Apodemus sylvaticus (European woodmouse): 127667249
Help
Entry
127667249 CDS
T10613
Symbol
Lrrk2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
asyl Apodemus sylvaticus (European woodmouse)
Pathway
asyl05012
Parkinson disease
asyl05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
asyl00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
127667249 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
127667249 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
asyl01001
]
127667249 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
asyl04131
]
127667249 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
asyl04147
]
127667249 (Lrrk2)
Enzymes [BR:
asyl01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
127667249 (Lrrk2)
Protein kinases [BR:
asyl01001
]
Serine/threonine kinases: TKL group
LRRK family
127667249 (Lrrk2)
Membrane trafficking [BR:
asyl04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
127667249 (Lrrk2)
Exosome [BR:
asyl04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
127667249 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR-B
Ras
COR-A
LRR_14
WD40_CDC20-Fz
Beta-prop_RSE1_2nd
WDR55
Beta-prop_WDR36-Utp21_1st
Beta-prop_EML_2
LRR_13
Arf
Ank_2
LRR_9
ABC_tran
Beta-prop_WDR19_1st
nSTAND3
MMR_HSR1
AAA_22
T2SSE
LRR_NXF1-5
GTP_EFTU
PduV-EutP
Beta-prop_EML
G-alpha
AAA_16
Beta-prop_WDR5
Kdo
HEAT_EZ
AAA_7
TPR_IPO5
Ank_3
Beta-prop_RIG_2nd
TniB
NACHT
MobB
Gtr1_RagA
LRR_6
Arm
AAA_29
WD40_Prp19
FtsK_SpoIIIE
NB-ARC
TrwB_AAD_bind
AAA_18
cobW
ARM_CUL7_CUL9
nSTAND_NTPase5
Motif
Other DBs
NCBI-GeneID:
127667249
NCBI-ProteinID:
XP_052016149
LinkDB
All DBs
Position
17:60349154..60492049
Genome browser
AA seq
2527 aa
AA seq
DB search
MASGACQGCDEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDMLVFTYSDRASKLFEGK
SFHVPLLIVLDSYMRVASVQQAGWSLLCKLIEVCPGTLQSLIGPQDIGNDWEVLGIHRLI
LKMLTVHHANVNLSIVGLKALDLLLDSGKITLLILDEECDVFLLVFDAMHRYSTNDEVQK
LGCKALHVLFERVSEEQLTEFVENKDYVILLSTFGSFRRDEEIVHHVLCCLHSLAVTCSN
VEVLMSGNVRCYNIVVEAMKAFPTSEKIQEVSCSLLHKLTLGNFFNILVLNEVHVFVVKA
VRQYPENAALQISALSCLALLTETIFLNQDLEERSETQEHSDEEDNEKLFWLEPCYKALM
RHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAA
AHALSTLLEQNVNFRKILLAKGVYLNVLELMQRHAHAPEVAESGCKMLNHLFEGSNPSLD
TMAAVVPKILTVMIAHGTSLSVQLEALRAILHFVVPGISEESRDDSQCKLNVLRKQCFRT
DIHKLVLAALNRFIGNPGIQKCGLKVIASLVHLPDAIETLSMHGAVDTVLHTLQMYPDDQ
EIQCLGLHLMGCLMTKKNFCIGTGHLLAKILVSTLQRFKDVGEVQTTGLQTILSILELSV
SFSKLLVHYSFDVVIFHQMSSSVVEQKDEQFLNLCCKCFAKVAVDDALKSTMLERACDQN
NSIMVECLLLLGADANQVKGTTSLIYQVCEKESSPKLVELLLNGGCREQDVRKALTVSIQ
KGDSQVISLLLRRLALDLANNSICLGGFCIGKIDPSWLGPLFPDKSSNLRKQTNTGSVLA
RKVLRYQMRNVLQEGVASGSDGNFSEDALARFGEWSFIPDSSMDSVFGQSDDLDSEGSES
SFLLKRKSNSISVGEVYRDPALQRCSPNAQRHSSSLGPVFDHEDLLRRKRKILSSDESLR
PSRLQSHMRQSDSSSSLASEREHITSLDLSANELKDIDALSQKCCLSSHLEHLTKLELHQ
NSLTSFPQQLCETLKCLTHLDLHSNKFASFPSFLLKMPSITNLDASRNDIGPTVVLDPAV
KCPSLKQFNLSYNQLSSIPDNLAQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNH
IPALPEDFLKACPKVESFSARVNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRS
LDMSHNNIEYLPGPAHWKSLNLRELIFSKNQISTLDLRENPHVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNSELRSFPNEMGKLSKIWDLPLDGLPLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKPELGVQGATVGIDVRDWSIQI
RGKRKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPTIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPVEFPVINRKHLLQLVRDH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLK
HPKGIISRRDVEKFLSKKKRFPKSYMMQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNRPESFLKITVPSGRKGCILLGRVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLHDIWTTGSRIMEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRYISIPKNITVECMVATNL
NSKNATLWLGCGNTEKGQLSLFDLNTERYSYEEVTDSRILCLALVHLAAEKESWIVCGTQ
SGALLVINAEDETKRHTLEKMTDSVTCLYCNSFAKQSKQSNFLLVGTADGNLMIFEDKTI
KCQGAAPLKMLRIGDVSTPLMCLSASMNSSERHITWGGCGTKIFSFSNDFTIQKLIETRT
NQLFSYSAFSDSNIIAVAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKI
NKESKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMAT
AQLGNLKNVMLVLGYKRKSTEGTQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADK
MRKTSVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggagcctgtcagggctgcgacgaggaagaggaggaggaggctctgaagaag
ttgatagtcaggctgaataatgtccaggaaggcaagcagatcgagacattgcttcagcta
ctggaggacatgctggtgttcacctactccgatcgcgcctccaagttatttgaaggtaaa
agtttccacgtgcctctgttgattgtcctggactcctacatgagagtcgccagcgttcag
caggcggggtggtcacttctgtgcaaattaatagaagtctgtccagggacattgcaaagc
ttaataggaccccaggatattggaaatgattgggaagtccttggtattcaccggctgatt
cttaaaatgttaaccgttcatcatgccaatgtaaacctgtcaatagttggactaaaagcc
ttagatctcctactagattcaggtaaaatcaccttgctgatattggatgaagaatgtgat
gtgttcttgttggtttttgatgccatgcacagatattcaaccaacgatgaagtccagaaa
cttggatgcaaggctttacacgtgctgtttgagagagtttccgaggaacaactgactgag
tttgttgagaacaaagattacgtgatactgctgagcaccttcggcagcttcagaagggac
gaggagatcgtgcaccacgtactttgctgcttgcattccctggcggttacctgcagcaat
gtggaggttctcatgagtgggaacgtcaggtgttacaatatcgtggtggaagccatgaaa
gcattccccacgagtgaaaaaattcaagaggtgagctgctccttgctccacaagcttaca
ttaggtaattttttcaacatcctggtgttgaatgaagtacacgtctttgtagtgaaagct
gtccggcagtatcctgagaacgcagccttacagatctcggcactcagctgtttagcgctt
ctcactgagactattttcttaaaccaagacttggaggaaagaagtgagactcaggagcac
agcgatgaggaggacaatgagaaacttttctggttggaaccctgctataaagccctgatg
cgccatcgaaagaacaaacacgtgcaggaagccgcctgctgggccctaaataatctcctg
atgtaccagaacagtttgcatgagaagataggagacgaagatggccagttccccgcacac
cgggaagtgatgttgtctatgctgatgcactcttcttccaaagatgtcttccaagcagct
gcgcatgctctgtccactctcttggaacaaaatgttaatttcaggaaaatcctgctggca
aaaggagtgtacctgaatgtcttggagttgatgcagaggcatgcccatgctcctgaggtg
gcagagagtggctgcaagatgctgaatcatctgtttgaaggaagtaacccttctctggat
actatggctgcagtggtccctaaaatcctcacagtgatgatcgcccacgggacatctctg
tcagtccagctggaggcgctgcgagctatattgcattttgtggtaccagggatatcagaa
gaatccagggatgactctcagtgcaaactgaacgtgctcagaaaacagtgcttcaggact
gacatccacaagctggttctagccgctctgaacaggttcattggaaatcctgggattcag
aaatgtggattgaaagtaatcgcttctctcgtgcatcttcctgatgccatagagacgtta
tccatgcatggtgcagttgacacagtcctccacaccttacagatgtatccagatgaccaa
gaaattcagtgtctgggcttacaccttatgggatgcttgatgacaaagaagaatttctgc
atagggacaggacacctcctggcgaaaattctggtttccactttgcagcgatttaaagat
gttggtgaagtgcagactacaggattacagacaatcttgtcaatactcgaactgtcagta
tctttctccaagctgctagtgcactattcatttgatgtggtcatatttcatcagatgtct
tccagtgttgtggaacaaaaggatgagcagttcctcaacttatgttgcaaatgctttgca
aaagtggctgtggatgatgcgctgaaaagcacgatgctagagagagcctgcgatcagaat
aacagcatcatggttgagtgcttgctcctcttgggagctgatgccaatcaagtgaagggg
acaacttctttaatctatcaggtatgtgagaaagaaagcagtcctaaattggtggaactg
ttacttaatggtgggtgccgtgaacaagatgtacggaaagccctgacagtcagcatccaa
aagggcgacagccaagtcatcagcttactcctgaggagactggccctggacctggccaac
aacagcatttgccttggaggattttgcataggaaaaattgacccttcttggcttggtcct
ctatttccagataagtcatcaaatttaaggaagcaaacaaacacaggatctgtcctagct
agaaaagtgctccggtatcagatgagaaatgtccttcaagaaggtgtggcttcaggcagt
gacggcaacttctctgaagatgcgctggcgagatttggtgaatggtccttcattccagac
tcttctatggacagcgtgtttggccagagtgatgatctggatagcgaaggcagcgagagc
tcatttctcttgaagaggaagtccaactcgattagtgtaggagaagtttacagagaccca
gccctgcagcgctgctcaccaaatgctcagaggcattccagttcactgggtcctgttttt
gatcatgaagatttactgagacgaaaaagaaaaatactgtcttcagatgagtctctcagg
ccctcaaggctgcagtcccacatgaggcaatcggatagctcttcttccctggcttctgag
agagaacatatcacgtcgttagacctatctgccaacgaactgaaagatatcgatgctctg
agccagaagtgctgcctcagtagccacctggagcatctcaccaaactggaacttcaccag
aactcactcacgagcttcccacagcagctgtgtgagactctgaagtgtttgacacatttg
gatttgcacagtaacaaatttgcctcatttccctccttcctgttgaaaatgccaagtatt
accaaccttgatgcctctcgaaatgacatcggaccaacagtagttttagaccctgcagtg
aagtgtccaagcctcaaacagttcaacctgtcctacaaccagctctcttccatcccagac
aatctcgcccaagtggtggagaaactcgagcagctcctactggaaggaaataaaatatct
gggatttgctctcccttgagcctgaaggaactgaagattttaaatcttagtaaaaaccac
attccagccctacctgaagactttcttaaggcttgtccaaaagtagagagtttcagtgcc
cgagtgaattttcttgccgccatgcctgccttaccttcctccataacaagcttaaaattg
tctcaaaactctttcacgtgcattccagaagcaattttcagtcttccacacttgcggtcc
ttggatatgagccacaacaacattgagtatctaccaggacctgcacattggaagtctctg
aacttacgggaactcatttttagcaagaatcagatcagcaccttagatttgagggaaaac
ccacacgtatggtcaagagtagagaaactgcatctctctcacaataaactaaaagagatt
cctccagaaattggctgtcttgaaaatctgacatccctcgatgtcagttacaactcggaa
ctgaggtcctttcctaatgaaatggggaagttaagcaaaatatgggatcttcccttggat
ggactgcctctgaattttgactttaagcacgtgggatgcaaagccaaagacatcataagg
tttctacagcagcgtctgaaaaaggctgtaccctacaaccgcatgaagctcatgattgtg
ggaaacacagggagcggcaagaccacactactgcaacaactcatgaaaatgaagaaacca
gaacttggcgtgcagggcgccaccgtcggcatcgacgtgcgagactggtccatccaaatc
cgaggcaaaaggaaaaaggaccttgttctaaacgtgtgggattttgcaggtcgtgaggag
ttctacagcactcacccacactttatgacccagagagctctctacctggctgtctatgac
ctcagcaaggggcaggcggaggtggatgccatgaaaccctggctcttcaatatcaaggca
cgtgcttcttcttccccggtgattctggtgggcacacacttggatgtttctgacgagaag
cagcgcaaagcctgcataagcaaaatcacgaaggaactcctaaataagcgaggattcccc
accatccgggactaccactttgtgaatgccacggaggagtcggatgcgctggcgaagctt
cggaaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgtggttgga
cagctaattccagattgctacgtagaactggagaaaatcattttatcagagcggaaagct
gtgcccgtcgagtttcctgtaattaaccggaaacacttactgcagcttgtgagagaccat
cagctgcagctggatgagaatgaacttccacacgctgtccatttcctaaacgagtcggga
gttcttctgcattttcaagatcccgcattgcagctaagtgacctgtactttgtggaaccc
aagtggctttgtaaagtcatggcccagattttgacagtgaaagtggacggctgcctgaaa
catcctaagggtatcatttcccggagagatgtggaaaagttcctttcaaagaaaaagcga
ttccccaagagttacatgatgcagtactttaaactattagaaaaattccagatcgcgttg
ccaataggggaagaatatctgctggttcctagcagcttatctgaccacaggcccgtgata
gagctccctcactgtgagaactctgagatcatcatccggctgtacgaaatgccatacttt
cccatgggattttggtcaagattgattaaccgattacttgaaatctcacccttcatgctt
tctggacgagagagagcgctacgcccaaacagaatgtactggcggcaaggaatctacttg
aattggtctccagaagcatattgtctggtaggctctgaagtcttagacaatcgcccagag
agtttcttgaaaattacggttccatctggaagaaaaggttgtattcttttgggccgagtt
gtggatcatattgactcactaatggaagaatggtttcctgggttgctggagattgacatt
tgtggggaaggagaaactctgttgaaaaaatgggccttgtacagttttaatgacggtgaa
gaacatcagaagatcttgcttgatgagctgatgaagaaggctgaagaaggggacctgtta
ataaatccagatcaaccaaggctcactattccaatatcccagattgctccagacttgatc
ttggccgacctgcctagaaatattatgttgaacaatgatgagctggaatttgaggaagca
cccgagtttctcttaggggacggaagctttgggtcagtttatcgagctgcctacgaagga
gaggaagtggccgtgaagatttttaataagcacacatcactcaggctcttaagacaggag
ttggtggtactttgccacctccaccatcccagcctgatatccttgctggcagctgggatt
cgtcctcggatgttggtaatggagttggcctccaagggttccttggatcgcctgctgcag
caggacaaagccagcctcaccagaaccctccagcacaggatcgcgttgcatgtggccgat
ggcctgaggtatctccactcagccatgataatttaccgtgacctgaagccccacaacgtg
ttgctttttaccctgtatcccaacgctgccatcattgcgaagattgctgattacgggatc
gcacagtactgctgcaggatgggcataaagacgtcagagggcaccccagggttccgggct
cctgaagttgccagaggaaatgtcatttataaccaacaggccgatgtttattcctttggc
ttactacttcatgatatttggacaactgggagtaggatcatggagggtttgaagttccca
aatgagtttgatgagttagccatacaagggaaattgccagatccagttaaagaatatggc
tgtgccccatggcctatggttgagaagttaattacaaagtgtttgaaagaaaatcctcaa
gaaagacccacttctgcccaggtctttgacattttgaattcagctgaattaatttgcctc
atgagatacatttcaatacctaagaacattactgttgaatgcatggttgctacaaatctc
aatagcaagaatgcaactctctggttgggttgtgggaacactgaaaaaggacagctttcc
ttatttgacttaaacacggagagatacagctatgaggaagttactgatagtagaatactg
tgtttagctttggtgcatcttgctgctgagaaagaaagctggattgtgtgtgggacacag
tctggggctctcctggtcatcaatgctgaagatgagacaaagagacatacacttgaaaag
atgactgattctgttacttgtttgtattgcaattcctttgccaagcagagcaagcaaagt
aactttcttttggtgggaactgctgatggtaacttaatgatatttgaagataagaccatt
aagtgccaaggcgctgcccccctgaagatgctacgcataggcgacgttagtacacccctg
atgtgcctgagcgcgtccatgaattcatctgaaagacacatcacatggggaggatgtggc
actaagatcttctccttttccaatgacttcaccattcagaaactcatcgagacaaggacc
aaccagctgttttcttattcagctttcagcgattctaacatcatagcggtggcagtagac
acagctctctatattgccaagaaaaatagccctgtggtagaggtgtgggacaagaaaaca
gaaaagctctgtgaattaatagactgtgtgcacttcttaaaggaggtgatggtaaaaata
aacaaggaatcgaaacataagctgtcctactctgggagggtgaaggcactctgcctgcag
aagaacacggccctctggatcggaactggaggaggccacatcctactcctggatctttcc
actcggcgagttatccgcaccattcacaatttctgtgattctgtgagagccatggccaca
gcacaattaggcaaccttaaaaatgtcatgctggttttggggtacaagcggaagagtaca
gagggtacccaagaacaaaaagagatacaatcttgtttgtctatttgggacctcaatctt
ccacacgaagtacaaaatttagaaaaacacattgaagtaagaacagaattagctgataaa
atgaggaaaacatctgttgaatag
DBGET
integrated database retrieval system
