Alosa sapidissima (American shad): 121699981 Help Entry 121699981         CDS       T11137                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism asad  Alosa sapidissima (American shad) Pathway asad04020   Calcium signaling pathway asad04260   Cardiac muscle contraction asad04261   Adrenergic signaling in cardiomyocytes asad04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:asad00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121699981 (ryr2a)    04020 Calcium signaling pathway     121699981 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     121699981 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     121699981 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:asad04040]     121699981 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:asad04990]     121699981 (ryr2a) Ion channels [BR:asad04040]  Voltage-gated cation channels   Ryanodine receptor    121699981 (ryr2a) Domain-containing proteins not elsewhere classified [BR:asad04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    121699981 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Other DBs NCBI-GeneID:  121699981 NCBI-ProteinID:  XP_041938494 LinkDB All DBs Position 24:complement(1892022..2005378) Genome browser AA seq 4971 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCSATINKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEEKAEGQVDVEKWKFMMKTAQGGGHRTLLYGHAVL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNDSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSTHARSLWRLETLRVAWSGSHTRWGQPFRLRHV TTGKYLSLMDDKSLLLMDKEKADIKSTAFCFRSSKEKLDLGFKKEVDGMGVPEIKYGDSV CYIQHVDTCLWMTYQSMDAKCARMGGIQRKAIMHHEGHMDDGLSLSRSQHEESRTARVIR STVFLFNTFIRGLDSLSKKGKSSTLDLPIESVSLSLEDLIGYFQPPEDHLEHEDKQNRLR ALKNRQNLFQEEGMISLVLECIDRLHVYSSAAHFADVAGKEAGEAWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTQLVNQVSSMRPNIF LGISEGSAQYKKWYYELIVDHVDPFITAEATHLRMGWASTHGYSPYPGGGEGWGSNGVGD DLYSYGFDGLHLWSGCIARTVSSPIQHLLRTEDVVSCCLDLSSPSISFRINGQPVQGMFE NFNSDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPNYAPCFEAVLPREKLRVEHTQEY KQDHGATRDLLGPTITLSQAAFTPTPVDTSQIVLTPHLERIREKLAENIHELWVMNKVEL GWTYGMIRDDNKRQHPCLVEFSKLPEQERSYNLQMSVETLKTLLALGCHVGVADEHAVEK VKKLKLPSKYELSSGYKPAPMDLSHIRLASAQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKSKRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYSLEAPDQDHASRADISNM SAERFRIFRAEKTYSVNIGKWYFEFEVVTAGEMRVGWARPACLPDQELGSDEHAFVFDGF KAQRWHQGNEHFGRSWQPGDVVGCMVDMSEHTMMFTLNGEVLLDDSGSELAFKDFEIWEG FIPVCSLGVCQIGRMNFGKEVSTLKYFTICGLQEGYEPFAVNMNRDLTMWLSKRLPQFIP VPSNHEHIEVTRIDGTVESSPCLKVTQRSFGSQNSSSDIVFYRLSMPIECAEVFCKSPGS TVPSNGRFFSSKKELEDLETESDFEVLMKSSHGHMGSNGPEKDTDEFNNHKDYNQEKPSK FKSRFMLKKTKPEFNTSQSSARLPEEVIADAERDDSGCLMQTSTYYYSVRIFPGQEPSSV WVGWVTSDFHQYDTAFQQDKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGESTSPGQGRN NNGLEIGCQVDCVSGVLTFTSNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGSIK NVMPLSAGLFKSERKNPVPQCPPRLHVQYLTPVLWSRVPNGFLRVEVARVSERLGWQVQC HDPLQFMSLHIPEENRSVDILELTEQRELLKFHYHTLRLYSAVCALGNNRVAHALCSHVD ESQLLYAIENKHMPGLLRTGYYDLLIDIHLSSYATARLMMNSEYIVPMTEETKSITLFPD EQKKHGLPGIGLSTSLRPRMRFSSPSFVGTDKSLSGDCFQYSPEFPLEILKTKTMEMLTE AVCEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGVFHNGDLRIILQLIEPSVFSKEGKA TSAPTHTAEGATVSEKTEALRKEGGKVEGEQTTKVPKEGLLQMKLPEPVKLQMCHLLQYL CDCQVRHRIEAVVGFSDDFVANLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQI NMLLGFKDEKQDCPCPDEIRGQLLDFHQDLMTHCGIELDDEKLGEVDGDFTIRGRLMSLV EKVNYLKKKMSDLPKKKKVKKPSTLQQLISETMVRWAQECVIEDPELVRAMFVLLHRQYD GIGGQVRALPKTYTINTVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNK VFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKA MFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCG LQSCMMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGP ALRGEGGNGLLAAMEEAINFSEDPCRDGPSPIAEASRTLSDSLEDEEDDTIHMGNAIMTF YSALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLEGVISIPFRMPTLAKDGSV VEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTPALSATD MALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEE CLLAVCGKLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFG AASDEELHLSRKLFWGIFDALSRKKYEHELFKLALPCLSAVAGALPPDYMESNYVAMMEK QSSMDAEGNFNPQPVDTSNVVIPEKLDNFIIKFAEHSHERWSMDKLTKGWVHGDQLCEFT KTHPLLKPYKSLSEKDKEIYRGPIKESLKTILAWGWLIERTREGDTASLHNRTRRISLSS QHSMEGTHGFSPRPIDMSNVTLSRDLHAMAELLAENYHNIWAKNKKSELEAKGGGSHPLL VPYDTLTAKEKSRDREKAQDILKFFQINGYTVSRAKKEQELDTPSIEKRFAYTFLLQLIT YVDQAHEHLLEFDASNQPKGEKMCHDQQMKFFGKVVLPLVDQYFKNHHLYFLSTALHPIS SGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDAASIVNCLHILGQTLDARTVMKTGLD TVKAALRAFFDNAAEDLEKTIENLQQGQFTHTRAQPKGVTQIINYTTVALLPVLSSLFEH ITQNLFGEDIILDDIQVSCYRLLNSLYLLGTSKSIYVERQRPAIGECLAAFSGAFPVAFL EPQLNTFNSHSIYNVKPSRERTTLGLPAQVEEMCPLIPSLEKSLEEIMELAESGMCYTQM PHVMEVVLPMLCSYMSRWWEHGPENNPERAESCCTSLTSNHMNTLLGNILKIIYNNLGID EGAWMKRLAVFSQPIISKAKPQLLKSHFLPLMEKLKKKAAIVLTDEENMKAEGRGEMSES ELLILDEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEIFIFWAKSHN FKREEQNFVVQNEINNMSFLITDTKSKMSKGGVSDQERKKMKKKGDRYSMQTSLIVAALK RLLPVGLNICAPGDQELIGLAKNRFSQKDTEEEVRETIRNNLHLQGKLEDPAIRWQMALY KDMPNRSEDTSDPEKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACF RMAPLYNLPRHRAVNLFLQGYLRSWIETEEHYFEDKLIEDLAKPGGEEPPEEDEATKHID PLHQLIQLFSRTALTEKCKLEEDALYMAYADIMAKSCHDEEDEDGEEVKSFEEKEMEKQK LLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAGLNGGNSTVQQKMLDYLKD KKDVGFFQSLAGLMQYCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTC DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDV IDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMK LSQDSSQIDLLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF DMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETDFLLSCVETDENET LDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPFLGRIE IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTI FEMQLAAQMSDASERLASKEDTERGEKPEVESPEMGFFSVTTVRTALLALRYNVLVLMKV LSMKSLKKQVKRAKKMTLQDMVMALAAFYWSVLIGLLHFAFSVSRGFFRIIYNTFLGGNL LEGAKTMKMSELITSMPDPTHEEVRGELEEGVENKSVEKPLTKEDLADLTVATDETELLS DIFGLDLRREGGQYKIMPHNPNASLTDLLNAPIPPPSPSPELRRQHQVKEDKGGTEDSKP EPEKAAGERVEKVEDKEQLKPKQRIRQVHISKSDEPDLQESAFCKKIIVYQRKLLNYFAR NFYNMRMLALFVAFAINFILLFYKVSTSSAVMEEKEVFRSPVDAGLHWNPLGATPDRTMT VHFVLEESSGYMEPTLRILAILHTVISFCCIIGYYCLKVPLVIFKREKEVARKLEFDGLY ITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAA LDFSDAHEKKKPKKDSSLAAVINSIDLKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNN FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKS EDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIV ILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLA NYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14916 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggaggagaaggcgaagatgaaattcagtttttgcgaaccgatgatgaagtg gtgctgcagtgctctgccaccatcaacaaagagcagcagaagctgtgtctggcagcggag ggctttggaaacagactctgctttcttgaatctacttccaattcaaagaatgttccccca gacctgtctatatgtaccttcgtccttgagcagtcactctcggttcgcgcccttcaagag atgcttgccaacacagaggagaaagctgaggggcaagttgatgtggaaaaatggaaattc atgatgaagactgcccagggtgggggacatcgtactttactttatggacatgcggttctc cttagacactcgtatagtggaatgtacctgtgctgtttatcaacatcacggtcctcaaca gataaactagcatttgatgtaggtctgcaggaggacacaacaggtgaggcatgttggtgg actattcatcccgcctctaaacaacggtcagaaggagaaaaggtgcgcgtcggtgatgac ctcattctggtcagtgtctcttcagaacgctacttgcacctgtcgtatgggaacgacagt ctgcatgtggatgcagccttccagcagaccctctggagtgtggcccctatctgctcagga agcgaggtggcacaaggcttcctgattggaggagatgtgttgcgcctgctccatggtcac atggatgagtgcctgactgtgccatctggagagcatggagaagagcagcgaaggacagtg cactatgaagggggagctgtgtccactcatgcccggtccctctggagactggagactctg cgagttgcatggagtggcagtcacactcgttggggccagccctttcgtctccgacacgta acaactgggaagtaccttagtctcatggatgacaagagcctactcctcatggacaaggaa aaggctgacatcaagtccacagcattctgtttccgctcctccaaggaaaaactggacttg ggcttcaagaaagaggttgatggcatgggtgtgcctgaaattaagtatggcgactctgtg tgctacatccagcatgttgatacatgtctgtggatgacatatcagtccatggatgctaaa tgtgcacggatgggtggaatacagaggaaggctataatgcatcatgagggtcacatggat gacgggctttcactgtcacgctctcagcatgaggagtcacgcaccgcccgtgtcatccgc agtacagtcttcctcttcaatacctttatcaggggtctagattccttgagtaaaaaaggg aagagttccacactggacttgcctattgaatctgtcagcttgagcctggaggatctgatt ggctactttcagcctccagaggaccatttagaacatgaggacaaacagaaccgcctccgt gcattgaagaatcgtcaaaacctgttccaagaggagggtatgattagcctggtgttagag tgcattgacaggctacatgtgtatagcagtgcagcccactttgctgatgtggcgggaaaa gaagctggtgaagcgtggaaatctatactaaactcattatatgagctgctggctgctctt ataaggggtaaccggaagaactgtgcccagttttcaggctctttggactggctgatcagt cgtttagaacgccttgaagcttcttctggtatactagaagttttgcattgtgtcttggtg gaaagtccagaagccttaaatataattaaggagggacacatcaaatcgattatctctctt ctggacaaacatgggcgtaaccataaggtgctggatgtgctgtgttctctgtgtgtatgc catggtgttgctgtgcggtccaaccagcacctcatctgtgataacctcctgccagggcga gatctgctgctgcagacgcagcttgtcaaccaagtcagcagcatgaggcccaacatcttc cttggcattagtgaaggctctgcccagtataagaagtggtactatgagctcattgtggac catgtagatcccttcatcactgctgaggctacccatctgcgaatgggctgggcctccaca catggctattctccctacccaggtggaggggagggctggggcagcaatggcgtgggtgat gacctgtactcttatggctttgatgggctacatctgtggtcaggttgcattgcccgtact gtcagctctcctattcagcatcttttgcgcacagaggatgtggtcagctgctgcctggac ctcagctcccccagtatctcctttcgcatcaatggccagccagtacagggcatgtttgag aacttcaattctgatgggctcttcttccctgtggttagcttctcagcaggagtcaaggta cgtttcctgttgggtggtcgtcatggtgagttcaaattcctaccaccacccaactatgct ccctgttttgaggctgtgcttccccgagagaagttgcgagtggagcacactcaagagtat aagcaggaccatggagctactagggacttgctgggccccacaatcaccctctcacaggct gccttcacccccacaccagtggacactagccagattgtgctgacacctcatttggaacgg attcgtgagaagcttgctgaaaatatccatgagctttgggtgatgaacaaggttgaactt ggttggacatatggcatgattcgggatgacaacaagagacagcatccctgtctcgttgaa ttctcgaagcttccagaacaagaacgtagctacaatctgcagatgtccgtggaaacactc aagaccctgctggcactaggctgccatgttggtgtggcagatgagcatgctgttgagaaa gtcaagaagcttaagctcccctccaaatatgaactctccagtgggtataagccagcccct atggacctgagtcacattagacttgcctctgcccaggaggccatggtggacaagctggca gaaaatgcccacaatgtttgggcaagggaccggattcgacagggctggacttatggcatc caacaggatgtaaagagcaagaggaacccacggcttgttccatatgtattgcttgatgaa cggaccaaaaaatccaacaaggacagcttgcgagaagcagtgcgtacacttctaggatac ggatatagccttgaagctccagaccaagaccacgcatccagagcagacataagtaatatg tcagccgagaggtttcgtatcttccgtgcggagaagacgtacagcgtgaacatagggaag tggtactttgagttcgaagtggtgactgctggagagatgagggtaggttgggcccggcca gcttgcctgcctgaccaggaactgggctctgatgaacacgcatttgtctttgatggattc aaggcacaacggtggcaccaggggaatgaacactttggccgctcctggcagccaggagat gtggttggatgcatggtggacatgagtgagcacaccatgatgttcacactaaatggggag gtgctgcttgacgactctggctcagagcttgcctttaaagattttgaaatttgggaagga ttcatccctgtgtgtagtctgggtgtatgtcagattggccgcatgaactttggcaaggaa gtaagcacattgaagtactttacaatatgtgggctacaagaaggttatgagccttttgct gtgaacatgaaccgagatttgaccatgtggttaagcaagaggctccctcagtttatacca gtcccttcaaaccatgagcacattgaggtcacaaggatagatggcaccgtggagagctca ccgtgtctaaaggtcacacagaggtcattcggctcacagaacagcagcagtgacatcgtc ttttaccgcctaagtatgcccatcgagtgtgcagaggtcttctgtaagtctccaggcagc acagtaccctcaaatggtagattcttctcctccaagaaagagctggaggaccttgaaaca gaatcagactttgaggttttgatgaagagttcccatggtcacatgggctctaacgggcca gagaaggacactgatgaatttaacaaccacaaggactataaccaggaaaagccatccaag ttcaaatcgaggtttatgcttaaaaagacaaagccagagttcaacaccagccagtcatca gcacgtctgccagaagaagtgattgcagatgctgaaagggatgactctgggtgtcttatg cagacctcaacatattactactctgtaaggatcttccctggccaagaaccatcaagtgtg tgggtgggttgggttacatctgacttccatcagtatgatactgcctttcagcaagataag gttaggactgttactgtgacccttggagatgagaaaggcaaggtccatgagagcatcaag cgcagtaattgctacatggtatgggcaggcgagagcaccagccctggtcagggtcgaaac aacaatggcctggagattggttgccaggtggactgtgtcagtggtgtgcttaccttcacc agcaatggcaaagagctcagcacctattaccaggtcgagcccagcaccaagctgttccct gcagtgtttgcacaggccaccagccccaacgtctttcagtttgaactgggaagcataaag aatgtgatgccattgtctgctggcctttttaaaagtgagcgtaaaaaccccgtgccacag tgtcctccccggctgcatgtgcaatatctgacgcccgtgttgtggagccgtgtgccaaat ggcttcttgagggtggaggtagcacgtgtcagtgagcgccttggctggcaggtgcagtgc cacgatccgctgcagttcatgtctctgcacatccccgaggaaaacaggtcggtggatatc ctggagctgacggagcagagagagctactaaagttccattaccataccctccgcctctat tcggctgtctgcgcactggggaacaaccgggtggcacatgcactatgcagccatgtggat gagtcccagctgctgtatgccattgagaacaagcatatgccaggcctgctgcggactggt tactatgatctactaatcgacatccaccttagcagctatgccacggcacgtctcatgatg aacagcgagtacatcgtacccatgacggaagaaacaaaaagcatcactctcttccctgac gaacagaagaagcacgggctgccaggcatcggcctgagcacgtcactgcggcctcgcatg cgcttctcctcccccagcttcgtgggcacggacaaaagtctcagtggcgactgtttccag tacagccctgagtttccgctggagatcctgaagaccaagaccatggagatgctgactgag gctgtgtgtgaggggagtctacatgtgcgggaccctgttggtggcagcacagagttcctg tttgtgccactaatcaagctcttctatacactgctcattatgggtgtcttccacaatggt gacctgcgaatcattctgcaactcattgagcctagtgttttctccaaggaaggcaaggcc acttctgccccaacccacacagctgagggtgcgacagttagtgagaaaacagaggcactg aggaaagaaggtggtaaggttgaaggagaacaaacaacaaaggtgcccaaagaaggtctg ctccagatgaagttgcctgagccagtcaagctccagatgtgtcatttgctgcagtacctg tgtgactgtcaggtacgtcaccggattgaggctgtggtaggcttctccgatgattttgtg gcaaacctgcaagacaatcagcgtttccggtacaacgaagtcatgcaagcgctgaacatg tcagccgctcttacagctcgaaagaccaaagagtttcgctcacctccccaggaacagata aacatgctgctaggcttcaaagatgaaaagcaggattgtccctgccctgatgaaatcaga gggcagttgttggacttccaccaagacttaatgactcactgcggaatcgagctggatgat gagaagcttggtgaagtggatggagatttcacaatacgcggtcgactgatgtccctggtg gaaaaagtgaattacttgaaaaagaaaatgtctgatctgcctaagaaaaaaaaagtcaaa aaaccaagcactcttcagcagcttatctctgagactatggtgcgctgggcacaggaatgt gttattgaggacccagagctcgtcagagcaatgtttgtgctcttgcatcgtcagtatgac ggtatagggggacaagtacgtgccttgcccaagacctacaccatcaatactgtgtctgtg gaggacaccatcaacctgctggcctctctaggccaaatacgctcactactcagtgtcagg atgggtcgtgaagaggagaaactcatgatacggggcctgggagatattatgaacaacaaa gttttctatcaacatccaaatctaatgagggccttgggcatgcatgagactgtgatggag gtcatggtgaatgttttgggtggtggagaatcaaaggaaattacttttcctaagatggtg gccaactgctgtcgttttctttgctacttctgccgcatcagtagacaaaaccaaaaagcg atgtttgatcacctcagttacttgcttgagaacagcagtgtgggacttgcctctccttct atgcggggttcaactcctctggatgtggctgctgcctcagtgatggataacaatgagctt gctttggccctgagggaaccagacctggagaaagtggtgcagtatttggccggctgtgga ctccagagttgcatgatgttagtctctaaaggctatcctgacatcggctggaaccctgtt gaaggagagcgttacttggactttctgcggtttgcggtcttttgcaatggagagagtgtt gaggagaatgctaatgtggttgtgaggctcctgattcggcgacctgaatgtttcggtcct gccttacgaggggagggcgggaatggccttctggctgccatggaagaggccatcaatttc tcagaagacccttgtagggatggaccctcacccatcgctgaagctagcagaacactgagt gattctctggaggatgaggaagatgacaccatccacatgggcaatgccatcatgacattt tactccgccctcattgacctgctgggacgctgtgctccagagatgcatctgatccatgct gggaagggcgaagccattcggatcagggcaattctgcgctctctaatccccattgaggac cttgagggtgtcatcagtatcccatttcgtatgcctactttggcgaaagatggatcagtt gttgagcctgacatgtcagcaggcttctgtcctgaccacaaggcagccatggttcttttc ttggatcgggtctatgggattgaggatcagaacttcctgctacatctcttggaagtgggc ttcctgcctgaccttcgtgcagcggcttcacttgacacaccagccctgagtgctacagat atggccctagccttgaaccgctacctgtgcacagctgtgctgcctttgcttactaaatgt gccccactgtttgctggcactgagccttttgcctcgctcattgactctctgttgcacact gtgtaccgcctgtcaaagggctgctgcctgactaaggcccagagggatgccatagaggag tgcttgctagctgtgtgtgggaaactgaggccctccatgatgcaacatttgctcagaagg ctggtatttgatgtccccctgctgaatgaacacactaaaatgccccttaagctgttgacc aaccactatgagcgttgctggaagtactattgcctgtctggaggctggggtagctttgga gctgcctctgatgaagagctacatctctccaggaagctgttctgggggatttttgatgcg ttgtcaaggaagaagtacgaacacgagctgttcaagttggcgttgccctgcctaagtgct gtggccggagccttgccaccagattacatggaatctaactatgtggccatgatggagaag cagtcctcaatggatgcagagggaaacttcaacccccagccagtcgatacttcaaatgtg gttatccctgaaaaactggataatttcatcatcaaatttgctgagcattctcacgagagg tggtctatggataagcttaccaaaggctgggtacatggtgaccagctctgtgaattcacc aagacacacccccttctaaaaccatacaaaagcttgtcagagaaggacaaagagatttat cggggtcccataaaggaatccctaaaaaccatcctggcatggggctggctcattgagagg actcgagagggtgacacagctagccttcacaaccgcacacgccggatatccttatcaagt cagcattctatggaaggcactcatggattcagccctagaccaatcgacatgagtaatgtg actctctctagagacttacacgccatggctgaactacttgcagaaaactatcataacata tgggccaagaataagaaatctgagcttgaagccaaaggtggagggagccatcctttgctg gtgccctatgacactctaacggccaaagagaaatcaagagacagagaaaaagcacaagac atcctgaagttctttcagataaatggttatactgtgtctagggctaaaaaggagcaggaa cttgacacaccctccatagagaagcgatttgcttacactttcctactgcaactcattacc tatgtggaccaagcccatgaacatttgctggaatttgatgccagtaatcagccaaaggga gaaaaaatgtgtcatgaccagcagatgaagttttttgggaaggtggtcttacccctcgtg gatcagtacttcaaaaaccatcacctgtacttcctgtctactgcattacaccctatcagc agtggtggccatgcctccaacaaagagaaagaaatggtgacgagcctcttctgcaaactt ggagttcttgtcagacataggatatcactgtttggaaatgatgcggcttctattgtaaac tgtctccacatactaggacaaacacttgatgccagaactgtgatgaagacaggtttggac acagtgaaagcagcactgcgggcattctttgacaatgctgctgaggacttggagaaaact atagagaacctgcaacagggccagttcactcacacccgtgctcagcctaagggagtaact cagatcatcaactacacaactgtggcattgctgcctgtgctctcctccctctttgagcac atcacacaaaacttgtttggggaggatatcatacttgatgatattcaggtgtcatgctat aggctacttaacagcctgtatttactgggcactagcaaaagcatttatgttgaaagacag cgaccagccataggggaatgcctggcagctttttcaggagctttccctgttgcctttttg gaacctcaactcaacacatttaatagtcactccatttataatgtcaaaccctcaagggag agaacaactcttggactacctgctcaggtggaggaaatgtgtcctctcattccatctctt gagaagtccttggaagagattatggagctagcggagtcaggcatgtgctacacacagatg cctcatgtgatggaggtggtgttacccatgttgtgcagctacatgtcacgctggtgggaa catgggccagagaacaaccctgaacgagcagagagctgctgcacctcactcacatccaat cacatgaacacgctgctggggaacatcctgaaaataatctataacaatctgggaattgat gaaggagcctggatgaagcggttggcagtcttctctcagcctattataagcaaggccaag cctcagcttttaaagtcccatttcctacctttgatggagaaactgaagaagaaagccgcc atcgttctgacagatgaggagaacatgaaggctgagggacggggagagatgtctgagtct gagcttctcatcctggatgagttcaccatccttgtccgtgatctatatgctttctaccct ctcctcatacgatttgtggattacaacagggcaaaatggcttaaagaacctaacccagag gcagaagagttattccgcatggtggcagaaatcttcatattttgggcaaaatcacataac ttcaaaagagaggagcaaaactttgttgttcagaatgagataaacaacatgtctttcctc attacggataccaaatcaaaaatgtcaaaaggaggtgtgtcagaccaggagaggaaaaag atgaagaaaaaaggtgaccgctactctatgcagacctctcttattgtagctgctctcaag aggttgctgcctgttggcctgaatatttgtgctccaggagatcaggaattgattggactt gctaagaatcgcttctctcagaaagatactgaagaggaggtgcgggagactatacggaac aatctccatcttcagggaaaactggaggatcctgctattcgctggcagatggcactatat aaagacatgcccaatcgaagtgaggatacttcagacccagagaaaacagtggagagggtg cttgatattgcccatgtgcttttccacctggaccaggttgaacatccccagaggagtaag aaagcagtgtggcacaagctcctgtctaagcagaggaagagagcagtggtggcctgtttc aggatggcgcctctttataacctgcccaggcaccgagcagtcaatctatttctgcagggt tacttgagatcctggatagaaacagaggaacactactttgaagacaagcttattgaagac ttggcaaaacctggaggagaggaaccccctgaagaagatgaagccaccaagcacatagac cccctgcaccagcttatccagttattcagtagaactgcactgaccgagaaatgtaaactt gaggaagacgccctctacatggcttatgcagatatcatggcaaagagttgccacgatgaa gaggatgaagatggtgaggaagtgaaaagttttgaagaaaaagagatggaaaagcagaaa ctactttaccaacaggcccgactacatgaccgaggtgctgcggagatggtccttcaaact atcagtgcgagtaaaggggagatgggaccaatggttgcatccacattaaagctggggatt gccggactaaatggaggaaattccactgtgcaacagaaaatgctggactatctgaaagat aagaaagatgtggggttttttcagagtctggcaggtctcatgcagtactgcagtgttcta gatctcaatgcattcgagagacaaaacaaagctgaaggcttgggtatggtgactgaggaa ggctcagtcatcactcatgagcgtggagagaaggtgatgcaagatgatgagttcacctgt gacctctttcgcttcttgcaacttctgtgtgaaggacataactcagatttccagaattat ctgagaacacagacaggaaacaacacaactgtcaacatcattatatctacagttgactac ctcctcagagtccaggagtccatcagtgatttctattggtattattctgggaaagatgtc attgatgaacaggggcaacgcaatttctccaaagctatcaatgtagcaaagcaagtcttc aacacgctgacagagtatatacagggcccatgcacaggaaatcagcagagtctagcccat agtcgcttatgggatgcagtggttggctttctgcatgtgtttgctcatatgcagatgaag ttgtctcaggattctagccaaattgatttgctgaaggagttaatggatctacaaaaagac atggttgtgatgttgctgtccatgttggaaggtaatgttgtgaatgggaccattggtaaa cagatggtggacatgctggtggaatcttccaacaatgtggagatgatactgaagttcttt gacatgttcctcaagcttaaagacctaacgtcctctgatgctttcaaagaatatgaccct gatgggaaaggggttatctcaaagcgagatttccataaagcaatggagagtcacaaacac tacacacaatctgaaacagacttcctgctctcctgtgtagagacagatgagaatgagact cttgactatgaggagtttgtggaaaggttccatgaaccagcaaaagacattggttttaat gtggctgtacttctaaccaacctttctgagcatatgccacatgattcacgccttcagact ttcttggagttggctgagagtgtacttaattacttccagcctttcttgggccgcattgag atcatgggtagtgccaagcgtatcgaacgtgtctactttgaaattagtgagtctagccgc acgcagtgggagaagccacaggtaaaagagtccaaacgacagtttatctttgatgttgtc aacgaaggtggtgagaaggaaaagatggagctttttgtcaatttctgtgaagacaccatt tttgagatgcagcttgcagcacaaatgtcagatgctagtgagcgcttggccagcaaggag gacacagagcgtggagaaaaacctgaggtggagagccctgagatgggcttcttctccgtt accactgtaaggacagcccttctagctctacgctataatgttctagtgttaatgaaagtg ctttccatgaagagcctgaagaaacaggtgaagagggccaagaaaatgacattgcaggac atggtgatggcactggcagccttttactggagtgtgctgattggacttctgcattttgca tttagcgtctcacgtgggttcttccgtattatatacaataccttccttgggggtaatctg ttggaaggtgccaagaccatgaaaatgtctgagctcataaccagcatgcctgacccaaca cacgaggaggtgcgtggggagcttgaagaaggtgtggaaaataaatcagtcgagaagccc ttgacaaaggaggacttagccgacctcactgttgctacagatgaaacagaacttctctca gacatctttggcttagatttacgaagagaagggggacagtacaagataatgcctcacaat ccaaatgccagcctgactgatttattaaatgccccaatacctcctcctagtccctcccct gagcttagaagacaacatcaggttaaagaagacaaaggaggaacagaagacagtaagcca gagccagagaaagcagcaggagaacgtgtggagaaagtagaagataaggaacagctaaag ccaaagcagaggatcagacaggtccatatctccaaatccgatgagccagacctgcaggaa tctgcattctgcaaaaaaatcattgtttaccagaggaagcttcttaactactttgccagg aacttctacaacatgaggatgttggcattgtttgtggcctttgctatcaactttatcctt ctcttctataaggtgtctacatcttctgctgtgatggaggagaaggaggtctttagaagc ccagtagatgcaggccttcactggaatcctctgggtgctacccctgaccgcaccatgact gtgcattttgtccttgaggaaagtagtggctatatggagcctactctgcgcatccttgcc atcctgcacacagtcatctcgttctgctgcatcatagggtactactgcctgaaggttccc ttggtgatcttcaagcgtgaaaaagaggtggctagaaagctggagtttgatggcctgtat attactgagcagccctcagaggatgacatcaaaggccagtgggataggctggtcatcaat actcagtcatttcctaataattactgggataagtttgtgaaaagaaaggtaatggacaag tatggggagttctatgggcatgaccgcatcagtgagctgctggggatggacaaagctgct ttggattttagtgatgcacatgagaagaagaagcccaaaaaggacagttcattagctgct gtaataaattccattgatttgaagtaccagatatggaaattaggagttgtcttcacagac aattccttcctgtatctggcctggtacatgacaatgtccatcctgggacactacaataac ttcttctttgcagctcacctcctggacatagccatgggtttcaagactttgaggacaatc ttgtcctctgttacccacaatggaaaacagttggtccttacagttggcttacttgcagta gtggtttatctttacactgtggtggccttcaacttcttccgcaaattctacaacaagagt gaggatggcgagtcaccagacatgaagtgtgatgacatgcttacatgctatatgttccac atgtacgtgggtgtgagggcaggaggtggcattggtgaccaaatagaggacccggctgga gatgaatacgagatttaccgtatcatctttgacatcaccttcttcttttttgttattgtc attctgctagccatcattcaaggtctcataattgatgcttttggtgaactgcgagaccaa caggaacaggtgaaggaagacatggagaccaaatgcttcatctgtggcatagggaatgat tactttgatactgtacctcatggctttgaaacacataccctgcaggagcacaacttggca aactatctattttttgtgatgtatctcattaataaagatgaaacagagcacaccggacag gaatcatatgtctggaaaatgtatcaggaacggtgctgggaatttttccctgcaggagac tgtttccgtaaacagtatgaagaccagctcaactag

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