Actinoplanes sp. SE50/110: ACPL_6845
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Entry
ACPL_6845 CDS
T02044
Symbol
gcs2
Name
(GenBank) Carboxylate-amine ligase
KO
K06048
glutamate---cysteine ligase / carboxylate-amine ligase [EC:
6.3.2.2
6.3.-.-]
Organism
ase
Actinoplanes sp. SE50/110
Pathway
ase00480
Glutathione metabolism
ase01100
Metabolic pathways
Brite
KEGG Orthology (KO) [BR:
ase00001
]
09100 Metabolism
09106 Metabolism of other amino acids
00480 Glutathione metabolism
ACPL_6845 (gcs2)
Enzymes [BR:
ase01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
ACPL_6845 (gcs2)
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GFIT
Motif
Pfam:
CP_ATPgrasp_2
CP_ATPgrasp_1
GCS2
Zn_ribbon_Brz
Motif
Other DBs
NCBI-ProteinID:
AEV87727
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Position
7535875..7538415
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AA seq
846 aa
AA seq
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MAESLTLGAEEELHVVDVTTRELTPRAPEILDRLDPAHFSAELHRSVVETNTPVTTTLDG
LREGITQRRRTAVAVAESLGLGLVAAGTVPLVDLDALPVTGTTRYRRMLHEYQMLVREQL
ICGAQVHVGVPDRDEAVSVAQRVAPALPALLALSASSPFWMGEDSGYASVRSLVWMRWPT
AGDSGVLHSAAEHEQLVSDLIASETISDPKMVYFDVRPSAHVPTVELRVTDACPDVDTVV
LLAGLFRALVRRAQHEHRAGVPLPPARPPLHRAAMWRAARSGLEGDLLDLPRTPAPVPAT
VAIEHLVGELRPHLEELGDWEQVCDLSARALSRGSAAARQRRALARRGRIADVVDLLITD
TRGTAAASVAGGGLSGPDRLLPYDVAGDEAFPAESVAPEYAEVLPVLTALGATGLRKRED
ARDEEQRANGVTFSVAGEAATRLFPFDLVPRIVPAADWAELRAGLTQRVRALNAFLSDVY
DDRAIVAEGIVPEWVIDGSPELRASGALIGGGAVRAQVAGVDLVRDADGGWCVLEDNLRV
PSGIAYAMQNRRLTESILPELPRPRNLTPVEDTPALLKDALLAAAGPAAGDDPALVVLSQ
GPEDSAWFEHRMLAEAMDVPVVRTTELFVDGGRVHRLRDGKRYPVDVIYLRMGEDSLVHA
PGADGMPLGPSLVAALHARTVTLANALGNGIGDDKAVYAYVSRMIEFYLGEKPLLADVPT
YLCGVAEQRAEVLSRLDELVCKPVDGYGGDRIVIGPHATADELDALRRQIRAAPHRWVAQ
DLVRLSTHPVFDGQRLAPRHVDLRAFVFTGRQPVVAPAALTRVAPAGSMIVNSSRGGGSK
DTWLLS
NT seq
2541 nt
NT seq
+upstream
nt +downstream
nt
atggcggagtccctgaccctgggcgcggaggaggagctgcacgtcgtcgatgtgacgacg
cgcgagctcaccccgcgggccccggagatcctcgaccgactcgacccggcgcacttctcg
gccgagctgcaccgctcggtcgtggagaccaacacgccggtcaccaccaccctggacggt
ctgcgcgaaggcatcacgcagcgtcgccggaccgccgtggcggtcgccgagtcgctcggc
ctcggcctggtggcggccggcaccgtgccgctggtcgacctggacgcgctgccggtcacc
gggaccacccggtaccgccggatgctgcacgaataccagatgctggtccgtgagcagctg
atctgcggcgcccaggtgcacgtcggggtgccggaccgcgacgaggcggtctcggtggcg
cagcgggtcgccccggccctgcccgccctgctggcgctctccgccagctcgccgttctgg
atgggcgaggactccgggtacgccagcgtccgctcgctggtctggatgcgctggccgacc
gccggcgacagcggcgtgctgcactccgcggccgagcacgagcagctggtcagcgacctg
atcgcgtccgagacgatcagcgacccgaagatggtctacttcgacgtccggccgtccgcg
cacgtgcccaccgtggagctgcgggtcaccgacgcctgcccggatgtggacaccgtggtg
ctgctggccgggctgttccgcgccctggtccggcgcgcccagcacgagcaccgcgccggc
gtcccgctgccgcccgcccgtcccccgctgcaccgcgccgcgatgtggcgggcggcccgc
tccggcctggagggcgacctgctcgacctgccccgcacgccggcgccggtgccggccacc
gtcgcgatcgagcacctggtcggcgagctgcgaccgcacctggaggagctgggtgactgg
gagcaggtctgcgacctgtccgcccgcgcgctgagccggggcagcgcggccgcccggcag
cggcgcgccctggcccggcgcggccggatcgccgacgtcgtcgatctgctgatcaccgat
acccggggcacggcggcggcctccgttgccggcggcggcctgtccgggcccgatcgattg
ctgccgtacgacgtggccggcgacgaggcgttcccggcggagtcggtggcccccgagtac
gccgaggtgctgccggtgctcaccgcgctcggcgcgaccgggctgcgcaaacgcgaggac
gcgcgggacgaggagcagcgcgccaacggggtgaccttcagtgtggccggcgaggcggcc
acccggctgttcccgttcgacctggtcccccggatcgttccggccgccgactgggccgag
ctgcgggccgggctgacccagcgggtccgcgcgctcaacgcgttcctctccgacgtgtac
gacgaccgggcgatcgtcgccgagggcatcgtcccggagtgggtgatcgacggctcaccc
gagctgcgggccagcggcgcgctgatcggcggcggcgcggtgcgcgcccaggtggccggc
gtcgacctggtccgggacgcggacggcggctggtgcgtgctggaggacaacctgcgggtg
ccgtccggcatcgcgtacgccatgcagaaccgccggctgaccgagagcatcctgcccgag
ctgccccggccgcggaacctgaccccggtcgaggacaccccggccctgctcaaggatgcg
ctgctcgccgcggccgggccggccgccggcgacgacccggcgctggtcgtgctcagccag
ggcccggaggactcggcctggttcgagcaccggatgctggccgaggcgatggacgtgccg
gtggtgcgcaccaccgagctgttcgtcgacgggggccgggtgcaccggctgcgcgacggc
aagcgctatccggtcgacgtgatctacctgcggatgggcgaggacagcctggtgcacgcg
ccgggcgcggacgggatgccgctgggccccagcctggtggcggcgctgcacgcgcggacc
gtgacactggccaacgcgctgggcaacgggatcggggacgacaaggcggtctacgcgtac
gtcagccggatgatcgagttctatctgggtgagaaaccgctgctcgccgatgtgccgacc
tacctgtgcggggtcgccgagcagcgcgccgaggtgctgtcccggctggacgagctggtc
tgcaagccggtcgacgggtacggcggcgaccggatcgtgatcggcccgcacgccaccgcc
gacgagctggacgcgctgcgccggcagatccgcgccgccccgcaccggtgggtcgcgcag
gacctggtccggctttccacccacccggtcttcgacgggcagcggctcgcaccccggcac
gtcgacctgcgcgcgttcgtcttcaccggccgacagcccgtggtcgccccggcggcactg
acccgggtcgccccggccggctccatgatcgtcaattcgtcccggggcggcggctccaag
gacacctggttgctcagttga
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