Acipenser ruthenus (sterlet): 117403391 Help Entry 117403391         CDS       T07327                                  Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism arut  Acipenser ruthenus (sterlet) Pathway arut04020   Calcium signaling pathway arut04260   Cardiac muscle contraction arut04261   Adrenergic signaling in cardiomyocytes arut04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:arut00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117403391    04020 Calcium signaling pathway     117403391  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     117403391    04261 Adrenergic signaling in cardiomyocytes     117403391  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:arut04040]     117403391    04990 Domain-containing proteins not elsewhere classified [BR:arut04990]     117403391 Ion channels [BR:arut04040]  Voltage-gated cation channels   Ryanodine receptor    117403391 Domain-containing proteins not elsewhere classified [BR:arut04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    117403391 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  117403391 NCBI-ProteinID:  XP_033861396 LinkDB All DBs Position 5:66730646..67011051 Genome browser AA seq 4893 aa AA seqDB search MMKTAHGGGHRTLLYGHAVLLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEPCWW TIHPASKQRSEGEKVRAGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSG SEVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRSVHYEGGAVSIHARSLWRLETL RVAWSGSHIRWGQAFRLRHVTTGKYLSFMDDKSLLLMDKEKADVKSTAFCYRSSKEKLDL AIKKEMDGMGVPEIKYGDSVCYIQHVDTCLWLTYQSVDAKSVRMGAVQRKAIMHHEGHMD DGLTLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKGKSSSIDLPIESVNLSLQDLI GYFQPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGK EAGEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLQRLEASSGILEVLHCVLV ESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGR DLLLQTRLVNHVSSMRPNIFLGISEGSAQYRKWYYELIVDHVETFVTAEATHLRIGWAST DGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGCIARTVNSPNQHLLRVDDVVSCCLD LSAPSISFRINGQPVQGMFENFNSDGLFFPVASFSAGVKVRFLLGGRHGEFKFLPPPGYA PCFEALLPREKMRVEPSRVYKQDHNGTRDLLGPTVTLTLAAFTPTPVDTSQIVLPPQLDR IREKLAENIHELWVMNKIELGWTYGSVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETL KTLLALGCHVGIADEHAEEKVKNLKLPTNYELSGGYKPAPMDLSHLKLTSTQEAMVDKLA ENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDERTKKSNKDSLREAVRTVLGY GYNLEAPDQDHAARSDIGCISAERFRIFRAEKTYAVNSGKWYFEFEAVTAGEMRVGWARP GCLPDQELGSDDQAFVFDGFKAQRWNQGNEHFGRSWQAGDVVGCMVDLNEHTMMFTLNGE VLLDDSGSELAFKDFEVLEGFIPVSSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFA VNMNRDITMWLSKRLPQFIPVPSDHEHIEVTRIDGTTDNSPCLKVTQRSFGSQNSHTDIF FYRLSMPVECAESFTRTAGGNLSSSFFSPKKNLEDFDADSDFEVLMKTAHGHLGSNGPEK EKESLKDEFNNHKDYTQEKPSRLKQRFMLKRTKPDYSTNHSSARLSEDVLADDRDDYEYL MQTSTYYYSVRIFPGQEPTNVWVGWVTSDFHQYDQSFELEKIQTVTVTLGDEKGKVHECI KRSNCYMVWAGESTSPGQGRNNNGLEIGCLVDTSAGLLTFTANGKEMSPYYQVEPSTKLF PAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSERKNPTPQCPPRLHVQFLTPVLWSRVP NHFLKVETSRVSERHGWLVQCSEALQFMCLHIPEENRSLDILELTEQEDLLKFHYHTLRL HSAVCALGNNRVAHALCSHLDEAQLLYAIENKYMPGLLRTGYYDLLIDIHLSTYATARLM MNNEYIVPMTEETKSITLFPDEKKKHGLPGIGLSTSLRPRMHFFSPSFVSVSGDYFQYSP EFPLEILKTKTIEMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGVFHNGDLK NILQLIEPSVFSEETSQEEAEDPESDGIKGVLRIEGPGGEEELKSEKVPKEGLLQMKLPE PVKLQMCHLLQYLCDCQVRHRIEAVVAFSDDFVASLQDNQRFRYNEVMQALNMSAALTAR KTKEFRSPPQEQINMLLNFKDEKQDCPCPEDIRELLLDFHEDLMAHCGIELDDDRANEGD CDFTIRGRLLYLVEKVAYLKNKMSDLPKKKKVKKPSTLQQLISETMVRWAQESVIEDPEL VRAMFVLLHRQYDGVGGQVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEK LMIHGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFL CYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREP DLEKVVQYLAGCGLQSCSMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVV VRLLIRRPECFGPALRGEGGNGLLAAMEEAIKISEDPARDGPSPTSGSSRTLDILDEEDD TIHTGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLEGVISVPF PMPTLAKDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAA SLDTAALSATDMALALNRYLCTAVLPLLTKCAPLLAGTEPFASLIDSLLHTVYRLSKGCC LTKAQRDAIEACLLAICGQLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKY YCLSGGWGNFGAASEEELHLSRKLFWGIFDALSQKETAFSTKQYMRMPFRTRYEQELFKL ALPCLSAVAGALPPDYMESNYVAMMEKQSSMDAEGNFNPQPADTLNVNVPEKLDYFINKY AEHSHEKWSMDKFANGWVYGEPLCEATKVHPLLKPYKLLVEKEKEVYRWPIKESLKTMLA WGWSIERTREGDAMGLHNRARRISQSSQISIDTAHGYSPRPIDMSNVTLSRDLHSMAELL AENYHNIWAKKKKLELEAKGSSMLLTDEGGGSHPLLVPYDTLTAKEKSKDREKAQEILKF FQINGYAVSRGLKEIELDTPSIEKRFAYSFLQQLIRYVDEAHQHMQEFDICTPGKGEKIP HEQEIKFFGKVVLPLVDQYFKNHRLYFLSTASRPLSSGGHASNKEKEMVTSLFCKLGVLV RHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLETVKAALRAFFENSAEDLEQTMENL KLGQFTHTRTQPKGVTQIINYTTGALLPVLSSLFEHIGQNQFGEDLILDDVQVSCYRILG SLYALGTSKNIYVERQRPALGECLAAFAVAFPVSFMEPHLNKHNTYSIYNTKGSRERAAL NLLTRVEEVCPNIPSLEKSLEEIMELAESGIRYTQMPHMMEVVLPMLCSYMSHWWEHGPE NNPEKMDMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIIGKAKPQLL KTHFLPLMEKLKKKAATVLLDEEHMKAEGRGDMSEAELLILDEFTILTRDLYAFYPLLIR FVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDT KSKMSKGAVSDQERKKLKRKGDRYSLQTSLIVAALKRLLPVGLNICAPGDQELIALAKNR FSLKDTEDEVRDVIRNNLHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKTVERVLDIA HVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKS WIETEEHYFEDKLIEDLAKPGGEEPPEEDEGTKPIDPLNQLILLFSRTALTEKCKLEEDF LYMAYADIMAKSCHDEEDEDGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQMISAS KGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNA FERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQ TGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLT EYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVM LLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDAKG VISKRDFHKAMENHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVL LTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWE KPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDTGERSSTKEEN EKDKHEGENPEMGFFSIITMRTALFALRYNVMMLMKLLSMKSLKKQMKKMKKMTVKDMIM TLISFYWSTLLGLFHFTFSVSRGFFRIMYSTFLGGSLVEGAKKIKVADLLANMPDPTQDE VRGEGEEIEKKHPDTALPSEDLADLAVASDDGDLLSDIFGLDLRREGGQYILMPHNPNAS LSELITSPSPLLPAPSPLLRRQHQGEGVKEEEREEKEDNKSEPEKAEGEDGEKQEKPKEE KPKQKIRQHHALKSDESEIQESAFWKKILAYQRKLLNYFARNFYNMRMLALFVAFAINFI LLFYKVSTSSAVIEEKEVVYTTTEEGVPRWNAMDREPHKMVTVHFVLEESSGYMEPTLRI LAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLV INTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDSQEKKKPKKDSSL SAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLR TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKNEDGDTPDMKCDDMLTCYM FHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELR DQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKDETEHT GQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14682 nt NT seq  +upstreamnt  +downstreamnt atgatgaagaccgcacatgggggaggccaccgcactcttctctatgggcacgcggtcctg ctcaggcactcgtacagtggaatgtatctctgttgtttgtctacttcgcgctcttcaact gacaaactggcatttgatgtgggcttgcaggaagatacgacaggagagccctgctggtgg actatacaccctgcctccaaacagaggtccgaaggtgaaaaggttcgagctggagatgac ctcatcttagtcagtgtttcttcagaaaggtatctgcatttatcatatgggaacggcagc ctgcatgttgatgcggccttccagcaaaccctctggagcgtggcgccaatttgctctggg agtgaagtcgcacaaggttacctcattggaggtgacgtgctgaggttattgcacggtcac atggacgagtgtctgactgtaccttcaggagaacatggggaagagcaacgaaggtcggtc cattatgaaggcggagctgtgtctattcacgctcggtctctctggaggttggagactctg cgagttgcgtggagtggaagccatatcagatggggacaggcgttccggctgaggcacgtc accacagggaaatatttgagcttcatggatgacaaaagccttcttctcatggacaaagaa aaagcagatgtgaaatccacagcattctgctatcggtcttccaaggaaaaattggatttg gcgataaagaaggaaatggatgggatgggagtaccagagataaagtatggcgattcagtg tgctacatccaacatgtggacacctgcctatggctcacctaccagtcagtggatgctaaa tctgtacggatgggagctgtgcagcgcaaggctataatgcatcatgaaggtcacatggat gacgggttaacactgtccagatcccaacacgaggagtcccggacagcccgggtcattcgt agcactgtcttccttttcaacagattcatcaggggtcttgatgccctgagcaagaaagga aaatcatccagcatagatttgccaattgaatcagtcaacctgagtctgcaggacttaatt ggctatttccaaccacccgatgagcatctagaacatgaagacaaacagaacaggctacga gcgctaaagaaccgacagaatctcttccaggaagagggtatgattaacctggttcttgaa tgcatcgaccgcctacatgtgtacagcagtgctgctcattttgctgatgtagctggaaaa gaagcaggagaggcctggaagtctatactaaactcattatatgagttactggctgccctg ataagaggaaatcgcaaaaactgtgcccaattctcaggctctcttgactggttaatcagc cggctgcagagattagaagcatcctctgggattctggaagttttacactgtgtacttgtg gaaagtcctgaagctctcaatattatcaaagaaggccatataaaatctataatttctctt cttgataaacatgggagaaatcacaaggttttggatgtattatgttccctgtgtgtatgc catggtgtagctgtgcgttccaaccagcatctcatctgtgacaacttactgccaggaagg gatctgttgttgcagacacgtcttgtcaaccatgtcagcagcatgcggccgaatatcttc ctgggaatcagtgaaggctctgcccagtacaggaagtggtactacgaactaatagtggat cacgtggaaaccttcgtaacagcagaggccactcacctgcgaattggctgggcctccaca gatgggtattctccatatccagggggcggggaaggctggggcggcaacggcgttggagac gatctttactcctatgggtttgacggtctgcacctatggtcaggctgcattgcccggaca gtaaactcacccaatcagcaccttctaagagtcgatgatgtggtcagctgctgcctggac ctgagcgctccgagtatctcgttccggatcaacgggcagcctgttcaaggcatgttcgag aatttcaactcagacggcctctttttccctgttgccagcttctctgctggagtaaaagta cgcttcctgctgggaggtcgccacggggaattcaagttcctgcctcctcctggttacgct ccctgcttcgaagccctgctgcccagagagaagatgagagtggaacccagcagggtatac aaacaagaccacaacggcacccgggacctgctggggccgaccgtcaccctcacactagct gccttcacacccacgcctgtggacacaagtcagattgttttgccacctcaattggatcga attcgtgaaaaactggcagagaacatccatgaactctgggtaatgaacaagattgagctt ggttggacctatggatcagtcagagatgacaacaaaagacaacacccatgtctggtggag ttctgcaagctgccggagcaagagcggaattacaacttacagatgtctctcgagacgctc aagacgcttcttgctttaggctgccatgtaggaattgctgatgagcatgcagaggaaaaa gtgaagaacctcaagctccccactaactacgagctatcaggagggtacaagccagccccc atggacctgagccacctaaagctgacttcaacccaggaagccatggtggataagctggct gagaatgcccacaatgtctgggctcgggaccgcattcgacaaggctggacttatggtatc cagcaggatgtgaagaacagaagaaaccctcgtcttgtcccctacgcgcttctggatgaa cggactaagaagtccaacaaagacagtctgagagaggcggtacgcactgtcctggggtac ggctacaatctggaggctcccgaccaagaccatgctgcaagatctgacatcggctgcatt tcagcagagaggttccgcatttttcgtgctgagaagacctacgctgtgaactctggcaaa tggtactttgagtttgaagcagtcactgctggggagatgcgtgtcggctgggcaagaccc ggatgcctgccagatcaagagctgggctcagatgaccaggcctttgtgtttgatggtttc aaggctcagcggtggaaccagggtaatgagcactttggtcgctcctggcaggctggagat gttgtcggctgtatggtagacttgaacgaacacaccatgatgtttacattgaacggtgaa gtcctacttgatgactcaggttcagaacttgctttcaaggactttgaagttctggaaggt tttattccagtaagcagtctcggagtttgtcaggtgggcaggatgaatttcgggaaggat gtcagcaccctgaagtacttcacaatctgtggattacaagaaggctacgaaccctttgct gtcaatatgaacagggacattaccatgtggttaagcaaaaggctgcctcagttcatccct gtcccttcagaccacgagcacattgaggtgacgagaatagatgggaccactgacaattca ccatgtttgaaggtcactcagaggtcatttggatctcaaaacagccacactgacattttt ttctaccgtctgagcatgcccgtggagtgtgcagagagcttcactagaacggcagggggc aatctcagcagcagcttcttctcaccaaaaaagaacctcgaagactttgatgcagattct gactttgaggtcctcatgaaaaccgcccacgggcacttgggctccaacgggccagagaaa gaaaaggaaagtttgaaggacgagttcaacaatcataaagattacacacaagagaaacca tctcgactgaaacagaggttcatgttgaaaagaacaaagccagactacagcacaaatcac tcttcagcacgtctctctgaagatgtactggcagatgacagggatgactatgaatatctg atgcagacgtcaacgtactattactctgtgagaatcttcccaggtcaggagcctacgaat gtctgggttggctgggttacctctgattttcaccagtacgaccaatcctttgaactggag aagattcagacagtgactgtcacgctgggggatgaaaaggggaaggtccacgaatgtatc aaacgcagcaactgctacatggtgtgggctggagagagcaccagtccaggacaaggccgc aataataacgggttggaaataggctgcttggtggatacttccgctggcttactgacgttc actgccaatggcaaagaaatgagtccctactatcaggtggagcctagcaccaagctattc cctgcagtgtttgctcaggcaaccagtcccaatgtttttcagtttgaacttggaaggata aagaatgtaatgcctctctcagcgggcctctttaaaagtgagcgtaaaaaccccactccg cagtgcccaccccggttgcatgtgcagttcctgacccctgttctctggagtcgggtacca aaccacttcctcaaggtggagacctccagggtcagcgagcggcatggctggctggtgcag tgctcagaggcgctccagttcatgtgtctgcacattcctgaggaaaacaggtctcttgat atcctggagctcacagaacaagaggacctgctaaaattccactaccacacactgcgcctg cactcggcagtctgcgcactgggaaacaacagggtggcccacgccctgtgcagtcacttg gacgaggctcagcttctgtatgccattgaaaacaagtacatgccgggcttgctcaggaca ggttactatgacttgctcattgacatccacctcagcacttacgctacagcccgcctcatg atgaacaatgaatacatcgtccctatgacggaggaaaccaaaagcatcaccctgttccca gacgagaaaaaaaaacatgggctcccgggtataggcctcagtacctccctcagacctagg atgcacttcttctcacccagttttgtgagtgttagcggggattacttccaatacagcccc gagttccccctggagatactaaagactaaaaccattgaaatgctgacagaggctgtacag gaaggcagccttcacgtgcgggaccctgtgggaggcagcactgagtttctctttgtgccc ctcattaagctgttttacactttgcttataatgggcgtcttccacaacggggacctgaag aacatcctgcagctcattgagcccagcgtcttctctgaggagacaagccaggaggaggct gaggatccagagtctgatgggatcaaaggagtgctgaggatagaaggcccgggaggagaa gaggaactcaagtctgagaaagtccctaaagaaggtttgctgcagatgaagcttccagag ccagtaaaactccagatgtgccatttgctacaatatctatgtgactgccaggtgcgccat cgcattgaggctgttgtggcattttcagatgactttgtagccagcctccaggataaccag cgtttccgctacaatgaagtgatgcaggctttaaacatgtccgcagcactgactgccaga aaaacaaaagaattccgctctcctcctcaggaacagataaacatgctgctgaatttcaaa gatgaaaagcaggactgcccatgccctgaagatattcgtgagctgctactcgacttccat gaagacctaatggctcactgtggtatcgaacttgatgatgatagagctaatgaaggggac tgtgatttcaccataagaggccgcctcctatacctggtagagaaagtggcctacctgaaa aacaaaatgtctgacttgccaaagaaaaaaaaagtaaagaagccaagtactttgcagcag ttaatatcagagaccatggtacgatgggcccaggagtcagttatagaagacccagagcta gtcagagccatgtttgtgctcttgcacaggcagtacgatggtgtaggaggacaagtgcgg gcgttgcccaagacttacaccatcaactctgtctctgtggaggacacaataaatctactg gcttccctgggacaaatccgctcgttgctcagtgtacgcatggggaaggaggaggagaaa ctaatgatccatggccttggagatattatgaacaataaagtgttctaccaacaccccaac cttatgagagccttggggatgcacgagacagtgatggaggtcatggtaaatgtccttgga ggaggggaatcgaaagaaatcacctttcccaaaatggtggccaactgctgtcgtttcttg tgctatttctgccgcatcagtaggcaaaaccagaaagctatgttcgatcaccttagttat ttgttggaaaatagcagtgttggactagcgtctccttcaatgcgaggctcgactcctctg gatgttgctgctgcttcagtgatggacaataatgaacttgccttagccttaagggagcct gacctagagaaagttgtgcagtacttggcgggatgcggtttgcaaagctgctccatgctg gtttctaaaggatacccagatattggctggaatcctgtggaaggagagcggtacttagat tttctcagattcgctgtgttctgcaatggagagagtgttgaagagaatgccaatgtagtt gtgaggctgttgatccgtcggccggagtgttttggcccagctttgcgtggagaaggtggg aatggtcttctggctgccatggaggaagccattaagatctcagaagatcctgccagagat ggaccctcgccgacctctggatccagcagaacccttgacatattggatgaagaagatgat actatacatacagggaatgccatcatgaccttctatgcagccctaattgacctccttggc cgctgtgctcctgaaatgcatcttatccatgctggaaagggtgaggccataaggataaga gccattctccgatccctgattcctattgaagatcttgagggagtcatcagcgttccgttt ccaatgccaacactagctaaagacggtacagtggtggagcctgacatgtcggccggcttt tgccctgatcataaggcagccatggtcctgttcctggaccgagtgtatggaattgaagat cagaacttcctacttcatcttttggaagtcggctttctccctgacctccgtgcagctgcc tccttagatacggctgccctgagtgctacagacatggcactggcattgaaccggtacctg tgcacagcggtattgcctttgctcactaagtgtgcccccctgcttgccggcactgagccc ttcgcttccctcatcgattccttactgcacactgtttacaggctctccaagggctgctgc ctcaccaaagcccagagagacgccattgaagcgtgcctgctggctatctgtggccagttg agaccatctatgatgcagcatcttctcaggaggttggtttttgatgttcctcttttgaat gaacacacaaaaatgccccttaagttgctgactaaccattacgagcgatgctggaagtat tactgcctgtctggaggatgggggaactttggagcggcctccgaggaagagcttcacctg tccagaaagttgttctggggaatatttgatgccctgtcccagaaggaaacggcattttct actaaacagtatatgaggatgccttttagaacgaggtacgagcaggagctctttaagctg gctctcccctgcttgagtgctgtggctggggccctgcctccagattacatggaatccaac tacgtggccatgatggagaaacagtcctcgatggacgctgagggaaacttcaacccacaa cctgctgataccttaaatgtaaatgttccagaaaaactggattacttcattaacaaatat gcagaacattcacatgaaaagtggtcaatggacaagtttgcgaatggttgggtttatgga gagcccctgtgtgaggctaccaaggtccaccctctactgaaaccatacaaactgcttgtg gagaaggagaaggaggtgtaccgatggcctattaaggagtctttgaaaacaatgcttgcc tgggggtggagcattgagaggacaagagaaggggatgccatgggcttacataaccgggca cgtagaatatcacagtccagtcagatttccatagacactgcacatggctacagtccacgg cctattgacatgagcaatgtaacactgtccagagatctgcattcaatggcagagcttctg gctgagaactaccacaacatctgggcaaaaaagaaaaaactagagctggaagccaaaggc agcagtatgttgttaactgatgaaggaggagggagccaccctttgctggtgccctatgat acattaacagccaaagaaaaatccaaagacagagaaaaagcacaagagatcctcaagttc tttcagataaatggatatgctgtttcaaggggtctgaaagaaattgaattagacacacct tcaattgagaaacgatttgcctacagcttcctccagcagctcatcagatatgtggacgag gcacatcagcatatgcaggagttcgatatttgcacgccgggtaaaggggaaaagattcct catgagcaagaaatcaagttttttgggaaggttgttcttccattagttgatcagtacttc aagaatcaccgtctctacttcctgtccactgcgagtcgaccgcttagcagtggaggccat gcatccaacaaggagaaggagatggtaacaagcctgttctgcaaacttggagttcttgtc agacacaggatatcactgtttggaaatgatgctacatctatagtgaactgtcttcacata ttgggccaaactctggatgccaggacggtaatgaagactggcttggagacggtgaaagca gctttgcgggcgttttttgaaaattcggctgaggacctggagcagacgatggagaatcta aagctcggccagttcacccacaccaggacgcagcccaaaggggtcacccagatcatcaac tacaccactggggcccttctgcctgtcctgtcctcgctgtttgagcacattgggcagaac cagtttggtgaagacctcatattagatgatgttcaggtatcatgctacaggatacttggc agcttgtatgcattgggcactagcaaaaatatttatgtagaaaggcagcggccagcactt ggagaatgtcttgctgcctttgctgttgccttcccagtatcgtttatggagcctcacttg aacaagcataacacctattccatatacaacaccaaagggtcaagagaaagagcagctctg aacttgcttacccgggttgaggaagtatgtccaaacatcccatccctggagaaatccttg gaggagataatggagctggctgagtctgggattcggtacacccagatgccccacatgatg gaggtggtgctaccaatgctgtgcagttacatgtctcattggtgggaacacgggcctgaa aacaacccagagaaaatggacatgtgctgcacagcgctgacatcggaacatatgaacaca ctgctggggaacattctgaagatcatctacaacaacctaggcatcgatgagggagcctgg atgaagcgactggcagtgttttcccagccaatcattggcaaagccaagccgcagctcctg aagacccacttcctgcccttgatggagaagctgaagaaaaaggctgcgacggtgttgttg gatgaggagcacatgaaggcggaggggcgaggggacatgtctgaggcggagctgctcatt cttgatgagttcaccatcctcacccgggatctctacgccttctacccgctcctcatcaga ttcgtagattacaacagagcaaagtggctgaaagaacccaacccagaggcagaagaatta tttcgcatggtggctgaagtgttcatattctgggcaaaatcccacaatttcaaaagggaa gagcagaactttgtggtccagaatgaaatcaacaacatgtcttttttgatcaccgatacc aagtcgaaaatgtcaaagggtgcagtttcagatcaggagagaaagaagctgaaacgaaag ggagaccgctattctctacagacctcactcattgtagctgcactaaagagactgcttcct gtggggttaaatatctgtgcacccggagatcaagaacttattgcattggcaaagaacaga ttcagtttgaaggacacagaggatgaagtaagagatgttattcgtaataatcttcatctt cagggaaagctggaggatcctgctataaggtggcagatggctctgtacaaagacttgcct aacagaacagatgacacgtcggatcctgagaaaacagtggagcgtgtgttagatatagca cacgtgttgtttcatcttgagcaggttgaacaccctcagagaagcaagaaggctgtgtgg cacaagctgctgtccaagcaaaggaaaagggcagttgtggcctgtttcaggatggcacct ttgtataatttgccaaggcatcgggctgtgaatctcttcctacaaggatatgagaagtct tggattgaaacagaggaacattattttgaagacaaactaattgaggatttagctaaacca ggaggagaagaacccccagaagaagacgagggaacaaaaccaattgaccctctaaaccag ctcatcttactgtttagtaggactgcactgacagagaagtgtaaactggaggaagacttc ctgtacatggcctacgctgacatcatggcaaagagctgtcatgatgaagaagacgaggat ggagaagaagtgaaaagctttgaagaaaaagaaatggaaaagcagaagcttctctaccag caggccaggcttcatgaccgaggggcagcagagatggtgttgcagatgattagtgccagc aaaggtgaaatgggtccaatggtagcatctactttgaagcttggaattgccatattaaat ggtggaaattctacggtacaacagaaaatgcttgactatctgaaggacaaaaaggatgtt ggcttctttcaaagccttgctggtctcatgcagtcttgcagcgttcttgacctcaatgct tttgaaagacagaacaaggcagaaggtcttgggatggttacagaggaaggatcagtcatc actcatgagcgtggagaaaaggtgatgcaggatgatgaatttacttgtgacctctttcgc tttcttcagctgctttgtgaaggacacaactcagactttcagaattatctgaggactcag acaggaaacaacaccacagtgaatattattatatctacagttgattacctactgcgagtt caggaatctatcagtgacttctactggtattattctggaaaagatgtgattgatgagcaa ggacagcgcaatttctccaaggcaattaatgtggccaaacaggttttcaatacacttaca gaatatatccagggcccatgcactggaaaccagcagagccttgcacacagcaggctgtgg gatgcagtggttgggtttcttcacgtgtttgcacacatgcaaatgaagttatcccaggac tccagtcaaattgagttactgaaagagttaatggacctccaaaaagacatggtagttatg ttgttgtcaatgttagaagggaatgtggttaatggaaccattggcaaacagatggttgac atgttagtagagtcctccaacaatgtggaaatgattctgaagttctttgacatgttcctc aagttaaaagacttgacgtcatctgatacttttaaagagtatgatcctgatgctaaaggc gtgatctcaaagagggactttcacaaggccatggaaaaccataaacactacacccagtca gaaacagaattccttctctcttgtgcggagacagatgagaacgagctgctggactacgag gagtttgtggaaaggttccacgaaccagccaaagacattggcttcaatgtggctgtcttg ttgaccaatctgtccgagcacatgcctcacgatacccgcctgcagacctttttggaactt gctgagagcgtgctaaattacttccagccttatcttggtcgtattgagatcatgggcagt gccaaacgcatcgagcgggtctactttgaaatcagtgagtccagtcgaacgcagtgggaa aagccacaggtgaaggagtccaagcggcagttcatctttgatgtggtgaatgagggaggg gagaaggaaaaaatggaactctttgtaaacttttgtgaggacaccatatttgaaatgcag ttagctgctcagatctctgagtccgatacgggtgaaaggtcttccaccaaggaggagaat gagaaggacaagcatgaaggtgaaaatccagaaatggggttcttctccatcatcactatg cgcacagctctatttgcattgaggtacaacgtcatgatgctcatgaagttgctttccatg aagagccttaaaaagcagatgaagaagatgaagaagatgactgtgaaagacatgatcatg accctcatctcattctactggagcacattgctgggacttttccatttcacattcagcgtg tcaaggggcttctttcgcatcatgtacagcacttttcttggtggaagtctggtggaagga gccaaaaaaattaaagtggctgacctcttagccaatatgcctgatccaacccaggatgag gtccgtggggagggcgaggaaatcgagaagaagcaccctgacacggcactgccttctgaa gacctagcagacttagcagttgcctctgatgatggtgacctcctttcagacatttttggg ttagatttaagacgggaaggtggacaatatatacttatgcctcataatccgaatgctagt ctgagcgaactaattacctcaccctctcctctgcttccagcaccctcacctttgctgaga agacaacaccagggtgagggggtcaaagaagaagaaagagaagaaaaagaagataataag tctgaaccagaaaaggcagaaggggaagatggcgagaagcaggaaaagccaaaggaagag aagcccaaacagaaaatcaggcagcaccatgccctgaaatcagatgagtcagaaatacaa gaatctgccttttggaagaaaattctagcatatcaacgaaagctgcttaattactttgca cgtaacttctataacatgaggatgctggctctgtttgttgcctttgcaatcaacttcatt ctgcttttctacaaggtgtccacctcctcagcagtaattgaagagaaggaggttgtttac accaccactgaggaaggagtcccaaggtggaatgccatggaccgtgagccccacaaaatg gtcacggttcattttgtgctggaggagagcagtggctacatggagcccacactgagaata ctcgctattctacacacagtcatctcctttttctgcataataggatattactgtttaaaa gttcctctggttattttcaaacgagagaaggaggtggcacggaagttggagtttgatgga ctctacatcacagagcaaccatcagaagatgacatcaaagggcagtgggatagacttgta attaatactcagtcttttccaaataattattgggacaaatttgtaaaacgaaaggtcatg gataaatatggagagttttatggccgggacaggatcagtgagttactgggaatggacaaa gctgctcttgacttcagtgattcacaagagaaaaagaagccaaagaaagacagttcatta tcagcagtgctgaactccattgatgtcaaatatcaaatgtggaaattaggagtagtattc acagacaattctttcctgtacctagcctggtacatgaccatgtctgtgcttgggcactac aacaactttttctttgctgcacatttactggatatagctatgggattcaaaacattacgg accattctctcatcagttacacacaacggcaaacagctggtgttaacagtggggttgctg gctgtcgttgtctacttgtacacggtagtagcttttaatttcttccgcaaattctacaac aagaatgaagatggagacacccctgatatgaaatgtgacgatatgctcacctgttacatg tttcacatgtacgtgggcgtccgtgctggcggtggcattggtgatgagatcgaagaccca gcaggagacgagtatgagatctataggatcatttttgacatcaccttcttcttctttgta attgtcattctgctggccatcattcaaggtttaattattgatgcctttggtgaattacga gaccaacaggaacaagtcaaagaagatatggagaccaaatgcttcatctgtgggattggc aatgactactttgacacagtaccccatggctttgaaactcacacactgcaggagcacaac ttggcaaactatctttttttcgtgatgtatctcattaacaaggacgaaacagagcacaca ggccaggaatcatatgtttggaaaatgtaccaggaacgctgctgggaattctttccagct ggagactgctttcgcaaacagtatgaagaccagctgaactga

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