Acipenser ruthenus (sterlet): 117411543 Help Entry 117411543         CDS       T07327                                  Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism arut  Acipenser ruthenus (sterlet) Pathway arut04020   Calcium signaling pathway arut04260   Cardiac muscle contraction arut04261   Adrenergic signaling in cardiomyocytes arut04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:arut00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     117411543    04020 Calcium signaling pathway     117411543  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     117411543    04261 Adrenergic signaling in cardiomyocytes     117411543  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:arut04040]     117411543    04990 Domain-containing proteins not elsewhere classified [BR:arut04990]     117411543 Ion channels [BR:arut04040]  Voltage-gated cation channels   Ryanodine receptor    117411543 Domain-containing proteins not elsewhere classified [BR:arut04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    117411543 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  117411543 NCBI-ProteinID:  XP_034777701 LinkDB All DBs Position 6:complement(6930360..7136103) Genome browser AA seq 4951 aa AA seqDB search MAEGGEGEDEVQFLRTADEVVLQCSATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGKFMMKTAHGGGHRTLLYGHAVLLRHSYSG MYLCCLSTSSSSTDKLAFDVGLQEDTTGEPCWWTIHPASKQRSEGEKVRAGDDLILVSVS SERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGYLIGGDVLRLLHGHMDECLTV PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS LMDDKSLLLMDKEKAGVKSTAFCYRSSKEKLDLGIKKEMDGMGVPEIKYGDSVCYIQHVD TCLWLTYQSVDAKSVRMGAVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFN RFIRGLDALSKKGKSSSIDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRTLKNRQN LFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKN CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGS AQYRKWYYELIVDHVETFVTAEATHLRVGWASTDGYSPYPGGGEGWGGNGVGDDLYSYGF DGLHLWSGCIARTVNSPNQHLLRVDDVVSCCLDLSAPSISFRINGQPVQGMFENFNSDGL FFPVASFSAGVKVRFLLGGRHGEFKFLPPPGYAPCFEALLPREKMRLEPSRVYKQDHNGT RDLLGPTVTLRLAAFTPTPVDTSQIILPPHLERIREKLAENIHELWVMNKIELGWTYGSV RDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKNLKLP SNYELSSGYKPAPMDLGHLKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR RNPRLVPYTLLDERTKKSNKDSLREAVRTVLGYGYNLEAPDQDHAARSDIGGISAERFRI FRAEKTYAVNAGKWYFEFEAVTAGEMRVGWAKPGCLPDRELGSDDQAFVFDGFKAQRWNQ GNEHFGRSWQAGDVVGCMVDLNEHTMMFTLNGEVLLDDSGSELAFKDFEVVEGFIPVCSL GVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDITMWLSKRLPQFIPVPSNHEH IEVTRIDGTIDSSPCLKVTQRSFGSQNSHTEIFFFRLSMPVECAESFARTAGGSLSSSFF SPKKDLEDFDADSDFEVLMKTAHGHLGSNGPEKEKESLKDEFNNHKDYTQEKPSRLKQRF LLKRTKPDYSTNHSSARLSEDVLADDRDDFEYLMQTSTYYYSVRIFPGQEPTNVWVGWIT SDFHQYDQAFELEKIRTVTVTLGDEKGKVHESMKRSNCYMVWAGESTSPGQGRNNNGLEI GCLVDTSAGLLTFTANGKEMSPYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLS AGLFKSERKNPTPQCPPRLHVQFLTPVLWSRVPNHFLKVETSRVSERHGWQVQCSEALQF MCLHIPEENRSIDILELTEQEDLLKFHYHALRLHSAVCALGNNRVAHALCSHLDEAQLLY AIENKYMPGLLRTGYYDLLIDIHLSTYATARLMMNNEYIVPMTEETKSITLFPDEKKKHG LPGIGLSTSLRPRMRFSSPSFVRVSGEYFQYSPEFPLEVLKTKTIEMLTEAVQEGSLHVR DPVGGSTEFLFVPLIKLFYTLLIMGVFHNGDLKNILQLIEPSVFSEETSQEEAEDPEYDG IKGALRIEGPGGEEELRSEKVPKKGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAVVA FSDDFVASLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDEKQDCP CPEGIRELLLDFHEDLMTHCGIELDDDKANEGDCDFTIRGRLLYLVEKVAYLKNKMSDLP KKKKAKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGVGGQVQALPKTYT INSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGM HETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSV GLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCSMLVSKGYPD IGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAM EEAIKISEDPARDGPSPTSGSSRTLDIMDEEDDTIHTGNAIMTFYAALIDLLGRCAPEMH LIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFPMPTLAKDGTVVEPDMSAGFCPDHKAA MVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPL LTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDSIEECLLAACGQLRPSMMQH LLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWG IFDALSQKRYEQELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSMDAEGNFNPQPAD TSNVNVPEKLDYFINKYAEHSHEKWSMDKFANGWVYGEPLCEATKVHPLLKPYKLLLEKE KEVYRWPIKESLKTMLAWGWSIERTREGDALGLHNRARRISQSSQISIDTAHGYSPRPID MSNVTLSRDLHSMAELLAENYHNIWAKKKKLELEAKGGGSHPLLVPYDTLTAKEKFKDRE KAQEILKFFQINGCGVSRGLKELELDTPSIEKRFAYSFLQQLIRYVDEAHQHMLEFDICI PGKGGKIPHEQEIKFFGKVVLPLVDQYFKNHRLYFLSTVSRPLSSGGHASNKEKEMVTSL FCKLGVLVRHRISLFGNDAASIVNCLHILGQTLDARTVMKTGLETVKAALRAFFENSAED LEQTMENLKLGQFTHTRMQPKGVTQIISYTTGALLPVLSSLFEHVGQNQFGEDLILDDVQ VSCYRILGSLYALGTCKSIYVERQRPALGECLAAFAVAFPVSFMEPHLNKHNTYSIYNTK GSRERAALNLPARVEEVCPNIPSLEKSLEEIMELAESGIRYTQMPHVMEVVLPMLCSYMS HWWEHGPENNPEKMDMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPII GKAKPQLLKTHFLPLMEKLKKKAATVLLDEEHMKAEGRGDMSEAELLILDEFTVLARDLY AFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINN MSFLITDTKSKMSKGAVSDQERKKLKRKGDRYSLQTSLIVAALKRLLPVGLNICAPGDQE LIALAKNRFSLKDTEDEVRDIIRNNLHLQGKLEDPAIRWQMALYKDLPNRTEDTSDPEKT VERVLDIAHVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNL FLQGYEKSWIETEEHYFEDKLIEDLAKPGGEEPPEEDEGTKPIDPLHQLILLFSRTALTE KCKLEEDFLYMAYADIMAKSCHDEEDEDGEEVKSFEEKEVEKQKLLYQQVRLHDRGAAEM VLQMISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQS CSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLR TQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNT LTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMV VMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDA KGLISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVA VLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQ WEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQLTGERSANKEENEK DKPEEENPEMGFFSINTMRTALFALRYNVMMLMKVLSMKSLKKQMKKMKKMTVKDMIMTL ISFYWSMLVGLFHFTFSVSRGFFRIMYSTFLGGSLVEGAKKIKVADLLANMPDPTQDEVR GEGEEIEKKHPDTAMPSEDLADLAVASDDGDLLSDIFGLDLRREGGQYKLMPHNPNASLS ELITSPSPPLPPPSPVLRRRHQGEGVKEEEREEKEENKSEPEKAEGEDGEKQEKPKEEKP KQKIRQHHALKSDESEIQESAFWKKILAYQRKLLNYFARNFYNMRMLALFVAFAINFILL FYKVSTSSAVIEEKEVVYTATEKGIPRWNAMDSEPQQFAAVHFVLEESSGYMEPTLRILA ILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVIN TQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDSQEKKKPKKDSSLSA VLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTI LSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEVGDTPDMKCDDMLTCYMFH MYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQ QEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKDETEHTGQ ESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14856 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggagaaggcgaggatgaagtccagttcttacgaactgctgacgaggtt gtgctgcagtgttctgcgaccgtccacaaagaacagcagaagctctgcctggctgcagag ggctttggcaacagactttgttttctagagtccacctcaaattccaagaatgtccctcca gacctctcgatctgcacctttgtgctggagcagtctctctccgtgcgggcccttcaggag atgctggccaacaccgaggagaaagcagaagggaaatttatgatgaagaccgcacatggg ggaggtcaccggactcttctctatgggcacgctgtcctgctcaggcactcgtacagtgga atgtatctgtgttgtttgtctacttcgagctcttcaactgacaaactggcattcgacgtg ggcttgcaggaagatacgacaggagagccctgctggtggacaatacaccctgcctccaaa cagaggtccgaaggtgaaaaggttcgagctggagatgacctaatcttagtcagtgtttct tcagaaaggtatctgcatttatcatatgggaacggcagcctccacgtcgatgctgccttc cagcaaaccctctggagcgtggcaccaatttgctctgggagtgaagtcgcacaaggttac ctcattggaggtgatgtgctgaggttgctgcacggtcacatggacgagtgtctgactgta ccttcaggagaacatggggaagaacaacgaaggacggtccattacgaaggcggagccgtg tctgttcacgctcgatcgctctggaggttggagactctccgagttgcgtggagtggaagc catatcagatggggacagccgttccgtctgaggcacgtcaccacggggaaatatctgagc ctcatggatgacaaaagcctacttctcatggacaaagaaaaagcaggagtgaaatccaca gcattctgctatcggtcttccaaggaaaagttggatttggggataaagaaggaaatggat gggatgggagtaccagagataaagtacggagattcggtgtgctacatccaacatgtggac acctgcctatggctcacctaccagtcagtggatgctaaatctgtacggatgggagctgtg caacgcaaggctataatgcaccacgaaggtcacatggatgatgggttaacactgtccaga tcacagcatgaggagtcccggacagcgcgggtcattcgcagcactgtcttccttttcaac agattcatcaggggtcttgatgccctgagcaagaaaggaaaatcatccagcatagatttg ccaattgaatcagtcagcctgagtctgcaggacttgattggctatttccaaccacctgat gagcatctagaacatgaagataaacagaacaggctacggacgctgaagaaccgacagaat ctcttccaggaagagggtatgattaacctggttctagaatgcatcgaccgcctacatgtg tacagcagtgctgctcattttgctgatgtagctggaaaagaagcaggagaggcctggaag tctatactaaactcattatatgagttactggctgccctgattagaggaaatcgcaaaaac tgtgcccagttctcgggctctcttgattggttaatcagccggctggagagattagaagca tcctctgggattctggaagttttacactgtgtacttgtggaaagtcctgaagctctcaat atcatcaaagaaggccatataaaatctataatttctcttcttgacaaacatgggagaaat cataaggttttggatgtattgtgttccctgtgtgtatgccatggtgtagctgtgcgttcc aaccagcatctcatctgtgacaacttactgccaggaagggatctgttgttgcagacacgt cttgtcaaccatgtcagcagcatgcggccaaatatcttcctgggaatcagtgaaggctct gcccagtacaggaagtggtactacgaactaatagtggatcacgtggaaacttttgtaacc gcggaggccactcacctgcgagttggctgggcctccacagatggatattctccgtatcca gggggcggggaaggctggggcggcaacggcgttggagacgatctttattcctatggcttt gacggcctgcacctatggtcaggctgcattgcccggacagtaaactcacccaatcagcac cttctgagagtcgatgatgtggtcagctgctgcctggacctgagcgccccgagtatctca ttcaggatcaacgggcagcctgttcaaggcatgttcgagaatttcaactcagacggcctc tttttccctgttgccagcttctctgctggagtaaaagtacgcttcctgctgggaggtcgc cacggggaatttaagttccttcctcctcctggttatgctccctgcttcgaagccctgctg cccagagagaagatgagactggaacccagcagggtatacaaacaagaccacaacggcacc cgggacctgctggggccgaccgtcaccctcagactggctgccttcacacccacgcccgtg gacacaagtcagattatattgccacctcacttggagcgaattcgtgaaaaactggcggag aacatccatgaactctgggttatgaacaagattgagcttggatggacctatggatctgtc agagatgacaacaaaagacagcacccgtgtctggtagagttctgcaagctgccggagcaa gagcggaattacaacttacagatgtctctcgagacgctcaagacacttcttgctttaggc tgccacgtaggaattgctgatgagcatgcagaggaaaaagtgaagaacctcaagctccca tctaactatgagctatcaagtgggtacaagccagcccccatggatctaggccacctgaag ctgacttcaacccaggaggccatggtggataagctggctgagaacgcccacaatgtctgg gctcgggaccgcattcgccaaggctggacttatgggatccagcaggatgtgaagaacaga agaaacccccgtcttgttccctacactcttctggatgaacggactaagaagtcgaacaag gacagtctgagagaggcggtgcgcactgtcctggggtacggctacaatctggaggctccg gaccaagaccatgctgcaagatctgacatcggaggtatttcagcagagaggttccgtatt tttcgtgctgagaagacctatgctgtgaacgctggcaaatggtactttgagtttgaagca gtgactgctggggagatgcgtgtcggatgggcaaaacctggatgcctgccagatcgagag ctgggctcagatgaccaggcctttgtgtttgatggtttcaaggctcagcggtggaaccag ggtaatgagcactttggtcgctcctggcaggctggagatgttgtcggctgtatggtagac ttgaatgaacacaccatgatgtttacattgaacggcgaagtcctacttgatgactcaggt tcagaacttgctttcaaggactttgaagttgtggaaggttttattccggtatgcagtctc ggagtttgtcaggtgggcaggatgaattttgggaaggatgtcagcaccctgaagtacttc acaatctgcggattacaagaaggctatgaaccctttgcagtcaacatgaatagggacatt accatgtggttaagcaaaaggctgcctcagttcatcccggtcccttcgaaccatgagcac attgaggtgacaagaatagatgggaccattgacagctcaccatgtttgaaggtcactcag aggtcatttggatctcaaaacagccacactgaaatttttttcttccgcctgagcatgccc gtggagtgtgcagagagcttcgctagaacagcagggggcagtctcagcagcagctttttc tcaccaaagaaggaccttgaggactttgatgcagattctgactttgaggtcctcatgaaa actgcccacgggcacttgggctccaacgggccagagaaagagaaggaaagtttgaaggat gagttcaacaatcataaagattacacacaagagaaaccatctcgactgaaacagaggttc ttgttgaaaagaacaaagccagactacagcacaaatcactcctcagcacgtctctctgaa gatgtactggcagatgacagagatgactttgaatacctgatgcagacgtcaacgtactat tattctgtgagaatctttcctggtcaggagcctacgaatgtctgggttggctggattacc tctgattttcaccagtacgaccaagcctttgagctggagaagattcggacagtgactgtc acgctgggggatgaaaaggggaaagttcacgaaagtatgaagcgcagcaactgctacatg gtgtgggcaggagagagcacaagtccaggacaaggccgcaataataacgggttggaaata ggctgcttggtggacacttctgctggcttactgacgttcactgccaatggcaaagagatg agtccttactatcaggtggaacccagcaccaagctattccctgcagtgtttgctcaggca accagtcccaatgtttttcaatttgaacttggaaggattaagaatgtaatgcctctctca gcaggcctttttaaaagtgagcgtaaaaaccccactccgcagtgcccgcctcggttgcat gtgcagttcctgaccccagttctctggagtcgggtacccaaccacttcctcaaggtggag acctccagggtcagcgagcggcatggctggcaggtgcagtgctcagaggcgctgcagttc atgtgtctgcacattccagaggaaaacaggtctattgatatcttggagctcacagaacaa gaggacctgctgaaattccactaccacgcactgcgcctgcactcagccgtctgcgcactg ggaaacaacagggtggcccatgccctgtgcagccacttggacgaggctcagctcctgtat gccattgaaaacaagtacatgccgggcttgctcaggacaggctactatgacctgctcatt gacatccacctcagcacttacgccacagcccgcctcatgatgaacaatgaatacatcgtc cctatgacggaggaaaccaaaagcatcaccctgttcccggatgaaaaaaaaaaacatggg ctcccgggtataggcctcagtacctccctcagacccaggatgcgcttctcctcacccagt tttgtgagagttagtggggaatacttccagtacagccctgagttccccctggaggtccta aagaccaaaaccattgaaatgctgacagaggctgtacaggaaggcagccttcacgtgcgg gaccctgtggggggcagcactgagtttctctttgtgcccctcattaagctgttttacact ttgctcataatgggtgtcttccacaacggggacctgaagaacatcctgcagctcattgag cccagcgtcttctctgaggagacaagtcaggaggaggctgaggatccagagtatgatggg atcaaaggagcgctgaggatagaaggcccgggaggagaagaggaactcaggtctgagaaa gtccccaaaaaaggtttgctgcagatgaagcttccggagccagtaaaactccagatgtgc catttgctacaatatctatgtgactgccaggtgcgccaccgcattgaggctgttgtggca ttttcagatgactttgtagccagcctccaggataaccagcgtttccgctacaatgaagtg atgcaggctttaaacatgtctgcagcgctgaccgccagaaaaacaaaagaattccgctct cctcctcaggaacagataaacatgctgctgaatttcaaagacgaaaagcaagactgccca tgccctgaaggtattcgtgaactgctactcgacttccatgaagacctaatgactcactgt ggtatcgaactcgatgatgataaagctaatgaaggggactgtgatttcaccataagaggc cgcctcctatacctggtggagaaagtggcctacctgaaaaacaaaatgtctgacttgcca aagaaaaagaaagcaaagaagccaagtactttgcagcagttaatatcggagaccatggtg cggtgggcccaggagtcagtgatagaagacccagagctggtcagagccatgtttgtgctc ttgcacaggcaatacgatggtgtaggaggacaggtgcaggcattgcccaagacatacacc atcaactctgtctctgtggaggacacaataaacctactggcttccctgggacaaatccgc tcgctgctcagcgtacgcatgggcaaggaggaggagaaacttatgatccgtggccttgga gatattatgaacaataaagtcttctaccaacaccccaacctcatgagagccttggggatg cacgagacagtgatggaggtcatggtaaatgtccttggaggaggggaatcaaaagaaatt acttttcctaagatggtggccaattgctgccgattcctgtgctatttctgccgcatcagt aggcaaaaccagaaagctatgttcgatcaccttagttatttgttggaaaatagcagtgta ggactagcatctccttcaatgcgaggctctactcctctggatgttgctgcggcttctgtg atggataataatgaacttgccttagccttaagggagcctgacctagagaaagttgtgcag tacttggcgggatgcggtttgcaaagctgctccatgctggtttctaaaggatacccagat attggctggaatcctgtggaaggagagcggtacttagattttctcagattcgctgtgttc tgcaatggagagagtgttgaagagaatgccaacgtagttgtgaggctgttgatccgtcgg ccggagtgtttcggcccagctttgcgtggagaaggtgggaatggtcttctggctgccatg gaggaagccattaagatctcagaagatcctgccagagacggaccctcgccaacctctgga tccagcagaacccttgacataatggatgaagaagatgacactatacatacggggaatgcc atcatgaccttctatgctgctcttattgacctgcttggccgctgtgctcctgaaatgcat cttatccatgctggaaaaggtgaggccataaggatacgagccattctccgatccctgatt cctattgaagaccttgagggagtcatcagcattccttttccaatgccaacactagctaaa gacggtacagtggtggagcctgacatgtcagctggcttttgccctgatcataaggcagcc atggttctgttcctggaccgagtgtacggaattgaagaccagaacttccttcttcatctt ttggaagtcggctttctccctgacctccgtgcagctgcctctttagatacggctgctctg agtgctacagatatggcgctggctttgaaccgatacctgtgcacagcggtattgcctttg ctcactaagtgtgccccgctgtttgccggcactgagcccttcgcatccctcattgattcc ttactgcacactgtgtacaggctctccaagggctgctgcctcaccaaagcccagagagac tcaattgaagagtgcctgctggctgcctgtggccagttgagaccatctatgatgcaacat cttctcagaaggttggtttttgatgttcctcttttgaatgaacacacaaaaatgcccctt aagttgctgactaaccattacgagcgatgttggaaatactactgcctgcctggaggatgg ggtaactttggagcggcctccgaggaagagcttcacctgtccagaaagttgttctgggga atatttgacgccctgtctcagaagaggtacgagcaggagctgtttaagctggctctcccc tgcctgagcgctgtggccggggccctgcctccagattacatggaatccaactacgtggcc atgatggagaaacagtcctcgatggacgctgagggaaacttcaacccacaacctgctgat acctcaaacgtaaatgttccagaaaaattggattacttcattaacaaatatgcagaacat tctcatgagaaatggtcgatggacaagtttgcgaatggttgggtttatggagaacccctg tgtgaggctaccaaggtccaccctctactgaaaccatacaaactgcttttggagaaggag aaggaggtgtaccgatggcctattaaggagtctttaaaaacaatgcttgcctgggggtgg agcattgagaggacaagagaaggggatgctttgggcttacataaccgagcacgtagaata tcacagtccagtcagatttccatagacactgcacatggttacagtccacggccaatagac atgagcaatgtgacgctgtccagagatctgcattcaatggcagagctcctggctgagaac taccacaacatctgggcaaaaaagaaaaaactagagctggaagccaaaggaggaggaagc catcctttgctggtgccctatgatacattaacagccaaagaaaaattcaaagacagagaa aaagcacaagagatcctcaagttctttcagataaatggatgcggtgtttcaaggggtctg aaggaacttgaattagacacaccttcaattgagaaacgctttgcctacagcttcctccag cagctcatcagatatgtggacgaggcacatcagcatatgctggagttcgatatttgcatt ccaggtaaagggggaaagattcctcatgagcaagaaatcaagttctttgggaaggttgtt cttccattagtagatcagtacttcaagaatcatcgtctctactttctgtccactgtgagc cggcctcttagcagtggaggccacgcctcaaacaaggagaaggagatggtaacgagcctg ttctgcaaacttggagttcttgtcagacataggatatcactgtttggaaatgatgcagca tctatagtgaactgtcttcacatcttgggccaaactctggacgccaggacggtaatgaag actggcttggagacggtgaaggcggctttgcgggcgttttttgaaaattcagctgaggac ctggagcagacgatggagaatctaaagctcggccagttcacccacaccaggatgcagccc aaaggggtcacccagatcattagctacactaccggggccctcctgcctgtcctgtcctcg ctgtttgagcatgttgggcagaaccagtttggagaagacctcatattagatgatgttcag gtgtcatgctacaggatacttggcagcttgtatgcattgggcacttgcaaaagtatatat gtagaaagacagcggccagcacttggagaatgtcttgctgcctttgctgttgccttccca gtttcgtttatggagcctcacttgaacaagcataacacctattctatatacaacaccaaa gggtcaagagaaagagcagctttgaacttgcccgcccgggttgaggaagtatgtccaaac atcccatccctggagaaatccttggaggagataatggagctggctgagtctgggattcgg tacacccagatgccccacgtgatggaggtggtgctgcccatgctgtgcagttacatgtct cactggtgggaacacgggcctgaaaacaacccagagaaaatggacatgtgctgcacagca ctgacgtcagaacacatgaacacactgctggggaacattctgaagatcatctacaacaac ctaggcatcgatgagggagcctggatgaagcgactggcagtattctcccagccaatcatt ggcaaagccaagccgcagctcttgaagacccacttcctgcccttgatggagaagctgaag aagaaggctgcgacagtgctgctggatgaggagcacatgaaggcagaggggcgaggggac atgtctgaggctgagctgcttattctcgatgagttcaccgtcctcgcccgggatctctac gccttctacccgctcctcatcagattcgtggattacaacagagcgaagtggctgaaagaa cccaacccagaggcagaagaattatttcgcatggtggctgaagtgttcatattctgggca aaatcacacaatttcaaaagggaagagcagaactttgtggtccaaaatgaaatcaacaat atgtcttttttgatcaccgacaccaagtcgaaaatgtcaaagggcgcagtttcagatcag gagagaaagaagctgaaacgaaagggagaccgctattctctacagacctcgctcattgta gctgcactaaagagactgcttcctgtggggttaaatatttgtgcacccggggatcaagaa cttattgcattggcaaagaacagattcagtttgaaagacacagaggacgaagtaagagat attattcgtaataatcttcaccttcagggaaagctggaggatcctgctatcaggtggcag atggctctgtacaaagacttgcctaacaggacagaagacacgtcggaccctgagaaaaca gtagagcgtgtgttagatatagcacatgtgttgtttcatcttgagcaggttgaacatcct cagagaagcaagaaggctgtgtggcacaagctgttgtccaagcagaggaaaagggcagtg gtggcctgtttcaggatggcacctttgtataatttgccaaggcatcgggctgtgaacctc ttcctacaaggttatgagaagtcatggattgaaacagaggaacattattttgaagacaaa ctaattgaggatttagctaaaccaggaggagaagaacccccagaagaagacgagggaaca aaaccaatcgaccctctacaccagcttatcttactgtttagtaggactgcactgactgag aagtgtaagctggaggaagacttcctttacatggcctatgctgacatcatggcaaagagc tgtcatgatgaagaagacgaggatggagaagaagtgaaaagctttgaagaaaaagaagtg gaaaagcagaagcttctctaccagcaggtcaggcttcatgaccgaggggcggcagagatg gtgctgcagatgattagtgccagcaaaggtgaaatgggtccaatggtagcatctactttg aagcttggaattgccatattaaatggtggaaattctacggtacagcagaaaatgcttgat tatctgaaggacaaaaaggatgttggcttctttcaaagccttgctggtctcatgcagtct tgcagcgtccttgatctcaatgcttttgaaagacagaacaaggcagaaggtcttgggatg gttacagaggaaggatcaggagaaaaggtgatgcaggatgatgagtttacctgtgacctc tttcgcttccttcagctgctttgtgaaggacataactcagactttcagaattatctaagg actcagactggaaacaacaccacagtgaatattattatatctacagttgattacctacta cgagttcaggaatctatcagtgacttctattggtattattctggaaaagatgtgattgat gagcaaggacagcgcaatttctccaaggcaattaatgtggccaaacaggttttcaataca cttacagaatacatccagggcccgtgtactggtaaccagcagagtcttgcacacagcaga ctgtgggatgcggtggttgggtttcttcacgtgtttgcacacatgcaaatgaagctatcc caggactccagtcaaattgagttactgaaagagttaatggacctccaaaaagacatggta gttatgttgttgtcaatgttagaagggaatgtggttaatggaaccattggcaaacagatg gttgacatgttagtagagtcctccaacaatgtggaaatgattctgaagttctttgacatg ttcctcaagttaaaagacttgacatcatctgatacatttaaagagtatgaccctgatgct aaaggcctgatttcaaagcgggactttcacaaggccatggaaagccacaaacactacacc cagtcagaaacggaattccttctctcttgtgcggagacagatgagaacgagctgctggac tacgaggagtttgtggaaaggttccacgaaccagccaaagacattggcttcaatgtggct gtcttgttgaccaatctgtccgagcacatgcctcacgatacccgtttgcagacttttttg gaacttgctgagagtgtgcttaattacttccagccttaccttggtcgtattgagatcatg ggcagtgccaaacgcatcgagcgggtctactttgaaatcagtgagtccagtcggacgcag tgggaaaagccacaggtgaaggagtccaagcggcagttcatctttgatgtggtgaatgag ggaggggagaaggaaaaaatggagctctttgtaaacttttgcgaggacaccatctttgaa atgcagctagctgctcagctaacaggtgagaggtctgccaacaaggaagagaatgagaag gacaagcctgaagaggaaaatccagaaatggggttcttctccatcaacacaatgcgcacg gctctctttgcactgaggtacaacgtgatgatgctcatgaaggtgctttccatgaagagc cttaaaaaacagatgaagaaaatgaagaagatgactgtgaaagacatgatcatgaccctc atctcattctactggagcatgttggtgggacttttccatttcacattcagcgtgtcaagg ggtttctttcgcatcatgtacagcacctttctcggaggaagtctggtggaaggagccaaa aaaatcaaagtggccgacctcttagccaatatgcctgatccaacccaggatgaggtccgt ggggagggcgaggaaatcgagaagaagcaccctgacacggcaatgccttctgaagaccta gcagacttagcagttgcctctgatgatggtgatctcctttcagacatttttgggttagat ttaaggcgtgaaggtggacaatataaacttatgcctcataatccaaatgctagtctgagc gagctaattacctcaccctctcctccgcttccaccaccctcacctgtgctacgaagacga caccagggcgagggggtcaaagaagaagaaagagaagaaaaagaagaaaataagtcagaa ccagaaaaggcagaaggggaagatggcgagaaacaggaaaagccaaaggaagagaaaccc aaacagaaaattagacagcaccatgccctgaaatcagatgagtcagaaatacaagaatct gcattttggaaaaaaattctagcataccaacgaaagctgcttaattactttgcacgcaac ttctacaacatgaggatgctggctctgtttgttgcctttgcaatcaacttcattctcctt ttctacaaggtgtccacctcctcagcagttattgaagagaaggaggttgtttacacagcc actgagaaaggaatcccaagatggaatgccatggacagtgagccccaacaattcgccgcc gttcattttgtgctggaggagagcagtggctacatggagcccacactgagaatactcgct attctacacacagtcatctcctttttctgcataataggatattattgtttaaaagttcct ctggttattttcaaacgagagaaggaggtggcacggaaactggagtttgatggactctac atcacagagcagccatcagaagatgacatcaaagggcagtgggacagacttgtaattaat acccagtcttttccaaataattattgggacaaatttgtaaaacgaaaggtcatggataaa tatggagagttttatggccgagacaggatcagtgagttactgggaatggacaaagctgct cttgacttcagtgattcacaagagaaaaagaagccaaagaaagacagttcactgtcagca gtactgaattccattgatgtcaaatatcaaatgtggaaattaggagtagtttttacagac aactctttcctgtacctagcctggtatatgaccatgtcggtgcttgggcactacaataac tttttctttgctgcacatttactggatatagccatgggattcaaaacattacggaccatc ctctcatcagttacacacaacggcaaacagctggtgttaacagtggggttgctggctgtc gttgtctacttgtacacggtagtagcctttaatttcttccgcaaattctacaacaagagt gaagtcggagacacccctgatatgaaatgtgacgatatgctcacctgttacatgtttcac atgtacgtgggcgtccgtgctggtggaggcatcggtgatgagatcgaagacccggcagga gacgaatatgagatatataggatcatttttgacatcaccttcttcttctttgtaattgtc attctgctagctatcattcaaggtttaattattgatgcctttggtgaattacgagaccaa caggaacaagtcaaagaagatatggagaccaaatgcttcatctgtgggattggcaatgac tactttgacacagtaccccatggctttgaaactcacacactgcaggagcacaacttggca aactatctttttttcgtgatgtatctcattaacaaagacgaaacagagcacacaggccag gaatcatatgtttggaaaatgtaccaggaacgctgctgggaattttttcccgctggagac tgctttcgcaaacaatatgaagaccagctaaactga

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