Bombus bifarius (two-form bumblebee): 117206696 Help Entry 117206696         CDS       T07537                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism bbif  Bombus bifarius (two-form bumblebee) Brite KEGG Orthology (KO) [BR:bbif00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:bbif04040]     117206696    04990 Domain-containing proteins not elsewhere classified [BR:bbif04990]     117206696 Ion channels [BR:bbif04040]  Voltage-gated cation channels   Ryanodine receptor    117206696 Domain-containing proteins not elsewhere classified [BR:bbif04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    117206696 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 CFAP143 Serglycin DASH_Spc34 Motif Other DBs NCBI-GeneID:  117206696 NCBI-ProteinID:  XP_033302136 UniProt:  A0A6P8LNL7 LinkDB All DBs Position Unknown AA seq 5158 aa AA seqDB search MADSEGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLS QCVFVIEQALSVRALQELVTAAGSETQQENLGKGTGSGHRTLLYGNAILLRHQNSDMYLA CLSTSSSNDKLAFDVGLQQHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYL HTTKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSTW GTTPSQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWLHPMRIRHLTTGRYLGVKEN NELYLVDRNEATTETSTFWLRQEKDDQKIILEDKDLEVIGTPIIKYGDSTVIMQHATTCL WVSYKSYETKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFTQF ITGLETLQVDRRASMFFQNVNLNEMVMCLEDLINYFAQPEDDMEHEEKQNRFRALRNRQD LFQEEGILNLILEAIDKINVITSQGFLVALSGDESGQAWDQISGYLYQLLAAIIKGNHTN CAQFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEK HGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASVRPNIFVGR VENSALYQKWYFEVTVDHIEQTTHMMPHLRIGWANTAGYMPYPGGGEKWGGNGVGDDLYS FGFDGAHLWTGGRKTQVVQNVTEPYIRKSDVIGCALDLTVPIITFTFNGAPIMGSFRNFN LDGMFFPAISCSSKLSCRFLLGGDHGRLKFQPPEEFSPLVESLLPQQILSLDPCFYFGNM NKVVLAGPWLVEDDTAFVPAPVDTSMINLPSYVEQIRDKLAENIHEMWAMNKIEAGWIYG EHRDDMRKIHPCIVQFERLPAAEKRYDTQLAVQTLKTILALGYYITMDKPPSRIKTLRLP NEPFLQSSGYKPAPLDLSAITLTPKMEELVDQLAENTHNLWAKERISQGWTYGLNEDSEM RRSPHLVPYPKVDEAIKKANRDTASETVRTLLVYGYMLEPPTGEQHEALLLEANRLRQLY FRTYRVEKHYAVSSGKWYFEFEVLTAGPMRVGWAKADCSPGNMLGSDESTWAFDGYNVTK VHAGIHESFGHRYQVGDVVGCFIDVADRTISFSLNGELLMDALGGETSFADVQGDCFVPA FTLGVGQKAKLTFGQDVNTLKFFTTCGLQEGYEPFCVNMNRPVTYWYTKDQPIFENTDDM ADTRIDVARIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICQSTFISESEKLRRW QEIKMRQNRLLSEQVEQAQQAAPSAQIEQIMRSGFSMSDIKGLQRNYSEDAVEADEMMKE SPLPMQRNKPLRPPRKGSLYGSRVGNMDNAISEVDMNGYGDMNGDIKDDKKKRGRSPFRK LSKEMEDAPFFSRKAKSPDAKSKTPEPPVRSDISDKSTKTQSMNKASNRPPQIRISNTDL KVVPPQIPERNAPKAMSMSALSGSGVEAIGNEIFDAECLKLMNEYFYGVRIFPGQDPTHV YVGWVTSQYHLHTKDFNLSRVRKGSVVITDDYDRPIEQVDRQSCYMVRADELYNEVTQDA SGKGASQGMFVGCFVDTATGWVSFTCEGKETSHKFKMEPDTKLFPAIFVEATSKEILQIE LGRTSTTLPLSAAVLQNSERHVIPQFPPRLKVQCLKPHQWARVPNQSLQVHALKLSDIRG WSMLCEDAISMLALHIPEEDRCIDILELIEMDKLLSFHAHTLTLYAALCYQSNYRAAHAL CQHVDQKQLLYAIRAEYMSGPLRQGFYDLLIALHLESHATTMEVCKNEYIIPLGQELKDL YENEEMKHSLRYLETESVRPQMKMTDIRDIPSSDQTIENIRSLYSPYFPLDVVRDYVMTA LNEAVEVNQVHNRDPIGGSNENLFLPLLKLVDRLLLVGMLRNEDVMKLLIMIHPETWDPT FDKEGKDEHKKGLLHMKMAEGAKLQMCYLLHHLNDIQLRHRVESIIAFSHDFVGDLQSDQ LRRYIEIKQSDLPSAVAAKKTREFRCPPREQMNAILSFKNMEFVDDPENSPCGEDLINRM NEFHNSLMSYVSLHALQEAADAVEEAEDAVQKPGAIKKLFNFINAVKELEEEPKPEPEPE RKTPEEVFRKVLIKTIVSWAEESQIETPKLVREMFSLLVRQYDTVGELIRALEKTYVTNS KTKDDVALMWVGLSQIRALLPVQMSQEEEELVRERLWKLVNNHTFFQHPDLIRVLRIHEN VMAIMMNTLGRRAQAQSDAQTQPQTTEGEPVSKEKDTSHEMVVACCRFLCYFCRTSRQNQ KAMFDHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSR CGLQSNSELVEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECL GPALRGEGEGLLRAIIDANKMSERIADRRKVHDEAEGTTALMQFEHPLPESDDDEDYIDT GAAILNFYCTLVDLLGRCAPDSSVIEQEASTESVGKNESLRARAILRSLVPLDDLQGVLS LRFTLLNPAAGEEKPKSDMPSGLIPGHKQSIVLFLERVYGIETRELFFKILEEAFLPDLR AATMLDRNDGYESDMALAMNRYIGNSILPLLIKHSKFYNEADNYASLLDATLHTVYRLSK NRMLTKGQREAVSDFLVALTRDVHELNVSQMQPSMLLKLLRKLTVDVSKLSEYTTVALRL LTLHYDRCAKYYGSTGGQGAYGASSDEEKRLTMVLFSNIFDSLSKMDYDPELFGKALPCL TAIGCALPPDYSLSKNYDDEWYGSKSASAQSPDGPYNPQPINTSSVVLNNDLNQIVQKFS EHYHDAWASRKLENGWTYGEQWSEVNKTHPRLKPYNTLNDYERERYKEPVRESLKALLAI GWSVEHAEVDVPSNNRSSMRRSSKSQADSAGPFNYNPHPVDMTNLTLSREMQNMAERLAD NAHDIWAKKKKEELITCGGGIHPQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHKP NRGGESEVATAGASVELRFAYSLLEKLIAYLDKATINMKLLKPSDTFSRRNSFKTSTRDI KFFSKVVLPLMEKYFSTHKNYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAA FGPDVRITVRCLQVLVKGIDAKSLVKNCPEFIRTSMLTFFNNTADDLGHTILNLQEGKYS HLRGTHLKTSTSLSYINSVVLPVLTAMFDHLAACEYGSDLLLDEIQVASYKMLASLYTLG VDASLTHDRKYLKTEIERHKPSLGSCLGAFSSCFPVAFLEPHLNKHNQYSLLNRIADHSL EAQDIMMKMESSMPTLETILTEVDQFVESEKTYNDLPHVVDIILPLLCSYLPFWWSQGPD NVNPTEGTYVSMVTSDHMNQLLKNVLKLIKKNIGNENAPWMTRIAAYTQQIIINSSEELL KDPFLPLAERVRKRTDTMFHKEESLRGFIKSSTDDTSQIEAQIQEDWQLLVRDIYSFYPL LIKYVDLQRNHWLRNNIPEAEDLYNHVAAIFNIWSKSQYFLREEQNFISANEIDNMVLIM PTATRRPTTISDGTAPSGGGKKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGR EQELVQHCKDRFLKKMPEYEISEFAKTQLTLPDKIDPADEMSWQHYLYSKLGQKKDSMEP VKAQQLEDVVARITDMAKVLYGLHMIDHPQQQSKGQYRSVVSIQRKRAVIACFRQTSLHS LPRHRAINIFARTYYELWLQDENVGQEVMIEDLTQSFEDAELKKMDKDEDEGKPDPLTQL VTTFCRGAMTERSGALQEDPLYMSYAQIISKSCGEEEEEGEDEGGGGGEEEGGASIHKRG YKPLMRPMHKLMEQEMEKQKLLFHQTRLANRGVAEMVLLHISACKGVPSEMVMKTLELGI SILRGGNIEIQRGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGSEG AAGEKNMHDAEFTCALFRFIQLTCEGHNLDWQNYLRTQAGNTTTVNVVICTVDYLLRLQE SIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLTEVIQGPCAQNQQALAHSRLWDA VGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTL VESASNVELILKYFDMFLKLKDLVSSPSFLEVDLNSDGWVYPKDFKEKMEQQKSYTDEEI EFLLACCETNHDGKIDYVAFMDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAG SVLNYFEPYLGRIEILGGNKKIERVYFEIKESNIEQWEKPQIKESKRTYFYNTVVEAGEK EKLETFINFCEDAIFEMQHASALMAVEESGGIGKARESSYTYMTEDDEERNKDPIRRGIQ TFKDSIYFFFSIFSPSNIKNKIAEMQQMTFLELFIGFFKMIFYAFYYSGFGVGCIIGYFM KLLLALMKGPHVEEPVVEVKEEEEKPIRHLPALPPTPDESNLQVQAFGMDITKEEGGQIK IAPHESATSTPQSSIEETGESTPEEATGEEGARAEGGGDMESPVSLADLLGGEQARAQAA AAAEAAAAQQAAMAAVEAEAKQETITEPSTSTIDFSEYTHRIVSFLARNFYNLKYVALVL AFCINFMLLFYKVTSLAGEGDEEGSGQMISDILAEMSGEGASGSGSGSGIEIGSGSGEDE SEEEEDAYALEYVEVSEDFYYMAHVIRLMAILHAIVSLAMLVAYYHLKVPLAIFKREKEI ARRVEFDGLYIAETPEEDDIKAHWDKMVISAKTFPVNYWDKFVKKKVRQKYSETYDFDYI SNLLGMEKTSFSQQEEEGSGLIHFIVNIDWRYQVWKAGVTITDNAFLYSLWYFTFSILGN YNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIVVYIYTVIAFNFFRKFY IQEEDDEVDKKCHDMLTCFVFHLYKGVRAGGGIGDEIGEPDGDDYEVYRIMFDITFFFFV IVILLAIIQGLIIDAFGELRDQLENVKTNMESNCFICGLGKEYFDTVPHGFDTHVQQEHN LANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQNEAVEEEAKKK NT seq 15477 nt NT seq  +upstreamnt  +downstreamnt atggctgacagcgagggtggctccgagcaggatgacgtatccttcctccgtacggaggac atggtatgtctgtcctgtaccgcaactggtgaaagggtttgcctcgcagctgagggattt ggtaatcgacactgtttcctcgagaatatcgcagacaagaacataccacctgacctgtcg caatgcgtattcgtaatagaacaagctctgtcggtgagagctctgcaggaattggtaacc gccgccggttccgagacgcagcaagaaaatttagggaagggcactggatctggacacaga acgttattgtatggcaacgctattttactgaggcatcaaaacagcgacatgtatttggcg tgtttatcgaccagctcgtccaacgacaagttggctttcgacgtaggtctgcaacagcat tctcaaggtgaggcgtgttggtggactgtgcatccagcatcgaagcagagatcagagggt gagaaggttcgagtcggtgatgaccttattctggtatctgtggccactgagagatacttg cacacaacaaaagagaacgacttatccgtggttaacgcctcgttccacgtaacccactgg tcggtacaaccttacggcactggaatcagccggatgaaatacgttggttacgtatttggc ggtgacgttctacgattttttcacggtggcgacgaatgcctcactataccgtcaacatgg ggcacaacaccgagtcaaaatatagtggtgtacgagggaggcagcgtaatgagtcaagct cgatctctatggagactggagctggcaagaactaaatgggccggtggttttatcaactgg ctgcatccgatgaggatcagacacttgacaactggacgttaccttggtgtcaaagaaaac aacgaactgtacctggtcgatagaaacgaggcaacgaccgagacttcaacgttttggtta cggcaagagaaggatgatcagaagatcattctcgaggataaggacctcgaagttatcggt acacccatcatcaagtatggtgactcgactgttatcatgcagcacgctactacttgcctc tgggtctcgtacaagtcgtacgagacgaagaaaaagggtgtgggcaaagtggaggagaag caagccgtccttcacgaagaaggaaagatggacgatggtttggacttctctcggtctcaa gaggaagagtcccggacagctcgtgtgatacgaaagtgcagcagtctgttcacccagttc atcacaggcctagagacgctgcaagtagatagaagagcgtctatgttcttccaaaatgtg aatctgaacgaaatggtgatgtgtctggaagacttgattaattattttgctcaacccgaa gacgacatggagcacgaagagaaacaaaacagattccgcgctctgagaaatcgtcaagac ctgtttcaagaagagggtatattgaacttgatactcgaagccatcgacaagatcaacgtg attacgtcacaaggtttcctcgtggcactttcgggagacgagagtggtcaagcttgggat caaatatcaggatacctgtatcaactattggcagctattatcaaaggaaatcacacaaac tgcgcgcaatttgctaacagcaatcgtttgaactggttgttcagtcgactcggatcgcag gcttccagcgaaggcactggaatgttggacgtgcttcattgcgttcttatcgactcgccc gaagctttaaacatgatgagggacgagcacattaaagtcatcatttccttgttggagaaa cacggaagagatccaaaagtcttggacgtactttgctcgctgtgcgtgggtaacggtgtg gctgttcgatcttcgcagaacaatatctgtgacttcttgctgccaggaaaaaatctcctt cttcaaacgcaactggtcgatcacgtggctagcgttagaccgaacatattcgtcggtaga gtcgagaactcggcgctttatcagaagtggtacttcgaagtcaccgtcgaccacatcgaa cagaccacgcacatgatgccgcatttgagaataggatgggcgaacaccgctgggtacatg ccataccccggtggtggcgagaaatggggtggaaacggtgttggcgacgacctctattca ttcggtttcgacggtgcacatctatggaccggtggtagaaaaactcaagttgttcagaat gtcacggaaccttacatcagaaagagcgacgtgatcggatgtgcattggatctcacagtg cccataatcactttcaccttcaacggagcacctatcatgggatccttccgaaatttcaac ctcgatggcatgttcttccccgcaatcagctgctcgtccaaactatcctgtagattcctg ttaggcggtgatcacggccgactcaagtttcaaccgccagaagaattctcacctttggtg gaaagcttattaccacagcaaattctatctttggatccctgtttctactttggaaacatg aacaaggtggtcctagctggcccatggttggtcgaggacgacacggctttcgtcccagct ccagtcgacacatctatgatcaatttaccatcttacgtcgagcaaatcagagataaacta gctgagaatatccacgagatgtgggcgatgaataaaatcgaagctggttggatatatgga gaacatagggacgatatgagaaagattcatccatgtatcgttcagtttgaacgattacca gctgcagaaaaacgttacgacactcagttggcagtgcaaacactgaagactattctagcc ttgggatattatatcacgatggataaaccaccctctagaataaagactctgaggcttcca aatgaacccttcctgcaaagcagcggatataaaccagcaccactcgatcttagcgccatt acactcacgccaaagatggaagaactggtagaccagcttgcagagaatactcataatttg tgggcaaaggaaaggattagtcagggatggacttatggtctgaacgaggattctgagatg agaaggagcccccatttggtaccctacccgaaggtggacgaagcgatcaagaaagctaat cgtgacaccgccagtgaaactgtgaggacacttttggtttatggatacatgttggaacca cctactggagaacaacacgaagcgctactgttggaagccaacaggttacgacaactatac tttaggacatatcgcgttgagaaacactacgcagtcagtagcggaaagtggtacttcgag ttcgaggtgctgacagctggccctatgcgagtcggttgggcaaaagctgactgctctccc gggaatatgctgggaagcgacgaatccacttgggcttttgacggctataacgtaactaaa gtacacgccggtatccacgagtcatttggtcacagatatcaagtgggcgacgtagttgga tgtttcattgacgtcgcagaccgaacgatcagcttttctctaaacggagaactgttgatg gatgcgctcggtggtgaaacgtctttcgctgacgtgcagggtgattgtttcgtaccagct ttcacgcttggtgttggacaaaaagcaaaattaactttcggacaggatgtaaataccttg aagttctttacgacctgcggtttgcaagagggatacgaaccgttctgtgtgaacatgaat cgtccagttacgtattggtacaccaaggatcaaccaattttcgagaacacggacgatatg gctgacacgaggatagatgtagccaggattccagcgggttccgatactccaccatgttta aagatctctcataacacgttcgaaactatggaaaaggcaaactgggagttcctgcgatta tctttaccggttatttgccaatcgacgtttatttcggaaagtgagaaactaaggagatgg caggaaatcaaaatgcgacagaatagactattgtctgaacaagtggagcaggctcaacag gcagcgccttctgctcaaatagagcagatcatgaggtctggatttagtatgagcgacatt aaaggattacaaagaaactattcggaggatgcagtggaagccgacgaaatgatgaaggag tcaccgcttcccatgcaaagaaacaagccgttgagacctccaagaaagggttccctctat gggtcacgggtcggaaacatggataacgcaattagcgaggttgacatgaatggatacggc gatatgaacggcgacatcaaagacgataagaagaaacgcgggcgctctccgttccgcaaa cttagcaaagaaatggaggatgccccattcttctctcgcaaagcgaagtctccggacgcg aaatcgaaaacgcccgagccaccagtacgttcagacatttctgataagagcaccaagact caatcgatgaacaaagcaagtaaccggcctccccaaattcgcatatcaaacacggacttg aaagtagtgccacctcagatcccagaacgcaacgcaccaaaagcaatgtctatgtctgct ctgagtggaagcggcgtcgaagcaatcggaaatgagatattcgatgcagaatgcttgaaa ttgatgaacgaatacttctacggagtgagaatctttcctggacaggatccaacgcacgtt tatgttggctgggtcacatcccagtatcatttgcatactaaagactttaatctgtctcgc gtgaggaagggctctgtagttattaccgatgactatgatcgtcctatagaacaggttgat agacagagctgctatatggtaagagcggatgagctttacaacgaagtaacgcaagacgca tccggcaagggagcttctcaaggaatgttcgttggatgtttcgtggataccgcaaccggt tgggtgtccttcacttgcgagggaaaggaaactagccacaaattcaagatggaacccgat acgaaattattccctgccatcttcgtagaagctaccagcaaggaaatacttcagattgaa cttggaagaacctccacaacgttaccattatccgctgctgtgttacaaaactcagaacgt catgtgataccacagttcccacctagattgaaggttcaatgtctgaaacctcaccaatgg gcaagagtaccaaatcaatcgcttcaggttcatgccttgaaactgtctgatatcagaggt tggtccatgctgtgcgaggatgccatatcaatgttggctttgcatatccctgaagaggat agatgtatcgatatattggagcttatcgagatggataagttacttagcttccatgcgcac actctgacactgtacgcagctctatgttatcagtcgaattacagagcagcacacgctcta tgccagcacgtcgatcaaaaacaattattgtacgcaattcgagcggaatacatgtccggg cccctacgacaaggattctacgacttgctgatcgccttgcatctcgagtcacacgcgact acgatggaagtgtgcaaaaatgaatacataattcctttaggccaagaactgaaggattta tacgaaaacgaggaaatgaagcacagtctcaggtatctagaaaccgagtcggttcgtcct caaatgaaaatgacagacatcagggatattccttccagcgatcaaacgatcgagaacata aggagcctctacagtccgtacttccctctggatgtagtgcgggactacgtgatgactgca ctgaacgaggccgttgaggtcaatcaagttcacaatcgggaccccattggtggcagcaat gagaatcttttcctgccacttttgaaactagtagacaggttgctcttggtcggaatgctc aggaacgaagacgttatgaagcttctgattatgattcatcctgagacttgggatccgacg tttgacaaagaaggaaaagacgagcacaagaagggactgcttcacatgaaaatggccgaa ggtgcgaaactacagatgtgctatcttcttcatcatctaaacgacatccagcttcgacat cgcgtcgagtccattatcgcatttagccacgacttcgtcggtgatcttcagtccgatcaa cttcggcgttacatcgaaatcaaacaatctgacttaccatcggcagtagcagcgaagaag acaagagaatttcgatgtccacctcgtgaacagatgaatgcgatcttaagtttcaagaat atggaattcgtggatgaccctgagaatagtccttgcggagaagatctgataaatcggatg aatgaattccataacagtctcatgtcctacgtgtccttgcacgccctgcaggaagctgcg gatgccgtggaggaggcagaagacgcagttcagaaacctggcgccattaagaagctattc aactttatcaacgcagtgaaagaactcgaagaggaacctaaacccgaacctgaacccgag agaaagactccagaagaggtgttccgtaaagttctgataaaaaccatcgtcagctgggcc gaggaatcgcaaatcgagactccgaagttggttcgagaaatgttcagtttactggttcgc cagtatgacacggtgggcgagttaattcgagctctagaaaaaacctacgtgaccaacagc aagacaaaggacgacgtcgctttgatgtgggtcggtttgagccaaattcgcgccttactg cctgtacaaatgtctcaagaggaagaagagctcgttcgggaacgactctggaaattagtc aacaatcatacgttcttccagcatccagatttaatcagagtgcttagaattcacgagaac gttatggcgatcatgatgaacacgctaggcagacgtgcacaggcgcaatcggacgctcaa actcagccccaaactaccgaaggagaaccagtttccaaggagaaggatacttctcacgaa atggtggtagcatgctgtagattcctgtgctacttttgtcgaacctccagacagaatcag aaggctatgttcgatcactttgactttttactggagaatagtaatatcttgttatcgaga ccatctttaagaggttccacgccattggacgtggcttattcttccctcatggaaaacacg gaactggctctggctctcagagaacattatcttgaaaaaattgccatatatctatcccgt tgtggtttgcaatcgaattcggaattagttgaaaaaggttatcccgatctgggatgggat ccggtggaaggcgaaagatatttggactttttgaggttctgcgtttgggttaatggtgaa agcgtcgaggaaaatgcaaacttggtgatccgtttgctgatcagaagaccggaatgtctg ggaccagcgcttcgtggcgagggtgagggtctattaagagctatcatagacgccaacaag atgtccgaacgaatcgctgatcgaaggaaagtgcacgacgaagcagaaggtacaacggcg ctcatgcaattcgaacatccgcttccggaatcagacgacgacgaagactatatcgataca ggagctgcgatcttgaacttttactgtaccttggtggacctattaggccgctgcgctcca gattcttctgttatcgaacaagaggcttctacagaatctgtcgggaagaacgagtctctt cgagcgagggctattcttcgatctctggttccactcgatgatctacaaggtgtcctgtct ttgaggttcacgttattgaatcccgcggcaggcgaagagaaaccaaaaagcgatatgccg tctggtttgattcctggacataaacagagcatcgttctgtttttggagcgcgtttacgga atcgaaaccagagaattgttctttaagatactcgaggaagcgtttttgcccgatctcaga gccgccactatgttggataggaacgatggatacgaatcagacatggcgttagcgatgaat cgttacattggaaacagtattctacctttgttgatcaagcattcgaaattctacaacgag gcggataactatgccagcttactggatgctacgttgcacaccgtgtatcgattgagcaag aacagaatgctcactaagggtcaacgtgaagcagtgtcggatttcctcgtggcattgacc agagacgtccacgagttaaatgtctcccaaatgcaacccagcatgttgctgaagctgctt cgaaagctgaccgtagacgtgtccaagctatcagaatatacgacagttgctctaaggttg ctgacccttcactacgatcgttgcgcgaaatattacggatcgaccggtggacaaggcgca tacggtgcatcgagcgatgaagagaaacgcctcactatggtcctcttcagcaacattttc gattcgttatccaagatggactacgacccagaactgtttggaaaagctctaccttgtctc acagctattggttgcgcgttaccgcctgattattcgttgtccaaaaattacgatgacgag tggtacggaagtaaatctgcatctgcacagtcgcctgatggaccttataatcctcagcca atcaatacctctagtgtggtcctcaataacgacctcaatcagatagtgcaaaagttctcc gaacattaccacgacgcttgggccagtcggaaattagaaaacggttggacctacggcgaa cagtggtctgaagtgaacaagactcatcccaggctgaagccgtacaacacgttgaacgat tacgaaagagaacgatacaaagagccagtcagagagagcttaaaagctttattggccata ggatggagcgttgaacatgcagaggtggatgtaccatctaacaatcgtagttccatgaga agatcatcgaaaagtcaagctgattcagcgggtccatttaattataatcctcatccagtt gacatgactaatttgactctgagcagagaaatgcaaaacatggcagagcgtctcgcggat aatgcgcacgatatttgggcgaagaagaagaaggaagaactcattacttgtggaggtggt attcatcctcaactagttccgtatgatcttttgaccgacaaggagaaacgaaaggatcgc gaacgttcccaagaattcctcaagtacctgcaatatcagggttacaagcttcataaacca aatagaggcggggaatcagaagttgcgacggctggagcctcggtggaattacgattcgcc tactcgttacttgaaaagttgatagcctacttggataaagccactatcaacatgaaattg ctgaaaccgtccgacacgttcagtcgtagaaatagctttaaaacgtccacaagagacatc aaattcttcagcaaagttgtcctgccactgatggaaaaatattttagcacacacaaaaac tatttcatcgctgtggcaacggctaccaacaatgtcggagctgcgtccttgaaagagaag gagatggtagcagctctattttgcaaattggccagtttattgagatctagattggctgct ttcgggccggatgttaggatcaccgtccgttgtcttcaagtactagtcaaaggcatagac gcgaagagtttagtgaagaattgtcctgagtttatcagaacgtctatgttaacgttcttc aacaacactgcagatgatttaggacacacgattcttaatcttcaagaggggaaatacagt catctgagaggaacacatttgaagacttctacatccttgtcgtatatcaatagcgtggtt ttgccagtgctcacagccatgttcgatcatttggctgcctgcgagtatggtagcgatttg ctactggacgaaattcaggtggcatcctacaaaatgctggcgtctttatacactctcggt gtagatgcctctctaacacacgacagaaaatatttgaagacagaaatcgagcgtcacaag cccagcttaggttcctgtctaggtgccttttctagttgtttccctgtggccttcctggag ccacatttaaacaagcacaatcagtattcccttttgaatcgtatagccgaccattccttg gaagcacaagatatcatgatgaagatggaatcgagtatgcccaccctagagacgatcttg acggaagtcgatcaattcgtcgagtctgagaaaacctacaacgatcttccccacgtagtt gacattattcttcctctgctttgctcctatctgcctttctggtggtctcaaggcccagac aatgtaaacccgacagaaggaacgtacgtcagcatggttaccagcgatcacatgaatcaa ctgctgaagaacgtattaaagttgattaaaaagaacatcggtaacgaaaatgctccttgg atgactcgtatcgctgcttacactcagcagatcattataaattcatcagaagagttgttg aaggatccattcttaccacttgccgagcgtgtcagaaaacgtacagacactatgttccac aaagaagaatctcttcgtggttttattaaatcatccacggatgacacgtcacaaatcgaa gcacagattcaagaagactggcaacttctggttcgcgatatttactcgttctatcctctt ttgattaagtacgttgatttgcaaaggaatcattggctgaggaataacattccagaagca gaggatctttataatcacgtagcagcgatatttaatatttggtccaagtctcagtacttc ttgagagaagaacaaaacttcatatcggctaatgagatcgataatatggtgctcattatg ccgacagcgaccagaagacctactactatttcggatggaacagcaccttccggaggaggc aagaaaaagaagaagcatcgtgacaagaaaagagacaaagacaaagaagtgcaggcttcc ctaatggtagcctgtttgaagaggttgcttccagttggtctgaacttatttgctggtcgc gaacaagaattagtgcaacactgcaaggacagattcctaaagaagatgccggaatacgag atctcggaattcgcgaagacgcaactcactttgccagacaaaatcgacccagctgacgaa atgtcctggcaacattatctgtactccaaactaggtcagaagaaggattccatggaacca gtgaaagcacaacagctagaggacgtggttgcaaggatcacagacatggccaaagttctt tacggtttacatatgatagatcatccgcaacagcagagcaagggtcaatatcgatccgtg gtgtcgatacaacgtaaacgagcagtgatcgcttgtttccgtcaaacttccctacattcc ctgcccaggcatcgggctataaatatcttcgcgcggacatactacgagctctggttgcag gatgagaatgttggccaagaagtgatgattgaagaccttacgcaatctttcgaggacgcg gaactgaagaaaatggacaaagacgaggacgaaggaaaaccagacccgcttacacaattg gtaacaacattctgtcgtggcgctatgaccgagcgatctggcgctcttcaagaagatccc ttgtacatgagttacgcgcaaattatatcaaaatcttgtggcgaagaggaagaggaaggc gaagacgagggtggaggaggaggcgaagaagaaggtggcgcctcgatccataagcggggc tataagccacttatgcgaccgatgcacaaacttatggaacaagaaatggagaagcagaaa cttcttttccaccaaacgcgtctcgccaatcgtggcgtagcagagatggttctgcttcat atttctgcgtgcaaaggtgtccctagtgaaatggtaatgaagactttggaattgggaatc tctatcctgcgaggtggtaacatagaaattcaacgaggaatgctgaaccacctgaaggaa aagaaggatgtaggcttcttcacttcgattgctggtctcatgaattcctgtagcgtattg gatttggatgcgttcgagaggaacacgaaagcagaaggtcttggagtcggctctgaagga gctgctggagagaagaatatgcacgatgctgaatttacgtgcgccctatttcgattcatt caattgacttgcgaaggccacaatcttgattggcagaattatctgaggacgcaagctggc aacacgacgacggtgaacgtggtcatctgcaccgtcgattatctactacgccttcaggaa tccatcatggacttttactggcattattccagcaaggaactcatcgatcctgctggcaag gctaatttctttaaagctatcggcgttgccagtcaagtattcaatacccttactgaagtg attcaaggaccttgcgctcagaatcaacaggcacttgcccactctcgattgtgggacgct gttggtggattccttttcctcttctctcatatgcaggacaagttatccaaacactcgagt caagtggaccttctgaaggaattgctgaacttacaaaaggatatgatcactatgatgctc tctatgctggaaggtaacgtcgtaaatggaactattggaaagcagatggtggacacgctg gtagaatccgcaagcaacgtcgagttgattctgaaatacttcgacatgttcttgaagctc aaagacctcgtatcgtcgccaagcttcttggaagtggatctcaacagcgatggctgggta tatccgaaagattttaaagagaaaatggaacaacagaagagttacaccgacgaggagatc gaatttttgttggcctgttgcgagacgaaccacgacggtaaaatcgattacgtggctttc atggatcgtttccacgaaccggctaaagaaatcggtttcaatcttgctgttctgttaaca aatttatcagaacatatgccaaatgaaccgagactggcaagatttctggaaacggcaggc tccgtattgaactacttcgaaccgtatcttggaagaatcgaaattctcggtggaaataag aagatcgagcgtgtatacttcgagattaaggagtcgaacatcgagcaatgggagaagccg caaattaaagagtcaaagagaacatacttctataataccgtagttgaagctggagaaaag gaaaaattggagaccttcatcaacttctgcgaggatgctatctttgaaatgcaacacgcg agtgcgctgatggcggtagaagaaagtggaggaatcggaaaggcgagagaatcatcgtac acctatatgacggaggatgacgaagaaagaaacaaagatcccatcagaagaggcattcaa acattcaaggacagcatttacttctttttctccatattctcccctagtaacatcaagaac aagatcgcagaaatgcaacagatgacgttcctggaactcttcattggtttcttcaagatg atattctatgcgttctattattctggttttggcgttggctgtataattggatactttatg aagctattgttggcgttaatgaaaggaccacatgtggaagaacctgtagtcgaggtgaag gaagaggaagaaaagccgataagacatttgcctgctttgccgccaacaccggatgaatct aatctacaggtacaagcgttcggaatggatataacgaaagaagaaggcgggcagataaag atcgcgccccacgaatcggcaacatcgactcctcaatcgagcatcgaagaaacgggcgaa agcacaccggaagaagctactggcgaagaaggtgcaagagctgaaggtggtggagacatg gaatcgcctgtttcattggctgatttattaggaggtgaacaagctagagcccaagcagca gccgcagcagaagcagcggccgctcaacaagcagccatggctgctgtcgaagcggaagcg aaacaggaaacgataacagagccttcaacatctactatcgacttctccgaatacacccat cgtatcgtctccttcttggctagaaacttctacaatctaaaatacgtggctctagttctc gctttctgtatcaatttcatgttgctgttctacaaggttacatcattggccggcgaaggg gatgaggaaggaagcggacaaatgattagtgacatattggcagagatgtctggcgagggt gcatctggttctggaagtggcagtggcatagaaataggcagcgggagcggggaagacgag tcggaagaagaagaagatgcgtacgcgttagaatacgtggaggtgtcggaagatttctat tacatggcacacgttataagactcatggctattcttcatgccatcgtctctcttgctatg ctggttgcctactatcacttgaaagtaccgctggctatcttcaaacgggaaaaggaaatt gcgcgacgcgtagagttcgatggtctgtacattgccgagacgccggaagaagatgacatc aaggcgcattgggacaagatggtgatatcggcgaaaacgttccccgtgaattattgggac aagttcgtgaagaaaaaagttcgacagaaatacagcgagacttacgacttcgattacata agcaacttgcttggcatggaaaagacttcgttcagccaacaagaggaagagggttctggt ttgatacactttatcgtaaatatcgattggagatatcaagtatggaaagctggagtcacc atcacggataacgcatttttgtatagtttatggtatttcacattttcgatccttggcaat tataacaacttcttcttcgctgcgcatttgctggatgtcgcggttggtttcaaaactctg agaacgatcttgcagtccgtcacgcacaatggcaaacaacttgtattaacagtgatgtta ttaactatcgtcgtctatatatacactgtcatagccttcaacttcttcagaaaattctat attcaagaagaggacgacgaagtcgacaagaaatgtcatgatatgttaacgtgcttcgta tttcatctgtacaaaggtgtcagggctggtggtggtatcggtgatgaaattggcgaaccc gatggcgatgactatgaagtctaccgtatcatgtttgatatcactttcttcttcttcgtc attgtcattctattggccattattcaaggtttgatcatcgatgcattcggtgagcttcga gaccagctcgaaaacgtaaaaacgaacatggagagcaactgtttcatttgtggcttagga aaagaatatttcgatacggtaccgcatggtttcgatacacatgttcaacaggagcataat cttgctaattatatgttcttccttatgcacttaatcaacaaaccagacacggaatacacc ggtcaagaaacgtacgtgtggaacatgtatcagcaaaggtgttgggactttttccctgtc ggtgattgcttccgcaaacagaacgaggcagtggaggaagaggcaaagaagaaataa

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