KEGG   Apodemus sylvaticus (European woodmouse): 127688925
Entry
127688925         CDS       T10613                                 
Symbol
Map2k1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
asyl  Apodemus sylvaticus (European woodmouse)
Pathway
asyl01521  EGFR tyrosine kinase inhibitor resistance
asyl01522  Endocrine resistance
asyl04010  MAPK signaling pathway
asyl04012  ErbB signaling pathway
asyl04014  Ras signaling pathway
asyl04015  Rap1 signaling pathway
asyl04022  cGMP-PKG signaling pathway
asyl04024  cAMP signaling pathway
asyl04062  Chemokine signaling pathway
asyl04066  HIF-1 signaling pathway
asyl04068  FoxO signaling pathway
asyl04071  Sphingolipid signaling pathway
asyl04072  Phospholipase D signaling pathway
asyl04114  Oocyte meiosis
asyl04140  Autophagy - animal
asyl04148  Efferocytosis
asyl04150  mTOR signaling pathway
asyl04151  PI3K-Akt signaling pathway
asyl04210  Apoptosis
asyl04218  Cellular senescence
asyl04270  Vascular smooth muscle contraction
asyl04370  VEGF signaling pathway
asyl04371  Apelin signaling pathway
asyl04380  Osteoclast differentiation
asyl04510  Focal adhesion
asyl04540  Gap junction
asyl04550  Signaling pathways regulating pluripotency of stem cells
asyl04613  Neutrophil extracellular trap formation
asyl04620  Toll-like receptor signaling pathway
asyl04650  Natural killer cell mediated cytotoxicity
asyl04660  T cell receptor signaling pathway
asyl04662  B cell receptor signaling pathway
asyl04664  Fc epsilon RI signaling pathway
asyl04666  Fc gamma R-mediated phagocytosis
asyl04668  TNF signaling pathway
asyl04720  Long-term potentiation
asyl04722  Neurotrophin signaling pathway
asyl04725  Cholinergic synapse
asyl04726  Serotonergic synapse
asyl04730  Long-term depression
asyl04810  Regulation of actin cytoskeleton
asyl04910  Insulin signaling pathway
asyl04912  GnRH signaling pathway
asyl04914  Progesterone-mediated oocyte maturation
asyl04915  Estrogen signaling pathway
asyl04916  Melanogenesis
asyl04917  Prolactin signaling pathway
asyl04919  Thyroid hormone signaling pathway
asyl04921  Oxytocin signaling pathway
asyl04926  Relaxin signaling pathway
asyl04928  Parathyroid hormone synthesis, secretion and action
asyl04929  GnRH secretion
asyl04934  Cushing syndrome
asyl04935  Growth hormone synthesis, secretion and action
asyl05010  Alzheimer disease
asyl05022  Pathways of neurodegeneration - multiple diseases
asyl05034  Alcoholism
asyl05132  Salmonella infection
asyl05135  Yersinia infection
asyl05160  Hepatitis C
asyl05161  Hepatitis B
asyl05163  Human cytomegalovirus infection
asyl05164  Influenza A
asyl05165  Human papillomavirus infection
asyl05166  Human T-cell leukemia virus 1 infection
asyl05167  Kaposi sarcoma-associated herpesvirus infection
asyl05170  Human immunodeficiency virus 1 infection
asyl05200  Pathways in cancer
asyl05205  Proteoglycans in cancer
asyl05206  MicroRNAs in cancer
asyl05207  Chemical carcinogenesis - receptor activation
asyl05208  Chemical carcinogenesis - reactive oxygen species
asyl05210  Colorectal cancer
asyl05211  Renal cell carcinoma
asyl05212  Pancreatic cancer
asyl05213  Endometrial cancer
asyl05214  Glioma
asyl05215  Prostate cancer
asyl05216  Thyroid cancer
asyl05218  Melanoma
asyl05219  Bladder cancer
asyl05220  Chronic myeloid leukemia
asyl05221  Acute myeloid leukemia
asyl05223  Non-small cell lung cancer
asyl05224  Breast cancer
asyl05225  Hepatocellular carcinoma
asyl05226  Gastric cancer
asyl05230  Central carbon metabolism in cancer
asyl05231  Choline metabolism in cancer
asyl05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:asyl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    127688925 (Map2k1)
   04012 ErbB signaling pathway
    127688925 (Map2k1)
   04014 Ras signaling pathway
    127688925 (Map2k1)
   04015 Rap1 signaling pathway
    127688925 (Map2k1)
   04370 VEGF signaling pathway
    127688925 (Map2k1)
   04371 Apelin signaling pathway
    127688925 (Map2k1)
   04668 TNF signaling pathway
    127688925 (Map2k1)
   04066 HIF-1 signaling pathway
    127688925 (Map2k1)
   04068 FoxO signaling pathway
    127688925 (Map2k1)
   04072 Phospholipase D signaling pathway
    127688925 (Map2k1)
   04071 Sphingolipid signaling pathway
    127688925 (Map2k1)
   04024 cAMP signaling pathway
    127688925 (Map2k1)
   04022 cGMP-PKG signaling pathway
    127688925 (Map2k1)
   04151 PI3K-Akt signaling pathway
    127688925 (Map2k1)
   04150 mTOR signaling pathway
    127688925 (Map2k1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    127688925 (Map2k1)
   04148 Efferocytosis
    127688925 (Map2k1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    127688925 (Map2k1)
   04210 Apoptosis
    127688925 (Map2k1)
   04218 Cellular senescence
    127688925 (Map2k1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    127688925 (Map2k1)
   04540 Gap junction
    127688925 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    127688925 (Map2k1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    127688925 (Map2k1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    127688925 (Map2k1)
   04620 Toll-like receptor signaling pathway
    127688925 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    127688925 (Map2k1)
   04660 T cell receptor signaling pathway
    127688925 (Map2k1)
   04662 B cell receptor signaling pathway
    127688925 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    127688925 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    127688925 (Map2k1)
   04062 Chemokine signaling pathway
    127688925 (Map2k1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    127688925 (Map2k1)
   04929 GnRH secretion
    127688925 (Map2k1)
   04912 GnRH signaling pathway
    127688925 (Map2k1)
   04915 Estrogen signaling pathway
    127688925 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    127688925 (Map2k1)
   04917 Prolactin signaling pathway
    127688925 (Map2k1)
   04921 Oxytocin signaling pathway
    127688925 (Map2k1)
   04926 Relaxin signaling pathway
    127688925 (Map2k1)
   04935 Growth hormone synthesis, secretion and action
    127688925 (Map2k1)
   04919 Thyroid hormone signaling pathway
    127688925 (Map2k1)
   04928 Parathyroid hormone synthesis, secretion and action
    127688925 (Map2k1)
   04916 Melanogenesis
    127688925 (Map2k1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    127688925 (Map2k1)
  09156 Nervous system
   04725 Cholinergic synapse
    127688925 (Map2k1)
   04726 Serotonergic synapse
    127688925 (Map2k1)
   04720 Long-term potentiation
    127688925 (Map2k1)
   04730 Long-term depression
    127688925 (Map2k1)
   04722 Neurotrophin signaling pathway
    127688925 (Map2k1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    127688925 (Map2k1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127688925 (Map2k1)
   05206 MicroRNAs in cancer
    127688925 (Map2k1)
   05205 Proteoglycans in cancer
    127688925 (Map2k1)
   05207 Chemical carcinogenesis - receptor activation
    127688925 (Map2k1)
   05208 Chemical carcinogenesis - reactive oxygen species
    127688925 (Map2k1)
   05230 Central carbon metabolism in cancer
    127688925 (Map2k1)
   05231 Choline metabolism in cancer
    127688925 (Map2k1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127688925 (Map2k1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    127688925 (Map2k1)
   05212 Pancreatic cancer
    127688925 (Map2k1)
   05225 Hepatocellular carcinoma
    127688925 (Map2k1)
   05226 Gastric cancer
    127688925 (Map2k1)
   05214 Glioma
    127688925 (Map2k1)
   05216 Thyroid cancer
    127688925 (Map2k1)
   05221 Acute myeloid leukemia
    127688925 (Map2k1)
   05220 Chronic myeloid leukemia
    127688925 (Map2k1)
   05218 Melanoma
    127688925 (Map2k1)
   05211 Renal cell carcinoma
    127688925 (Map2k1)
   05219 Bladder cancer
    127688925 (Map2k1)
   05215 Prostate cancer
    127688925 (Map2k1)
   05213 Endometrial cancer
    127688925 (Map2k1)
   05224 Breast cancer
    127688925 (Map2k1)
   05223 Non-small cell lung cancer
    127688925 (Map2k1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    127688925 (Map2k1)
   05170 Human immunodeficiency virus 1 infection
    127688925 (Map2k1)
   05161 Hepatitis B
    127688925 (Map2k1)
   05160 Hepatitis C
    127688925 (Map2k1)
   05164 Influenza A
    127688925 (Map2k1)
   05163 Human cytomegalovirus infection
    127688925 (Map2k1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    127688925 (Map2k1)
   05165 Human papillomavirus infection
    127688925 (Map2k1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    127688925 (Map2k1)
   05135 Yersinia infection
    127688925 (Map2k1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127688925 (Map2k1)
   05022 Pathways of neurodegeneration - multiple diseases
    127688925 (Map2k1)
  09165 Substance dependence
   05034 Alcoholism
    127688925 (Map2k1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    127688925 (Map2k1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127688925 (Map2k1)
   01522 Endocrine resistance
    127688925 (Map2k1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:asyl01001]
    127688925 (Map2k1)
Enzymes [BR:asyl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     127688925 (Map2k1)
Protein kinases [BR:asyl01001]
 Serine/threonine kinases: STE group
  STE7 family
   127688925 (Map2k1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 127688925
NCBI-ProteinID: XP_052044019
LinkDB
Position
7:64757938..64828755
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDEAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLDFQDFVNKCLIKNPAERADLKQLMVHVF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgatggttcggcggtt
aacgggaccagctcggccgagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgatgagcagcagcggaagcgcctcgaggcctttctgacgcagaagcagaaggtg
ggagaactgaaggatgatgactttgagaagatcagcgagctgggggctggcaatggtgga
gtggtcttcaaggtctcccacaaaccatctggcctggttatggctagaaagctaattcac
ctagagatcaaacctgcaatccgcaaccagatcatccgggagctgcaggtgctgcatgaa
tgtaactccccttacatcgtgggcttctacggggccttctacagtgacggcgagatcagc
atctgcatggagcacatggatggtgggtccttggatcaagttctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtgataaaaggcctgacatatctg
cgggagaagcacaagattatgcacagagatgtcaagccttccaacattctagtgaactca
cgaggggagatcaaactctgtgattttggggtcagcgggcagctaattgactccatggcc
aactccttcgtgggcacgaggtcctacatgtcgcccgagagactccaggggactcactac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttgggaga
taccccattcctcctcctgatgccaaggagctggagctgctgtttggatgccatgtggaa
ggagacgaagccgaaactccacccaggccaaggacccctggaaggcccctcagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacattgtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggactttcaagattttgtgaataaa
tgcttaataaagaaccctgcagagagagcagatctgaagcagctcatggtacatgttttt
atcaaaagatctgatgccgaggaggtagacttcgcaggctggctctgctccaccattggg
cttaaccagcccagcacaccaacccatgctgccagcatctga

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