Balaenoptera acutorostrata scammoni (minke whale): 103012691
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Entry
103012691 CDS
T03086
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
KO
K00922
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:
2.7.1.153
]
Organism
bacu
Balaenoptera acutorostrata scammoni (minke whale)
Pathway
bacu00562
Inositol phosphate metabolism
bacu01100
Metabolic pathways
bacu01521
EGFR tyrosine kinase inhibitor resistance
bacu01522
Endocrine resistance
bacu01524
Platinum drug resistance
bacu04012
ErbB signaling pathway
bacu04014
Ras signaling pathway
bacu04015
Rap1 signaling pathway
bacu04024
cAMP signaling pathway
bacu04062
Chemokine signaling pathway
bacu04066
HIF-1 signaling pathway
bacu04068
FoxO signaling pathway
bacu04070
Phosphatidylinositol signaling system
bacu04071
Sphingolipid signaling pathway
bacu04072
Phospholipase D signaling pathway
bacu04081
Hormone signaling
bacu04140
Autophagy - animal
bacu04145
Phagocytosis
bacu04150
mTOR signaling pathway
bacu04151
PI3K-Akt signaling pathway
bacu04152
AMPK signaling pathway
bacu04210
Apoptosis
bacu04211
Longevity regulating pathway
bacu04213
Longevity regulating pathway - multiple species
bacu04218
Cellular senescence
bacu04360
Axon guidance
bacu04370
VEGF signaling pathway
bacu04380
Osteoclast differentiation
bacu04510
Focal adhesion
bacu04517
IgSF CAM signaling
bacu04518
Integrin signaling
bacu04550
Signaling pathways regulating pluripotency of stem cells
bacu04611
Platelet activation
bacu04613
Neutrophil extracellular trap formation
bacu04620
Toll-like receptor signaling pathway
bacu04625
C-type lectin receptor signaling pathway
bacu04630
JAK-STAT signaling pathway
bacu04650
Natural killer cell mediated cytotoxicity
bacu04660
T cell receptor signaling pathway
bacu04662
B cell receptor signaling pathway
bacu04664
Fc epsilon RI signaling pathway
bacu04666
Fc gamma R-mediated phagosome formation
bacu04668
TNF signaling pathway
bacu04670
Leukocyte transendothelial migration
bacu04722
Neurotrophin signaling pathway
bacu04725
Cholinergic synapse
bacu04750
Inflammatory mediator regulation of TRP channels
bacu04810
Regulation of actin cytoskeleton
bacu04910
Insulin signaling pathway
bacu04914
Progesterone-mediated oocyte maturation
bacu04915
Estrogen signaling pathway
bacu04917
Prolactin signaling pathway
bacu04919
Thyroid hormone signaling pathway
bacu04923
Regulation of lipolysis in adipocytes
bacu04926
Relaxin signaling pathway
bacu04929
GnRH secretion
bacu04930
Type II diabetes mellitus
bacu04931
Insulin resistance
bacu04932
Non-alcoholic fatty liver disease
bacu04933
AGE-RAGE signaling pathway in diabetic complications
bacu04935
Growth hormone synthesis, secretion and action
bacu04960
Aldosterone-regulated sodium reabsorption
bacu04973
Carbohydrate digestion and absorption
bacu05010
Alzheimer disease
bacu05017
Spinocerebellar ataxia
bacu05020
Prion disease
bacu05100
Bacterial invasion of epithelial cells
bacu05132
Salmonella infection
bacu05135
Yersinia infection
bacu05142
Chagas disease
bacu05146
Amoebiasis
bacu05160
Hepatitis C
bacu05161
Hepatitis B
bacu05162
Measles
bacu05163
Human cytomegalovirus infection
bacu05164
Influenza A
bacu05165
Human papillomavirus infection
bacu05166
Human T-cell leukemia virus 1 infection
bacu05167
Kaposi sarcoma-associated herpesvirus infection
bacu05168
Herpes simplex virus 1 infection
bacu05169
Epstein-Barr virus infection
bacu05170
Human immunodeficiency virus 1 infection
bacu05171
Coronavirus disease
bacu05200
Pathways in cancer
bacu05203
Viral carcinogenesis
bacu05205
Proteoglycans in cancer
bacu05206
MicroRNAs in cancer
bacu05207
Chemical carcinogenesis - receptor activation
bacu05208
Chemical carcinogenesis - reactive oxygen species
bacu05210
Colorectal cancer
bacu05211
Renal cell carcinoma
bacu05212
Pancreatic cancer
bacu05213
Endometrial cancer
bacu05214
Glioma
bacu05215
Prostate cancer
bacu05218
Melanoma
bacu05220
Chronic myeloid leukemia
bacu05221
Acute myeloid leukemia
bacu05222
Small cell lung cancer
bacu05223
Non-small cell lung cancer
bacu05224
Breast cancer
bacu05225
Hepatocellular carcinoma
bacu05226
Gastric cancer
bacu05230
Central carbon metabolism in cancer
bacu05231
Choline metabolism in cancer
bacu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
bacu05415
Diabetic cardiomyopathy
bacu05417
Lipid and atherosclerosis
bacu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
bacu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
103012691 (PIK3CA)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
103012691 (PIK3CA)
04014 Ras signaling pathway
103012691 (PIK3CA)
04015 Rap1 signaling pathway
103012691 (PIK3CA)
04370 VEGF signaling pathway
103012691 (PIK3CA)
04630 JAK-STAT signaling pathway
103012691 (PIK3CA)
04668 TNF signaling pathway
103012691 (PIK3CA)
04066 HIF-1 signaling pathway
103012691 (PIK3CA)
04068 FoxO signaling pathway
103012691 (PIK3CA)
04070 Phosphatidylinositol signaling system
103012691 (PIK3CA)
04072 Phospholipase D signaling pathway
103012691 (PIK3CA)
04071 Sphingolipid signaling pathway
103012691 (PIK3CA)
04024 cAMP signaling pathway
103012691 (PIK3CA)
04151 PI3K-Akt signaling pathway
103012691 (PIK3CA)
04152 AMPK signaling pathway
103012691 (PIK3CA)
04150 mTOR signaling pathway
103012691 (PIK3CA)
09133 Signaling molecules and interaction
04081 Hormone signaling
103012691 (PIK3CA)
04517 IgSF CAM signaling
103012691 (PIK3CA)
04518 Integrin signaling
103012691 (PIK3CA)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagocytosis
103012691 (PIK3CA)
04140 Autophagy - animal
103012691 (PIK3CA)
09143 Cell growth and death
04210 Apoptosis
103012691 (PIK3CA)
04218 Cellular senescence
103012691 (PIK3CA)
09144 Cellular community - eukaryotes
04510 Focal adhesion
103012691 (PIK3CA)
04550 Signaling pathways regulating pluripotency of stem cells
103012691 (PIK3CA)
09142 Cell motility
04810 Regulation of actin cytoskeleton
103012691 (PIK3CA)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
103012691 (PIK3CA)
04613 Neutrophil extracellular trap formation
103012691 (PIK3CA)
04620 Toll-like receptor signaling pathway
103012691 (PIK3CA)
04625 C-type lectin receptor signaling pathway
103012691 (PIK3CA)
04650 Natural killer cell mediated cytotoxicity
103012691 (PIK3CA)
04660 T cell receptor signaling pathway
103012691 (PIK3CA)
04662 B cell receptor signaling pathway
103012691 (PIK3CA)
04664 Fc epsilon RI signaling pathway
103012691 (PIK3CA)
04666 Fc gamma R-mediated phagosome formation
103012691 (PIK3CA)
04670 Leukocyte transendothelial migration
103012691 (PIK3CA)
04062 Chemokine signaling pathway
103012691 (PIK3CA)
09152 Endocrine system
04910 Insulin signaling pathway
103012691 (PIK3CA)
04923 Regulation of lipolysis in adipocytes
103012691 (PIK3CA)
04929 GnRH secretion
103012691 (PIK3CA)
04915 Estrogen signaling pathway
103012691 (PIK3CA)
04914 Progesterone-mediated oocyte maturation
103012691 (PIK3CA)
04917 Prolactin signaling pathway
103012691 (PIK3CA)
04926 Relaxin signaling pathway
103012691 (PIK3CA)
04935 Growth hormone synthesis, secretion and action
103012691 (PIK3CA)
04919 Thyroid hormone signaling pathway
103012691 (PIK3CA)
09154 Digestive system
04973 Carbohydrate digestion and absorption
103012691 (PIK3CA)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
103012691 (PIK3CA)
09156 Nervous system
04725 Cholinergic synapse
103012691 (PIK3CA)
04722 Neurotrophin signaling pathway
103012691 (PIK3CA)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
103012691 (PIK3CA)
09158 Development and regeneration
04360 Axon guidance
103012691 (PIK3CA)
04380 Osteoclast differentiation
103012691 (PIK3CA)
09149 Aging
04211 Longevity regulating pathway
103012691 (PIK3CA)
04213 Longevity regulating pathway - multiple species
103012691 (PIK3CA)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103012691 (PIK3CA)
05206 MicroRNAs in cancer
103012691 (PIK3CA)
05205 Proteoglycans in cancer
103012691 (PIK3CA)
05207 Chemical carcinogenesis - receptor activation
103012691 (PIK3CA)
05208 Chemical carcinogenesis - reactive oxygen species
103012691 (PIK3CA)
05203 Viral carcinogenesis
103012691 (PIK3CA)
05230 Central carbon metabolism in cancer
103012691 (PIK3CA)
05231 Choline metabolism in cancer
103012691 (PIK3CA)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
103012691 (PIK3CA)
09162 Cancer: specific types
05210 Colorectal cancer
103012691 (PIK3CA)
05212 Pancreatic cancer
103012691 (PIK3CA)
05225 Hepatocellular carcinoma
103012691 (PIK3CA)
05226 Gastric cancer
103012691 (PIK3CA)
05214 Glioma
103012691 (PIK3CA)
05221 Acute myeloid leukemia
103012691 (PIK3CA)
05220 Chronic myeloid leukemia
103012691 (PIK3CA)
05218 Melanoma
103012691 (PIK3CA)
05211 Renal cell carcinoma
103012691 (PIK3CA)
05215 Prostate cancer
103012691 (PIK3CA)
05213 Endometrial cancer
103012691 (PIK3CA)
05224 Breast cancer
103012691 (PIK3CA)
05222 Small cell lung cancer
103012691 (PIK3CA)
05223 Non-small cell lung cancer
103012691 (PIK3CA)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
103012691 (PIK3CA)
05170 Human immunodeficiency virus 1 infection
103012691 (PIK3CA)
05161 Hepatitis B
103012691 (PIK3CA)
05160 Hepatitis C
103012691 (PIK3CA)
05171 Coronavirus disease
103012691 (PIK3CA)
05164 Influenza A
103012691 (PIK3CA)
05162 Measles
103012691 (PIK3CA)
05168 Herpes simplex virus 1 infection
103012691 (PIK3CA)
05163 Human cytomegalovirus infection
103012691 (PIK3CA)
05167 Kaposi sarcoma-associated herpesvirus infection
103012691 (PIK3CA)
05169 Epstein-Barr virus infection
103012691 (PIK3CA)
05165 Human papillomavirus infection
103012691 (PIK3CA)
09171 Infectious disease: bacterial
05132 Salmonella infection
103012691 (PIK3CA)
05135 Yersinia infection
103012691 (PIK3CA)
05100 Bacterial invasion of epithelial cells
103012691 (PIK3CA)
09174 Infectious disease: parasitic
05146 Amoebiasis
103012691 (PIK3CA)
05142 Chagas disease
103012691 (PIK3CA)
09164 Neurodegenerative disease
05010 Alzheimer disease
103012691 (PIK3CA)
05017 Spinocerebellar ataxia
103012691 (PIK3CA)
05020 Prion disease
103012691 (PIK3CA)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
103012691 (PIK3CA)
05418 Fluid shear stress and atherosclerosis
103012691 (PIK3CA)
05415 Diabetic cardiomyopathy
103012691 (PIK3CA)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
103012691 (PIK3CA)
04932 Non-alcoholic fatty liver disease
103012691 (PIK3CA)
04931 Insulin resistance
103012691 (PIK3CA)
04933 AGE-RAGE signaling pathway in diabetic complications
103012691 (PIK3CA)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103012691 (PIK3CA)
01524 Platinum drug resistance
103012691 (PIK3CA)
01522 Endocrine resistance
103012691 (PIK3CA)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
bacu04131
]
103012691 (PIK3CA)
Enzymes [BR:
bacu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
103012691 (PIK3CA)
Membrane trafficking [BR:
bacu04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
103012691 (PIK3CA)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI3Ka
PI3_PI4_kinase
PI3K_C2
PI3K_rbd
PI3K_p85B
DUF2321
ABC1
Ribosomal_S15
Motif
Other DBs
NCBI-GeneID:
103012691
NCBI-ProteinID:
XP_007198799
LinkDB
All DBs
Position
Un
AA seq
1068 aa
AA seq
DB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFXRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRQGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
GSVVKFPDMSVIEEHANWSVSREAGFSYSYAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq
3207 nt
NT seq
+upstream
nt +downstream
nt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatgggatgatagtgactttagaatgcctccgtgaggct
acattaataactataaagcatgaactatttaaagaagcgagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaattcgatatggttaaagatccagaagtacaggactttnga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatctcaattcaccgcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattggataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgacgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctaatggctaaagaaagcctctactctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcacttagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttctatttgttctgttaaaggccgacagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgtttagagttggagtttgactggttc
ggcagtgtggtgaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagttattcctatgcaggactgagtaacagactagctagagat
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctctg
tctgaaatcactgagcaagagaaggattttctgtggagccatagacactattgtgtaact
atccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgcaattacccagatcctatggttcgaggttttgctgttcgatgcttagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctacttgtgaggtttttactcaaaaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatttgaag
cacctgaataggcaggttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaaatttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacagggctttctatcgcctctaaaccctgctcatcag
ctgggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtcc
attggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt
cagtgtaaaggaggcctgaaaggtgccctgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaagggagaaatatatgatgcagccatcgatctatttacacgttca
tgtgctggatattgtgttgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaattcggttataaacgagagcgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgagcaggaggctttggaatatttcatg
aaacaaatgaatgatgcacaccatggtggctggacgacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga
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integrated database retrieval system
