctgatataaaa gctaccatacatcaagctaagaaaactaagtatgatgcatttgtgtacttacgttatatt tcttgtcacgttcttccttatcttgagcatcagtcctccacattggacttgctgtcagag tttccattactgctcaatctcattcatgaggtctaccaactgatagcgttagctactgat tctcacagaagaatgatagagcaatttcttattactatgacaaagacactcccccctcca tctatacttaagttactgccaatgataatggacgatattaaagatttgagcaagccttcc ttcactgtagcactcaaaattctgaccgttcaccattctcatcactcgcgttattatacg acagggtctgtgataggtcagtacaaattatgtcgtccatctcacaaggaaagagtgtac atagctctcctcttcagcttggttcttaagtcactctgtcatgctaaggaggcatcaatt gctggtatcattaaccagtgtttagaatctcttgcttgtgctatattgccagagatacta gttcctcctattgcagaactcaaggcactatcagtggagactgctactctttctccttct catacttcaactccatcctcaactccatcccctccattagaggatgaaggctcctctctt acaaggattgtcaataatctatcggcttatattgatcaaattgagttttccagcgaatat cattcccacgtgtttgagtttgccaagttttgccacgagaattgggtatatgaaatgcaa caagtaaacggttggtcttatgatcacgtaagcaaccctgatacgtatcatgatgacagg ctaagaccttttgaatacattaatgatgagttgggtgatagggtggttgatgaggtcaaa caggttctgcaggtgctcttattttatggttgtgtgtttaatgaaggcaatggtggggga caattggagagtataccactaaagcctaaactgttgtgtttatttggggcaaataaaaag aaggtattaagaaccataacagatgatcctgatacgtggtactcatacgaaccattagtt gtagatttggatcaaatagaattgccactacacgctcttatcattgttagttcagccaac actataatgaatcatatagtgcttcctacagttgaagaaaggggagacactcagagtgat cttggaacttacgacccaatcaggttgatgtactacgaaaaaacaaacaggaggtcttac ggtcttattgaggatttcttaaagtttatgaaagttaaaggtttaactgtagctaatcca tttgcagctataccaggctcaatgcagtacatgctatcaaaaactattgacagcaagcct ttctctctacagctgtttgagtgtttcttaacagtattacggtatgaatgctgttgcact gctggttatacttgtcgctgtcagtctcataaacaggagatttttcctgctttttgctcc tacctcaatacccacgccagctatttcaatcctaacatagagggggaagagaggaggctc acctttgctacccttgatgagaaaataccattaataaagctgttttttgaagttcattct tacatcgggagccatttggattcctttcttatcagtacctctaagactgcaacagtagca cctggggaagccactacttcaaaaggagaaatctcctggaatactgaattacaagcgatt aaagagaggaatcagaaactgttaaatcgattgttgtctttatcaatgagtctcattaaa gtccttgatgttagtcagtttggagttttggaagaaactaaaagttttttctcgtacgtc atctcaactttagagtcccttgaaaagtcattaaataaaataaactctaaccagtcaaac cagtttgacaagaaactctttctatacgttactcattgtcttgctccatcactgacagct ctttttagacgttgtgaagatattgttatgagtccagtcaatggagtggtaaaatcacga ttcagtgatgtctttagttgtgttttctcacttgtttgtaatgaaattactattttcatt gaaagtgatactttgtctattattgggcagtgtctatctgaagtgtgcttagctgattcc aagtttcagtgttcccgctttgaaaatcgtcttgctatgcttctactcaagcgtggtgca cttctcaaactttctacgcagaaaatctcttttgttgcacttgtgattgcacctgtgctg acaaatcgttccatcagagaagcaaagaacggctctaatgttgaagtggataaagtcctt aagcttgtattgaggatcctctcagagtaccagggtgataaagaaacaacttggatgaaa gacttatcctgttcagtatgtcacttagccagctattgctcaatccctgtatacaagact catttgattccgttgttgatgaaaatgagtgatcgtggttcaagactctggcaagaggag caacttgtaacatcgtcactgagcattaaagaaagtgatctccttatcaaacaaaaacaa tttgaaaagagattgaaattatatggacaggatttggtctcagtcttgctattcttagta ttcttcactgagaagaaccccagccttgttgctgatctgagaaataagactttatttcat cacactgccctcattctcaatcactattttacttcacagaaattctcatcaatccttaac tcatgcagcactagcttcattcaaaatgtcagaggaaggaagacagaaagatggaacata ttgatatcatttgctatgacaatcatacgacatttgccttcatctgctttccagtttctc cagcagttaaacccactgtttgatcaacctggtaaatcatctgcagacatagatcaagct attctagacctcattaagtgtctcgctgagagcgacagtagaactggtattgacgtcaag ctcaatggaaggaatcatgatgaggaaaaaagagaaatattacagattctcatgacatac aagactgctccttttgttattcaaagttttgctcgtgtccagcggctcatgagacaaatt gtcacaccgtccctcattgtgagagaaagatggagggatgcaatgtcaaggaagaagaga gagggcattgtggcttgtttaaaagctgtaccttttcacaggctcaaaaagcacagagca atgaaccttttcttgcaagagtactcaagtagctggctttcacaatgccattcattcaat atggagaatctttgtgaagaaattatagataaagaagagtattatcaagagaaacaagcc agatcatctgttattagtttaattaatgatagatatgttgatcctctggaacaactcttc tcattgctgggaatgcaagcatctacaggacaatggtatggcaacagcactgatctttat gattcctttgctaatgctgtcattgaaacatttcagactatgattgatgatgcagaagaa ttagaaggaaacagtatttatgataattttgaaagcattaggtatcaagtggtcgcaaag cagggattgcttattaagaaaaaagtccctgaaatgatactggcaattctaacctcctca aacggtaaactatgtcctcttgtccacattaccttgaaactgggcatagtacaactggaa ggaggtaacgcttcagctcaagagagaataatggagaaagtaaaatccctcggcagtgag ttttggactagtatagctggtttgatatcacattttggaactcttgactggaatatttat gaaaagtctcagattgtcgtacaggatcaaaataacattggtgaaagagtgtttcccaca tcagatcaagtacttgccctattcagattcttacaattgctatgtgaaggacacaatgaa ggttttcaaaatcttcttcgcacacaaggctccaatgccatgtccactaacattgtcata gcgactgttgattatctcctcaagctccaggactcaatcagggatttctattggtaccac gctaagcaggactcgcttgagcttcctgctagggagaccttccttttatcattcaaagtt gctaagcagttgttcagaacactcactgagtatatacagggcccttgtgttggcaaccag gaagctctagctaagagtcgtttttgggatgccatgggtggctttttgcatgtttttgtc gcccttcagcagaagctgttctgttacaccagtcacatggagctccttcttgaattgtta ggcttacaagaagaatactttattttactgcttgctatgcttgaaggtactacaaaggtt agtgcagttggcgagcacatgctaaacatgcttcacgagtctgatcaattcttgaaagaa cttatcacattttacaatatatttatcaagctgaaagatgtttcatcatcaacagcattt aaagagtatgatctcaataaagatggcctcatttcatatcaggaatttgagcaagcaatg agagcacagcaattttatactaaaagcgaaatacagtatttaatgaaactagctgacact aataaagatggactgttggactatcaggaattcactgagagattctatcagcctacgcat aaactaggttttcatttgtgtgctttgatacgtcagctaagcgacacaatgccggggaac ccaaaactaaaagaaatagagaaaaattgcctcaaactctccgagtactttgaggacaac ataggctgcattgaaatgatgggaaagagtggaaatgttgagcgagtttacttccacatt aagacttcacacgcattgcaatggaatgacccagctatcaaggagtcgagacataatttc ctgcacagttttgattggaccagccagaaggaaaagctaggggagtttatgaatttttgt gaagacactatttttcagatgacgtataatgacaggatgtttaatgtggagcaagaggag agagagaagagaacagataatcttcgaaaatctcaatttcctgaaacagcacagtataac acaagatcaatgttgagttctgcacaaactaagcttctgtcattgggtattactgatcct ggacacatctatcttaaagctcatagccttctctcattcatttggtttacattgattctt ggagtaattgtagcacctctcactcatttggtacattacaccagagtattttatgatttc tgtttctatggaggtcaaggtccattgaagtattcctctagcaatccttcattcctcaaa caatatttcatgcaatattttcgaccagcccagttttatttaccaaggactatgtacgca tctaaatctctgagaggtcatttggcacacagttactacatgattaaatattgtcttgtt ctcacgacaattttaatcaattttctcattctcatttcaattcaagctgataaaaatgaa gattcgatttcattgtacttatccattcacttacactttgttctctcttgtctattgatg gtatcattctggcacttaaaagtaccacttataatttttcaaaaagaaaagaatattgca agaagattagagaaacacaaaggatctgtgacaagtgaccacttctctttctttgacagg ctcgcactgagatctccttcattcccaagacgattctgggacagacaaataaaggaaagg gtgtttgataaaagtccttcagagaataggaccaaacttgcaagtgctcttgggattgtt aacaagtcaaggtttgatgaagtttcaagatatgaacaattatcaaatgcaatagcctct ttgattgatgttagatatcaggcatggaggatagtaatgatatgcttcagtgatatgact ttcaggtatcaccttgggtattgtctactcagtttggccggaatcaaatacaatgttttc tttttctctcttcatctactcgaactgaccctccaatctaaaactctcgttaacgtcctt cgctctctaaaaatcaacatgaaacaacttttgatgacattagtggtgacatcagttgtc atatacatatacagtgctgtggcttttagcttcttcagaaagttttatgttcaacaggtt gagtctggttatgtgagggacaactgtggaaacatgttgacatgcttcctctttcacatt gatcacggtcttagatcaggtggtggaatagctgatgttatcctctctgcttttgaagac caagtctatttggggagactagtgtttgatttgacatacttctttgttgtcattgtcatc ttgttggctgtttttcaaggtctcatcattgatgcttttggcgaattgaggaagaaagac gacttagtattagaagaattgaaaaacaagtgtttcatctgcggcctgtctcttgcagat ttcaaaaatccccacgagtttgatactcacatcaaccgccatcattcacttaaggactac atgttcttcttgcttcatttgatcagcaagccagacactgaatttactggacaggagtca atgatatggagtctgtatctggagcaaacgtgggatttctttcctgctggcacctgcttt cagactcaagagagaagagcatctgatgctctagcaaactag

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