KEGG   Actinomyces slackii: NCTC11923_01666
Entry
NCTC11923_01666   CDS       T06783                                 
Symbol
leuA_1
Name
(GenBank) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
asla  Actinomyces slackii
Pathway
asla00290  Valine, leucine and isoleucine biosynthesis
asla00620  Pyruvate metabolism
asla01100  Metabolic pathways
asla01110  Biosynthesis of secondary metabolites
asla01210  2-Oxocarboxylic acid metabolism
asla01230  Biosynthesis of amino acids
Module
asla_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:asla00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    NCTC11923_01666 (leuA_1)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    NCTC11923_01666 (leuA_1)
Enzymes [BR:asla01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     NCTC11923_01666 (leuA_1)
SSDB
Motif
Pfam: HMGL-like IPMS_D2 LeuA_dimer NblA
Other DBs
NCBI-ProteinID: VEG75014
UniProt: A0A448KDJ7
LinkDB
Position
1:1977493..1979286
AA seq 597 aa
MRTAPPAPQQPSGMPYAKYLPFVETLATDLPDRTWPTRRITQAPRWLSTDLRDGNQSLIE
PMGPAAKRAIFDLLVGMGFKEIEIGFPAASQTDYDFVRSLVDDDAIPADVTISVLTQSRG
DLIDRTLDACVGIPRATIHLYNAVAPLFRDVVFRMDRGQVRDLAVEGTRQVMARAEKVLG
EETIVGFEYSPEIFVDTEREYALEVCSAVMDVWEPGQGREIILNLPATVERATPNVYADQ
IEWMSRNLPHREHVCLSLHNHNDRGSGVAATELGLLAGGQRVEGCLFGHGERTGNVDLVT
LALNLFSQGVDPMLDISDIDHIRRTVEQATGMDVPPRTPYSGDLVYTSFSGSHQDAIKKG
FAARAAKVQAQRDQGLDEAAAETAVPWQMPYLPIDPHDVGRSYEAVVRVNSQSGKGGVAY
LLGATRKLDLPRRLQIEFSRIVQRHTDTYGGEVDAMTLWRIFADEYLPAHGAHDSEGLDG
LEPWGRYELAGATLTSAGSGQDSELTVTIRDSGQETTLTAQGSGPVDAFVTALETTGIQV
RILDYAEHALSQGRDAQAASYVECEVGGQVLWGVGIDASITTASFKAIISAVNRALR
NT seq 1794 nt   +upstreamnt  +downstreamnt
atgcgcaccgcaccccccgcacctcagcagccctccggcatgccctacgccaagtacctc
cccttcgtcgagaccctcgccacggacctgccggaccgcacctggcccactcgtcgcatc
acccaggccccccgctggctgtccaccgacctgcgcgacggcaaccagtccctcatcgag
cccatggggccggccgccaagcgcgccatcttcgacctgctcgtgggcatgggcttcaag
gagatcgagatcggcttcccggccgcctcccagaccgactacgacttcgtgcgctccctg
gtcgatgacgacgccatcccggccgacgtcaccatctccgtgctcacccagtcccgcggc
gacctcatcgaccgcaccctggatgcctgcgtgggcatcccgcgggccaccatccacctc
tacaacgccgtggcccccctcttccgcgacgtcgtcttccgcatggaccgcggccaggtc
cgcgacctggccgtcgagggcacccgccaggtcatggcccgagccgagaaggtcctgggg
gaggagacgatcgtcggcttcgagtactccccggagatcttcgtggacaccgagcgcgag
tacgccctggaggtgtgcagcgccgtcatggacgtgtgggagcccggccagggccgcgag
atcatcctcaacctgcccgccacggtcgagcgcgccacccccaatgtctacgccgaccag
atcgagtggatgagccgcaacctgccccaccgcgagcatgtgtgcctgtccctgcacaac
cacaacgaccgcggctcgggcgtggccgccaccgagctgggcctgctggccggcggccag
cgggtcgagggctgcctgttcggccatggcgagcgcaccggcaacgtggacctggtgacc
ctggccctcaacctgttcagccagggagtcgaccccatgctggacatctccgacatcgac
cacatccgccgcaccgtggagcaggccaccggcatggatgtgcccccgcgcaccccctac
tccggcgacctggtctacacctccttctccggctcccaccaggacgccatcaagaaggga
ttcgccgcccgcgccgccaaggtccaggcccagcgcgatcagggcctggatgaggcggcg
gccgagaccgccgtgccctggcagatgccctacctgcccatcgacccccacgatgtgggg
cgctcctacgaggccgtggtgcgcgtcaactcccagtccgggaaggggggcgtggcctac
ctgctgggcgccacccgcaagctcgacctgccgcgccgcctgcagatcgagttctcccgg
atcgtccagcgccacaccgacacctacggcggggaggtggatgccatgaccctgtggcgc
atcttcgccgatgagtacctccccgcccacggcgcccacgactccgagggcctggacggg
ctggagccgtggggccgctacgagttggcgggggcgaccctgacctcggcgggctcgggc
caggactccgagctgacggtcaccatcagggactccggccaggagacgaccctgaccgcg
cagggcagcggccccgtggacgccttcgtcaccgccctggagaccaccggcatccaggtg
cgcatcctggactacgccgagcacgccctgagccaggggcgcgacgcgcaggccgcctcc
tatgtggagtgcgaggtcggtgggcaagtcctgtggggcgtgggcatcgacgcctccatc
accaccgcctccttcaaggccatcatctcggccgtcaaccgcgccctgcgctga

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