Anolis sagrei ordinatus (Brown anole): 132761211 Help Entry 132761211         CDS       T09595                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism asao  Anolis sagrei ordinatus (Brown anole) Pathway asao04020   Calcium signaling pathway asao04260   Cardiac muscle contraction asao04261   Adrenergic signaling in cardiomyocytes asao04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:asao00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     132761211 (RYR2)    04020 Calcium signaling pathway     132761211 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     132761211 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     132761211 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:asao04040]     132761211 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:asao04990]     132761211 (RYR2) Ion channels [BR:asao04040]  Voltage-gated cation channels   Ryanodine receptor    132761211 (RYR2) Domain-containing proteins not elsewhere classified [BR:asao04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    132761211 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  132761211 NCBI-ProteinID:  XP_060609854 LinkDB All DBs Position Unknown AA seq 4955 aa AA seqDB search MAELGEGEDEIQFLRTDDEVVLQCTATAHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICNFVLEQSLSVRALQEMLANTEEKAEGLVDMEKWKFMMKSAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRTSMDKLAFDVGLQENTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLRVDAAFQQTLWSVAPISSGSEVAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEDQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWAQPFRLRHI TTGKYLSLMDDKSLLLTEKEKADVKSTAFCFRSSKEKLDIGIRKEVDGMGAPEIKYGDSV CFIQHVDTGLWLTYQSVDAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGETWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGISEGSAQYRKWYYELMVDHVEPFPTAEATHLRVGWASTEGYSPYPVGGEEWGGNGVGD DLYSYGFDGLHLWSGCVARAVNSPNQHLLRTDDVISCCLDLSTPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAILPKEKLKVEHSREY KKDHNDMRDLLGPNISLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFAKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEK VKKLKLPKNYLLSSGYKPAPMDLSCIKLTPSQESMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLIGYGYNLEAPDQDHAARTDMFSA MMEKFRIFRTEKTYAVKTGKWYFEFEAVTAGDMRVGWAKPGCQPEQELGSDEQAFVFDGF KAQRWHQGNEHFGRSWLTGDIVGCMVDLNERTMMFTLNGEILLDDSGSELAFKDFEVGDG FIPACSLGLSQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLP VPPNHEHIEVTSIDGTADSSPCLKVTQKSFGSQNSKTDIMFYRLSMPIECAEVFAKMPGG GVPNSNLFGPKNDMDDFDADSDFEVLMKTAHGHLVSDRVEKEVAKAEFNNHKDYTQEKPS RLKQRFMLRRTKPDYSTSHSTRLTEDVLADERDDYDYLMQTSTYYYSVRIFPGQEPANVW VGWITSDFHQYDTNFDLDRVRTVMVTLGDDKGKVHESIKRSNCYMVCAGESMSPGQGRNN NGLEIGCLIDAATGLLSFTTNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKN VMPLSAGLFKSEHKNPIPQCPPRLHVQFLTHVLWSRVPNHFLKVDISRVNERQGWSVQCL EPLQFMSLHIPEENRSIDILELSEQEELLRFHYHTLRLYSAVCALGNNRVAHAMCSHVDE SQLLYAIENKYMPGLLRTGFYDLLIDIHLNTYATARLMMNNEFIVPMTNETKSITLFPDE NKKHGLPGIGLSTSLRPRMQFSSPSFVRINNECYQYSPEFPLEILKAKTIEMLTEAVQEG SLHVRDPVGGTTEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPSVFKEDTGHENETR ILVKQPITEGLNSEGGEMVPAEGLLQMKLPEPVKLQMCHLLQYLCDCQIRHRIEAIVAFS DDFVAKLQENQRFRYNEVMQALNMSAALTAKKTKEFRSPPQEQINMLLNFKDDKNDCPCP EEIRDHLLDFHEDLMAHCGIQLDEDGYLDGNSDLTITGRLLYLVERIIHLKKKQAEKQVD DDSMKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGVGGLVQALPKTYTIN GVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHE TVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGL ASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLISKGYPDIG WNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEE AIDMSEDPSRDGPSPTNGSNKTLSEVEEEEDTIHMGNAIMTFYAALIDLLGRCAPEMHLI HAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSEGFCPDHKAAMV LFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTVALSATDMALALNRYLCTAVLPLLT RCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQMRPSMMQHLL RRLVFDIPLLNEHAKMPLKLLTNHYERCWKYYCLSGGWGNFGAASEEELHLSRKLFWGIF DALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVGVMEKQASMDSDGNFNPQPVDTS NITIPEKLEYFINKYAEHSHDKWCMEKFANGWIYGETYSESSKVQPLMKQYKLLTEKEKE IYRWPIKESLKTMLAWGWRVERTREGDTMALYNRPRRISQTSQVSVDTVHGYSPRAIDMS NVTLSRELHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEKAKDREK AQDILKFLQINGYVVSRGLKELELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSR GKGEQFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSSASRPLSSGGHASNKEKEMVTSLF CKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRTFLDNAAEDL EKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQI SCYRILGSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLNNHNTYSIYNTKT TKDRTGLSLPNSVEELCPNIPSLDKLMEEIVELAESGIRYTQMPHVMEVVLPMLCSYMSH WWEHGPESNPDKSEMCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIIS KVKPQLLKTHFLPLMEKLKKKAALVIADEEHLRAEGRGDMSETELLILDEFTILTRDLYA FYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNM SFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSLIVAALKRLLPVGLNICAPGDQEL IALAKNRLSMKDTEDEVRDIVRNNLHLQGKLEDPAIRWQVALYKDLPNRTEVTSDPEKTV VRVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLF LQGYDKSWVETEDHYFEDTLIEDLAKPGDEPPEEDECIKRVDPLHQLILLFSRTALTEKC KLEEDYLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMV LQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSC SVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDF QNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAK QVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDL QKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTFSDAFKE YDPDGKGIISKRDFQKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDI GFNVAVLLTNLSEHMPHDTRLQTFLELADSVLNYFQPFLGRIEIMGSAKRIERVYFEISE SSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNER SVNKEENENEKPEDQDPRMGFFSVVTIKSALIALRYNIMTLMKMLSMKSIKKQMKKMKKM TMKDMIMALFSSYWSIFMGLMHFISSVFRGFFQIICSLLLGGSLVEGAKKIKVAELLANM PDPTQDEVRGEGDEVERKPTEVALPAEDLTDLKALSEDSDLLSDIFGLDLKREGGQYKLI PHNPNAGLSDLLSSPSPLPLPEVKEKIQEQKVNEDEKHEREETKFEHEKGEGDDGEKEDK AKEEKGTQKPKQHHKHRHGELETQESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFA INFILLFYKVSTSAVVEEKDAPVVDIAENNKLSSLESPSHRIITVHYVLEESSGYMEPTL RILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDR LVINTQSFPNNYWDKFVKRKVMDKYGEFYGKDRISELLGMDKAALDFSDTREKKKPKKDS SLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKT LRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDMPDMKCDDMLTC YMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGE LRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETE HTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14868 nt NT seq  +upstreamnt  +downstreamnt atggctgagctgggcgaaggcgaggacgagatccagttcctccggactgatgatgaagtg gttcttcagtgcactgctaccgctcacaaagaacaacagaaattgtgccttgctgcagaa ggatttggcaacaggctttgcttcttggaatccacttcaaattccaagaatgttcctccg gatctctcaatctgcaattttgtgctggaacagtctttgtcagtgagagctctccaggaa atgttggctaatacggaggaaaaagcagaagggctagttgatatggaaaaatggaaattt atgatgaagtctgctcaaggtggcggtcatcggacgctcctttatgggcatgcaatattg ctgcgccattcttacagtggtatgtatctgtgctgcctctccacctcacgaacatcaatg gacaaactggcatttgatgtgggcttgcaagaaaatactacaggtgaggcttgctggtgg actatccaccctgcctccaaacagcgttcagaaggagaaaaagttcgtgttggggatgac cttatccttgtcagtgtctcttcagaaagatacttgcacttatcttatggcaatggcagc ttacgtgttgatgcagccttccagcaaacactttggagtgttgctccaataagttcagga agtgaagtagctcaaggttatctgataggaggcgatgtgctgagattattacatggccat atggacgaatgcctcactgttccttcaggagaacacggagaagaccaaagaagaactgtc cattatgaaggtggtgctgtgtcaattcatgcccgttctctttggcggctagagactctg agagttgcgtggagtggaagtcatattagatgggcacaaccattcagattaaggcatata actacagggaaatatttaagcctcatggatgacaagagtcttcttctaacagagaaagag aaagctgatgtgaaatctacggcattttgttttcggtcctccaaggaaaaattggatata ggaataaggaaagaggtggatggcatgggagcacctgagataaagtatggagattcagtc tgctttatacagcatgtcgacacgggtttgtggcttacgtaccagtcagtagacgcaaag tctgtaagaatgggatctgtgcaacgcaaagctatcatgcaccatgaaggccatatggat gatggcctaactttgtccagatcgcagcatgaagaatcacgtactgcacgagtaattcgt agtacagtcttccttttcaatcggttcataaggggccttgatgctctcagcaagaaagca aagtcttccactgttgacttacctattgagtcagtcagccttagcctccaggacttgatt ggttacttccatccacctgatgagcatttagagcatgaagacaagcagaaccgactaaga gcactgaagaatcggcagaatctcttccaggaagagggtatgatcaacttggtgcttgaa tgtattgatcgcttgcatgtctacagcagtgcagcacattttgctgatgtagcagggaag gaggcaggagagacttggaaatctattctaaactcattatatgaattgttagcggctttg attagagggaatcgtaaaaattgtgcccagttttctggatctcttgattggctcatcagt agattggaaagactggaagcatcttctggaattcttgaagttttgcattgtgtgttggtg gaaagtcctgaagcattaaatattatcaaagaagggcacattaaatcaattatatgcctg ttggacaaacatggaagaaaccataaggtgttagatgttttatgctctctgtgtgtatgt catggagtagctgtgagatctaatcaacatttgatctgtgacaatcttctgccaggaagg gatctacttctccagacacgccttgtcaaccatgtgagcagtatgagacccaatattttc cttggaatcagtgaagggtctgctcagtacaggaaatggtattatgaactaatggttgac cacgtggagccatttccaacagcagaagccactcaccttcgtgtgggctgggcgtcaaca gaaggctattcaccatatcctgtgggaggagaagagtggggaggtaatggtgttggtgat gatctatattcctatggtttcgatggacttcatctatggtcaggttgtgtagcaagagct gtgaattctcccaaccagcatttactaaggactgatgatgtgatcagctgctgccttgac ctgagtactccaagcatttcattccggataaatgggcagccagtccaagggatgtttgag aatttcaacatagatggtcttttcttcccagttgtcagtttttctgcaggaataaaggta cgctttttgcttggaggccgccatggggaatttaaatttcttccacctccaggatatgct ccttgttttgaggccattctgccaaaagagaaattgaaagtagaacacagcagagaatac aaaaaggaccacaatgacatgagggacctactgggtccaaatatttctttgtcacaagca gcttttacgccagtacctgttgataccagtcagattgtattaccaccacatttggaaaga attagagaaaaactggctgaaaacattcatgaactttgggttatgaataaaattgagctt ggatggcaatatggtcctgttagggatgacaacaagcgacagcatccttgtctggttgag tttgcaaagcttccagaacaagaacgaaattataacctgcaaatgtctctagaaacatta aaaaccttgctggcattaggatgtcatgttggaattgctgatgagcatgctgaagaaaaa gtgaagaaactaaagcttccaaagaactatttattgtctagtggctataagcctgctcct atggatctgagctgtatcaagctgaccccatctcaggaatccatggtggataaactggca gagaatgctcacaatgtgtgggcaagggatcgtatcagacagggttggacatatggaatc caacaggacgtgaagaaccgtcgaaaccctcgtcttgtaccctatacactccttgatgat cgcactaagaaatcaaataaagatagcctacgagaagcagttcgtacacttattggctat ggttataaccttgaggctccagatcaagatcatgctgctagaacagacatgttttctgct atgatggaaaagtttaggattttccgcacagagaagacatatgcagtgaaaactgggaaa tggtactttgaatttgaagcagtgacagcaggagacatgagagttggctgggccaagcca ggctgtcaaccagagcaagaacttggatcagatgaacaagcgtttgtatttgacggattc aaggctcaacgctggcaccaaggaaatgagcattttggtcgttcttggctgacaggggat attgtgggatgtatggttgatttgaatgagcgcactatgatgttcactctcaatggcgaa atccttcttgatgactcaggttctgagcttgcattcaaggattttgaggttggtgatggc tttatacctgcatgtagcttgggattgtcacaagttggcagaatgaactttggcaaagat gtcagcaccctgaaatatttcaccatttgtggtttacaagaagggtatgaaccttttgca gtgaatacaaaccgggacatcaccatatggctgagcaagcgattacctcagtttcttcca gtaccaccaaaccatgaacatattgaggttaccagcatagatggaactgcagacagctca ccatgcttaaaagttactcagaagtcatttggatctcaaaatagcaaaacagatatcatg ttctatcgtctcagcatgcccatagagtgtgcagaagtctttgctaaaatgcctggagga ggagtgccaaattccaatctttttggcccaaagaatgacatggatgattttgatgcagat tctgactttgaagtccttatgaagactgctcatggccatcttgtatctgatcgtgtcgaa aaagaagtggcaaaggcagaattcaataaccataaagactatacgcaagaaaaaccttca cgcctcaagcaaagatttatgctgagaagaacgaagccagactacagcacaagccactcc acaaggctcactgaagatgtcctagcagatgaaagagatgattatgattacttaatgcaa acttccacatattattattctgtgcggatcttcccgggacaagaacctgccaatgtctgg gtgggctggattacatctgatttccatcagtatgacacaaactttgatttggacagagtc cgcactgttatggtaaccctaggagatgataaaggaaaagttcatgagagtatcaaacga agcaattgctatatggtatgtgcaggagaaagcatgagtccaggacaaggacggaataac aatggattagagattggttgcttgatagatgctgcaactggccttctctccttcacaacg aacggcaaagagttaagcacctattatcaggttgaaccaagcactaaactatttcctgcg gtatttgcacaagctacaagccctaatgttttccagtttgagttgggaagaataaagaat gtcatgccattgtcagctggcttattcaaaagtgagcataaaaaccccattccccagtgc cctcctcgtctccatgttcagtttctgacgcatgtgctttggagtagagtgccaaaccat ttcctgaaggttgatatatcccgtgtcaatgagcgacaaggctggtcggtacagtgcctg gagcctttacagttcatgtcccttcatatcccagaggaaaacaggtctatagatatttta gagttgtcagaacaagaagaattattgaggtttcactaccacactcttcgtttgtactca gctgtctgtgctcttggtaacaaccgagttgcccatgccatgtgcagccatgttgatgaa tctcagcttctgtatgcaattgagaacaagtatatgccaggcttattacgtacaggtttt tatgatcttcttattgatattcaccttaatacttatgcgacggcaaggcttatgatgaac aatgaatttattgttccaatgacaaatgaaacgaaaagcattactttgtttcctgatgaa aacaaaaaacatggtctacctggcattggactcagcacttctttgcggcccagaatgcag ttttcctctcctagttttgtaagaattaacaatgaatgctaccagtatagtcctgaattt cctttggaaattttaaaggccaaaacaatagagatgctcacagaggcagttcaagaggga agtcttcatgtccgagatccagttggtggcaccacagagttcctgtttgttcctttgatc aagcttttttacacactacttataatgggaattttccataacggagacctgaagcatatt ttgcagctgattgaaccgagtgtctttaaggaagatacaggccatgaaaatgagactaga atactagtgaaacaaccaatcacagaaggattaaattcagaaggaggagagatggtccca gcagaaggacttcttcaaatgaaacttcctgagcctgtgaaactacagatgtgtcattta cttcagtacctttgtgactgtcagatccgccaccggatagaagccattgtagcattttca gatgactttgtagcaaaacttcaggagaatcagcgttttcgatacaatgaagtcatgcaa gcattaaatatgtctgctgcactgacagccaagaaaacaaaagaattccgttctccacca caggaacagattaatatgctgctgaattttaaagatgacaaaaatgattgtccttgtcct gaagaaataagggatcatctcctggattttcacgaagatttgatggcacattgtggaatt cagctagatgaagatggatacctggatggaaacagtgatttaacaattacaggtcgactg ctctatcttgtggaaaggatcatacatttgaaaaagaaacaagcagagaaacaagttgat gatgattctatgaaaccatcgactctccagcagttgatatcagagaccatggtacgatgg gctcaagaatcagtaatcgaagacccagaattggtgagggccatgtttgttttattacat cgccagtatgatggagttggtggcctagtccaagccttgccaaagacatacactattaat ggagtatcagtggaagatactatcaacttactagcatctcttgggcagatccgttctctc ctcagtgttagaatgggcaaggaggaagagaaacttatgattcgtggattaggggatatc atgaataacaaagttttttaccaacatcctaatcttatgagggcgctggggatgcacgaa actgtaatggaagtaatggtgaatgttcttggaggaggagagtcaaaggaaatcaccttt cctaagatggtggccaattgttgtcgctttttgtgctacttttgccgcattagtagacaa aatcaaaaggctatgtttgaccatcttagttatcttttggaaaacagcagtgttggtctt gcatccccttctatgcgtgggtcaacacctttagatgttgcagcagcttctgttatggac aacaatgaacttgcactagctttgagagagcctgatttagaaaaggtagtccgctacttg gctggatgtggtttgcagagctgtcctttgctgatctctaaaggctacccagatattggt tggaatcctgttgaaggagaacgatatctggattttcttcggtttgctgttttttgcaat ggagaaagtgttgaagagaatgctaatgtggtggtcaggttactcattcggcgtcctgag tgctttggaccagcactgagaggagaaggtggaaatggcttacttgctgccatggaggaa gccattgacatgtcagaagacccttcaagagatggaccttcaccaactaatggatccaat aaaacactaagtgaggtggaagaagaagaagatactattcacatgggaaatgccatcatg actttttatgctgctctgattgatctcctaggacgctgtgccccagaaatgcacctaatc catgctggcaaaggggaagccattagaatccgatctattctgcgatctttgattcctttg gaggatttggtgggtgtaattagcattcctttccatatgccaacaatagcaaaagatggt actgtggtggaacctgatatgtcagaggggttttgcccagaccacaaggcagccatggta ttattccttgacagggtctatgggattgaagatcaagattttcttctacatcttctagaa gttggctttctaccagaccttcgtgctgctgcttcattagatacggttgctctgagtgct acagacatggccctggctctcaatcggtacctctgcactgctgttttgcctttattaact agatgtgctcctctttttgctggcacagaacaccatgcttctcttatagattccttgcta cacactgtataccgactttccaagggctgttctcttaccaaagctcagcgggactctatt gaagagtgcctactctccatttgtggtcaaatgagaccttcaatgatgcaacatttattg agaagattagtatttgatattcctttgctaaatgagcatgcaaagatgcctcttaagttg ctgacaaatcattatgaaagatgctggaagtattactgtttatcagggggttggggtaac tttggtgctgcttcagaagaagaacttcatttgtccagaaagttgttctggggtattttt gatgccttatctcaaaagaaatatgaacaggaactattcaaactagctttgccctgcctg agtgcagtagcaggagcattacctcctgattacatggaatcaaattatgttggtgtgatg gaaaagcaggcttctatggattcagatgggaattttaatccacaacctgttgatacttca aacattacaattcctgagaaactagagtactttattaacaaatatgctgaacattcccat gacaaatggtgcatggaaaagtttgcaaatgggtggatatatggtgaaacatactctgaa tcttcaaaagtgcagccattaatgaaacaatataaactattaacagaaaaggaaaaagaa atttatagatggccaatcaaagagtctctgaaaaccatgcttgcttggggatggcgggtt gaaagaacaagggaaggcgatactatggctttatacaatagaccacgtcggatatcacag acaagtcaggtttctgtagatactgtccatggctatagtccccgtgcaattgacatgagt aatgttaccctctccagagaactgcatgctatggctgagatgatggctgaaaactatcat aacatatgggcaaagaaaaagaaaatggaacttgaggcaaaagtgggaggaggaaatcac cccttacttgttccctatgatacactgacggccaaagaaaaagcaaaggatagagagaaa gctcaagatatcctgaagttcctgcaaataaatggatatgtggtctctagaggtctaaag gagcttgagctagatacaccctccattgagaagcgatttgcttacagttttcttcagcag cttatacgatatgtagatgaagcccatcagtatattctggagtttgatggtggcagtaga ggcaaaggagaacaatttccttatgaacaagaaatcaagttctttgctaaagttgtactt cctttaattgatcagtatttcaaaaaccatcgactatatttcctctcctcagcaagcaga cccctcagcagtggtgggcatgcctctaacaaggaaaaagaaatggtaacaagcctattc tgcaaacttggagtacttgtcaggcataggatatcactgtttggaaatgatgcaacttca attgtcaattgtcttcatatcttgggtcaaaccttggatgcaaggacggtgatgaagaca ggtttggagtctgttaaaatggctttgagaacctttctggataatgctgcagaagatctg gagaaaacaatggagaaccttaaacaagggcaattcacacataccaggagtcaaccaaaa ggagtgacacaaataattaattacaccactgtagctctcctgccagtgctatcttccttg tttgaacatattggacagcatcaatttggagaagatctgatattggaagatgttcaaatc tcttgttacagaatattgggcagcttgtatgctctgggaaccagcaagagtatctacgtg gaacggcagcgttctgctctaggtgaatgcttagctgcttttgctggagcctttcctgtg gcatttttagaaactcacctaaacaatcacaacacgtattccatttataataccaagact acaaaagacagaacaggtctcagcttacccaacagtgtagaagagctctgtccaaacatt ccttctttagacaaactgatggaagaaattgtggaattagctgagtctggcattcgctat acacaaatgcctcatgtcatggaagttgtcttgcccatgctctgtagctacatgtcacat tggtgggaacacggaccagaaagcaatcctgacaagagcgaaatgtgctgcacggctttg acttccgaacatatgaatacacttctgggaaacatactgaaaatcatatataataacttg ggcatagatgaaggagcttggatgaagagattagcagtgttttctcagcctatcataagc aaagtgaagcctcagctcttaaagacacattttctgccactgatggagaagctaaagaaa aaagctgccctcgttattgctgatgaagagcacttaagagcagaaggcagaggagacatg tctgagacggaactccttatcctagatgagttcactatattaacacgtgatctctacgca ttctacccattgttgatcagatttgtggactacaacagagcaaaatggctgaaagaacct aaccctgaagctgaggacctgttccgtatggttgctgaagtattcatttactggtcaaaa tcacataattttaaaagggaagaacagaactttgttgtgcaaaatgaaatcaacaacatg tctttccttattactgacaccaaatccaagatgtccaaggcagctgtttcagatcaggaa agaaagaaaatgaagaggaaaggtgatcgttactcaacccagacttcccttattgtggca gctttaaaaaggttgttacctgttgggctaaatatttgtgcacctggggaccaagaatta attgcactggcgaagaacaggttaagtatgaaagacactgaagatgaagttcgagatatt gttcgtaacaaccttcacttacagggcaagcttgaagatcctgccattaggtggcaggta gccctttataaagatctaccaaacagaactgaagttacttcagatccagagaagacagta gttcgggttctcgatatagccaatgtgcttttccatctggaacaggttgagcatcctcag agatcaaaaaaagcagtatggcataaacttttatccaaacaaaggaaaagagcagtggtc gcttgtttcagaatggcacccctctataatcttccaaggcaccgggctgtcaatcttttt cttcaaggatatgacaaatcctgggtggaaacagaagaccactactttgaagatactctt atagaagatctagctaaacctggagatgagccaccagaggaagatgaatgcataaagaga gttgatcctttgcatcaacttattttactatttagtagaacagcattaacggaaaaatgt aaactggaagaagattacctttatatggcatatgctgatattatggcaaagagctgtcat gatgaagaagatgatgatggtgaagaggaggtgaagagttttgaagaaaaagaaatggaa aaacaaaaacttttgtaccagcaagcaagattgcatgatcggggagctgccgagatggtt cttcagacaattagtgctagtaaaggtgagatgggaccaatggttgcagctacactaaaa cttgggattgccatattgaatggtggaaattctactgttcaacagaaaatgcttgactac cttaaagacaaaaaggatgtaggattctttcagagccttgctggccttatgcagtcttgt agtgtacttgacctaaacgcttttgaacggcagaacaaagcagaaggccttggcatggtt acagaagaaggatcagtcatcactcatgagcgtggagagaaggtgatgcaggatgatgaa tttacttgtgacctcttccggttccttcagttactctgcgaagggcataactcagatttt caaaattacttgcggactcagactggtaacaatacaactgtcaatattatcatatcaact gtggattatttattgagagttcaggaatcaattagtgatttctattggtattattctgga aaggatgttatcgatgaacaaggacaacgtaatttctctaaagcaattcaagttgcaaag caggtcttcaatactcttacagaatatatccagggaccatgtacagggaaccagcagagc cttgcacatagcagactatgggatgcagtggttgggtttcttcatgtatttgcccatatg cagatgaagctctctcaggattctagccaaattgaattactaaaagaattaatggatctt cagaaggatatggtggtcatgctgctatcaatgttagaaggcaatgttgtgaatggaaca atcggcaagcagatggttgacatgctagtggaatcttccaacaatgttgaaatgatttta aagttttttgatatgttcctgaaactgaaggatttaactttctctgatgcatttaaagaa tatgatcccgatggtaaaggtattatttccaaaagagatttccagaaagcaatggaaagc cataagcactacactcagtctgaaacagaatttctgctctcttgtgctgaaacagatgag aatgagactctggattatgaggaatttgtgaaacggtttcatgagccagccaaagacatt ggcttcaatgttgctgttctcctgacaaacctgtcagagcacatgcctcatgatactaga ttacagactttccttgaacttgctgacagtgttctgaactattttcagccattcttaggg cgcatagaaataatgggcagtgcaaagcgcattgaaagagtatactttgaaataagcgaa tcaagtaggacacagtgggaaaagcctcaagtcaaagaatcgaagagacagtttatcttt gatgtggtcaatgaaggtggcgaaaaggaaaaaatggaactttttgttaatttctgtgaa gataccatctttgaaatgcaattggctgctcagatctcagagtcagatttgaatgagaga tcagtgaataaagaagagaatgagaatgagaagcctgaggatcaagacccaaggatgggc ttcttctctgttgtgactatcaaatctgctttgatagctctcaggtataacataatgact ctcatgaaaatgttgagcatgaaaagcataaagaaacagatgaagaaaatgaaaaaaatg acaatgaaagacatgataatggctttattttcttcttactggagcattttcatgggctta atgcattttatatcaagtgtcttccgaggcttctttcaaattatatgcagtttgctcctt ggaggaagcctggttgaaggagctaagaaaatcaaagtggctgaacttttagccaatatg cctgaccccactcaggatgaagtgcgtggcgaaggggatgaagtggaaaggaagccaaca gaagttgcattgcctgcagaagatctaacagatctcaaagccttatcagaagatagtgac ctcctctcagacatatttggcttggatttaaaaagagagggagggcagtataaactaatt cctcacaatccaaatgcaggcctgagtgatttgttgagcagtccttctccacttccttta cctgaagtgaaagagaaaatacaggagcagaaggtgaatgaagatgaaaaacatgagaga gaagaaaccaaatttgaacatgaaaaaggagaaggagacgatggagaaaaggaagataaa gcaaaagaagagaaaggaacacagaagccgaagcagcatcataaacataggcatggcgaa ctagaaacacaagaatcggccttctggaagaaaataattgcatatcaacagaagcttctt aattattttgctcggaatttctacaatatgaggatgctggctttgtttgttgcatttgcc attaacttcattctactattctacaaggtctcaacatctgcagtggttgaagaaaaagat gcccctgtggttgatattgctgaaaacaacaagctaagcagcctagaaagtccatcacat cgaatcattactgtgcactatgttcttgaagaaagcagtggttacatggaacctacactc cgtattttagccattctgcatacagtcatctccttcttctgcatcattggatactattgt ttgaaagttccactagttatatttaaacgagaaaaagaagttgcaaggaaattggaattt gatgggctatatattacagaacagccttcagaagatgatattaaagggcagtgggataga ctggtcatcaacacacagtcatttcctaacaactattgggacaagtttgtgaaaagaaag gttatggataaatatggagagttctatggtaaggacagaatcagtgagttgctcggaatg gacaaagccgcactggatttcagtgatacacgagaaaaaaagaagcccaaaaaagatagt tctttatcagctgtgttgaattctattgatgtaaagtatcagatgtggaaattaggagtt gttttcacagataattcttttctttacctggcctggtatatgaccatgtcaattcttggc cattacaacaactttttctttgctgctcaccttcttgacatagcaatgggattcaaaaca ttgcgaacaattctgtcatctgtgactcacaatgggaaacagcttgtgctgacagtgggc ttactggcagtggtagtttacctatacacagtagttgcattcaattttttccgcaaattc tacaataaaagtgaagatggagatatgccggatatgaaatgtgatgacatgctaacgtgc tatatgtttcacatgtatgtgggtgtccgtgctggtggtggcattggggatgaaattgaa gacccagcaggcgatgaatatgaaatctatcgaatcatttttgatattacatttttcttc tttgtaattgttattctactagctatcatacaagggttaattattgatgcattcggtgaa ttgagagatcagcaggagcaagttaaagaagacatggagaccaaatgttttatctgtggg ataggtaatgattacttcgacacagtgccccatggttttgaaacacacacattacaggag cacaacttggctaattatttatttttcctaatgtatctcatcaataaagatgaaacagaa catactggacaggaatcctatgtatggaaaatgtatcaggaaagatgttgggaatttttc cctgctggtgattgttttcgaaagcagtatgaagaccagcttaactaa

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