KEGG   Apodemus sylvaticus (European woodmouse): 127687648
Entry
127687648         CDS       T10613                                 
Symbol
Plce1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
  KO
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Organism
asyl  Apodemus sylvaticus (European woodmouse)
Pathway
asyl00562  Inositol phosphate metabolism
asyl01100  Metabolic pathways
asyl04014  Ras signaling pathway
asyl04015  Rap1 signaling pathway
asyl04020  Calcium signaling pathway
asyl04024  cAMP signaling pathway
asyl04070  Phosphatidylinositol signaling system
asyl04919  Thyroid hormone signaling pathway
asyl04933  AGE-RAGE signaling pathway in diabetic complications
asyl05205  Proteoglycans in cancer
Module
asyl_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:asyl00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    127687648 (Plce1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    127687648 (Plce1)
   04015 Rap1 signaling pathway
    127687648 (Plce1)
   04020 Calcium signaling pathway
    127687648 (Plce1)
   04070 Phosphatidylinositol signaling system
    127687648 (Plce1)
   04024 cAMP signaling pathway
    127687648 (Plce1)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    127687648 (Plce1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    127687648 (Plce1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    127687648 (Plce1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:asyl04131]
    127687648 (Plce1)
Enzymes [BR:asyl01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     127687648 (Plce1)
Membrane trafficking [BR:asyl04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    127687648 (Plce1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    127687648 (Plce1)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y RasGEF RA C2 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 127687648
NCBI-ProteinID: XP_052042434
LinkDB
Position
1:complement(23021909..23321001)
AA seq 2279 aa
MTSEEMAASSVLIPVTQRKVASAQSVAEERSEKVSEAAIPKARTGRQDARIPRTLSQWNK
PEEESSRSDLSNVFSIARGRLVSDENHNEKCWEGTEPDSAKNHAVNCNSLVQSHWRACDS
VTEEDLCLQPGIPSPLERKAFPGIQLEMEDSPMDVSPLGNQPGILESRGPHSDGNTAVFH
FHYEADRTMSDAFHTLSEKLILDDCANCVSLPGGQQNKNCMAYTCKLVELTRACGSKNGQ
LKCDHCTSLRNEYLCFESSCPKAADDYEDDASGGGFCEDRFAHGSAAKTFLSPLEDFSDN
CEDVDDILKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIMRTLPSGHIGPVAWNYVDQK
KAGLTWPCGNVTGPLSTMDTRQSGRPSLSEAQWCLIYSAVRRGEETEDTVGSLLHFSTQL
PNSETAHGRIRDGPCLKQCVRDTECEYRATLQRTSIAQYITGSLLEATTSLGARSGLLSS
FGGSTGRIMLKERQPGTSMASSNPVPSSSAGISKELIDLQPLIQFPEEVASILTEQEQNI
YRRVLPMDYLCFLTRDLSSPECQRSLPRLKASISESILTSQCGEHNALEDLVMRFNEVSS
WVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQS
DIETMRSLKDVMAQHESSVEYKKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLLKL
CPRYSSQEEALEFVADYSGQDNFLQRVGQNGLKNSEKELTVNSIFQIIRSCSRSLEMEEE
DGASEGNGSRKNSLKDKTRWQFIIGDLLDSENDIFEKSKECDPHGSEESQKAFDHGTELI
PWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWMKPPTASPAGARP
KLSVLSSMAEPNKFPSLGNAGVNGLAEGILDLFSVKAVYMGHPGIDIHTVCVQNKLSSML
LSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTTAVRKIRKFPDQRQQWLRKQ
YVSLYQEEGRYEGPTLAHAVELFGGRRWSTRNPSPGMSAKNAEKPSMQRNNTLGISTTKK
KKKTLMRGESGEVTDDEMATRKAKMYRECRSRSGSDPQDVNEQEESEANVITNPPNPLHS
RRAYSLTTAGSPNLATGMSSPISAWSSSSWHGRIRGGLKGFQSFMVSDSNMSFIEFVELF
KSFSIRSRKDLKDIFDIYSVPCNRSASESAPLYTNLTIEENTSDLQPDLDLLTRNVSDLG
LFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIYGVGILQLNDFLVNCQGEHCT
YDEILSIIQKFEPSISMCHQGLLSFEGFARFLMDKDNFASKNDESQENKKELQLPLSYYY
IESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPF
KEVVEAIDRSAFITSDLPIIISIENHCSLPQQRKMADIFKSVFGEKLVAKFLFETDFSDD
PMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQAQAFTGGNANPPPASNEEE
EDEEDEYDYDYESLSDDNILEDRPENKSCTDKLQFEYNEEVPKRIKKADNSSGNKGKVYD
MELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNSSGSSRGKERKSRKSIFG
NNPGRMSPGETASFNRTSGKSSCEGIRQTWEESSPLSPSTSLSAIIRTPKCYHISSLNEN
AAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPL
HLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLGTMDPAIYSLTIISGQNVCP
SNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFEDLVFLRFAVVEN
NSSAITAQRIIPLRALKRGYRHLQLRNLHNEILEISSLFINSRRMEENPSGSTMPASLMF
NTEERKCSQTHKVTVHGVPGPEPFAVFTINEGTKAKQLLQQILAIDQDTKLTATDYFLME
EKHFISKEKNECRKQPFQRAVGPEEDIVQILNSWFPEEGYVGRIVLKPQQETLEEKSIVH
DDREVSLSPEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILNNPN
PCDYVLLEEVVKDTSNKKSSTPKSSQRILLDQECVFQAQSKWKGAGKFILKLKEQVQASR
EDKRRGISFASELKKLTKSTKQSRGLTSPPQLVASESVQSKEEKPVGTLAPSDAVGYQP
NT seq 6840 nt   +upstreamnt  +downstreamnt
atgacgtccgaagaaatggccgcttcctccgtcctcatccctgtgactcaaaggaaagtg
gcttctgcccagtcagtggcagaagagaggagtgaaaaggtctcagaagccgctattccg
aaggctcgcactggcaggcaggatgcgcgcatccctcgcaccctctcacagtggaacaaa
cctgaggaagagtcttctagaagcgatttgtccaatgtcttctcgatagcgagggggcgg
ctcgtcagcgatgagaatcacaacgaaaagtgctgggagggaactgaaccggattccgcg
aaaaaccacgcggtgaactgcaacagcctagtgcaaagccactggcgagcctgtgactcg
gtcacagaagaagacctgtgtttgcagcctggaattccttctccactggaaaggaaggcg
ttccctggaatccagctggagatggaggactctcccatggacgtgagcccgttgggaaat
cagcctgggatcctggagtcccgcggacctcactctgatggcaacacggcggtatttcat
ttccattacgaagctgataggacaatgtcggatgcttttcataccctgtcagaaaaatta
attttggatgactgtgcaaattgtgtttctcttcctggggggcagcaaaataaaaattgc
atggcgtatacttgtaaactggtggagttgacaagagcctgtggtagcaagaatgggcag
ctgaagtgtgaccattgtacctcgctgcgcaatgaatacctgtgctttgaaagctcctgc
ccaaaggccgcggacgactacgaagacgacgcctcaggcggtggcttttgcgaggaccgc
tttgctcatggttctgctgccaagacttttctgagccctttggaggatttctctgataat
tgtgaagacgtggacgatattttaaaaagcaaaaaggagcggtccactttactagtccga
aggttttgtaaaaatgacagggaggttaagaagtctgtgtatactgggacgcgagcgatc
atgagaactctgccttctggccatattgggccagttgcttggaattatgtcgatcagaag
aaagctggtctcacatggccttgtgggaatgtaacggggcctctgtcaacaatggacaca
aggcaaagtgggaggccaagtctgtctgaagcccagtggtgtctgatctacagtgctgtg
agaagaggggaagagacagaagatacggttggatctcttctccatttctccacacagctc
ccaaactctgagacagcccatggaaggattagagacggtccctgcttaaagcaatgtgta
cgagacaccgaatgtgagtaccgtgccaccctccaaaggacgtccatagctcagtacatc
actggttctctcctagaggcaaccacatctttaggagcaagaagcggccttctcagttcc
ttcggaggatccactggacgaatcatgctgaaagaacgccaaccgggcacctctatggcc
agctccaatcctgttccttcaagttcagctggaatcagcaaggagctgattgatctccag
cctctcattcagttcccagaggaagtagccagcatcttaacagaacaggaacagaacatt
taccgcagggtcctgcccatggactacctctgtttcttaacccgggacttgagttcccct
gaatgccagagatcactgcctcgtctcaaagcttccatctcagaatcaatcctcacgtct
caatgtggagagcacaatgcccttgaagatctcgtgatgagatttaacgaggtgagctcc
tgggtaacatggctgatcctcacggcaggctccatggaggagaagcgggaagtcttctct
tatttggtgcatgtagccaaatgctgctggaacatgggcaactacaatgctgtcatggag
ttcctggctggcctcaggtcaaggaaagttctaaagatgtggcagttcatggaccagtct
gacatcgagaccatgcggagcctgaaggacgtcatggctcagcatgagtcttccgtggag
tacaagaaggtagtgacccgagccttgcacatccccggctgcaaagtggttcccttctgc
ggggtgttcctgaaggagctctgtgaggtgcttgatggcgcctccggcctcctgaagctc
tgcccacggtacagctcccaagaagaagctctggagtttgtagccgattacagcggacag
gataacttcttacaacgagtgggacagaatggcttaaagaactcagagaaggagctcacg
gtcaacagcatcttccagatcatccggagctgcagccgaagcttggagatggaggaggag
gatggtgccagcgaagggaacggctctaggaaaaactccctgaaggacaagacccggtgg
cagtttataattggagatttgctggattcagaaaatgacatctttgagaagtccaaagag
tgtgaccctcatggatcagaggagtcacaaaaagcctttgatcatgggacggagctcatc
ccatggtacgtgttgtccatccaagcggatgtgcaccagttcctattgcagggggccaca
gtcatccactatgaccaggacacacatctctccgcccgctgctttctccagttgcagcca
gacaatagcaccttgacctggatgaagcctcccactgcctccccagctggtgccagaccc
aagctcagtgtgcttagtagcatggctgagcccaacaagttcccatcactgggcaacgct
ggggtgaacggcctggcagagggaatcctggatctgttttcagtgaaggctgtgtatatg
ggacaccctggcattgatatacacactgtgtgtgtccagaacaaacttagtagcatgctt
ctgtcagagactggggtgacactgctctatgggcttcagaccaccgacaatagattattg
cactttgtggcaccaaagcacacagctaagatgctgttcagtggactgctggaactcact
acagctgtgagaaagataaggaagttccctgaccaaagacagcagtggcttcggaaacag
tatgtcagcctctatcaggaggaaggccggtatgaaggcccaaccctggcacatgctgtg
gagttgtttggtggtagacgatggagcacaagaaaccccagccctgggatgtcagcaaag
aacgctgagaagcccagcatgcagaggaacaacaccctgggcataagcaccaccaagaaa
aagaagaaaacgctcatgaggggagagagtggagaggtgacggatgatgaaatggctacc
cgcaaggccaaaatgtacagagagtgtcgaagccggagcggctctgatcctcaagacgtc
aacgaacaagaagagtcggaggccaatgtcatcactaaccctcccaaccccctccattcc
agaagagcctactctttgaccacggctgggtccccgaacttggctaccgggatgtcatct
cccatcagtgcctggagcagtagcagctggcatggacggatcagaggaggactgaaaggc
ttccagagcttcatggtctcagacagtaacatgagtttcattgaattcgttgagctgttc
aaatcattcagcataaggagccgcaaggacttgaaggacatctttgacatctactccgta
ccctgcaatcggtctgcctcagagtcagccccactgtacaccaatctgacaatcgaagaa
aataccagtgaccttcagcctgatctagatttgctgactagaaacgtctccgacttgggg
ctgttcattaagagtaaacagcagctttctgacaaccagaggcagatatctgacgccatc
gctgctgcaagcattgtgaccaatggcactgggattgaaagcacatccctgggcatatat
ggggtcggcatactccagctcaatgacttcctggtgaattgtcaaggagaacactgcaca
tatgatgaaatcctcagcatcatccagaaattcgagcctagcatcagcatgtgtcatcaa
ggcctattgtcatttgaagggttcgcaaggtttctgatggataaagacaatttcgcttca
aaaaatgacgagtcccaggagaacaagaaagaactgcagctacccctctcctactattac
attgaatcttcacacaatacctacctcaccggccatcagctgaagggggagtcctctgtg
gagctctacagccaggtcctcctgcagggatgtagaagcatagagctggactgctgggat
ggagatgatggaatgcccatcatttaccatggacatacactgacaaccaagatccccttc
aaggaagttgtggaagccatcgaccgcagtgccttcatcacctctgacctgccaatcatc
atatccattgagaaccattgttcattgcctcagcaacgaaaaatggcagatattttcaag
agtgtctttggagaaaagttggtggctaagttcttgttcgagaccgatttctcagatgac
ccaatgcttccctcgcctgaccagcttagaaggaaagtgcttcttaaaaacaagaagcta
aaggcccatcagacacctgtggacatcctaaaacaaaaggctcatcagttagcatccatg
caggctcaggctttcactggtgggaacgccaacccaccacctgccagtaatgaggaagag
gaagatgaggaggacgaatatgattatgattacgagtccctttccgatgacaacattctg
gaagacagacctgagaataaatcatgtactgacaagcttcaatttgagtacaatgaagaa
gtccccaagaggataaagaaagcagacaactcctctggcaataagggaaaagtgtatgac
atggaacttggagaggagttttaccttcctcagaacaaaaaagaaagcaggcagattgca
ccggagctctctgacctcgtcatctattgccaggcagtaaaatttccaggcctgtcaact
ctaaattcatctggctcaagcagagggaaagaaaggaaaagcaggaagtccatttttggc
aacaatcctggcagaatgagcccaggggagacagcatcatttaacagaacatctggaaaa
agctcctgtgaaggaattcgacaaacctgggaggaatcctctccactcagcccaagcaca
tccctcagcgccatcattagaactcccaaatgctatcatatctcgtcactgaatgaaaat
gccgccaaacgtctgtgtcgcaggtattctcagaaactgatccagcacactgcttgtcag
ctactgaggacctaccccgcagcgaccagaatcgactcctccaatcccaaccccctcatg
ttctggctccacgggatacagcttgtagctctaaactaccagacggatgatcttccttta
catttaaatgctgccatgtttgaggcgaatggtgggtgtggttatgttttgaagccccct
gtcctgtgggataaaagctgtcccatgtaccagaagttttctccactggaaagagaccta
ggcaccatggatcctgctatttattctttaactatcatctctggccagaatgtgtgtcct
agtaacagcaccggaagtccatgcattgaagttgacgtcttgggcatgcccctggacagc
tgccacttccgcacaaaacccatccatcgaaatactctgaaccccatgtggaatgagcag
tttctcttccgggttcactttgaagatcttgtatttcttcgttttgcagttgtggaaaac
aacagttcggcgataacggctcagagaatcattcccctgagagctttaaaacgagggtat
cggcatcttcagctacggaacctccacaatgaaatcttggaaatctccagcttattcata
aacagcagaaggatggaagaaaatccctctggcagtaccatgccagcctcattgatgttt
aatactgaagagaggaaatgttcccagactcacaaagtcacggtgcatggtgtcccaggt
ccagagccctttgctgttttcactataaacgaaggcaccaaggcaaagcagcttctccaa
cagattttggcgattgaccaagacaccaaacttactgccacagactattttctgatggaa
gaaaagcattttatatctaaggaaaagaatgagtgcaggaaacaaccattccagagagct
gtgggtccagaggaagatatcgtgcagattttaaacagctggttcccggaagaaggctac
gtaggcaggattgtcttaaagccccaacaggaaaccctagaagagaaaagcattgtccat
gatgacagagaggtgagcttgagcccggaagaggagagtttctttgttcaagtgcatgat
gtctctccagagcagccccgaactgtcatcaaagcccctcgtgtcagcactgcacaggat
gtgattcagcagaccttatgcaaagccaaatactcctacagcatcttaaacaaccccaat
ccatgtgactacgtgcttttggaagaggtggtgaaagacacgtctaataagaagtcttct
accccaaagtcctcacagaggatcctcttggaccaagaatgtgtgtttcaagcccaaagc
aagtggaagggtgcagggaaattcatccttaagctgaaggaacaggtgcaggcatcaaga
gaagataaaaggaggggcatctcctttgcaagtgaactcaagaaactcacgaagtccact
aagcagtcccgaggactcacatcccctcctcagcttgtggcctcagaaagtgtccagagc
aaggaggagaaacccgtgggtaccttggcccctagtgatgcagtgggttaccagccatga

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