Apteryx rowi (Okarito brown kiwi): 112971038 Help Entry 112971038         CDS       T07573                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism arow  Apteryx rowi (Okarito brown kiwi) Pathway arow04020   Calcium signaling pathway arow04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:arow00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112971038 (RYR3)    04020 Calcium signaling pathway     112971038 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:arow04040]     112971038 (RYR3) Ion channels [BR:arow04040]  Voltage-gated cation channels   Ryanodine receptor    112971038 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR Ins145_P3_rec SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 TBK1_ULD Motif Other DBs NCBI-GeneID:  112971038 NCBI-ProteinID:  XP_025931841 Ensembl:  ENSARWG00000016325 LinkDB All DBs Position Unknown AA seq 4870 aa AA seqDB search MAEGGEGGEDEIQFLRTDDEVVLQCVASIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCICNFVLEQSLSVRALQEMLANTGDNASEGAAQGGGHRTLLYGHAILLRHSFSEMYL TCLTTSRSQTDKLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSMSNGSIQVDASFMQTLWNVHPTCSGSNITEGYLLGGHVVRFFHGHDECLTIPSTD QNDSQQKKVLYETGGAGVRARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGEYLALNED EGLVMLDREKSDTTSTAFCFRASKELKEKQDSALKRDIDGMGVPEIKYGDSICFIQHVAS ALWLTYKAQDAKSARLGLLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTSLFSK FISGNNRTLSPIALPVEEMVQTLQDLITYFLPPKEELEHEDKQSKLRSLKNRQNLFKEEG MLALVLNCIDRLNDYNSAAHFAGIAIEENGTAWKEILNLLYKLLAALIRGNRNNCTQFSS NLDWLISKLDRLESSSGILEVLHCILIESPEALNVIAEEHIKSIISLLDKHGRNYKVLDV LCSLCLCNEVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRVPRAVASVNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFENFSTEGFFFPVVS LSAGVKVRFLLGGRHGEFKFLPPAGYAPCYEALLPKEMMKLEPVKEYKRDSDGVRDLLGT TQFLSQASFIPCPIDTSQIALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNKR HHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHTNPAAEEDLKKVKLPKNYVMS NGYKPAPLDLSEVKLLPSQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFAGYGYSIEPPDQEIADQTVEKVSIDKIRFFRVEKSY AVKSGKWYFEFEAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSGFFGR CWQPGDVVGCMINLDDKSIIFTLNGELLITSKGSELAFADFGIESGFVPICALGLSQIGR MNLGMDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIEIWRID GTIESPPRLKVTHKTFGKQNSNSDMIFCRLSMPIEFRSSFNFGMGVENASSDAFQKRKQS QEIAFPSTTCFYSLRIFAGQDPSSVWVGWVTPDYHFYSENFDLNKNCTVTVTLGDERGRV HESVKRSNCYMVWGGDIIANSQRSGRSNVDLEIGCFVDLATGMLSFTANGKELGTCYQVE PNTKLFPATFVQPTSTNLVQFELGKLKNTMPLSAAIFKSEERNPVPQCPPRLDVQTITPV LWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMKFH YHTLKLYSSVCALGNTRVAYALCSHVDLSQLFYTIDNQYLPGLLRSGFYDLLISIHLEHA KQAKLMMNNEFIIPVTEETRTIKLYPDETKKHGLPGVGLSTCLKPSFNFSTPCFIVTSEE HQTSSPEIPLDTLKSKAISMLTEAVQCSGAHIRDPVGGQVAFQFVPVLKLIATLLIMGVF DDDDVKQVLLLIDPNVFGDHKEDLEERTEKEEVTQVEEKAVEAGEKAIKETKAPVKGLLQ TRLPESVKLQMCHLLSYFCDCELQHRVEAIVSFADRYVSKLQYNQKYRYNELMQALNMSA ALTAKKTKEFRSPPQEQINMLLNFRLGEDCPCPEEIRDELYDFHDDLLIHCGIPLEEEEE EEEDASLTGRLRSLMYKIKGPPKAEKVEPREEEEQSPTTLKELISQTMVRWSQEDQIQDP ELVRIMYTLLRRQYDSIGELLQALRKAYTISAVSVEDTINLLAALGQIRSLLSVRMGKEE ELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMDVMVNVLGGDKSQIAFPKMVASCCRF LCYFCRISRQNQKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELALALEE PDLEKVVTYLAGCGLQSCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEENASV VVKLLIRRPECFGPDLRGEGGNGLLAAMQEAIRISENPARDLPSQGYKREGDDEEEEEEI VHMGNAIMSFYSALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIISIPLK LSTVNKDGTVNEPDMSANFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRASAS LDTVSLSTTEAALALNRYICSAVFPLLKRCAPLFSGTEHHASLVDSMLHTIYRLSKGRSL TKAQRDTIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYY CLPSGMGSYGIAAEEELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPDYL DTRIRSTLEKQTSVDPEGNFDPKPVSTANLVLPEKLEYIVSKYAEHSHDKWAFDKTNSGW KYGVSLDENMKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAMGWSLERTKEGGETMIH QRENEKLRNMSQSSQGNGYSPAPLDLSNVVLSRELQGMVEVMAENYHNIWAKKKKMELES KGGGSHPLLVPYDTLTAKEKSRDREKAQELFKFLQVNSILISRGLNDMELDASSMEKRFA FKFLKKILKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLY FLSSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHILAQSLD TRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVAL LPILTSIFEHISQYQFGVDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECLAS LAAAIPVAFLEPSLNHYNPLSVFNTKSARERAILGMPDTVEEMCPEIPQLDGLIKEINDL AESGARYTEMPHVIEVILPMLCNYLSYWWERGSESMPESSGPCCTMITSEHLSIILGNIL KIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKTHFIPTLEKLKKKAIKIVMEEEQLR ADNKNDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDADSDELFRMVAE VFILWCKSHNFKREEQNFVIQNEINNLAFLTGDTKSKMSKAMQVKSGGQDQERKKSKRRG DLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYSYRDTDDEVKEHLRNNLHLQ EKSDDPAVKWQLNLYKDILKSDEPTDPEKTVERVQRISAALYHLEQVEQPLRSKKAVWHK LLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQNYWIETEEYSFEEKLVQDLATPPK KEEEEEEETEKKHPDPLHQIILYFSRSALTERSKLEDDPLYIAYSAMMAKSCQDEEEEEE DEEKEKTFEEKEMEKQRTLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLGIAIL NGGNTIVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTL IVRERGEKVLQHDEFTRDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLR LQESISDFYWYYSGKDVIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRL WDAVVGFLHVFANMQMKLSQDSAQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMV DTLVESSSNVEMILKFFDMFLKLKDLTNSDAFKEHDPDSKGIISKKEFQKSMEAQKQYIQ SEIEFLLSCAEADENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQSLLE PAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRMQWEKPQVKESKRQFIFDVVNEG GEQEKMELFVNFCEDTIFEMQLASQISETDLPERPEEEEVAEPYYVMDIGDDEEEKSLES ASAFAIACVAVKKNVANFFKMVTVKNLRKQYRKVRKMTVKEMVKVFFSFFWMLFVGIFQL FFSVVWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVMEAEKAEGAEH GIRAEFVQFVKGEKGESDIISDIFGIHTKKEGGSKHGHDAGLGDIAEILGSDIPSSLENT VRKKKGVQAPEIAKEAETERKTESEKADMEDGEKQDKAKEVQSEHLEEGKMKKKKRRHGQ KIEKPEAVMANFFKALEIYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLD EAEEDSNLWNTFDEEEEEDGMVFFVLEESTGYMAPTLRALAVIHTVISFVCVIGYYCLKV PLVVFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN KYGDLYGAERIAELLGLDKNALDFSPVEESEPEEASLVSWLSSIDTKYHIWKLGVVFTDN SFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDC FRKQYEDQLG NT seq 14613 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaaggaggggaagatgaaatacagttcctacgaactgatgacgaa gtagtacttcagtgtgttgccagtattcacaaagaacaacgaaagttctgcttggcagct gagggacttgggaatcgcttgtgctttttggaaccaacatcagaagctaaatatgttcct ccagacctttgcatctgtaattttgtacttgaacagtccctctctgtcagagccctgcaa gaaatgctggccaacacaggggataatgctagtgaaggggcagctcaaggtggtggtcac agaaccctactgtatggccatgctatactacttcgacattcgtttagtgaaatgtatttg acatgtctaacaacatcaagatcccagacggataaacttgcatttgatgtggggctacga gaaaatgcagcaggtgaggcatgctggtggacaatacatcctgcttctaaacagaggtca gaaggagaaaaagttcgaattggtgatgatcttatcctagtcagtgtgtcttccgaaagg tatctgcatctctccatgtccaatggaagtattcaggtggatgcctcctttatgcagaca ctatggaatgtacatcctacatgctcaggaagtaacattacagaaggatatcttcttggt gggcatgtagtacgttttttccatggccatgatgagtgtttgaccattccatctacagat cagaatgattcacagcaaaagaaagtgctttatgaaacaggaggagctggtgttcgagca aggtctttgtggagagtagaaccccttcgaataagctggagtggaagtaacatcagatgg ggacagccttttcgtcttcgacacattacaacaggagagtacttagctctgaatgaagac gaaggacttgtaatgttagacagagaaaagtcggacacaacctctactgccttttgtttt agagcatcaaaggagttaaaggagaaacaggattctgctcttaaacgtgacatagatgga atgggggtcccagaaataaagtatggtgattcaatctgcttcatccagcatgtggccagt gccttgtggttgacttacaaagcacaagatgctaaatcagcacgtttaggtctcttgaaa agaaaggttatactacaccaagaaggccatatggatgatggtctaaccttacaaagatgt cagcatgaagaatcccaggctgctcgaatcattcgcaatactacaagcttattcagcaaa tttataagtggaaacaatagaacactatcacccattgccctgcctgttgaggagatggtt cagactctgcaagacctgattacttacttcctgcctcccaaagaagaactggagcatgaa gataagcaaagcaaacttcgttcactcaagaacagacaaaatctattcaaagaagaggga atgctggctctagttttgaattgcattgatcgcttaaatgactacaatagcgcagctcat tttgcaggaattgcaatagaagaaaatggtacagcatggaaagaaattctgaatctcctt tacaaattgttagctgctctcattcgtggcaacagaaacaattgtactcagttctccagt aaccttgattggttaataagtaaattggacagattagaatcttcctcaggtattttggaa gtgttgcactgcatcttgattgaaagcccagaagctttaaatgtaatagctgaggaacat atcaaatctattatctcattgttggataaacacgggcgcaattacaaggttcttgatgtg ctttgctctctctgtctctgtaatgaagttgcagttcgtgccaatcagaatttgatctgt gacaatctactgcctagaagagacttactcctgcaaacacgtttgattaatgatgtgaca agcataaggccaaacatttttttgggtgttgctgagggctctgcacaatataagaagtgg tactttgaattaataattgatcaggttgatccattcttgacggcagaacccacccattta cgggttggatgggcctctacatcaggttatgccccttatcctggtggtggagaaggatgg ggaggcaatggtgttggtgatgacctatactcctatggttttgatggccttcatctgtgg tctggtcgagtgcccagagctgtagcatctgtcaatcagcatttgttggcatctgatgat gtggttagctgctgcttggatttaggtgtgcccagcatttcattccgcattaatggacag cctgtacaaggaatgtttgagaacttcagtacagaagggtttttctttcctgttgtaagc ttatcagcaggtgtaaaagttcgtttcctcctgggtggacgtcatggagagtttaaattt ctgcctcctgctggctatgctccctgttatgaagctttacttccaaaagagatgatgaaa ctggaaccagtgaaagaatataagagagattctgatggagtgagggatttgctgggtaca acacagttcttgtcccaagcttcctttatcccttgtccgatcgacaccagtcagattgct ctcccttttcatctcgaaaagatcagggacaaactagctgaaaatatccatgaactgtgg ggaatgaataaaatagaactgggctggacatatggcaagatacgggatgataataaaagg catcatccttgtcttgtggaattctcaaaattacctgaaacagagaagaactataatcta caaatgtcaacagaaaccctaaaaacccttttggcccttggatgtcacattgttcatact aatccagcagctgaggaagatcttaaaaaagttaaacttcctaaaaattacgtgatgtca aacggatataaacctgcccctcttgatctttctgaagtgaaattgttaccttctcaagaa tttctagttgataaactagcagaaaatgcacataatgtctgggcaaaagacagaataaaa caaggatggacctatggcattcagcaggatcttaagaacaaacgtaatcctcgcttagtg ccatatgcattgttagatgaacgtactaaaaaatcaaacagagatagcctccgtgaagct gttaggacatttgcaggctacggctatagtattgagccaccagaccaagaaatagctgac caaacagtggaaaaagtcagcattgacaagattcgttttttcagagtagagaagtcttat gcagtgaagtctggaaagtggtattttgaatttgaagctgtgacaggtggagatatgcgt gttggctgggccaggccaggatgtcggcctgatatagaattgggagcggatgaccaagcg tttgtttttgaaggaagcaaagggcaacgctggcatcaaggcagtggattctttggacga tgttggcaaccaggagatgtggttggttgcatgataaacttggatgacaagtcaattatc tttactctgaatggagagttgcttataacgagtaaaggttcagaacttgcatttgctgac tttggaatagaaagtggttttgttccaatttgtgcactgggtctgtctcagattggccgc atgaaccttggaatggatgccagtacgttcaagtattacacaatgtgcggccttcaagaa ggttttgaaccttttgctgtcaacatgaacagagatgttgctatgtggtttagtaaacgc ttaccgacatttgtcaatgtgccaaaaaatcatcctcacattgagatatggagaattgat ggaactattgagagtccacctcgattaaaagttactcacaaaacatttggcaaacagaac agcaattcagatatgatattttgccgtttgagtatgcccatcgagttccgttcatcattc aactttggcatgggtgtggaaaatgcctcatctgatgctttccaaaaacgaaaacagagc caagaaattgcttttccttctaccacatgtttttattcactgcggatatttgctggccaa gacccgtcctctgtctgggttggctgggtaacaccagactatcatttttacagtgagaat tttgacctaaataaaaattgtacagtgacagttactttaggtgatgagagaggcagggtt catgaaagtgtgaagcgcagtaattgctatatggtttgggggggagacataattgctaac tcccagagatcaggtcgcagtaatgttgatttagaaatcggatgctttgttgatctggct actggaatgttgtcgttcacagccaatggaaaagagcttggcacttgttaccaggttgaa ccaaacacaaagctttttccagcaacttttgtacagccaacaagcacaaacttggttcag tttgaacttggtaaattaaagaatactatgcctttatcagcagcaatttttaaaagtgaa gagagaaatcctgttcctcaatgtccccctcgccttgatgtgcaaacgattacccctgtt ttatggagcagaatgccaaacagctttctgaaagtagaaactgagcgtgtcagtgaacgt catggctgggttgtgcagtgtttggaacctctgcaaatgatggcacttcacatcccagag gaaaacagatgcgttgatattttggaactatgtgaacaagaagatttgatgaagtttcac taccacactttaaaactgtatagctcagtgtgtgctctaggtaacactagagttgcttac gctctttgtagccatgtggacttatctcagttattttacacaatagataatcagtattta cctggactcctacgttctggattctatgatttgctcattagtattcatctggaacatgcc aagcaagccaagctcatgatgaacaatgaatttatcattcccgttacagaggaaactcga actattaaattatatcctgatgaaacaaagaagcatggtttacctggagtagggcttagc acttgtctgaaaccaagctttaatttttctactccttgctttattgtgaccagtgaagaa catcagacatcaagcccagagataccacttgatacactcaaatccaaggccataagcatg ctaacagaggcagtacaatgtagtggtgctcatatacgagaccctgttggaggacaggtt gcattccagtttgttcctgttcttaaactgatagcaaccttgctcataatgggggttttt gatgatgatgacgtgaagcaggtgttactcctcattgatcctaatgtatttggagatcac aaggaagatttagaagagaggacagagaaggaagaagttacacaagttgaagaaaaagct gtagaagctggagagaaagcaataaaagaaacaaaagctcctgtaaagggcttattgcag acaagattaccagaatctgttaaacttcagatgtgccatttactcagttatttctgtgac tgtgagctacaacacagggtggaggcaattgtatcatttgcagaccgttatgtatcaaag ctgcaatataatcagaaatacaggtacaatgaactcatgcaagccttgaacatgtctgct gcattgactgccaagaagactaaagaatttcgttctcctcctcaagaacagattaatatg ttgctgaattttcgattgggagaggattgcccttgtccagaagagattcgggatgagctg tatgactttcatgatgatcttctaattcactgtggtattccactagaagaggaggaagag gaagaggaagatgcctcattgactggtagactccgttcattaatgtacaaaatcaagggt ccaccaaaagcagaaaaagtagaacctagggaggaggaagaacaatctcctactacgctg aaggaactcatatcccagactatggtgcgctggtcccaggaagaccagattcaagatcca gaattagttcggattatgtacaccctccttcgtaggcaatatgacagcattggcgagcta ctgcaagctctgaggaaggcatacactattagtgctgtctctgtggaggataccattaat ctgcttgcagcactgggacagattcgctcgcttctcagtgtcagaatgggaaaagaggag gaattgctaatgattaacggattaggggatataatgaacaacaaggtgttttatcagcat cctaacttaatgagagtcttgggcatgcatgagacagttatggatgtgatggtaaatgtg cttggaggagataaatctcagattgcttttcctaagatggtggcaagctgttgtcgattc ctgtgctacttctgtcgaattagtcgtcaaaaccaaaaagccatgtttgagcatcttagt tacttactggaaaacagcagcgttgggctggcatttccttcaatgagaggttcgacacca ctagatgttgcagcagcctctgtaatggacaacaatgagcttgcactagcattggaggag ccagacctcgagaaggttgttacctacctggcaggttgtggcctgcagagttgtccagta ttgctagcgaaaggatatccagacattggatggaatcctatagagggtgaacgttacctg tcattcttaagatttgcagtttttgttaacagtgaaagtgtcgaggaaaatgcaagtgtt gttgtcaagctccttattcgacgcccagaatgctttggaccagaccttaggggtgaaggt ggaaatggtttgctggcagctatgcaagaagctatcaggatctcggagaatcctgctcgt gaccttccctctcagggttataaaagagaaggtgatgatgaagaggaggaggaggaaatc gtgcacatgggcaatgcgatcatgtcattttactcagctctcatagatttgcttggacgc tgtgcaccagaaatgcatcttattcaaagtggaaaaggtgaagctattcgaatcagatca atccttcgatctctagtgccaactgaagacttggttgggattataagtataccactaaag ctgtcaacagtcaacaaagacggcacagtgaatgagccagacatgtctgcaaatttctgt cctgatcataaagcacccatggtgctcttcttggaccgtgtctatggtattaaggaccaa agctttctccttcacttactggaagttggatttttaccagatttaagagcctctgcctct ctggatacagtttctctaagcactacagaggcagctcttgcactaaatagatatatttgc tcggctgtgtttccattactcaaaagatgtgctcccctcttttctggaacggagcatcac gcctctctggttgactccatgcttcacacaatatataggttatccaagggacggtccctt acaaaagcacaaagagacactattgaagagtgcctgcttgctatttgccaccacttacgc ccctctatgctacaacagctgttgagaaggctagtttttgatgtacccctgctcaatgaa tactgtaaaatgcctctcaagcttctgacaaatcactatgagcagtgctggaaatattat tgcctgccttcaggaatgggaagttacggaattgcagcagaagaagaattacatttaact gaaaaacttttctggggaatatttgattccttgtctcataagaagtatgatccagagctc tttcgaatggccttgccttgtctaagtgctatagctggtgccttgcctcctgattattta gatacacgaattagatcaactttggaaaagcagacttcagtggatccagaaggaaatttt gatcccaaacctgtcagcacagcaaaccttgtacttcccgaaaagttggagtatattgta agcaagtatgccgaacattcccatgataaatgggcctttgataagactaatagcggatgg aaatatggtgtttcattggatgaaaatatgaagactcatccattaataagacctttcaaa actttaactgaaaaggaaaaggaaatttaccgttggccggccagagaatctctgaaaacc atgttggcaatgggatggagcttagaaaggaccaaggagggaggagaaacaatgatacat cagcgtgaaaatgaaaagcttcgtaacatgtctcagtctagccaaggaaacggatatagc ccggcaccacttgatctttctaatgttgtactttctagggagcttcagggaatggttgag gtaatggcagaaaactaccataatatatgggccaaaaagaagaaaatggagttggaaagc aaaggtggaggtagtcatcctttattggtaccttacgacacattgacagccaaggagaaa tcacgggaccgtgaaaaggcacaagagctgtttaaattccttcaagtgaatagtatcctc atatctcggggtctgaatgacatggagttggatgcttcatccatggaaaagagatttgca tttaagtttctgaagaaaattttaaaatacgttgactctgctcaagagtttattgcgcat ttggaagccattgtaaccagtggaaaaactgaaaaatctccacatgaccaagaaattaaa ttctttgccaaagttcttttaccattagttgatcagtactttacaaatcactgcctgtac ttcctgtcttctccaacaaaaacactcagtagcagtggatatgcatcaaataaggaaaaa gaaatggtagccagcttgttctgcaagctagctgctcttgttagacataggatttcactt ttcggtagtgattctgctacaatggtgagctgcttgcacatcttagctcagtctcttgac acacgaactgttatgaaatcgggatctgagctagttaaagctggattgcgtgcctttttt gaaaatgcagctgaagatctggaaaaaacatcagaaaatcttaaacttggaaaatttacc cattcacgaacacagatcaagggtgtttcacagaatattaattacactacagtagcgttg ttacctatcttgacatcaatttttgaacatatttcacagtatcagtttggagttgattta cttttgggtgatgtacaagtttcatgttacagaattctatgtagcctctattcccttggg actgggaagaacatctatgttgaaaggcagcgcccagcacttggtgagtgcttagcatct cttgcagcagccattccagtagcattccttgaaccttctctcaaccattacaatcctctg tctgtcttcaacacaaaaagtgcaagagaaagagccattttaggtatgcctgatacagta gaagagatgtgtccagagatccctcagttggatggactaataaaggaaattaatgattta gcagagtccggtgccaggtatactgaaatgcctcatgtaattgaggttatcttacccatg ctatgcaactatttgtcgtactggtgggaaagagggtctgaaagtatgcccgaaagttct gggccctgctgtactatgataacatctgagcatctgagcatcattctgggaaacattttg aaaatcatcaacaacaatctgggaatagatgaagcatcttggatgaagagaattgcagtt tatgctcaacccatcatcagcaaagccaggccagatctgctgaaaactcactttattcca acattggagaaattgaagaagaaagctataaagatcgtgatggaagaggagcagctraga gcagacaataaaaatgatacccaagaagctgagctactcattcttgatgagtttgctgtt ctttgtcgagacctctacgccttctatccaatgttgattcgttatgtagacaacaacaga gccaattggctaaagaaaccagatgctgattctgatgaactctttcgaatggtagctgaa gttttcatcctgtggtgtaaatcacataatttcaaaagagaagaacaaaattttgtgatt cagaatgaaatcaacaatttggcatttttaacaggagacaccaagagcaagatgtctaaa gccatgcaagtaaagtctggaggacaagatcaagaaagaaagaaatcaaaacgtagaggg gatttgtactcaatacaaacttccttgattgtagctgcacttaaaaagatgcttcctatt ggcttgaatatgtgtactcctggagatcaagagctcatctctttggctaagactagatac agctatagggacactgatgacgaagtcaaagaacatttacgtaacaacttacatttacag gaaaagtctgatgatccagctgtgaaatggcagttaaatctgtacaaagacattttgaag agtgatgaacctactgaccctgagaaaactgtggaacgtgtgcagaggatatcagctgct ctgtatcatctggagcaggttgaacagccgctcagatcaaagaaagctgtttggcacaaa ctcctgtcaaaacaacgcaaaagggctgtagttgcatgtttcagaatggcaccattatac aacctgccaaggcaccgttctattaacctcttcctccatggctatcagaactattggata gaaacagaggaatattcatttgaggagaaactagttcaggatttggctacacctccaaaa aaagaggaagaggaagaggaagagactgagaaaaaacatcctgatccacttcatcagatt atcctctattttagtcgcagtgctctcacagagaggagcaaactagaagatgatccttta tatattgcctattctgccatgatggcaaagagctgtcaggatgaagaggaggaagaggag gatgaagaaaaagagaagacatttgaggagaaagaaatggaaaaacagagaactctctat cagcaagctcgcttgcatgatcgtggagctgctgagatggtccttcagatgattagtgca agcaaaggccatacaggacccatggttgttgaaacattaaaacttggtattgctatttta aatggtgggaataccatagttcaacagaaaatgctggactacctgaaggagaaaaaggat gctggattttttcaaagtctctctggcttgatgcagtcttgcagtgttcttgacttgaat gcgtttgagagacaaaataaagcagaaggcctgggaatggttactgaagaaggaactctc atcgttcgtgagcgtggtgaaaaagtgctgcagcatgatgaatttactcgagatctattt agatttctacagctgctctgtgaagggcataacaatgattttcaaaattacctacgtact cagatgggcaacaccacaacagtcaatattatcatcagtacagttgattatctcttgcgt cttcaggaatcaatcagtgacttctactggtactattcaggaaaagatgtcattgatgaa tcaggacaacgtaacttctctaaagctttggctgtcaccaaacaaatattcaattcactt acagaatatatccagggcccttgcataggtaaccaacagagtctggctcatagtaggctg tgggatgcagttgttggcttccttcatgtctttgccaatatgcagatgaaactttcacag gactctgctcagattgaattgcttaaagaactactggatctcctaaaggatatggtagta atgctgctgtctctgcttgaaggtaacgttgtaaatggaactattggaaaacaaatggta gacacgctggtagaatcatctagcaatgtagaaatgattttgaagttctttgacatgttt ctcaagttaaaagatctaactaactcagatgctttcaaagagcatgacccagacagtaaa ggcatcatctcaaagaaagaattccagaaatcaatggaagctcagaaacaatacatacag tcagagattgaattcctgctatcctgtgcagaagctgatgaaaatgatatgtttaactat gttgattttgtggaacgatttcatgaaccagccaaagacattggatttaatgtagcagta ttgttaacaaatctttcagagcatatgcctaatgattcacgccttcagagcttactagaa cctgcggaaagtgttcttaattactttgaaccttaccttggccgtattgagataatgggt ggagccaagaagatagagagagtttactttgaaatcagtgaatccagcagaatgcagtgg gagaagccacaggtgaaggaatccaaaaggcagttcatatttgacgttgtgaatgaaggt ggagagcaagaaaaaatggagctctttgtgaatttctgtgaagacacaatctttgaaatg cagttagcatcccagatctctgagactgatttacctgaaaggcctgaggaggaggaagtg gcagagccttattatgtaatggatattggagatgatgaggaagaaaagtccctggaatcg gcctcagcttttgcaatagcctgtgttgcagtgaagaagaatgttgctaacttttttaaa atggtcactgtgaagaacctaaggaaacaatacaggaaagttagaaagatgacagtaaaa gagatggtgaaagtgtttttctcctttttctggatgctatttgtagggatattccaactg ttcttttctgtagtatggggaattttccagattctttggagcactgtatttgggggtggc ctggttgaaggagccaagaacatcaaagttactaaaatattgggggacatgcctgaccca acacagtttggaatccatgatgatgttatggaagcagaaaaagctgaaggtgctgagcat ggcattagagctgaatttgtgcaatttgtaaagggtgaaaagggagaaagtgacatcatc tcagatatttttggcattcatacaaagaaagaaggtggctctaaacatggtcatgatgct ggacttggagatattgcagaaatacttggttctgatattccttcttctctggaaaacaca gttcgtaagaaaaaaggagtacaggcacctgaaatagcaaaagaagctgaaacagaaaga aaaacagaatctgagaaggctgacatggaagatggtgaaaagcaagataaagcaaaggaa gtacaatctgagcatctggaagagggaaaaatgaagaaaaagaagcgaaggcatggacaa aaaattgagaaacctgaggctgttatggctaacttctttaaagctttggaaatctatcaa acaaaaatgctgcattacttggcaagaaatttttataacctacggtttcttgctctgttt gttgcatttgccatcaactttatcctgctattttacaaggtaacagaagagccacttgat gaagcagaggaagactctaatctctggaacacttttgatgaagaggaagaggaggacggc atggtgttttttgttttagaagaaagtacgggttacatggcacctactctcagagcattg gcagttattcatactgttatctcctttgtctgtgtgattggatactattgcttaaaggtt cctctggttgtattcaagagagaaaaggaagtagctagaaagctggaatttgatggtctg tacataactgaacagccatctgaggatgatattaaaggacaatgggaccgcctggttata aacactccgtcctttcctaacaattactgggacaaatttgtaaaacggaaggttattaac aagtacggggatttatatggagcagagcgcatagcagaacttttgggtttggacaaaaac gcccttgattttagtccagtagaagagagcgaaccagaagaggcatctcttgtatcatgg ttaagctccattgatacaaagtaccacatttggaagcttggtgttgtttttaccgataat tcatttttatacttagcttggtacacaactatgtctatccttgggcactacaacaatttc ttctttgctgctcatctgctggatattgctatgggtttcaagacattgagaaccattctg tcttcagtaactcacaatggcaaacagcttgtgcttactgtaggactcctggctgtagta gtgtatctttacactgttgtggcgttcaacttcttccgcaaattctacaacaaaagtgaa gatgaagatgaaccagacatgaaatgcgatgacatgatgacgtgttatctgttccacatg tatgtgggtgtaagagctggtggtggcattggagatgaaatcgaggatcctgctggagac ccttacgaaatgtatcgaattgtctttgacatcacatttttcttctttgtcattgttatc ctactggccattattcaaggtctgattattgatgcttttggtgaattaagagaccagcaa gaacaagtgagagaggatatggagaccaaatgttttatttgtggaatcggcaatgactat tttgacacaaccccacatggctttgaaacacatactttgcaagagcacaacttggcaaac tacctgttctttttaatgtatctcattaacaaggatgaaactgagcatactggccaggag tcattcgtgtggaagatgtaccaagaaagatgctgggatttcttcccagcaggagactgc tttcggaaacagtatgaggatcagcttggctaa

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